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Search Results: 1 - 10 of 22113 matches for " Olindo Assis;Pereira "
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Humoral immune response of patients bitten by the snake Bothrops erythromelas
Luna, Karla Patricia Oliveira;Xavier, Edeneide Maria;Pascoal, Vanessa Peruhype Magalh?es;Martins-Filho, Olindo Assis;Pereira, Valéria Rêgo Alves;
Revista da Sociedade Brasileira de Medicina Tropical , 2010, DOI: 10.1590/S0037-86822010000600027
Abstract: introduction: snake envenomings are a health problem in rural areas of tropical and subtropical countries, but little is known regarding the immune response presented by bitten individuals. the igm production of patients bitten by bothrops erythromelas snake was analyzed to identify the effectiveness of treatment in this type of envenomation. methods: bothrops erythromelas venom was submitted to electrophoresis and transferred to a nitrocellulose sheet, following incubation with patients' sera. results: a 38 kda protein was detected before and 24 h after therapy. conclusions: the result suggests that this protein could be used as a marker for individuals envenomed by bothrops. erythromelas.
Screening and fractionation of plant extracts with antiproliferative activity on human peripheral blood mononuclear cells
Souza-Fagundes Elaine M,Queiroz Ana BR,Martins Filho Olindo Assis,Gazzinelli Giovanni
Memórias do Instituto Oswaldo Cruz , 2002,
Abstract: Three hundred and thirteen extracts from 136 Brazilian plant species belonging to 36 families were tested for their suppressive activity on phytohemaglutinin (PHA) stimulated proliferation of human peripheral blood mononuclear cells (PBMC). The proliferation was evaluated by the amount of [3H]-thymidine incorporated by the cells. Twenty extracts inhibited or strongly reduced the proliferation in a dose-dependent manner at doses between 10 and 100 μg/ml. Three of these extracts appeared to be non-toxic to lymphocytes, according to the trypan blue permeability assay and visual inspection using optical microscopy. Bioassay-guided fractionation of Alomia myriadenia extract showed that myriadenolide, a labdane diterpene known to occur in this species, could account for the observed activity of the crude extract. Using a similar protocol, an active fraction of the extract from Gaylussacia brasiliensis was obtained. Analysis of the 1H and13C NMR spectra of this fraction indicates the presence of an acetylated triterpene whose characterization is underway. The extract of Himatanthus obovatus is currently under investigation.
Fulminant Nonocclusive Mesenteric Ischemia Just after Hip Arthroplasty
Maria Auxiliadora-Martins,Gil Cezar Alkmin-Teixeira,Omar Feres,Olindo Assis Martins-Filho,Anibal Basile-Filho
Case Reports in Medicine , 2010, DOI: 10.1155/2010/250436
Abstract: Nonocclusive mesenteric ischemia (NOMI) is not a rare clinical entity in intensive medicine, and it can be a consequence of several clinical or surgical situations. This pathology results from reduced intestinal microvascular blood supply associated with an acute inflammatory process, culminating with bowel necrosis. This is a case on a female patient who developed immediate postsurgical NOMI following hip arthroplasty and died. Since diagnosis of this potentially fatal condition remains a dilemma, NOMI should always be considered an eventual postoperative complication in high-risk surgical patients such as elderly individuals with previous history of nicotine abuse, congestive heart failure, and essential hypertension. The present paper highlights the importance of early diagnosis and prompt adequate treatment of NOMI in subjects with diminished cardiac output and severe abdominal pain.
Innate immunity and regulatory T-cells in human Chagas disease: what must be understood?
Sathler-Avelar, Renato;Vitelli-Avelar, Danielle Marquete;Teixeira-Carvalho, Andréa;Martins-Filho, Olindo Assis;
Memórias do Instituto Oswaldo Cruz , 2009, DOI: 10.1590/S0074-02762009000900031
Abstract: there is a general consensus that during chronic trypanosoma cruzi infection, the host immune system induces complex processes to ensure the control of parasite growth while preserving the potential to mount and maintain a life-long controlled humoral and cellular immune response against the invading pathogen. this review summarises evidence in an attempt to elucidate "what must be understood" to further clarify the role of innate immunity in the development/maintenance of clinical chagas disease and the impact of etiological treatment on host immunity, highlighting the contributions of the innate immunity and regulatory t (treg) cells. recently, increasing focus on innate immunity suggest that chronic t. cruzi infection may cause morbidity when innate effector functions, or the down-regulation of adaptive regulatory mechanisms are lacking. in this context, stable asymptomatic host-parasite interactions seem to be influenced by the effector/regulatory balance with the participation of macrophages, natural killer (nk) and cd8+ t cells in parallel with the establishment of regulatory mechanisms mediated by nkt and treg cells. moreover, a balanced innate immune activation state, apart from treg cells, may play a role in controlling the adverse events triggered by the massive antigen release induced by trypanosomicidal agents during chagas disease etiological treatment.
Dênia Monteiro de Moura,Jo?o Cláudio do Carmo Paneto,Eustáquio Resende Bittar,Olindo Assis Martins Filho
Ciência Animal Brasileira , 2009,
Impact of a Non-Saccharomyces Yeast Isolated in the Equatorial Region in the Acceptance of Wine Aroma  [PDF]
Mariana Oliveira Assis, Adriana Pereira Coelho Santos, Carlos Augusto Rosa, Maria Eugênia de Oliveira Mamede
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.59086

The aim of this work was to isolate and identify the yeasts prevalent in fresh grapes cultivated in the “São Francisco Valley” region (Brazil), as well as evaluating the cell growth of these indigenous yeasts during the fermentation of grape musts and their contribution to the improvement of wine aroma. The Chenin Blanc grape must fermented by H. opuntiae presented higher acceptance means at the three points analyzed (6.74, 6.78 and 7.30) and in the fermentation carried out by the yeasts H. opuntiae and S. cerevisiae, the highest mean acceptance (7.22) was observed after 120 hours, with no statistical difference from the sample fermented by H. opuntiae alone. Since these samples that showed higher acceptance means also receiving higher scores for purchasing intention, corresponding to the concepts of “definitely would buy” and “probably would buy”. The present study suggests that the fermentations of grape musts carried out by the yeast H. opuntiae and mixed cultures of H. opuntiae and Saccharomyces cerevisiae, positively influenced the sensory qualities of the wines and showed greater potential to increase the aroma of the musts and to develop specific wine styles.

Floristica da restinga de Camburi, Vitória, ES
Pereira, Oberdan José;Assis, André Moreira de;
Acta Botanica Brasilica , 2000, DOI: 10.1590/S0102-33062000000100009
Abstract: the flora of the camburi restinga in the municipality of vitoria, espírito santo state, brazil, was surveyed and vegetation types were classified. monthly visits to the area resulted in a list of 211 species from 70 plant families of which the most important, according to species richness, were fabaceae (19), myrtaceae (14), euphorbiaceae (10), rubiaceae (10), cyperaceae (9), sapindaceae (7) and lauraceae (7). this coastal plain still supports remnant patches of dry restinga forest, open ericaceae scrub and sedge marsh, as well as disturbed areas dominated by pioneer species. most of the species are widely distributed along the brazilian coast other patterns, however, being found. erythmxylum tenue plowman, ocotea nutans (nees) mez, miconia brevipes benth., prescottia pilntaginea lindl., pseudolaelia vellozicola (hoehne) porto & brade and coccocypselum hirsutum bartl. ex dc. are reported for the first time in the restingas of espírito santo.
Poema sujo: dois tempos, dois sujeitos num corpo lírico = Dirty poem: two times, two subjects in a lyrical body
Assis, Maria do Socorro Pereira de
Letras de Hoje , 2011,
Abstract: O Poema sujo, de Ferreira Gullar, é o corpo lírico sobre o qual especulamos a existência da voz de um sujeito histórico transubstanciada numa linguagem que acolhe o passado e o presente no mesmo instante. Essa voz possui a aparência do real, sem sê-lo; nela há signos que atestam o objeto temporal situado, ao mesmo tempo em que o fazem eterno. No encontro do regime estético da arte proposto por Jacques Ranciére, com a ideia de memória engajada – síntese teórica de proposi es de Jean Paul Sartre e Paul Ricoeur – discutimos o duplo caráter desse poema que tem sido visto apenas como memorialístico, afirmando o dasein de uma poética de amalgamento de pensamento e linguagem. Le Poema sujo [Poème sale], de Ferreira Gullar, est le corps lyrique à partir duquel est spéculée l’existence de la voix d’un sujet historique transformée en un langage qui accueille en même temps le passé et le présent. Cette voix possède l’apparence du réel sans l’être, elle est porteuse de signes qui attestent de l’objet temporel tout en le rendant éternel. En partant du régime esthétique de l’art proposé par Jacques Rancière et l’idée de mémoire engagée – une synthèse théorique des propositions de Jean-Paul Sartre et Paul Ricoeur – ce travail analyse le double caractère de ce poème jusqu’alors simplement per u comme mémorialistique, en affirmant le dasein d’une poétique mêlant pensée et langage. $$bfre
Ovarian cancer and DNA repair: DNA ligase IV as a potential key
Joana Assis,Deolinda Pereira,Rui Medeiros
World Journal of Clinical Oncology , 2013, DOI: 10.5306/wjco.v4.i1.14
Abstract: Ovarian cancer (OC) is the sixth most common cancer and the seventh cause of death from cancer in women. The etiology and the ovarian carcinogenesis still need clarification although ovulation may be determinant due to its carcinogenic role in ovarian surface epithelium. The link between ovarian carcinogenesis and DNA repair is well established and it became clear that alterations in DNA damage response may affect the risk to develop OC. Polymorphisms are variations in the DNA sequence that exist in normal individuals of a population and are capable to change, among other mechanisms, the balance between DNA damage and cellular response. Consequently, genetic variability of the host has a great role in the development, progression and consequent prognosis of the oncologic patient as well as in treatment response. Standard treatment for OC patients is based on cytoreductive surgery, followed by chemotherapy with a platinum agent and a taxane. Although 80% of the patients respond to the first-line therapy, the development of resistance is common although the mechanisms underlying therapy failure remain mostly unknown. Because of their role in oncology, enzymes involved in the DNA repair pathways, like DNA Ligase IV (LIG4), became attractive study targets. It has been reported that variations in LIG4 activity can lead to a hyper-sensitivity to DNA damage, deregulation of repair and apoptosis mechanisms, affecting the susceptibility to cancer development and therapy response. To overcome resistance mechanisms, several investigations have been made and the strategy to target crucial molecular pathways, such as DNA repair, became one of the important areas in clinical oncology. This review aims to elucidate the link between DNA repair and OC, namely which concerns the role of LIG4 enzyme, and how genetic polymorphisms in LIG4 gene can modulate the activity of the enzyme and affect the ovarian carcinogenesis and treatment response. Moreover, we try to understand how LIG4 inhibition can be a potential contributor for the development of new cancer treatment strategies.
Orthokeratinized odontogenic cyst: a report of two cases in the mandible = Cisto odontogênico ortoqueratinizado: relato de dois casos em mandíbula
Pereira, Francisco de Assis Caldas et al.
Revista Odonto Ciência , 2012,
Abstract: Objetivo: Descrever os aspectos clinicopatológicos de dois casos de cisto odontogênico ortoqueratinizado e a compará-los a relatos anteriores. Relato do caso: No caso 1, uma mulher de 17 anos de idade, apresentou edema endurecido e indolor na mandíbula posterior esquerda. Radiograficamente, uma área radiolúcida com uma radiopacidade foi observada. O diagnóstico clínico de ameloblastoma ou tumor odontogênico ceratocístico foi estabelecido. O exame histopatológico revelou um cisto odontogênico ortoqueratinizado. No caso 2, uma mulher de 23 anos apresentou duas les es radiolúcidas circundadas por halos radiopacos simetricamente distribuídas, associada aos terceiros molares inferiores irrompidos. Um diagnóstico clínico de cisto dentígero bilateral (DC) foi estabelecido. O exame histopatológico mostrou ser um cisto odontogênico ortoqueratinizado. Conclus o: Cisto odontogênico ortoqueratinizado deve ser considerado no diagnóstico diferencial das les es que ocorrem na mandíbula associado com dentes impactados, especialmente aqueles casos que simulem o cisto dentígero. Além disso, observamos a importancia de tomadas radiográficas antes do tratamento ortod ntico no diagnóstico de patologias bucais. Purpose: To describe the behavior clinical and pathological features of two cases of odontogenic cyst orthokeratinized. Case description: In case 1, a 17-year-old woman presented hard and painless swelling in the left posterior mandible. Radiographically, a radiolucent area with a radiopaque was observed. A clinical diagnosis of ameloblastoma or odontogenic keratocystic tumor was established. The histopathological examination revealed an orthokeratinized odontogenic cyst. In case 2, a 23-year-old woman presented a radiolucent lesion surrounded by radiopaque halo symmetrically distributed on both partially erupted lower third molars. A clinical diagnosis of bilateral dentigerous cyst (DC) was rended. The histopathological examination showed bilateral orthokeratinized odontogenic cyst. Conclusion: Orthokeratinized odontogenic cyst should be considered in the differential diagnosis of lesions occurring in the jawbones associated with an impacted tooth, particularly those cases simulating dentigerous cyst. In addition, we observed the importance of radiographs taken prior to orthodontic treatment as an important tool in the diagnosis of oral pathologies. Performing routine radiograph is of high clinical value, especially before orthodontic treatment.
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