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Search Results: 1 - 10 of 191411 matches for " Olimpia D'Onofrio "
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A new mutant genetic resource for tomato crop improvement by TILLING technology
Silvia Minoia, Angelo Petrozza, Olimpia D'Onofrio, Florence Piron, Giuseppina Mosca, Giovanni Sozio, Francesco Cellini, Abdelhafid Bendahmane, Filomena Carriero
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-69
Abstract: To apply TILLING to tomato, a new mutant collection was generated in the genetic background of the processing tomato cultivar Red Setter by treating seeds with two different ethylemethane sulfonate doses (0.7% and 1%). An associated phenotype database, LycoTILL, was developed and a TILLING platform was also established. The interactive and evolving database is available online to the community for phenotypic alteration inquiries. To validate the Red Setter TILLING platform, induced point mutations were searched in 7 tomato genes with the mismatch-specific ENDO1 nuclease. In total 9.5 kb of tomato genome were screened and 66 nucleotide substitutions were identified. The overall mutation density was estimated and it resulted to be 1/322 kb and 1/574 kb for the 1% EMS and 0.7% EMS treatment respectively.The mutation density estimated in our collection and its comparison with other TILLING populations demonstrate that the Red Setter genetic resource is suitable for use in high-throughput mutation discovery. The Red Setter TILLING platform is open to the research community and is publicly available via web for requesting mutation screening services.Tomato (Solanum lycopersicum) is one of the most important vegetable plants in the world. Its fruits are end products both for the fresh market and food processing industry. Tomato presents a relatively small genome highly syntenic to others economically important Solanaceae species and was selected as a reference species for sequencing a Solanaceae genome. In addition to the availability of a number of genomic resources, including transcriptome [1-3] and metabolome [4], large collections of genetic resources are available to dissect the biochemical and the metabolic pathways in tomato [5]. Large EMS and fast neutron mutant collections, in the background of M82 tomato cultivar, have been generated and more then 3,000 phenotype alterations catalogued [6]. An EMS-induced mutation library of the miniature dwarf tomato cultivar Mi
Concep o retórica e concep o semantica da metáfora
Salvatore D'Onofrio
Alfa : Revista de Linguística , 2001,
Abstract: O Autor realiza um estudo sobre as duas principais teorias surgidas para o entendimento da estrutura e do funcionamento do processo metafórico: a teoria retórica, que considera a metáfora apenas como uma figura de estilo, e a teoria semantica, que vê na metáfora o princípio onipresente e indispensável para a renova o da linguagem humana e para a cria o do texto poético.
Os motivos da sátira romana
Salvatore D'Onofrio
Alfa : Revista de Linguística , 2001,
SUSY Searches with Jets at CDF
M. D'Onofrio
Physics , 2008,
Abstract: We present the most recent results on searches for squarks and gluinos in ppbar collisions at sqrt(s)=1.96 TeV, in events with large missing transverse energy, leptons and multiple jets in the final state, based on 1.8 to 2.8 fb-1 of data collected by the CDF Run II detector at the Tevatron. No evidence of new physics is found and exclusion limits in several MSSM scenarios are extracted.
Beauty production cross section measurements at Ecm=1.96 TeV
Monica D'Onofrio
Physics , 2005,
Abstract: The RunII physics program at the Tevatron started in spring 2001 with protons and antiprotons colliding at an energy of $\sqrt{s}$=1.96 TeV, and it is carrying on with more than 500 pb-1 of data as collected by both the CDF and D0 experiments. Recent results on beauty production cross section measurements are here reported.
Fractal growth of tumors and other cellular populations: Linking the mechanistic to the phenomenological modeling and vice versa
Alberto d'Onofrio
Quantitative Biology , 2013, DOI: 10.1016/j.chaos.2008.04.014
Abstract: In this paper we study and extend the mechanistic mean field theory of growth of cellular populations proposed by Mombach et al in (Mombach J. C. M. et al., Europhysics Letter, 59 (2002) 923) (MLBI model), and we demonstrate that the original model and our generalizations lead to inferences of biological interest. In the first part of this paper, we show that the model in study is widely general since it admits, as particular cases, the main phenomenological models of cellular growth. In the second part of this work, we generalize the \emph{MLBI} model to a wider family of models by allowing the cells to have a generic unspecified biologically plausible interaction. Then, we derive a relationship between this generic microscopic interaction function and the growth rate of the corresponding macroscopic model. Finally, we propose to use this relationship in order to help the investigation of the biological plausibility of phenomenological models of cancer growth.
A general framework for modeling tumor-immune system competition and immunotherapy: mathematical analysis and biomedical inferences
Alberto d'Onofrio
Quantitative Biology , 2013, DOI: 10.1016/j.physd.2005.06.032
Abstract: In this work we propose and investigate a family of models, which admits as particular cases some well known mathematical models of tumor-immune system interaction, with the additional assumption that the influx of immune system cells may be a function of the number of cancer cells. Constant, periodic and impulsive therapies (as well as the non-perturbed system) are investigated both analytically for the general family and, by using the model by Kuznetsov et al. (V. A. Kuznetsov, I. A. Makalkin, M. A. Taylor and A. S. Perelson. Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis. Bulletin of Mathematical Biology 56(2): 295-321, (1994)), via numerical simulations. Simulations seem to show that the shape of the function modeling the therapy is a crucial factor only for very high values of the therapy period $T$, whereas for realistic values of $T$, the eradication of the cancer cells depends on the mean values of the therapy term. Finally, some medical inferences are proposed.
A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA
David J D'Onofrio, Gary An
Theoretical Biology and Medical Modelling , 2010, DOI: 10.1186/1742-4682-7-3
Abstract: Presented herein is a descriptive framework that compares DNA and its associated proteins and sub-nuclear structure with the structure and function of the computer hard drive. We identify four essential properties of information for a centralized storage and processing system: (1) orthogonal uniqueness, (2) low level formatting, (3) high level formatting and (4) translation of stored to usable form. The corresponding aspects of the DNA complex and a computer hard drive are categorized using this classification. This is intended to demonstrate a functional equivalence between the components of the two systems, and thus the systems themselves.Both the DNA complex and the computer hard drive contain components that fulfill the essential properties of a centralized information storage and processing system. The functional equivalence of these components provides insight into both the design process of engineered systems and the evolved solutions addressing similar system requirements. However, there are points where the comparison breaks down, particularly when there are externally imposed information-organizing structures on the computer hard drive. A specific example of this is the imposition of the File Allocation Table (FAT) during high level formatting of the computer hard drive and the subsequent loading of an operating system (OS). Biological systems do not have an external source for a map of their stored information or for an operational instruction set; rather, they must contain an organizational template conserved within their intra-nuclear architecture that "manipulates" the laws of chemistry and physics into a highly robust instruction set. We propose that the epigenetic structure of the intra-nuclear environment and the non-coding RNA may play the roles of a Biological File Allocation Table (BFAT) and biological operating system (Bio-OS) in eukaryotic cells.The comparison of functional and structural characteristics of the DNA complex and the computer hard
“Of the Virus Party”: Ecofeminist Perspectives on Dissent in AIDS Science.
Anderlini-DOnofrio, Serena
Nebula , 2004,
Abstract: My analysis of the controversies in AIDS science demonstrates that due to the influence of the allopathic scientific collective, the course of mainstream research about the disease has been overdetermined. During the disease’s early outbreaks, allopathic medicine dominated medical discourse. As a result, AIDS science focused on infectious rather than environmental and ecological causes. Later, this focus caused controversies voiced by dissenters from a more holistic perspective. I argue that persisting uncertainties in the etiology of AIDS challenge conventional understandings of this disease. In an ecofeminist perspective, these challenges can be seen as signs of an important shift in the philosophy of health. Thomas Kuhn would describe this shift as harbinger of a “scientific revolution,” resulting from a new “scientific paradigm” struggling to get center stage. If, as ecofeminists claim, the Earth is an animated being and not a Cartesian res extensa, humans are particles of the larger superorganism environmentalists often call Gaia. In this perspective, AIDS is an illness of the biosphere that affects its human particles. This planetary illness denotes toxicity in Gaia’s body, including its air, soil, and waters. If so, AIDS reads as an environmental disease, not an infectious one. This hypothesis is based on a holistic philosophy of health, which is the major current challenge to allopathic philosophy. In his article, I argue that AIDS can be situated at the interstice between cause and effect in the paradigm change, where the collision of two modes of thinking produces new perspectives.
Inclusive Search for Squarks and Gluinos Production at CDF
Monica D'Onofrio,for the CDF Collaboration
Physics , 2007,
Abstract: We present preliminary results on a search for squarks and gluinos in proton-antiproton collisions with a center-of-mass energy of 1.96 TeV and based on 1.1 fb-1 of data collected by the CDF detector in the Tevatron Run II. Events with multiple jets of hadrons and large missing transverse energy in the final state are studied within the framework of minimal supergravity and assuming R-parity conservation. No excess with respect to Standard Model predictions is observed and new limits on the gluino and squark masses are extracted.
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