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Search Results: 1 - 10 of 4960 matches for " Olga DelaRosa "
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Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential
Olga DelaRosa,Eleuterio Lombardo
Mediators of Inflammation , 2010, DOI: 10.1155/2010/865601
Abstract: Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both chronic inflammatory and autoimmune diseases. Toll-like receptors (TLR) ligands have been linked with the perpetuation of inflammation in a number of chronic inflammatory diseases due to the permanent exposure of the immune system to TLR-specific stimuli. Therefore, MSCs employed in therapy can be potentially exposed to TLR ligands, which may modulate MSC therapeutic potential in vivo. Recent results demonstrate that MSCs are activated by TLR ligands leading to modulation of the differentiation, migration, proliferation, survival, and immunosuppression capacities. However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role. Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies. In this review, we discuss the available data on the modulation of MSCs activity through TLR signalling. 1. Introduction Adult mesenchymal stem cells (MSCs) represent an innovative tool for cell-based therapy of degenerative disorders, chronic inflammatory, and autoimmune diseases or allograft rejection. The understanding of the mechanisms that mediate and/or modulate the therapeutic potency of MSCs is important from both a physiological and a clinical point of view. In this context, one key interest is to better understand the modulation of MSC biology by Toll-like receptors (TLRs) as they have been linked to the perpetuation of chronic inflammatory responses (Chron’s disease, Rheumatoid Arthritis) through the recognition of conserved pathogen-derived components or endogenous ligands (also known as “danger signals”) that MSCs will likely encounter in the sites of injury. Here we will review the most recent data on these topics. 2. Adult Mesenchymal Stem Cells and Cell Therapy 2.1. Differentiation Capacity of MSCs MSCs have been isolated from multiple tissues of mesodermal origin, such as bone marrow (BM-MSCs), adipose tissue (AD-MSCs), umbilical cord blood and peripheral blood. MSCs can be easily isolated by adhesion to plastic and expanded in vitro in serum containing media with no additional requirements for growth factors or cytokines. In culture, they acquire a fibroblast-like morphology. Despite ample efforts, no exclusive surface markers have been identified for MSCs. Thus, to date they are defined according to the criteria of the International
Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
María Pita-Lopez, Inmaculada Gayoso, Olga DelaRosa, Javier G Casado, Corona Alonso, Elisa Mu?oz-Gomariz, Raquel Tarazona, Rafael Solana
Immunity & Ageing , 2009, DOI: 10.1186/1742-4933-6-11
Abstract: Peripheral blood from HLA-A2 healthy young, middle-aged and elderly donors was analysed by multiparametric flow cytometry using the HLA-A*0201/CMV pp65495–504 (NLVPMVATV) pentamer and mAbs specific for the molecules analysed. The frequency of CMV pp65-specific CD8 T cells was increased in the elderly compared with young and middle-aged donors. The proportion of na?ve cells was reduced in the elderly, whereas an age-associated increase of the CCR7null effector-memory subset, in particular those with a CD45RAdim phenotype, was observed, both in the pentamer-positive and pentamer-negative CD8 T cells. The results also showed that most CMV pp65-specific CD8 T cells in elderly individuals were CD27/CD28 negative and expressed CD85j and CD244.The finding that the phenotype of CMV pp65-specific CD8 T cells in elderly individuals is similar to the predominant phenotype of CD8 T cells as a whole, suggests that CMV persistent infections contributes to the age-related changes observed in the CD8 T cell compartment, and that chronic stimulation by other persistent antigens also play a role in T cell immunosenescence. Differences in subset distribution in elderly individuals showing a decrease in naive and an increase in effector-memory CD8 T cells may be relevant in the age-associated defective immune response.Human cytomegalovirus (CMV) infection in immunocompetent individuals is normally asymptomatic, but can be a major cause of morbility in immunosuppressed individuals. After primary infection the virus persists throughout life in a latent form in a variety of tissues, particularly in precursor cells of the monocytic lineage [1]. Host defence against infection by CMV is ensured in great part by cytotoxic CD8 T lymphocytes directed against the tegument protein pp65 [2]. In immunosuppressed, and occasionally immunocompetent persons, CMV can be reactivated and, in these situations, the presence of CMV-specific CD8 T cells which are not producing IFNγ, and therefore potentially
Comments for Current Interpretation EEG Alpha Activity: A Review and Analysis  [PDF]
Olga Bazanova
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.22027
Abstract: Introduction: Exploring the EEG alpha oscillations generates considerable interest because there is well known its role in cognitive and psycho emotional aspects of human life. However, till now there isn’t well determined definition what is alpha activity phenomena and which indices are characterize it. Method: This article focuses on the attempt to determine EEG alpha-activity phenomena, its physical, molecular and morphological nature, to highlight its indices and their role in optimal functioning. Results: Specifically, this article examines individual alpha activity indices: 1) the individual alpha peak frequency; 2) activation magnitude measured by estimation the amount of alpha amplitude suppression in response to eyes open and individual alpha band width; 3) three alpha “autorhythmicity” indices: intra-spindle amplitude variability, spindle length and steepness. Conclusions: Throughout, the article provides a number of suggestions which alpha activity indices and in which conditions could be applied in psycho physiological investigations, what is their role in optimal functioning and what are possible directions for future research.
Legal Support of Planning in the PRC  [PDF]
Olga Kucher
Beijing Law Review (BLR) , 2013, DOI: 10.4236/blr.2013.42007
Abstract:

Looking at the Peoples Republic of China (PRC) reforms it is necessary to mention that they were not resulted from foreign experts or from other countries experience they were a result of a long term Chinese strategy. This strategy includes such aspects as economy system, social benefits national safety provided that PRC is open to international influence. This long term strategy has its main tools of planning system. With the help of such system government can control all market processes which, for sure, lead to the growth and success in economy. Alongside of such model, Chinese government before and nowadays use methods of direct and indirect regulations as well as administrative influence. It means that such government interference in market process will make state structures powerful and experienced players in this game. It is necessary to say that in the period of globalized world economy multinational corporations started influencing all processes more and more, and we need to review role of government regulation. In this work next step will be directed at legal support and identification of effective government functions which can influence and control private sector. These government functions regulation can help to create balance between state, private assets and international organization in order to have a good basis for competitive world economic position. The article has a purpose to analyze key features of Chinese planning system, distinguish peculiarities and apply to other systems. In the article following methods are used chronological development of the system starting from the beginning; dialectical method of making conclusion basing on facts; and elements of comparative analysis. Result of this article is opportunity to apply such characteristics to other countries.

Modification of Steel Surface Using the Laser Energy Olga Chudina  [PDF]
Olga Chudina
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2014, DOI: 10.4236/jsemat.2014.44021
Abstract:

The article is devoted to surface hardening of steels by alloying with the use of laser energy. Two combined technologies were proposed: first—laser alloying by nitride-forming elements followed by nitriding, and secondthe local laser alloying followed by metallization in atmosphere of ammonia. It is shown that laser alloying in continuous radiation forms a layer with a homogeneous fine-grained structure with thickness of 600 microns. The subsequent nitriding increases the microhardness of the surface layer of low-carbon steels to 20,000 MPa, increases wear-resistance in a 3 - 15 times and crack resistance in a 1.5 times. Two-stage technology of metallization allows getting diffusion layer on the surface of steels with the thickness, which is 1.5 - 2 times higher than after traditional metallization. In addition, this method of surface modification can significantly reduce the temperature of diffusion metallization and reduce the processing time to 3 hours. The optimal regimes of both technologies, which provide homogeneous multiphase diffusion layers with high hardness and wear resistance, were determined.

The Significance and Role of Aesthetic Education in Schooling  [PDF]
Olga Denac
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.519190
Abstract: Every child needs planned, aesthetic education in order to influence the experiencing, feeling and enjoying of beautiful things as a counterbalance to our currently rationalized world. Since the contemporary school strives for the development of professional knowledge and skills on the basis of intellectual actions, while (at the same time) neglecting other dimensions of the child’s personality (emotions, feelings, etc.), it is one of the most important tasks of the education of children and young people to develop the ability to enjoy art and beauty, and in one’s inner and outer life to act in accordance with a sense of proportion, harmony and beauty. The purpose of the article is to highlight the significance of aesthetic education in the development of the personality as a whole, to shed light on the aims of aesthetic education, to define the aesthetic dimension of experience and to ascertain the reasons for the neglect of aesthetic education in theory and practice.
Siblings of a Child with a Serious Disease: Educational Family Guidelines for Developing the Emotional Health of This Minority Group  [PDF]
Olga Lizasoain
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.38005
Abstract: Diagnosis of a serious disease in childhood is a traumatic experience, not only for the sick child but also for those living in the same environment. The family life changes drastically, and the family members go through a period of time which is both hard and full of the unknown. Fear, confusion, anger and sadness will be the principal feelings present in each one of the family members. The sick child becomes the central focus of attention at the expense of the other children in the family, children who now take a secondary role, shifting into the background. Therefore, it is very important to offer support and give special care to these other children, not excluding them from everything that is occurring in the family. This article focuses on the feelings experienced by these group of siblings. The adaptation process when facing this difficult situation will be analyzed and educational guidelines which can help the family manage the emotional impact made by the serious disease will be offered, putting special emphasis on communication.
Carrying out the Principle of Horizontal Connectedness and Professional Justification in the Planned Curriculum for Kindergartens in the Field of Music Education  [PDF]
Olga Denac
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.617191
Abstract: The article presented the results of a study which included 159 pre-school teachers from all over Slovenia. The aim of the research was to determine whether teachers in the process of operative planning of the educational process account for the principles of horizontal integration and professional justification. We analyzed the planned curriculum in terms of structure, activities, goals, principles and contents. The results of the research show that the music education has been losing professional autonomy within the field of art, as kindergarten teachers only partially carry out individual principles of the curriculum in the planning of the educational process.
Malnutrition and Mortality Patterns among Internally Displaced and Non-Displaced Population Living in a Camp, a Village or a Town in Eastern Chad
Gilles Guerrier,Mala?ka Zounoun,Olimpia Delarosa,Isabelle Defourny,Michelo Lacharite,Vincent Brown,Biagio Pedalino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008077
Abstract: Certain population groups have been rendered vulnerable in Chad because of displacement of more than 200,000 people over the last three years as a result of mass violence against civilians in the east of the country. The objective of the study was to assess mortality and nutritional patterns among displaced and non-displaced population living in camps, villages and a town in the Oudda? and Salamat regions of Chad.
Recent Developments in the Nasal Immunization against Anthrax  [PDF]
Sandra Jesus, Olga Borges
World Journal of Vaccines (WJV) , 2011, DOI: 10.4236/wjv.2011.13008
Abstract: Bacillus anthracis is the causative agent of anthrax, a bacterial infection with a high mortality rate [1-3]. Although anthrax infection can be cutaneous, gastrointestinal or pulmonary, the pulmonary form is the most deadly [2,3]. Thus, the release of Bacillus anthracis spores that can be inhaled represents a potent bioterrorism threat; the capacity of B. anthracis spores to act as a bioterrorism weapon was demonstrated in 2001, with the intentional infection of 22 persons in the U.S.A. [2,4]. Until recently, the available vaccines were developed to confer protection against cutaneous infection; despite this, these vaccines demonstrated experimental efficacy against pulmonary infection in multiple animal models [1,2]. Nevertheless, there are many limitations for these vaccines to be considered successful and effective vaccine, including the intensity of the required vaccination schedule, the administration route and the presence of local adverse effects experienced after vaccination [1,3,5,6]. To develop more efficient vaccines against pulmonary anthrax, intranasal formulations with adjuvant have been studied. These formulations have advantages because they are easy to administer and because they are expected to induce both systemic and respiratory tract mucosal immune responses. Therefore, the main goal of this review is to compare the different experimental adjuvants used with anthrax antigens and the different approaches regarding the vaccination schedule and consecutive boosters.
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