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Search Results: 1 - 10 of 1348 matches for " Ola Samuelsson "
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Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms
Lynn R Goldin, Magnus Bj?rkholm, Sigurdur Y Kristinsson, Jan Samuelsson, Ola Landgren
Genome Medicine , 2009, DOI: 10.1186/gm55
Abstract: Although many cancers show familial clustering, identification of the predisposing germline genes is challenging. Mutations in genes such as p53, BRCA1, CDKN2 and HNPCC causing high risk of tumors (often at an early age) were discovered from studies of rare families with striking tumor clusters [1]. However, these mutations explain only a small fraction of cancer susceptibility in the general population. More common cancers among older individuals also show familial aggregation and are probably the result of a combination of germline genes and environmental or other factors. The attempt to identify common susceptibility genes with smaller effects has been facilitated by the ability to conduct large-scale genome-wide association studies in cases and controls.Somatic changes found in tumors may also be a result of germline susceptibility genes in the same region. Three recent articles in Nature Genetics [2-4] successfully demonstrate the potential of this approach by identifying a gene involved in susceptibility to developing chronic myeloproliferative neoplasms (MPNs) that is likely to have both germline and somatic effects. It is useful to review the recent history around this discovery and determine the lessons learned that could be applied to other cancers.On the basis of the current World Health Organization criteria, MPNs include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (MF) [5]. They are all stem-cell-derived clonal proliferative diseases whose shared and diverse phenotypic characteristics can be attributed to dysregulated signal transduction because of acquired somatic mutations [6]. They are uncommon tumors with yearly incident rates of 2.3 in 100,000 in the United States [7] and primarily affect older adults, with a variable clinical presentation. For example, approximately half of all MPN patients are reported to be asymptomatic at diagnosis [5,8]. Among PV and ET patients, the major symptoms are associated with hyper
Twiddler’s Syndrome in a Patient with Dystonic Tremor Treated with DBS  [PDF]
Jennifer Samuelsson, Patric Blomstedt
Open Journal of Modern Neurosurgery (OJMN) , 2014, DOI: 10.4236/ojmn.2014.44034
Abstract: Background and Importance: Twiddler’s syndrome is a rare complication of DBS. This condition occurs when the IPG is consciously or inadvertently rotated in its pocket, resulting in torsion and possible dislodgement of implanted electrodes, with subsequent loss of function. Methods: Here we present a patient diagnosed with Twiddler’s syndrome. The patient presented with straining cables at the neck five months after bilateral Gpi DBS and an x-ray demonstrated Twiddler’s syndrome. Initial revision with preventive measures proved futile. After some time the condition recurred, now with dislocation of one of the intracerebral electrodes. In a second revision the IPG was placed under the pectoralis muscle, which has so far prevented further rotation. Results and Conclusion: While Twiddler’s syndrome is fairly uncommon, it remains to be a risk associated with DBS, recognizing the potential risks and signs might allow for preventive measures avoiding dislocation of the intracerebral electrodes.
Building up Systematic Client-Centred Data as a Base for Clinical Outcome within Outpatient Neurorehabilitation  [PDF]
Jessica Vollertsen, Kersti Samuelsson
Open Journal of Therapy and Rehabilitation (OJTR) , 2016, DOI: 10.4236/ojtr.2016.41002
Abstract: Objective: This study describes the development and use of a specific database supporting personnel within outpatient neurological rehabilitation to reflect on existing interventions and improve future rehabilitation. Methods: Five outpatient rehabilitation centres in one county council in Sweden were involved in developing and implementing a systematic data collection template within the existing digital medical record system. Data were collected to get more information on the effects of outpatient stroke rehabilitation in patients who received rehabilitation the first year after a stroke (ICD-I64) and patients who received further rehabilitation 1 year or more after a stroke (ICD-I69). Data analysis included evaluation of balance, movement, activity/participation, health-related quality of life, and self-rated health. Results: The ICD-I64 group had positive results after treatment (p < 0.05) for all variables and the ICD-I69 group had positive results for balance and activity/participation. Conclusions: The use of systematic data collection provided a platform for employees and managers to discuss and use clinical results to improve the type and quality of rehabilitation interventions.
Wheelchair Seating: Peak Pressure Distribution in Young versus Elderly Healthy Controls  [PDF]
Marina Timm, Kersti Samuelsson
Open Journal of Therapy and Rehabilitation (OJTR) , 2019, DOI: 10.4236/ojtr.2019.72003
Abstract: Background: People may use a wheelchair when they need assistance with mobility. Some users have to remain seated in their wheelchair for most of their awake time and for a lot of activities. The need for a well fitted and supportive wheelchair is important and, for those who use the wheelchair for many hours, peak pressure distribution is of interest to prevent pressure ulcers and discomfort. Aim: To describe how high local peak pressures may be distributed over risk areas for pressure ulcers in different wheelchair settings. Methods: Two groups of healthy adults were recruited (40 elderly and 30 younger individuals). Two standard models of manual wheelchairs were used together with two types of wheelchair cushions. Results: The elderly group had a higher peak pressure over the ischial tuberosity and increased posterior pelvic rotation in the shaped seat cushion. Both groups had higher peak pressure over the trochanter in the shaped seat cushion. Peak pressure was also higher over the coccyx for the elderly in the shaped seat cushion compared with the plain cushion; this was lower for the younger group. Discussion: The results indicate that age might influence the important physical prerequisites when fitting a wheelchair to an individual.
Oxidative Stress and Inflammation in Renal Patients and Healthy Subjects
Diana M. Lee, Kenneth W. Jackson, Nicholas Knowlton, Joshua Wages, Petar Alaupovic, Ola Samuelsson, Aso Saeed, Michael Centola, Per-Ola Attman
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022360
Abstract: The first goal of this study was to measure the oxidative stress (OS) and relate it to lipoprotein variables in 35 renal patients before dialysis (CKD), 37 on hemodialysis (HD) and 63 healthy subjects. The method for OS was based on the ratio of cholesteryl esters (CE) containing C18/C16 fatty acids (R2) measured by gas chromatography (GC) which is a simple, direct, rapid and reliable procedure. The second goal was to investigate and identify a triacylglycerol peak on GC, referred to as TG48 (48 represents the sum of the three fatty acids carbon chain lengths) which was markedly increased in renal patients compared to healthy controls. We measured TG48 in patients and controls. Mass spectrometry (MS) and MS twice in tandem were used to analyze the fatty acid composition of TG48. MS showed that TG48 was abundant in saturated fatty acids (SFAs) that were known for their pro-inflammatory property. TG48 was significantly and inversely correlated with OS. Renal patients were characterized by higher OS and inflammation than healthy subjects. Inflammation correlated strongly with TG, VLDL-cholesterol, apolipoprotein (apo) C-III and apoC-III bound to apoB-containing lipoproteins, but not with either total cholesterol or LDL-cholesterol. In conclusion, we have discovered a new inflammatory factor, TG48. It is characterized with TG rich in saturated fatty acids. Renal patients have increased TG48 than healthy controls.
Plants used in traditional medicine as sources of drugs
Gunnar Samuelsson
Bulletin of the Chemical Society of Ethiopia , 1987,
Abstract: Bull. Cherm. Soc. Ethiop. ,1 (1) ,47-54(1987).
F ltarbete i sl jdpraktiker
Marcus Samuelsson
Techne Series : Research in Sloyd Education and Craft Science A , 2011,
Abstract: Denna artikel beskriver verv ganden gjorda inf r och under ett f ltarbete i tv sl jdpraktiker, en skolsl jdspraktik och en sl jdklubbspraktik, liksom verv ganden inf r rapportering av detta f ltarbete. Artikeln knyter an till vetenskapliga discipliner som antropologi, etnologi och sociologi d r f ltarbete under stora delar av 1900-talet anv nts f r f rstahandsregistreringar av interaktionen m nniska – m nniska, m nniska – kultur. Metodologiska aspekter som tid problematiseras med exemplifieringar fr n ett halv rsl ngt f ltarbete i tv olika sl jdpraktiker. P s s tt beskrivs hur kontakt med f lten eller sl jdpraktiker kan etableras, uppr tth llas och avslutas genom olika slags portvakter. Vidare problematiseras hur f ltforskare har att f rh lla sig till och reflektera ver sin roll som medakt r under det att deltagande observationer, f ltanteckningar, samtal, dokument- och f rem lsanalyser genomf rs. Artikeln skildrar ocks hur forskaren genom hela f ltarbetet medvetet arbetar med att f rh lla sig reflexiv, vara n ra och vara distanserad, i f rh llande till f lten. Vidare framh lls hur f ltforskaren genom att v xla mellan empirisk och teoretisk n rhet g r det m jligt att verraskas och p s s tt f rs ka etablera nya, annorlunda, s tt att se p och f rst det som sker i f lt. Artikeln avslutas med reflektioner ver senmoderna f ltarbetens potential f r att studera kommunikation, inneh ll och meningserbjudanden i sl jdpraktiker. S kord: metod, sl jd, f ltarbete, deltagande observation URN:NBN:no-29953
How students interact when working with mathematics in an ICT context
Joakim Samuelsson
Seminar.net , 2007,
Abstract: There is a common assumption that computers will change the conditions for teaching mathematics. This paper discusses expectations regarding changes in working methods and, specifically, adolescents’ interaction in the computer-aided teaching of mathematics in middle school. The empirical material was collected through interviews with eighteen teachers in grades 7-9. The author also participated in all of the computer-aided lessons given by two teachers during one year, which means access to 700 lessons where teachers and students could use computers. During this year they used computers in only 18 lessons. This particular study reports from a closer analysis of seven observed lessons and 18 teacher interviews.In sum, using the computer when solving mathematical problems with peers is not always a successful learning method. The empirical data indicate that the linguistic interaction consists mostly of one student posing a question and another giving an answer. There was a lot of communication in the classroom but very little could be signified as dialogic. The different forms of interaction observed also tell us that students are not involved in communication about scientific concepts. Their communicative ability is therefore not developing to any large extent. When students collaborate in order to solve math problems they oscillate between disjunctive and complementary tasks. It means that different students practice different skills, some that are important for their mathematical ability and some that are not.
Plants used in traditional medicine as sources of drugs
Gunnar Samuelsson
Bulletin of the Chemical Society of Ethiopia , 1987,
Abstract: Bull. Cherm. Soc. Ethiop. ,1 (1) ,47-54(1987).
Full Counting Statistics of Multiple Andreev Reflections in incoherent diffusive superconducting junctions
P. Samuelsson
Physics , 2007, DOI: 10.1007/s00339-007-4191-6
Abstract: We present a theory for the full distribution of current fluctuations in incoherent diffusive superconducting junctions, subjected to a voltage bias. This theory of full counting statistics of incoherent multiple Andreev reflections is valid for arbitrary applied voltage. We present a detailed discussion of the properties of the first four cumulants as well as the low and high voltage regimes of the full counting statistics. The work is an extension of the results of Pilgram and the author, Phys. Rev. Lett. 94, 086806 (2005).
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