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Search Results: 1 - 10 of 5721 matches for " Oi-Wa Choi "
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Finding disease candidate genes by liquid association
Ker-Chau Li, Aarno Palotie, Shinsheng Yuan, Denis Bronnikov, Daniel Chen, Xuelian Wei, Oi-Wa Choi, Janna Saarela, Leena Peltonen
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-10-r205
Abstract: Studies aiming to identify susceptibility genes in complex diseases have proceeded along two lines. The traditional candidate gene approach is limited by our ability to come up with a comprehensive list of biologically related genes. On the other hand, the 'hypothesis free' approach relies on genome-wide scans for disease loci, typically via linkage in exceptionally large families or via association in case control studies. Multiple sclerosis (MS), which is one of the most common neurologic disorders affecting young adults, is characterized by demyelination and reactive gliosis [1]. Analogous to many complex traits, genome scans in MS have identified numerous chromosomal loci often with only a nominal evidence for linkage to MS [2-6]. With the notable exception of the human leukocyte antigen (major histocompatibility complex [MHC]) locus on 6p21, evidence for specific MS genes emerging from these studies is still scanty. Thus far, the only associated non-HLA genes replicated in multiple populations are the PRKCA gene [7] and the recently reported IL2RA and IL7R genes [8]. For MS, as for most complex traits, the loci derived from linkage scans have remained quite wide because of multiple uncertainties concerning the disease model in statistical analyses. To expedite the process of gene identification in these wide DNA regions, we need novel approaches to identify potentially involved pathways and to prioritize genes on identified loci for further sequencing efforts.Our idea is to turn to full genome functional studies for these goals. As illustrated in Figure 1, our approach takes advantage of the availability of abundant microarray data and a wealth of genomic/proteomic knowledge base from the public domain. Our intention is to integrate information from both the candidate gene and the full genome scan (thus far mostly family-based linkage) approaches. In this report we use two previously reported MS susceptibility genes, identified in the same study sample [7,9], n
Deflationism, Rationalism, and Anti-Rationalism: Three Views of Superego Morality  [PDF]
Ching Wa Wong
Open Journal of Philosophy (OJPP) , 2015, DOI: 10.4236/ojpp.2015.56045
Abstract: Philosophers of psychoanalysis have for years been debating over Freud’s criticism of morality as a sheer product of irrationality originated in our superego development. In this paper I shall consider three views on Freud’s moral psychology, which I call the “deflationist”, the “rationalist”, and the “anti-rationalist” view. I argue that both the deflationist and the rationalist view are untenable, as they fail to distinguish among different senses of irrationality that we can attribute to morality. By contrast, I shall develop and defend an anti-rationalist view, to the effect that an inherently irrational superego is no threat to morality’s place in human life, as long as it’s capable of making us experience an integrated form of life. And as this desired interaction does not always come easily, we can naturally see the point of introducing psychoanalysis to our lives.
Physico-Chemical Stability Studies of Neem (Azadirachta indica) Seed Oil Cream
OI Aremu
African Research Review , 2009,
Abstract: Neem oil cream is a semi solid formulation that is being developed for its therapeutic activity dermatologically. The need for stability of the new formulation over the period of its shelf life remains a sacred factor. In the present study, neem oil had been extracted from the ripe seed of Azadirachta indica (A. juss) plant. The oil was formulated using vanishing cream base because of its cosmetic advantage at concentrations (0%w/w – 10.0% w/w) with 0% w/w serving as control formulation. The formulations at storage temperature 250C – 300C were observed for physical changes using basic parameters over a period of 12 months representing long term stability studies approach. Chemically, the formulations were investigated for changes in pH, viscosity and specific gravity during the period of study. The result shows that neem oil cream formulations maintain its physical and chemical integrity throughout the entire period of study concern. Hence, stability is not a problem for neem oil in a vanishing cream base formulation.
The Implementation of the Creative Arts Curriculum in Secondary Schools in Nigeria
OI Godwin
African Research Review , 2009,
Abstract: This paper focuses on the status of the implementation of the creative arts curriculum at the secondary school level. The New National Policy on Education recognized the creative Arts as core subjects at the junior secondary school level, but at the senior secondary school level, they are optional. With very good laid down objectives, one had expected that the curriculum would be able to produce creative, patriotic and productive Nigerians who will contribute optimally to national development, rather what we have on ground is a far cry from expectation, due to the poor implementation of the programme. Creative Art practices in our secondary schools presently is relegated to subordinate position to other subjects. Parents, sort of encourage their children/wards to paying more attention to science based discipline. Creative art teachers on their own part are not able to perform to the optimum, due to extraneous factors militating against the full realization of the laid down objectives. It is hoped that the result of this study will redirect educational planners to effect positive changes in the implementation of the creative arts curriculum. Through survey of a number of schools, interview and questionnaires administered to both teachers and students, a number of problems of implementation were identified and possible solutions were proffered.
Health workers' attitude and perception toward routine pre-marital HIV screening
OI Musa
African Journal of Clinical and Experimental Microbiology , 2005,
Abstract: More than half of all new HIV infections occur among young adults, however, the rate of new infections among women surpasses men's especially in Sub-Saharan Africa. This rising infection rates, particularly among women, exposes children to increased HIV risk even before they are born. This descriptive cross-sectional study was conducted to determine the attitude and perception of health workers to routine pre-marital HIV screening that is currently practice by some religious institutions as part of initiative directed towards controlling the spread of the infection. Three hundred (300) self-administered questionnaires distributed to the health workers in their respective units were analyzed. Majority of the respondents 270 (90%) agreed that pre-marital HIV screening is necessary and advantageous to couples intending to get married. Although more than half of the respondents (56.7%) believed that the screening exercise is associated with some disadvantages, as many as 205 (68.3%) were in support of its enforcement for all couple. Majority 260 (86.7%) agreed that religious leaders/institutions have important role to play in HIV control and most of them 265 (88.3%) would prefer that Government health facilities be used as screening centres; and medical doctors should be the person to reveal the test results to the couples 275 (91.7%). About two-third of the respondents felt that the couples should initiates request for HIV screening, and on the issue of whether or not the marriage should be contracted following a positive result in one or both partners, 180(60%) respondents felt that the decision should be made by the couple. Counseling of couples before and after HIV screening, adequate training of health workers on HIV counseling skill and making HIV screening free to couple were suggested by the respondents as incentive that would enhance voluntary pre-marital HIV testing. Afr. J. Clin. Exper. Microbiol. Vol.6(1) 2005: 46-52
Eye injury requiring hospitalisation in Enugu Nigeria: A one-year survey
OI Okoye
Nigerian Journal of Surgical Research , 2006,
Abstract: BACKGROUND: - Eye injuries are becoming relatively important, not only as a cause of presentation but also a cause for admission at health centres in Nigeria. In view of this trend being observed and the fact that most eye injuries requiring hospital admission may give rise to grave ocular consequences. This study set out to highlight the pattern of eye injuries admitted into the eye ward of a Nigerian Teaching Hospital over one year. This is with a view to providing suitable protocols in the management and prevention of such injuries and their attendant ocular complications. MATERIALS AND METHODS: - A retrospective study of all cases of eye injury admitted into the eye ward of the University of Nigeria Teaching Hospital, Enugu, Nigeria in the year 2003 was conducted. All the hospital records of such cases were studied. RESULTS: - Eye trauma constituted 15.95% of 257 admissions. Males comprised 78%, and children comprised 22%. The commonest agents of injury were gunshot pellets, glass, metal and wood pieces. Activities implicated commonly were assault/combat, agricultural/artisan work-related accidents and road traffic accidents. A variety of sight threatening complications were noted in these subjects. Visual acuity on presentation ranged between 6/12 and no light perception (NPL). After treatment, approximately 80% of the injured eyes were blind. CONCLUSION: - Eye injuries requiring hospitalisation in Nigeria are not only common, but also severe. Safety measures and health education campaigns should help reduce this public health problem.
Therapeutic potential of selected micronutrients in malaria: an in vivo study in Plasmodium berghei infected mice
OI Iribhogbe
Biology and Medicine , 2012,
Abstract: The study involves an in vivo evaluation of the role of some antioxidant micronutrients in the therapeutics of malaria. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. In the first stage of the experiment, a 4 day suppressive test was conducted using 40 mice of either sex weighing 20.05 6 0.02 g which were inoculated intraperitoneally with 1 3 107million P. berghei infected erythrocyte and were administered with 0.2ml of distilled water, 0.2ml of vehicle, Tween 80 (control and vehicle group), chloroquine 25mg/kg (standard drug group), vitamin A 60mg/kg, vitamin E 100mg/kg, selenium 1mg/kg, zinc 100mg/kg, and vitamin C 200mg/kg (test groups D, E, F, G, and H respectively) 3 hours post-inoculation. Similarly, 35 mice of either sex were used to conduct a 4 day curative test after the initial screening test. Selenium demonstrated significant (p , 0.05) chemosuppressive (82.01%) and schizonticidal activity (76.16%) when compared with negative control during the 4 day suppressive and 4 day curative test respectively. Mean parasitemia was significantly reduced (p , 0.05) in the micronutrient treated groups after the 4 day curative test when compared with negative control. This was also significant between groups (F 5 7.04; p  0.05). Conclusively, antioxidant micronutrients have potential antimalarial activity and may be of benefit in malaria therapeutics.
Semi-classical and anharmonic quantum models of nuclear wobbling motion
Makito Oi
Physics , 2005, DOI: 10.1016/j.physletb.2005.12.061
Abstract: A semi-classical model for wobbling motion is presented as an extension to the Bohr-Mottelson model of wobbling motion. Using the resultant wobbling potential, a quantum mechanical equation is derived for anharmonic wobbling motion. We then attempt to explain the anharmonicity observed in the excited bands of two wobbling phonons in the A=160 region.
A description of the yrast states in 24-Mg by the self-consistent 3D-cranking model
Makito Oi
Physics , 2005, DOI: 10.1103/PhysRevC.72.057304
Abstract: With the self-consistent 3D-cranking model, the ground-state rotational band in 24-Mg is analysed. A role of triaxial deformation is discussed, in particular, in a description of the observed two I=8+ states.
Description of superdeformed bands in light N=Z nuclei using the cranked HFB method
Makito Oi
Physics , 2007, DOI: 10.1103/PhysRevC.76.044308
Abstract: Superdeformed states in light $N=Z$ nuclei are studied by means of the self-consistent cranking calculation (i.e., the P + QQ model based on the cranked Hartree-Fock-Bogoliubov method). Analyses are given for two typical cases of superdeformed bands in the $A \simeq 40$ mass region, that is, bands where backbending is absent ($^{40}$Ca) and present ($^{36}$Ar). Investigations are carried out, particularly for the following points: cross-shell excitations in the sd and pf shells; the role of the g$_{9/2}$ and d$_{5/2}$ orbitals; the effect of the nuclear pairing; and the interplay between triaxiality and band termination.
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