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Search Results: 1 - 10 of 37 matches for " Nouhoum Diani "
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Total Thyroidectomy in Multinodular Goiter: An African Experience  [PDF]
Moussa Abdoulaye Ouattara, Seydou Togo, Ibrahima Sankaré, Kadiatou Singaré, Sekou Koumaré, Issa Maiga, Allaye Ombotibé, Jacques Saye, Assa Traoré, Nouhoum Diani, Zimogo Ziè Sanogo, Sadio Yena
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.612075
Abstract: Introduction: Total thyroidectomy is an operation that involves the surgical removal of the whole thyroid gland, with the preservation of the parathyroid glands. The aim of the present study was to assess the complication rates of total thyroidectomy on benign indication and first-time thyroid surgery and investigate the early outcome after opotherapy. Materials and Methods: In this retrospective study, patients who underwent total thyroidectomy for benign multinodular goiter in the department of thoracic surgery in our Hospital from January 2012 to December 2014 were included. In postoperative time, we evaluated surgical complication, histopathological examination and opotherapy. Results: A total 53 patients underwent total thyroidectomy for multmodular goiter; they were 49 (92.45%) bilateral and 4 (7.55%) unilateral (recurrence). The mean age was 47 years and mean diameter of goiter was 10.75 cm. Among the patients 88.68% were females and 11.32% were male. Preoperative hormonal statuses were (70%) in euthyroid and (30%) hyperthyroid following surgery complications like transient laryngeal nerve palsy (3.77%), transient hypocalcemia (7.55%), hematoma (1.9%) and wound infection (1.9%). On histopathological examination of the surgical specimen, 5.7% were reported to be malignant. Six month following surgery 92.45% of patients was a good hormonal balance. Conclusion: Total thyroidectomy for multinodular goiter has a low morbidity and mortality; this procedure olves both the problem of recurrence of disease and reintervention. The opotherapy is doable with a good hormonal balance.
Cervical Thoracic Necrotizing Fasciitis with the Mammary Gland Spread of Odontogenic Origin  [PDF]
Seydou Togo, Moussa Abdoulaye Ouattara, Jaques Saye, Ibrahim Boubacar Maiga, Cheick Ahmed Sékou Touré, Ibrahim Sankaré, M.A.C. Cissé, Nouhoum Diani, Sékou Koumaré, Moussa Camara, Adama Konoba Koita, Sadio Yéna, Zimogo Zié Sanogo, Djibril Sangaré
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.74024
Abstract: Necrotizing fasciitis is an uncommon infection, but potentially lethal, especially when associated with systemic disorders such as diabetes. We report the case of a 35-year-old female with uncontrolled diabetes mellitus, presenting with edema of the neck, facial and left mammary gland, secondary to untreated dental infection, progressing to a full-blown necrotizing fasciitis in a short period of time with sepsis. The patient was managed with aggressive multidisciplinary medical and surgical treatment. Despite the technologic advances in diagnosis and treatment, complications still result with astounding high mortality. Clearly, the morbidity associated to this infection, even in diabetic patients, can be minimized if an early diagnosis and effective debridement are done.
Statistical Analysis of Hyper-Spectral Data: A Non-Gaussian Approach
Acito N,Corsini G,Diani M
EURASIP Journal on Advances in Signal Processing , 2007,
Abstract: We investigate the statistical modeling of hyper-spectral data. The accurate modeling of experimental data is critical in target detection and classification applications. In fact, having a statistical model that is capable of properly describing data variability leads to the derivation of the best decision strategies together with a reliable assessment of algorithm performance. Most existing classification and target detection algorithms are based on the multivariate Gaussian model which, in many cases, deviates from the true statistical behavior of hyper-spectral data. This motivated us to investigate the capability of non-Gaussian models to represent data variability in each background class. In particular, we refer to models based on elliptically contoured (EC) distributions. We consider multivariate EC-t distribution and two distinct mixture models based on EC distributions. We describe the methodology adopted for the statistical analysis and we propose a technique to automatically estimate the unknown parameters of statistical models. Finally, we discuss the results obtained by analyzing data gathered by the multispectral infrared and visible imaging spectrometer (MIVIS) sensor.
Statistical Analysis of Hyper-Spectral Data: A Non-Gaussian Approach
N. Acito,G. Corsini,M. Diani
EURASIP Journal on Advances in Signal Processing , 2007, DOI: 10.1155/2007/27673
Abstract: We investigate the statistical modeling of hyper-spectral data. The accurate modeling of experimental data is critical in target detection and classification applications. In fact, having a statistical model that is capable of properly describing data variability leads to the derivation of the best decision strategies together with a reliable assessment of algorithm performance. Most existing classification and target detection algorithms are based on the multivariate Gaussian model which, in many cases, deviates from the true statistical behavior of hyper-spectral data. This motivated us to investigate the capability of non-Gaussian models to represent data variability in each background class. In particular, we refer to models based on elliptically contoured (EC) distributions. We consider multivariate EC-t distribution and two distinct mixture models based on EC distributions. We describe the methodology adopted for the statistical analysis and we propose a technique to automatically estimate the unknown parameters of statistical models. Finally, we discuss the results obtained by analyzing data gathered by the multispectral infrared and visible imaging spectrometer (MIVIS) sensor.
Conservative Management of Pulmonary Artery Dissection  [PDF]
S. Togo, M. A. Ouattara, I. Sankaré, S. Yéna, N. Diani, A. M. Camara
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.67047
Abstract: The pulmonary artery dissection (PAD) is a rare and life-threatening event, usually secondary to a chronic pulmonary artery hypertension. We report the case of pulmonary artery dissection undergoing medical treatment by conservative management, discovered by performing a computed tomography (CT), and describe the clinical and therapeutic characteristics with the literature review.
Stream Network Modelling from Aster GDEM Using ArcHydro GIS: Application to the Upper Moulouya River Basin (Eastern, Morocco)  [PDF]
Khadija Diani, Hassan Tabyaoui, Ilias Kacimi, Fatima El Hammichi, Chafik Nakhcha
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.55001
Abstract: This paper discusses the integration between GIS and hydrological models and presents a case study relating to the upper section of Moulouya River Basin (UMRB) situated in the east of Morocco. The Basin is an inland water-shed with a total area of approximately 10,000 km2, stretching in the junction between the Middle Atlas, the High Atlas Mountain and the Middle Moulouya basin. From ArcGIS ArcHydro framework data models, different parameters of the Moulouya River and its catchment area have been defined. DEM based ArcHydro model was run on Aster-GDEM V2 data at a horizontal spatial resolution of 30 meters. Several raster and vector products of the Upper Moulouya River and its catchment area have been defined at the end of the model. Final results of the models were discussed and compared with the reality. These results can be used in baseline for advanced hydrology and geomorphology research on the catchment area. They can support for decision-making on ground and surface water resource, distribution and management.
Depletion of Human Histone H1 Variants Uncovers Specific Roles in Gene Expression and Cell Growth
Mónica Sancho,Erika Diani,Miguel Beato,Albert Jordan
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000227
Abstract: At least six histone H1 variants exist in somatic mammalian cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be actively involved in the regulation of gene expression. However, it is not well known whether the different variants have distinct roles or if they regulate specific promoters. We have explored this by inducible shRNA-mediated knock-down of each of the H1 variants in a human breast cancer cell line. Rapid inhibition of each H1 variant was not compensated for by changes of expression of other variants. Microarray experiments have shown a different subset of genes to be altered in each H1 knock-down. Interestingly, H1.2 depletion caused specific effects such as a cell cycle G1-phase arrest, the repressed expression of a number of cell cycle genes, and decreased global nucleosome spacing. On its side, H1.4 depletion caused cell death in T47D cells, providing the first evidence of the essential role of an H1 variant for survival in a human cell type. Thus, specific phenotypes are observed in breast cancer cells depleted of individual histone H1 variants, supporting the theory that distinct roles exist for the linker histone variants.
Comparative assessment of low-molecular-weight heparins in cancer from the perspective of patient outcomes and survival
Falanga A, Vignoli A, Diani E, Marchetti M
Patient Related Outcome Measures , 2011, DOI: http://dx.doi.org/10.2147/PROM.S10099
Abstract: mparative assessment of low-molecular-weight heparins in cancer from the perspective of patient outcomes and survival Review (1789) Total Article Views Authors: Falanga A, Vignoli A, Diani E, Marchetti M Published Date November 2011 Volume 2011:2 Pages 175 - 188 DOI: http://dx.doi.org/10.2147/PROM.S10099 Anna Falanga, Alfonso Vignoli, Erika Diani, Marina Marchetti Division of Immunohematology and Transfusion Medicine, Ospedali Riuniti, Bergamo, Italy Abstract: Patients with cancer are at high risk of developing venous thromboembolism (VTE), including deep venous thrombosis and pulmonary embolism. Compared to non-cancer patients, VTE in cancer is more frequently associated with clinical consequences, including recurrent VTE, bleeding, and an increase in the risk of death. Low-molecular-weight heparins (LMWHs) are commonly recommended for the prevention and treatment of VTE in cancer patients because of their favorable risk-to-benefit profile. Indeed, compared with vitamin K antagonists, LMWHs are characterized by a reduced need for coagulation monitoring, few major bleeding episodes, and once-daily dosing, which make these drugs more suitable in the cancer setting. Guidelines have been published recently with the aim to improve the clinical outcomes in cancer patients at risk of VTE and its complications. Coagulation activation in cancer may have a role not only in thrombosis but also in tumor growth and dissemination. Hence, inhibition of fibrin formation has been considered a possible tool against the progression of malignant disease. Clinical studies show that anticoagulant drugs may have a beneficial effect on survival in cancer patients, with a major role for LMWHs. Recently a number of prospective randomized clinical trials to test LMWHs to improve cancer survival as a primary endpoint in cancer patients have been conducted. Although the results are controversial, the interest in this research area remains high.
Comparative assessment of low-molecular-weight heparins in cancer from the perspective of patient outcomes and survival
Falanga A,Vignoli A,Diani E,Marchetti M
Patient Related Outcome Measures , 2011,
Abstract: Anna Falanga, Alfonso Vignoli, Erika Diani, Marina MarchettiDivision of Immunohematology and Transfusion Medicine, Ospedali Riuniti, Bergamo, ItalyAbstract: Patients with cancer are at high risk of developing venous thromboembolism (VTE), including deep venous thrombosis and pulmonary embolism. Compared to non-cancer patients, VTE in cancer is more frequently associated with clinical consequences, including recurrent VTE, bleeding, and an increase in the risk of death. Low-molecular-weight heparins (LMWHs) are commonly recommended for the prevention and treatment of VTE in cancer patients because of their favorable risk-to-benefit profile. Indeed, compared with vitamin K antagonists, LMWHs are characterized by a reduced need for coagulation monitoring, few major bleeding episodes, and once-daily dosing, which make these drugs more suitable in the cancer setting. Guidelines have been published recently with the aim to improve the clinical outcomes in cancer patients at risk of VTE and its complications. Coagulation activation in cancer may have a role not only in thrombosis but also in tumor growth and dissemination. Hence, inhibition of fibrin formation has been considered a possible tool against the progression of malignant disease. Clinical studies show that anticoagulant drugs may have a beneficial effect on survival in cancer patients, with a major role for LMWHs. Recently a number of prospective randomized clinical trials to test LMWHs to improve cancer survival as a primary endpoint in cancer patients have been conducted. Although the results are controversial, the interest in this research area remains high.Keywords: venous thromboembolism, VTE, LMWH
New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
Maria Grazia Romanelli,Erica Diani,Patricia Marie-Jeanne Lievens
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141122906
Abstract: Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in several post-transcriptional regulatory events of gene expression. Initially described as a pre-mRNA splicing regulator, PTB is now widely accepted as a multifunctional protein shuttling between nucleus and cytoplasm. Accordingly, PTB can interact with selected RNA targets, structural elements and proteins. There is increasing evidence that PTB and its paralog PTBP2 play a major role as repressors of alternatively spliced exons, whose transcription is tissue-regulated. In addition to alternative splicing, PTB is involved in almost all steps of mRNA metabolism, including polyadenylation, mRNA stability and initiation of protein translation. Furthermore, it is well established that PTB recruitment in internal ribosome entry site (IRES) activates the translation of picornaviral and cellular proteins. Detailed studies of the structural properties of PTB have contributed to our understanding of the mechanism of RNA binding by RNA Recognition Motif (RRM) domains. In the present review, we will describe the structural properties of PTB, its paralogs and co-factors, the role in post-transcriptional regulation and actions in cell differentiation and pathogenesis. Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression.
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