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Search Results: 1 - 6 of 6 matches for " Noriace Excelle Zohoun "
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Quality of Life of Chronic Haemodialytic Patients at Cotonou Teaching Hospital (BENIN)  [PDF]
Elhadji Fary Ka, Jacques Vigan, Ahmed Tall Lemrabott, Noriace Excelle Zohoun, Mohamedou Moustapha Cissé, Séraphin Ahoui, Maria Faye, Younoussa Keita, Khodia Fall, Bruno Léopold Agboton, Abdou Niang, Boucar Diouf
Open Journal of Nephrology (OJNeph) , 2014, DOI: 10.4236/ojneph.2014.44019
Introduction: The objectives of this work were to assess haemodialytic patients’ quality of life (QoL) and to identify factors affecting this QoL. Patients and Methods: It was a three (03) month monocentric and transversal study (from October 24, 2011 to January 27, 2012) conducted in the haemodialysis unit at Hubert Koutoukou Maga Teaching Hospital (CNHU-HKM) in Cotonou. Patients included were residents of Benin, aged 18 years and above, chronic haemodialysis in this unit for over 3 months, and willfully gave their consent. Quality of life was evaluated using questionnaire on Kidney Disease Quality of Life Short-Form French version 1.2 (KDQoL-SF 36). Epidemiological data, nephropathy etiologies and purification parametres were recorded in patients files. Data statistical analysis was performed using SPSS software 11.5. Results: In total 131 patients were involved in the study. The average age was 50.27 ± 12.17 years with a sex ratio of 1.69. Nephroangiosclerosis was the 1st cause. Most patients 128 (97.71 %) received two haemodialysis sessions on weekly basis. The Average Overall Score (AOS) based respectively on SF 36 and KDQoL was 48.55 and 58.55. The average of both SF 36 and KDQoL AOS was 53.55. Factors affecting hemodialytic patients quality of life were vitality, limitations related to mental health and physical condition, burden of kidney disease, effect of the disease on daily life and occupational status. The study revealed that: Patients education level was correlated with vitality (p < 0.017); The number of haemodialyses sessions was correlated with the consequences of kidney disease on daily life (p < 0.025). Conclusion: It is necessary to streng-then the staff by providing a psychologist and a dietician and also build new haemodialysis centres.
Effect of the Ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters on Rabbit’s in Glucose Overload Condition  [PDF]
Essé Agossou, Mélanie Ahokpe, Justin Behanzin, Marcellin Takin, Ganiou Yessoufou, Loica Zohoun, Lamine Baba-Moussa, Alphonse Sezan
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.61027
Abstract: The effect of the ethanolic extract Khaya senegalensis on some biochemical parameters was tested in rabbits with normal glucose and glucose overload. Phytochemical screening after three batches of 6 rabbits race (TBD) were treated with the extract in oral doses of respectively 10, 25 and 50 mg/kg body weight for 30 days; three other groups receiving respectively these doses of the extract were placed under a priori temporary overload of glucose; a control group received instead distilled water treatment. Blood glucose, triglycerides and total cholesterol were measured by spectrophotometry and weight gain of the animals was performed at the beginning of the experiment and every 2 weeks during the study period. The phytochemical screening revealed the presence of polyphenolic compounds (majority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 mg/kg body weight (BW) there was a significant decrease (p < 0.05) in blood glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.
Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou  [PDF]
Godonou Gratien Sagbo, Laeticia Zohoun, Gilles Bognon, Joseph Agossou, Caroline Padonou, Yévèdo Tohodjèdé, Florence Alihonou, Blaise Ayivi
Open Journal of Pediatrics (OJPed) , 2017, DOI: 10.4236/ojped.2017.73019
Abstract: Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify the advantages of artesunate compared with quinine in the treatment of severe malaria in children. Methods and patients: This study was a cross-sectional, descriptive and analytical study focused on children hospitalized for severe malaria in the CNHU who were treated with quinine or artesunate. Findings: The hospital-based frequency rate of severe malaria in pediatric patients was estimated to be 28.3% (n = 848). One hundred five children were treated with artesunate, and 743 were treated with quinine. The mean age of the children was 47 months old. The primary signs of severity were anemia (n = 776), neurological manifestations (n = 309) and hemolysis (n = 137). The average duration of treatment was 1.95 days for artesunate versus 2.45 days for quinine, and the difference was statistically significant (p = 0.001). The average length of stay (ALOS) in the hospital was 5 days for the artesunate group versus 5.75 days for the quinine group, and the difference was statistically significant (p < 0.001). Six of the children who received artesunate died, whereas 24 children who treated with quinine died. The total average cost of healthcare was 50,600 FCFA (77 euros) per child treated with artesunate versus 57,100 FCFA (87 euros) per child treated with quinine. Conclusion: The treatment of severe malaria with artesunate is superior to quinine-based treatment.
The Determinants of Fatal Outcomes during Severe Malaria in Children at the HKM University Teaching Hospital of Cotonou-Benin  [PDF]
Godonou Gratien Sagbo, Florence Alihonou, Marouf Jules Alao, Yévèdo Tohodjèdé, Lutécia Zohoun, Gilles Bognon, Joseph Agossou, Alphonse Noudamadjo, A?da Orou-Guidou
Open Journal of Pediatrics (OJPed) , 2017, DOI: 10.4236/ojped.2017.74028
Abstract: Introduction: Malaria particularly affects children in sub-Saharan African countries. This study aimed to investigate the factors associated with death in cases of severe childhood malaria to better understand the determinants of death in these children. Patients and Methods: This cohort, descriptive and analytical study was conducted from April 1 to August 15, 2015, at the CNHU-HKM pediatric clinic in Cotonou. Recruitment was exhaustive for all patients under 15 years of age who were admitted for severe malaria, as confirmed by thick smear microscopy. Results: Among the 1774 admitted patients, 449 had severe malaria caused by Plasmodium falciparum (i.e., a hospital frequency of 25.31%). The age group most affected consisted of children younger than 60 months of age (73%); female predominance was noted. The lethality rate of malaria was 13.1% (n = 59). The factors associated with death were coma (p = 0.032), poor convulsive status epilepticus (p = 0.08) and bacterial co-infection by gram negative bacteria (p = 0.021) with respectively correlations coefficient of 0.003, 3.940 and 2.424. Conclusion: Reduction of the malaria mortality rates in Benin
Epidemiology of Anemia at the Internal Medicine Department in Borgou Departmental Hospital Center (DHC) in Parakou (Benin)  [PDF]
Comlan Albert Dovonou, Adébayo Alassani, Cossi Angelo Attinsounon, Serge Ade, Kadidjatou Sake, Jivaterd Degla, Séraphin Ahoui, Mo?se Adegbindin, Prosper Gandaho, Djimon Marcel Zannou, Fabien Houngbe, Isidore Zohoun
Open Journal of Internal Medicine (OJIM) , 2018, DOI: 10.4236/ojim.2018.82013
Abstract: Objective: To describe clinical and biological characteristics of anemia in the Internal Medicine department of Borgou Departmental Hospital Center (DHC). Methods: This was a transversal and descriptive study for an analytic purpose. All patients hospitalized in the Internal Medicine department of Borgou DHC who had a hemogram for their care were included in the study. Anemia was defined as a hemoglobin level lower than 12 g/dL for men and lower than 11.5 g/dL for women. Results: Frequency of anemia was 61.8% (76 of 123 patients). Anemia was moderate in 47.4% of the cases and severe in 27.6% of the cases. Basing on the mean corpuscular volume, microcytic anemia accounted for 36.8%, anemia was normocytic in 46.1% and macrocytic in 17.1% of cases. According to the mean corpuscular hemoglobin concentration, normochromic anemia accounted for 81.6% of the series and hypochromic in 18.4%. The most common pathologies found in anemic patients came from digestive origin (17%), the renal causes were also found in 17% of the cases. Cardiac pathologies were responsible for anemia in 13% of cases. Malaria and pulmonary pathologies were responsible for anemia in respectively 12% and 9%. The main factors associated with anemia were young age (young adult) and neurological pathologies. Conclusion: Anemia hospital prevalence is very high in the Internal Medicine Department of Borgou DHC. Awareness of populations and practitioners for the early management of various pathologies which provide anemia could improve this presentation.
In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat
M. Elouennass,A. Zohoun,A. El Ameri,N. Alem,J. Kasouati,Y. Benlahlou,I. El Yaagoubi,M. Frikh,A. Lemnouer,A. Benouda
Interdisciplinary Perspectives on Infectious Diseases , 2012, DOI: 10.1155/2012/646480
Abstract: Objective. To study the sensitivity level of extended spectrum beta-lactamase-producing Enterobacteriaceae to Carbapenems (Imipenem, Ertapenem) marketed in Morocco and discusses the place of Ertapenem in the treatment of extended spectrum-beta-lactamase-producing. Materials and Methods. A retrospective study of 110 extended spectrum beta-lactamase-producing Enterobacteriaceae. Isolates obtained from blood cultures, superficial and deep pus, and catheters were conducted. The minimum inhibitory concentrations of Imipenem and Ertapenem were done by the E-test. The modified Hodge test was conducted for resistant or intermediate strains. Results. 99.1% of isolates were susceptible to Imipenem. For Ertapenem, 4 were resistant and 4 intermediate. The modified Hodge test was positive for all 08 isolates. A minimum inhibitory concentration comparison of K. pneumoniae, E. cloacae, and E. coli for Imipenem has noted a significant difference between E. cloacae on one hand and E. coli, K. pneumoniae on the other hand ( ). No significant difference was noted for minimum inhibitory concentration of Ertapenem. Conclusion. Our results confirm in vitro effectiveness of Ertapenem against extended spectrum beta-lactamase-producing Enterobacteriaceae as reported elsewhere. However, the emergence of resistance to Carbapenems revealed by production of carbapenemases in this study confirmed a necessary bacteriological documented infection before using Ertapenem. 1. Introduction Extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-EB) represent a major health problem because of their multiple resistances to antibiotics. Treatment options are limited, often using the Carbapenems, cephamycins, fosfomycin, furans, and colimycin [1–4]. The results of clinical studies suggest that Imipenem remains the primary choice of treatment for bacteria that produces ESBLs [5–9]. These results increase in overall the prescription of Imipenem, an overbill and an additional selection pressure on the ecosystem, causing and maintaining in our region the multidrug resistance Acinetobacter baumannii and Pseudomonas aeruginosa endemicity, and recently the emergence of Enterobacteriaceae carbapenem-resistant strains [10, 11]. In Morocco, there are two available Carbapenems: Imipenem (IMP) and Ertapenem (ERT). Ertapenem is the second molecule of the family on the market since 2008. The aim of our work was to study the ESBL-EB sensitivity to Carbapenems marketed in Morocco, to discuss the impact of use of Imipenem on the emergence of resistance to Carbapenems, and the Ertapenem place’s in
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