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Search Results: 1 - 10 of 50969 matches for " Nishida Y "
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Effect of impact angles on ejecta and crater shape of aluminum alloy 6061-T6 targets in hypervelocity impacts
Nishida M.,Hayashi K.,Ito Y.
EPJ Web of Conferences , 2012, DOI: 10.1051/epjconf/20122601006
Abstract: The effect of the impact angle of projectiles on the crater shape and ejecta in thick aluminum alloy targets was investigated in hypervelocity impacts. When polycarbonate projectiles and aluminum alloy 6061-T6 target were used, the impact angle of the projectiles clearly affected the crater shape, as expected. The impact angle also affected the ejecta mass, ejecta size and scatter angle. However, the effect at 15° and 22.5° was not great. When the impact angles were 30° and 45°, the effect was clearly confirmed. The impact angle clearly affected the axial ratio of ejecta fragments, c/a.
Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching
Hayasaka M,Takahashi Y,Nishida Y,Yoshida Y
Vascular Health and Risk Management , 2013,
Abstract: Masatoshi Hayasaka,1 Yasuo Takahashi,2 Yayoi Nishida,2 Yoshikazu Yoshida,1 Shinji Hidaka,3 Satoshi Asai41Department of Pharmacy, Nihon University Itabashi Hospital, Tokyo, 2Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, 3Laboratory of Pharmaceutical Regulatory Science, Department of Pharmacy, School of Pharmacy, Nihon University, Chiba, 4Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, JapanBackground: Clopidogrel and aspirin are antiplatelet agents that are recommended to reduce the risk of recurrent stroke and other cardiovascular events. Dual antiplatelet therapy with clopidogrel and aspirin has been shown to increase the risk of hemorrhage, but the effects of the drugs on laboratory parameters have not been well studied in real-world clinical settings. Therefore, we evaluated and compared the effects of combination therapy with clopidogrel plus aspirin and aspirin monotherapy on laboratory parameters.Methods: We used data from the Nihon University School of Medicine Clinical Data Warehouse obtained between November 2004 and May 2011 to identify cohorts of new users (n = 130) of clopidogrel (75 mg/day) plus aspirin (100 mg/day) and a propensity score matched sample of new users (n = 130) of aspirin alone (100 mg/day). We used a multivariate regression model to compare serum levels of creatinine, aspartate aminotransferase, and alanine aminotransferase, as well as hematological parameters including hemoglobin level, hematocrit, and white blood cell, red blood cell, and platelet counts up to 2 months after the start of administration of the study drugs.Results: There were no significant differences for any characteristics and baseline laboratory parameters between users of clopidogrel plus aspirin and users of aspirin alone. Reductions in white blood cell and red blood cell counts, hemoglobin levels, and hematocrit in users of clopidogrel plus aspirin were significantly greater than those in users of aspirin alone.Conclusion: Our findings suggest that adverse hematological effects may be greater with combination clopidogrel plus aspirin therapy than with aspirin monotherapy.Keywords: clopidogrel, aspirin, laboratory parameter, antiplatelet therapy, propensity score matching
The chemical mechanism of oxidative stress due to the non-transferrin-bound iron (NTBI)  [PDF]
Yuzo Nishida
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.327131
Abstract: Plasma iron is normally bound to the iron transport protein transferrin, but there are some iron ions not associated with transferrin. The latter ions are generally termed as non-transferrin-bound iron (NTBI) or labile plasma iron. The NTBI has been thought to play an important role in iron-induced cell damage with resultant peroxidation of cell membrane lipids and other biomolecules, and such oxidative damage is implicated as an important contributor in the pathogenesis of cancer, cardiovascular disease, aging and other degenerative disorders, but little is understood about the chemical composition of NTBI and the origin of toxicity due to NTBI. In this review, we demonstrated the several chemical models for NTBI, and elucidated the chemical mechanism of iron toxicity due to NTBI in human body on the basis of my concept on the mechanism of oxygen activation in biological oxygenases. This has lead to the conclusion that 1) NTBI are divided into two groups, water-in-soluble and water-soluble ones, 2) some of the water-soluble NTBI react with oxygen or hydrogen peroxide, changing these molecules to those exhibiting the reactivity similar to singlet oxygen (1△g), and this is the main reason for NTBI to induce the oxidative stress, and 3) the responsibility of hydroxyl radical or free singlet oxygen is negligible as a “reactive oxygen species” in the human body. Based on the discussions described in this article we have proposed a new technique to prevent the oxidative damage due to NTBI. In order to achieve the purpose, we have synthesized the new superpolyphenols which contain more than 100 molecules of catechol derivative in one polymeric compound; these are sometimes water-insoluble, and in another cases, water-soluble. We have observed that some of these compounds can eliminate NTBI effectively from the plasma, and also some of these derivatives can remove hydrogen peroxide from the solution. Thus, we can hope that our new super-polyphenols should depress greatly the oxidative stress due to NTBI, which may be consistent with the facts that the Japanese tea catechins which contain polyphenols exhibit high preventing effects against lifestyle-related diseases, and that some polyphenols have been known to protect the pathogenesis of Alzheimer’s disease. We also discussed the antioxidative function by zinc(II) ion, which depresses the oxidative damage by NTBI by promoting the formation of iron deposition.
Hamiltonian Representation of Higher Order Partial Differential Equations with Boundary Energy Flows  [PDF]
Gou Nishida
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.311174
Abstract: This paper presents a system representation that can be applied to the description of the interaction between systems connected through common boundaries. The systems consist of partial differential equations that are first order with respect to time, but spatially higher order. The representation is derived from the instantaneous multisymplectic Hamiltonian formalism; therefore, it possesses the physical consistency with respect to energy. In the interconnection, particular pairs of control inputs and observing outputs, called port variables, defined on the boundaries are used. The port variables are systematically introduced from the representation.
Evaluation of electric and magnetic field monitoring of Miyake-jima volcano monitoring of Miyake-jima volcanomonitoring of Miyake-jima volcano (Central Japan): 1995-1999
Y. Sasai,J. Zlotnicki,Y. Nishida,M. Uyeshima
Annals of Geophysics , 2001, DOI: 10.4401/ag-3585
Abstract: full abstract in pdf
Choroidal findings in idiopathic uveal effusion syndrome
Harada T, Machida S, Fujiwara T, Nishida Y, Kurosaka D
Clinical Ophthalmology , 2011, DOI: http://dx.doi.org/10.2147/OPTH.S26324
Abstract: roidal findings in idiopathic uveal effusion syndrome Case report (3554) Total Article Views Authors: Harada T, Machida S, Fujiwara T, Nishida Y, Kurosaka D Published Date November 2011 Volume 2011:5 Pages 1599 - 1601 DOI: http://dx.doi.org/10.2147/OPTH.S26324 Tomomi Harada, Shigeki Machida, Takamistu Fujiwara, Yasunori Nishida, Dajiro Kurosaka Department of Ophthalmology, Iwate Medical University School of Medicine, Iwate, Japan Purpose: We report choroidal findings by means of enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) in a patient with idiopathic uveal effusion syndrome (IUES). Case report: A 41-year-old man was referred to us with ciliochoroidal and non-rhegmatogenous retinal detachments. Sclerectomies and sclerostomies were performed at the equator in the lower quadrants, resulting in resolution of the ciliochoroidal and retinal detachments. EDI-OCT demonstrated low-reflective areas in the outer choroid. The subfoveal choroidal thickness measured vertically from the outer border of the RPE to the inner border of the sclera was 787 μm which was significantly thicker than the normal value (272 ± 90 μm, n = 131) obtained from age-matched normal controls. Conclusions: The findings made by EDI-OCT have provided additional evidence that choroidal alterations play a role in the pathological process in IUES.
Development of geothermal field following the 2000 eruption of Usu volcano as revealed by ground temperature, resistivity and self-potential variations
M. Saba,Y. Nishida,S. Takakura,N. Matsushima
Annals of Geophysics , 2007, DOI: 10.4401/ag-3088
Abstract: The 2000 eruption of Usu volcano, NE Japan, took place on the foot of the somma, and formed a cryptodome of 65 m high accompanying numerous faults. We made repeated measurements of ground temperature, Self-Potential (SP) and electrical resistivity, in order to clarify the mechanism of development of the newly formed geothermal field on the fault zone. Prior to the expansion of the geothermal field, we detected a resistive zone at the center of the geothermal zone and it supposed to evidence that the zone involving dry steam phase had been formed beneath the fault zone. A rapid expansion of the geothermal field followed along the fault zone away from the craters. The place of maximum amplitude of the SP field also migrated following the expansion of the high ground temperature zone. The high resistive part has shrunk as a consequence of the progress of condensation to warm the surroundings. Based on the observations, we delineated the process of the hydrothermal circulation. Considering the topographic effect of the SP field observed on the highly permeable zone in the Usu somma, the potential flow along the slope of the soma was expected to play an important role to promote the rapid expansion of the geothermal field and the migration of the most active part.
Biomechanics Determination of dynamic material properties for poly(L-lactic acid)/ poly( -caprolactone) blends: Experiments and simulation using split Hopkinson pressure bars
Nishida M.,Ito Y.,Gustafsson G.,H?ggblad H.-?.
EPJ Web of Conferences , 2012, DOI: 10.1051/epjconf/20122603001
Abstract: Coefficients of Cowper-Symonds constitutive equation for PLLA/PCL = 80/20 were determined using the results of compressive tests at high and low strain rates. The simulation of split Hopkinson pressure bar using the coefficients was carried out under the same condition as the experiments. The diameter and thickness of specimens were measured by a high-speed video camera. The stress and strain histories of specimens, the thickness and the diameter in the simulations at high strain rate were compared with those in the experiments.
Choroidal findings in idiopathic uveal effusion syndrome
Harada T,Machida S,Fujiwara T,Nishida Y
Clinical Ophthalmology , 2011,
Abstract: Tomomi Harada, Shigeki Machida, Takamistu Fujiwara, Yasunori Nishida, Dajiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanPurpose: We report choroidal findings by means of enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) in a patient with idiopathic uveal effusion syndrome (IUES).Case report: A 41-year-old man was referred to us with ciliochoroidal and non-rhegmatogenous retinal detachments. Sclerectomies and sclerostomies were performed at the equator in the lower quadrants, resulting in resolution of the ciliochoroidal and retinal detachments. EDI-OCT demonstrated low-reflective areas in the outer choroid. The subfoveal choroidal thickness measured vertically from the outer border of the RPE to the inner border of the sclera was 787 μm which was significantly thicker than the normal value (272 ± 90 μm, n = 131) obtained from age-matched normal controls.Conclusions: The findings made by EDI-OCT have provided additional evidence that choroidal alterations play a role in the pathological process in IUES.Keywords: uveal effusion syndrome, spectral-domain optical coherence tomography, EDI-OCT, OCT, choroid
Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching
Hayasaka M, Takahashi Y, Nishida Y, Yoshida Y, Hidaka S, Asai S
Vascular Health and Risk Management , 2013, DOI: http://dx.doi.org/10.2147/VHRM.S39351
Abstract: mparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching Original Research (603) Total Article Views Authors: Hayasaka M, Takahashi Y, Nishida Y, Yoshida Y, Hidaka S, Asai S Published Date February 2013 Volume 2013:9 Pages 65 - 70 DOI: http://dx.doi.org/10.2147/VHRM.S39351 Received: 18 October 2012 Accepted: 10 December 2012 Published: 18 February 2013 Masatoshi Hayasaka,1 Yasuo Takahashi,2 Yayoi Nishida,2 Yoshikazu Yoshida,1 Shinji Hidaka,3 Satoshi Asai4 1Department of Pharmacy, Nihon University Itabashi Hospital, Tokyo, 2Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, 3Laboratory of Pharmaceutical Regulatory Science, Department of Pharmacy, School of Pharmacy, Nihon University, Chiba, 4Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan Background: Clopidogrel and aspirin are antiplatelet agents that are recommended to reduce the risk of recurrent stroke and other cardiovascular events. Dual antiplatelet therapy with clopidogrel and aspirin has been shown to increase the risk of hemorrhage, but the effects of the drugs on laboratory parameters have not been well studied in real-world clinical settings. Therefore, we evaluated and compared the effects of combination therapy with clopidogrel plus aspirin and aspirin monotherapy on laboratory parameters. Methods: We used data from the Nihon University School of Medicine Clinical Data Warehouse obtained between November 2004 and May 2011 to identify cohorts of new users (n = 130) of clopidogrel (75 mg/day) plus aspirin (100 mg/day) and a propensity score matched sample of new users (n = 130) of aspirin alone (100 mg/day). We used a multivariate regression model to compare serum levels of creatinine, aspartate aminotransferase, and alanine aminotransferase, as well as hematological parameters including hemoglobin level, hematocrit, and white blood cell, red blood cell, and platelet counts up to 2 months after the start of administration of the study drugs. Results: There were no significant differences for any characteristics and baseline laboratory parameters between users of clopidogrel plus aspirin and users of aspirin alone. Reductions in white blood cell and red blood cell counts, hemoglobin levels, and hematocrit in users of clopidogrel plus aspirin were significantly greater than those in users of aspirin alone. Conclusion: Our findings suggest that adverse hematological effects may be greater with combination clopidogrel plus aspirin therapy than with aspirin monotherapy.
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