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Search Results: 1 - 10 of 3924 matches for " Nishi Patel "
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Formulation and Evaluation of Once Daily Sustained release matrix tablet of Pramipexole Dihydrochloride
Patel Nishi A,Makwana Sandip T,Patel Zubin P,Solanki Sejal M
International Journal For Pharmaceutical Research Scholars , 2012,
Abstract: The objective of this study was to formulate & evaluate sustained release matrix tablet of PramipexoleDihydrochloride. Pramipexole Dihydrochloride being highly water soluble drug so, hydrophilic matricesalone are not able to control the drug release for 24 hours. Matrix forming agents like hydroxyl propylmethyl cellulose, rosin & glyceryl behenate in varying concentrations were studied to get the desiredsustained release profile over a period of 24 hours. The granules were evaluated for bulk density, angleof repose, compressibility index. Matrix tablets were evaluated for weight variation, hardness, friability& in-vitro release. Release profile of F11 with 15% gum rosin and 25% glyceryl behenate was found tobe 99.7% in 24 hrs which was considered as the optimized formulation. Release profile of formulationF11 was found to be very close to theoretical profile of Pramipexole. The drug release followed zeroorder and found to be diffusion controlled with erosion having high correlation for Higuchi relatedpattern.
A VAR Analysis for the Growth Regime and Demand Formation Patterns of the Japanese Economy Une analyse par autorégression vectorielle pour le régime de croissance et de formation de demande sur l’économie japonaise Un análisis por autoregresión vectorial para el régimen de crecimiento y de formación de la demanda sobre la economía japonesa
Hiroshi Nishi
Revue de la Régulation : Capitalisme, Institutions, Pouvoirs , 2011,
Abstract: This study examines the income distribution and demand formation pattern of the Japanese economy using the VAR model. The post-Keynesian model is used for theoretical reference. The VAR model in this paper includes income distribution, consumption growth rate, export demand, GDP, and capital accumulation. The results of this study indicate that between 1985 and 2008, the profit-led demand formation pattern was dominant in the Japanese economy. In this regime, both domestic and external demands have a positive relationship with GDP growth. In the bubble period, favourable macroeconomic performance was sustained by active consumption and investments realized from the rise in asset prices and improvement in economic outlook. However, after the bubble burst, a rise in wage share did not maintain consumption demand, and investment demand stagnated due to the deterioration of profitability, stock adjustments, and a credit crunch. Hence, the Japanese economy has failed to realize a domestic demand-led growth sincethe 1990s. After 2002, export demand expanded and profit share recovered, which induced investment expansion. Consequently, there was an improvement in the Japanese macroeconomic performance, led by external demand, until the subprime shock occurred. Cet article examine le régime de croissance et de formation de la demande dans l’économie japonaise avec un modèle VAR. Le modèle post-keynésien est utilisé comme référence théorique. Le modèle VAR inclut la distribution du revenu national, le taux de croissance de la consommation, des exportations, du PIB et le taux d’accumulation du capital. Nos résultats montrent que le régime de formation de la demande tiré par le profit a été dominant de 1985 à 2008 dans l’économie japonaise. Dans ce régime, la croissance des demandes domestiques et externes a une relation croissante avec le PIB. Dans la période de bulle, la bonne performance macroéconomique a été soutenue par le dynamisme de la consommation et de l’investissement entretenu par la hausse des prix des actifs et l’optimisme des anticipations sur l’économie. Cependant, après l’éclatement de la bulle, la hausse de la part des salaires n’a pas permis de stabiliser la consommation, et l’investissement a stagné à cause de la détérioration de la rentabilité, de l’ajustement des surcapacités, et de la contraction du crédit. Depuis les années 1990, l’économie japonaise n’a pas pu s’engager dans un régime de croissance tiré par la demande. Après 2002, les exportations ont progressé, et la part des profits s’est reconstituée, ce qui a entra né la croissance des i
Indian Investor's Perception towards Mutual Funds
Nishi Sharma
Business Management Dynamics , 2012,
Abstract: The concept of mutual fund emerged in Netherlands in 18th century and introduced in India by Unit Trust of India in1960s. As the mutual fund industry provides an option of diversified investment structure with varying degree of risk, it was supposed to be the most lucrative market for Indian investors. It was believed that it will surely tap the savings of common man. But in practice it failed to become a primary choice for investment to Indian investor. During almost six decades (1965-2011) the value of assets under management of mutual fund industry experienced great swings. As against the developed countries where almost every second investor is a mutual unit holder, the product could not get much popularity in India. In this reference, the present paper attempts to investigate the reasons responsible for lesser recognition of mutual fund as a prime investment option. It examines the investor's perception with reference to distinct features provided by mutual fund companies to attract them for investing in specific funds/schemes. The study uses principal component analysis as a tool for factor reduction. The paper explored three factors named as fund/scheme related attributes, monetary benefits and sponsor's related attributes (having respectively six, four and four variables) which may be offered to investors for securing their patronage. The results are expected to provide fruitful insight to mutual fund companies for tailoring their offers suitable to cater the needs and expectations of Indian investors.
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons
Akinori Nishi
Frontiers in Neuroanatomy , 2011, DOI: 10.3389/fnana.2011.00043
Abstract: In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons, and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output to substantia nigra pars reticulata. Such roles of D1 receptors are important for the control of motor functions. In addition, the roles of D1 receptors are implicated in reward, cognition, and drug addiction. Therefore, elucidation of mechanisms for the regulation of dopamine D1 receptor signaling is required to identify therapeutic targets for Parkinson’s disease and drug addiction. D1 receptors are coupled to Gs/olf/adenylyl cyclase/PKA signaling, leading to the phosphorylation of PKA substrates including DARPP-32. Phosphorylated form of DARPP-32 at Thr34 has been shown to inhibit protein phosphatase-1, and thereby controls the phosphorylation states and activity of many downstream physiological effectors. Roles of DARPP-32 and its phosphorylation at Thr34 and other sites in D1 receptor signaling are extensively studied. In addition, functional roles of the non-canonical D1 receptor signaling cascades that coupled to Gq/phospholipase C or Src family kinase become evident. We have recently shown that phosphodiesterases (PDEs), especially PDE10A, play a pivotal role in regulating the tone of D1 receptor signaling relatively to that of D2 receptor signaling. We review the current understanding of molecular mechanisms for the modulation of D1 receptor signaling in the striatum.
Kummer's Original Type Congruence Relation for the Universal Bernoulli Numbers
Yoshihiro ?nishi
Mathematics , 2003,
Abstract: In this paper we give Kummer's original type congruence relation modulo a prime power for the universal Bernoulli numbers. Although the index of the power is half of original congruence, this estimate is best possible.
Theory of The Generalized Bernoulli-Hurwitz Numbers for The Algebraic Functions of Cyclotomic Type and The Universal Bernoulli Numbers
Yoshihiro ?nishi
Mathematics , 2004,
Abstract: Hurwitz numbers are the Laurent coefficients of an elliptic function $\wp(u)$ of cyclotomic type, and they are natural generalization of the Bernoulli numbers. This paper gives new generalization of Bernoulli and Hurwitz numbers for higher genus cases. They satisfy completely von Staudt-Clausen type theorem, an extension of von Staudt second theorem, and Kummer type congruence relation. The present paper is revised and combined version of math.NT/0304377 and math.NT/0312178 containing many numerical examples.
Theory of Generalized Bernoulli-Hurwitz Numbers in the Algebraic Functions of Cyclotomic Type
Yoshihiro ?nishi
Mathematics , 2003,
Abstract: In this paper we announce some results obtained for certain algebraic functions, which we call of cyclotomic type. The main results properly resemble von Staudt-Clausen's theorem and Kummer's congruence for the Bernoulli numbers, and such theorems for the Hurwitz numbers.
Hurwitz integrality of power series expansion of the sigma function for a plane curve
Yoshihiro ?nishi
Mathematics , 2015,
Abstract: This paper shows Hurwitz integrality of the coefficients of expansion at the origin of the sigma function \(\sigma(u)\) associated to a certain plane curve which should be called a plane telescopic curve. For the prime \(2\), the expansion of \(\sigma(u)\) is not Hurwitz integral, but \(\sigma(u)^2\) is. This paper clarifies the precise structure of this phenomenon. Throughout the paper, computational examples for the trigonal genus three curve (\((3,4)\)-curve) \(y^3+(\mu_1x+\mu_4)y^2+(\mu_2x^2+\mu_5x+\mu_8)y=x^4+\mu_3x^3+\mu_6x^2+\mu_9x+\mu_{12}\) (\(\mu_j\) are constants) are given.
Determinant Expressions for Hyperelliptic Functions (with an Appendix by Shigeki Matsutani)
Yoshihiro ?nishi
Mathematics , 2001,
Abstract: In this paper we give quite pretty generalization of the formula of Frobenius-Stickelberger to all hyperelliptic curves. The formula of Kiepert type is also obtained by limiting process from this generalization. In Appendix a determinant expression of D.G. Cantor is also given.
Determinant Expressions for Abelian Functions in Genus Two
Yoshihiro ?nishi
Mathematics , 2001,
Abstract: In this paper we generalize the formula of Frobenius-Stickelberger and the formula of Kiepert type to the genus-two case.
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