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Search Results: 1 - 10 of 133962 matches for " Nilesh V Patel "
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF TRIAZOLE AND FUSED TRIAZOLE DERIVATIVES
VORA,JABALI J; PATEL,DINESH R; BHIMANI,NILESH V; AJUDIA,PARAG V;
Journal of the Chilean Chemical Society , 2011, DOI: 10.4067/S0717-97072011000300011
Abstract: triazole and fused heterocyclic triazole derivatives like schiff bases, thiadiazoles, thiadiazepine, thiadiazine etc. were synthesized and characterized by ir, ms and 1h nmr. the triazole derivatives were evaluated for their antibacterial activity against the gram-positive bacteria b. megaterium and s. aureus, the gram-negative bacteria e. aerogenes and p. aeruginosa using dmso as a solvent.
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF TRIAZOLE AND FUSED TRIAZOLE DERIVATIVES
JABALI J VORA,DINESH R PATEL,NILESH V BHIMANI,PARAG V AJUDIA
Journal of the Chilean Chemical Society , 2011,
Abstract: Triazole and fused heterocyclic triazole derivatives like Schiff bases, thiadiazoles, thiadiazepine, thiadiazine etc. were synthesized and characterized by IR, MS and 1H NMR. The triazole derivatives were evaluated for their antibacterial activity against the gram-positive bacteria B. megaterium and S. aureus, the gram-negative bacteria E. aerogenes and P. Aeruginosa using DMSO as a solvent.
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations
Mandayam O Nandan, Amr M Ghaleb, Beth B McConnell, Nilesh V Patel, Sylvie Robine, Vincent W Yang
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-63
Abstract: At 12 weeks of age, ApcMin/KRASV12 mice had three times as many intestinal tumors as ApcMin mice. This increase in tumor number was reduced by 92% in triple transgenic ApcMin/KRASV12/Klf5+/- mice. The reduction in tumor number in ApcMin/KRASV12/Klf5+/- mice was also statistically significant compared to ApcMin mice alone, with a 75% decrease. Compared with ApcMin/KRASV12, tumors from both ApcMin/KRASV12/Klf5+/- and ApcMin mice were smaller. In addition, tumors from ApcMin mice were more distally distributed in the intestine as contrasted by the more proximal distribution in ApcMin/KRASV12 and ApcMin/KRASV12/Klf5+/- mice. Klf5 levels in the normal-appearing intestinal mucosa were higher in both ApcMin and ApcMin/KRASV12 mice but were attenuated in ApcMin/KRASV12/Klf5+/- mice. The levels of β-catenin, cyclin D1 and Ki-67 were also reduced in the normal-appearing intestinal mucosa of ApcMin/KRASV12/Klf5+/- mice when compared to ApcMin/KRASV12 mice. Levels of pMek and pErk1/2 were elevated in the normal-appearing mucosa of ApcMin/KRASV12 mice and modestly reduced in ApcMin/KRASV12/Klf5+/- mice. Tumor tissues displayed higher levels of both Klf5 and β-catenin, irrespective of the mouse genotype from which tumors were derived.Results of the current study confirm the cumulative effect of Apc loss and oncogenic KRAS activation on intestinal tumorigenesis. The drastic reduction in tumor number and size due to Klf5 heterozygosity in ApcMin/KRASV12 mice indicate a critical function of KLF5 in modulating intestinal tumor initiation and progression.Cancer is the result of deregulated cellular homeostasis and is typically characterized by increased proliferation and/or decreased apoptosis [1]. The mammalian intestinal epithelium is a continuously renewing system that is carefully orchestrated throughout life [2]. Several important signaling pathways are involved in maintaining intestinal epithelial homeostasis and include the Wnt, Notch, Eph/Ephrin, Hedgehog and bone morphogeneti
GPS-TEC Variation during Low to High Solar Activity Period (2010-2014) under the Northern Crest of Indian Equatorial Ionization Anomaly Region  [PDF]
Nilesh C. Patel, Sheetal P. Karia, Kamlesh N. Pathak
Positioning (POS) , 2017, DOI: 10.4236/pos.2017.82002
Abstract: The measurements of ionospheric TEC (total electron content) are conducted at a low latitude Indian station Surat (21.16°N, 72.78°E Geog.), which lies under the northern crest of the equatorial anomaly in Indian region. The data obtained are for a period of five years from low to high solar activity (2010- 2014) using GPS (Global Positioning System) receiver. In this study, we report the diurnal and seasonal variation of GPS-TEC, dependence of GPS-TEC with solar activity, geomagnetic condition and EEJ strength. From the seasonal analysis, it is found that greater values of the GPS-TEC are observed during equinox season followed by winter and summer. The appearance (in the year 2011 and 2014) and disappearance (in the year 2010 and 2012) of “winter anomaly” have been observed at the station. From the correlation of GPS-TEC with different solar indices, i.e. solar EUV flux, F10.7 cm solar radio flux and Zurich sunspot number (SSN), it is concluded that the solar index EUV flux is a better controller of GPS-TEC, compared to F10.7 cm and SSN. Further, it is observed that there is no effect of rising solar activity on correlation. Moreover, the percentage variability of GPS-TEC and the standard deviation of GPS-TEC obtained for quiet and disturbed days show that dependence of GPS-TEC on geomagnetic condition is seasonal. Also, there is a positive correlation observed between GPS-TEC and EEJ strength.
Design and Simulation of Two Stage OTA Using 0.18μm and 0.35μm Technology
Hitesh Modi,Nilesh D. Patel
International Journal of Engineering and Advanced Technology , 2013,
Abstract: The OTA is an amplifier whose differential input voltage produces an output current. Thus, it is a voltage controlled current source. Operational transconductance amplifier is one of the most significant building-blocks in integrated continuous-time filters. Here we design a two stage operational transconductance amplifier in TSMC 0.18μm and 0.35μm technology with all the transistor in the saturation region. The simulated output frequency response is shown for a supply voltage of 1.8V and 3.3V using IC studio in Mentor Graphics. DC gain is 47.86dB and 46.75dB, power consumption is 2mW and 3.2mW and slew rate is 37.58 V/μs and 31.67 V/μs for 1.8V and 3.3V respectively.
Mini-subvastus approach for total knee arthroplasty in obese patients
Shah Nilen,Nilesh G,Patel Narendra
Indian Journal of Orthopaedics , 2010,
Abstract: Background: Mini-subvastus approach for Total Knee Arthropalsty allows a faster recovery. It is traditionally not utilized for obese patients because of difficulty in exposure of the knee and eversion of the patella. We hypothesized that obesity should not really cause a problem for patients undergoing a TKA with the mini-subvastus approach as the anatomy of the quadriceps in the obese and the nonobese patient population is the same. We present an analysis of the use of mini-subvastus approach in obese patients. Materials and Methods : 97 obese patients (109 knees) 81 females + 16 males with mean age 64 years underwent total knee arthroplasty (TKA) by mini-subvastus approach between January 2006 to July 2007. 16 patients (18 kness) were morbidly obese. All patients were prospectively evaluated by pre- and postoperative Knee Society and function score. The average follow-up was 18 months (range from 1 to 3 years) with minimum 1 year follow-up. Results: The approach provided adequate exposure in all knees, with an average surgical time of 90 minutes. The patella could be everted easily after the tibial and femoral cuts. The average Knee Society score improved from 42 to 89 and the function score from 48 to 65. The complications included medial collateral ligament injury (one case) and patellar tendon avulsion (one case). Conclusion: Our results compare favorably with other reported series in obese patients. The mini-subvastus approach can be considered in obese patients.
Modification in Atmospheric Refractivity and GPS Based TEC as Earthquake Precursors  [PDF]
Sheetal P. Karia, Kamlesh N. Pathak, Kunvar S. Yadav, Nikita P. Chaudhary, Nilesh C. Patel. Ranjan Jana
Positioning (POS) , 2014, DOI: 10.4236/pos.2014.52006
Abstract: The present paper reports the modification in GPS TEC (total electron content) and atmospheric refractivity prior to the Iran earthquake that had occurred on 16 April 2013 in Iran (28.10°N, 62.05°E). The analysis of GPS-based TEC from two GPS receivers, Surat (21.16°N, 72.78°E) and Lucknow (26.91°N, 80.95°E ) and results of atmospheric refractivity profile for radiosonde observation stations (Shiraz, Iran and Delhi, India) around the fault line are presented in this paper. It is seen that atmospheric refractivity gets modified from 8 to 6 days prior to the earthquake at Shiraz, Iran and Delhi, India. The GPS TEC showed variations a few days prior to the earthquake. We conclude that in search of precursory signatures for an earthquake, both GPS TEC and refractivity are important parameters.
Outcomes of decompression for lumbar spinal canal stenosis based upon preoperative radiographic severity
Bradley K Weiner, Nilesh M Patel, Matthew A Walker
Journal of Orthopaedic Surgery and Research , 2007, DOI: 10.1186/1749-799x-2-3
Abstract: Twenty-seven consecutive patients undergoing decompression for isolated degenerative spinal canal stenosis at L4-L5 were included. We measured cross-sectional area on MRI using the technique of Hamanishi. We categorized the severity of stenosis using Laurencin and Lipson's 'Stenosis Ratio'. We determined pre-operative status (prospectively) and post-operative outcomes using Weiner and Fraser's 'Neurogenic Claudication Outcome Score'. We determined patient satisfaction using standardized questionnaires. Each of these is a validated measure. Formal statistical evaluation was undertaken.No patients (0 of 14) with a greater than 50% reduction in cross-sectional area on pre-operative MRI had unsatisfactory outcomes. In contrast, outcomes for patients with less than or equal to 50% reduction in cross-sectional area had unsatifactory outcomes in 6 of 13 cases, with all but one negative outcome having a cross-sectional area reduction between 32% and 47%.The findings suggest that there appears to be a relationship between severity of stenosis and outcomes of decompressive surgery such that patients with a greater than 50% reduction in cross sectional area are more likely to have a successful outcome.The prognosis for a satisfactory outcome following lumbar decompressive surgery for degenerative spinal canal stenosis depends upon several factors such as comorbid diabetes, peripheral vascular disease, and cardiopulmonary insufficiency which are known to have a negative impact [1]. Another factor, the degree of preoperative spinal canal stenosis, may also be of prognostic significance. However, the current literature is unclear as to its importance. Separate studies by Herno[2], Airaksinen[3], K-E. Johnson[4], and B. Johnson[5] all found a correlation between the severity of stenosis and the surgical outcome. In contrast, independent studies by Surin[6] and Paine[7] showed patients with milder stenosis did better post-operatively. Finally, Amundsen[8] and Mariconda[9] found no
Energy Efficient Clear Channel Assessment for LR-WPAN
Praveen Kaushik,Nilesh Kumar R Patel,Jyoti Singhai
International Journal of Computer Science Issues , 2011,
Abstract: IEEE 802.15.4 LR-WPAN is a specification for low-cost, low-powered and low data rate transmission. This standard uses CSMA/CA protocol for contention resolution. One of the tasks performed by CSMA/CA algorithm is Clear Channel Assessment (CCA), used to find the status (IDLE or BUSY) of the channel. There are three operating modes to perform CCA. As per the standard CCA mode 2 and 3 are based on carrier sensing where as CCA mode 1 is based on Energy Detection Threshold (EDThreshold). CCA in most of the WPAN is based on carrier sense. EDThreshold dependent CCA mode 1 is more advantageous in case of energy constraint networks, as minimum energy is consumed in channel allocation using EDThreshold. This property of EDThreshold is utilized in CCA for LR- WPAN and is implemented in NS2. Simulation results of EDThreshold based mode 1 CCA indicate that number of packets dropped decreases, network as well as node throughput increases and energy consumption is also less when compared to Carrier Sense Threshold (CSThreshold) based mode 1 CCA. It is also observed from the results that MAC_PACKET_ERROR is also acceptable, that is, less than 1%.
Self correcting monolithic floating matrix tablets of dipyridamole: Influence of formulation variables
Patel V,Patel N
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: The present investigation describes the influence of content of polyethylene oxide and ratio of lactose to starch 1500 on dipyridamole release from self correcting floating matrix tablets using 32 full factorial design. Tablets were evaluated for in vitro floating ability and drug release study using USP 24 type II apparatus using 0.1 N HCI at 100 rpm and temperature of 37±0.50. Multiple regression analysis and two way analysis of variance followed by Tukey test were performed for dependent variables. All formulations floated within 2 min regardless of factors studied and had total floating time of more than 12 h. It was observed that both the factors had significant influence on all dependent variable studied ( P< 0.05) except the ratio of lactose to starch 1500 did not significantly contribute for Q1 ( P > 0.05). As content of polymer increased the release rate declined with increase in value of diffusion exponent giving anomalous drug release to zero order drug release ( P < 0.05). It was observed that above a certain threshold level of polymer content further increase did not contribute significantly for percentage drug release. Lactose gave higher drug release with release mechanism towards zero order compared to starch 1500 which gave slower release with release mechanism towards diffusion based. Although both the factors significantly contribute for percentage drug release at different time point, the content of polymer dominated. It was observed that polymer content was a dominant controlling factor for drug release kinetics and it could be controlled by employing various blends of fillers.
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