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Search Results: 1 - 10 of 180 matches for " Nikolas Kortes "
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Outcome Results of Treatment with Selective Internal Radiation Therapy (SIRT) in Patients with Hepatocellular Carcinoma: A Single Center Experience  [PDF]
Jan Pfeiffenberger, Tatjana Zimmermann, Daniel N. Gotthardt, Christoph Springfeld, Wolfgang Stremmel, Peter Schirmacher, Henning Schulze-Bergkamen, Arianeb Mehrabi, Christoph W. Michalski, Katrin Hoffmann, Nikolas Kortes, Boris Radeleff, Uwe Haberkorn, Clemens Kratochwil, Karl Heinz Weiss, Carsten Grüllich
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.84031
Abstract: Background: Hepatocellular carcinoma (HCC) has a poor prognosis. Selective internal radiation therapy (SIRT) with microspheres is a treatment option for HCC. This study aimed to assess safety and survival (OS) in patients with HCC treated with SIRT, to stratify patients with tumor vascularization and analyze the impact of sequential sorafenib treatment. Methods: Thirty-nine patients who received SIRT for HCC between 2010 and 2013 at our center were included in this retrospective analysis. Tumor vascularization was assessed using a combination of MRI, MAA-scintigraphy and angiography. Tumor vascularization was correlated with survival. Subgroups are treated with two commercially available 90Y-labeled products SIR-Spheres (n = 16) and TheraSpheres (n = 23) and sequential therapy with sorafenib compared to SIRT only was analyzed. Results: Adverse events occurred in 49% of patients with only four grade 3 and no grade 4 event. Median survival for all patients was 12.5 months (95% CI: 8.7 - 16.3). No significant differences were detectable between Thera Spheres or SIR Spheres. Survival was shorter in patients with low tumor vascularization score (OS: 3.8 months (95% CI 0 - 15.0), p = 0.043). Survival was longer with sorafenib upon progression after SIRT (n=16) with an OS of 17.4 months (95% CI: 12.1 – 22.7) compared to no sorafenib (n = 13; 9.1 months; 95% CI: 3.0 - 15.1) or progression upon sorafenib before SIRT (n = 10; 8.6 months; 95% CI: 5.5 - 11.7). Conclusions: SIRT is safe in HCC patients. Tumor vascularization by radiography and scintigraphy may predict survival benefit. Sorafenib is active after SIRT and significantly prolongs survival.
An Overview of the Greek Islands’ Autonomous Electrical Systems: Proposals for a Sustainable Energy Future  [PDF]
Nikolas M. Katsoulakos
Smart Grid and Renewable Energy (SGRE) , 2019, DOI: 10.4236/sgre.2019.104005
Abstract: Among the Greek islands, 61 are based—currently—on autonomous electrical systems for covering the electrical energy demand and are characterized as Non-Interconnected Islands (NII). The average electricity production cost in the NII is 2.5 times higher than in areas with access to the main, interconnected electricity grid (IEG) of Greece. In this paper, an analytic overview of the autonomous electricity systems of Greek islands is provided, focusing on electricity consumption and production, as well as on the relative costs. For investigating possibilities for improving the situation, especially in small, remote islands, simulations for the energy system of Astypalea are conducted. It is proved that further use of renewables in combination with energy storage can lower the current, high energy costs. Expansion of the IEG is not economically viable for islands which are far away from the mainland and their peak loads are less than 10 ΜW.
Psicologia como uma ciência social
Rose, Nikolas;
Psicologia & Sociedade , 2008, DOI: 10.1590/S0102-71822008000200002
Abstract: psychology played an important role in society during the 20th century, helping to build the world and the people we became. in that sense, it established itself as a "social science", promoting a "psychologization" of individual and public lives; inventing and transforming several ideas in psychological terms. this text aims at understanding this evolution of psychology which found its space as a regulation technique, a presumed knowledge about people with an institutional objective of managing, shaping and reforming them. it discusses social psychology of post-war periods with its attitude researches and works about groups; reaching its climax with the notion of enterprise, building and regulating human actions. it ends with a discussion over the importance of the biological body in the 21st century, in which new technologies of image, biological psychiatry, neurochemistry and neurobiology emerge at the same time that brainhood is strengthened.
?La muerte de lo social?: Re-configuración del territorio de gobierno
Rose,Nikolas;
Revista argentina de sociolog?-a , 2007,
Abstract: the social, as a plane of thought and action, has been central to political thought and political programs since the mid-nineteenth century. this paper argues that, while themes of society and concerns with social cohesion and social justice are still significant in political argument, the social is no longer a key zone, target and objective of strategies of government. the rise of the language of globalization indicates that economic relations are no longer easily understo- od as organized across a single bounded national economy. community has become a new spatialization of government: heterogeneous, plural, linking individuals, families and others into contesting cultural assemblies of identities and allegiances. divisions among the subjects of government are coded in new ways; neither the included nor the excluded are governed as social citizens. non-social strategies are deployed for the management of expert authority. antipolitical motifs such as associationism and communitarianism which do not seek to govern through society are on the rise in political thought. the paper suggests some ways of diagnosing and analyzing these novel territorializations of political thought and action.
Avian influenza biosecurity: a key for animal and human protection
Nikolas Charisis
Veterinaria Italiana , 2008,
Abstract: Modern biosecurity methods have provided the best way of preventing the spread of a communicable disease since people realised that human and animal contact can transmit exotic diseases. The avian influenza virus is readily transmitted through animal vectors and inanimate matter and incurs heavy losses to the poultry industry. Biosecurity measures include the prevention of vaccination of flocks in an endemic area and the isolation of farms from the surrounding world (villages, other farms, fields, etc.). Veterinary services work in liaison with owners to implement national quarantine and vaccination measures for the benefit of farmers and the industry and for protection of public health.
Die deutschsprachige Mittelalterforschung und Katalonien: Geschichte, Schwerpunkte, Ertr ge [Medieval research in the German-speaking countries and Catalonia: History, main topics, and results]
Jaspert, Nikolas
Zeitschrift für Katalanistik , 2004,
Abstract: The article presents a report on German medieval research on Catalonia in four steps: first, the different levels of contacts between Catalonia and Germany in medieval times – i.e. diplomatic, economic, and cultural contacts – are described. The second part of the article gives an overview of the German-speaking medievalists who have dedicated their research to the Catalan medieval history between the mid-19th century and the present. The third part of the contribution intends to systematically describe the areas of research most popular among the German scholars of Catalonian medieval history, naming at the same time some subjects that remained less well studied. Finally, the more recent contributions are evaluated according to the traditions they pursue, and the innovations that they introduce. An extensive bibliography completes the article.
Introduction to the special issue ‘A politics of receptivity’
Nikolas Kompridis
Ethics & Global Politics , 2011, DOI: 10.3402/egp.v4i4.14831
Abstract:
Receptivity, possibility, and democratic politics
Nikolas Kompridis
Ethics & Global Politics , 2011, DOI: 10.3402/egp.v4i4.14829
Abstract: In this paper I present a model of receptivity that is composed of ontological and normative dimensions, which I argue answer to the critical-diagnostic and to the possibility-disclosing needs of democratic politics. I distinguish between ‘pre-reflective receptivity,’ understood ontologically as a condition of intelligibility, and ‘reflective receptivity,’ understood normatively as a condition of disclosing new possibilities.
Inadequacy of zero-width approximation for a light Higgs boson signal
Nikolas Kauer
Physics , 2013, DOI: 10.1142/S0217732313300152
Abstract: The zero-width approximation (ZWA) restricts the intermediate unstable particle state to the mass shell and, when combined with the decorrelation approximation, fully factorizes the production and decay of unstable particles. The ZWA uncertainty is expected to be of O(Gamma/M), where M and Gamma are the mass and width of the unstable particle. We review the ZWA and demonstrate that errors can be much larger than expected if a significant modification of the Breit-Wigner lineshape occurs. A thorough examination of the recently discovered candidate Standard Model Higgs boson is in progress. For M_H ~ 125 GeV, one has Gamma_H/M_H < 10^(-4), which suggests an excellent accuracy of the ZWA. We show that this is not always the case. The inclusion of off-shell contributions is essential to obtain an accurate Higgs signal normalization at the 1% precision level. For gg -> H -> VV, V = W,Z, O(5-10%) corrections occur due to an enhanced Higgs signal in the region M_VV > 2 M_V, where also sizable Higgs-continuum interference occurs. We discuss how experimental selection cuts can be used to suppress this region in search channels where the Higgs mass cannot be reconstructed. We note that H -> VV decay modes in non-gluon-fusion channels are similarly affected.
NLO automated tools for QCD and beyond
Nikolas Kauer
Physics , 2012,
Abstract: Theoretical predictions for scattering processes with multi-particle final states at next-to-leading order (NLO) in perturbative QCD are essential to fully exploit the physics potential of present and future high-energy colliders. The status of NLO QCD calculations and tools is reviewed.
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