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Search Results: 1 - 10 of 410557 matches for " Nihal M. El Rouby "
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Atenolol Induced HDL-C Change in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study
Caitrin W. McDonough, Nancy K. Gillis, Abdullah Alsultan, Shin-Wen Chang, Marina Kawaguchi-Suzuki, Jason E. Lang, Mohamed Hossam A. Shahin, Thomas W. Buford, Nihal M. El Rouby, Ana C.C. Sá, Taimour Y. Langaee, John G. Gums, Arlene B. Chapman, Rhonda M. Cooper-DeHoff, Stephen T. Turner, Yan Gong, Julie A. Johnson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076984
Abstract: We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in participants with mild to moderate hypertension. We genotyped 768 hypertensive participants from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study on the Illumina HumanCVD Beadchip. During PEAR, participants were randomized to receive atenolol or hydrochlorothiazide. Blood pressure and cholesterol levels were evaluated at baseline and after treatment. This study focused on participants treated with atenolol monotherapy. Association with atenolol induced HDL-C change was evaluated in 232 whites and 152 African Americans using linear regression. No SNPs achieved a Bonferroni corrected P-value. However, we identified 13 regions with consistent association across whites and African Americans. The most interesting of these regions were seven with prior associations with HDL-C, other metabolic traits, or functional implications in the lipid pathway: GALNT2, FTO, ABCB1, LRP5, STARD3NL, ESR1, and LIPC. Examples are rs2144300 in GALNT2 in whites (P=2.29x10-4, β=-1.85 mg/dL) and rs12595985 in FTO in African Americans (P=2.90x10-4, β=4.52 mg/dL), both with consistent regional association (P<0.05) in the other race group. Additionally, baseline GALNT2 expression differed by rs2144300 genotype in whites (P=0.0279). In conclusion, we identified multiple gene regions associated with atenolol induced HDL-C change that were consistent across race groups, several with functional implications or prior associations with HDL-C.
Assessment of Genotoxic and Cytotoxic Hazards in Brain and Bone Marrow Cells of Newborn Rats Exposed to Extremely Low-Frequency Magnetic Field
Monira M. Rageh,Reem H. EL-Gebaly,Nihal S. El-Bialy
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/716023
Abstract: The present study aimed to evaluate the association between whole body exposure to extremely low frequency magnetic field (ELF-MF) and genotoxic , cytotoxic hazards in brain and bone marrow cells of newborn rats. Newborn rats (10 days after delivery) were exposed continuously to 50 Hz, 0.5 mT for 30 days. The control group was treated as the exposed one with the sole difference that the rats were not exposed to magnetic field. Comet assay was used to quantify the level of DNA damage in isolated brain cells. Also bone marrow cells were flushed out to assess micronucleus induction and mitotic index. Spectrophotometric methods were used to measure the level of malondialdehyde (MDA) and the activity of glutathione (GSH) and superoxide dismutase (SOD). The results showed a significant increase in the mean tail moment indicating DNA damage in exposed group (<0.01,0.001,0.0001). Moreover ELF-MF exposure induced a significant (<0.01,0.001) four folds increase in the induction of micronucleus and about three folds increase in mitotic index (<0.0001). Additionally newborn rats exposed to ELF-MF showed significant higher levels of MDA and SOD (<0.05). Meanwhile ELF-MF failed to alter the activity of GSH. In conclusion, the present study suggests an association between DNA damage and ELF-MF exposure in newborn rats.
Detection of a Point Mutation at Codon 12 of the Kirsten-Ras (K-ras) Oncogen
Howida M. Sharaf, Nihal S. El-Kinawy, Ayman Omar* and Manal A. Ali
Egyptian Journal of Hospital Medicine , 2012,
Abstract: Background: Mutations in ras genes have been observed in a variety of cancers and were found to play an important role in human leukemogenesis and in preleukemic disease as myelodysplastic syndrome (MDS). The purpose of this study was to determine the prevalence of mutated K-ras oncogene in myelodysplastic syndrome (MDS); with a special emphasis on their possible role in affecting clinical status, relation to karyotypic pattern; response to therapeutic measures; its impact on the fate of the disease and overall survival.Subjects & methods: Detection of point mutation of Kirsten-ras (K-ras) gene in 30 patients suffering from myelodysplastic syndrome was carried out using quantitative enriched polymerase chain reaction (QEPCR) and was confirmed by sequencing. QEPCR is a two- stage PCR procedure with modified primers that enriches mutant alleles, via restriction endonuclease digestion of normal alleles and enables identification of one mutant allele among 100,000 normal alleles. Results: Activating mutations of the codon 12 of K-ras gene were detected in 7/30 (23.3%)cases of MDS, the most common mutation involved a substitution of aspartic acid for glycine (GGT→GAT). The incidence of K-ras mutations was found to be significantly associated with refractory anemia with excess blasts type II (RAEBII) and unclassified (UC) MDS than other subtypes (p=0.005), and was significantly associated with hypercellular bone marrow (p=0.04) showing marked dyserythropoitic changes. Furthermore, mutant K-ras gene was found to be significantly associated with abnormal karyotypes (p=0.04). Patients with mutated K-ras gene were significantly associated with either high or intermediate risk according to International Prognostic Scoring System (IPSS) (p=0.001). 6/7(85.7%) of those carrying the mutation showed poor response to treatment compared to non carriers with a statistical significant difference (p=0.009). Five out of eight (62.5%) patients who were transformed to AML carried the mutant K-ras gene, their subtypes were RAEB and unclassified MDS with abnormal cytogenetics mainly Monosomy 7. Overall survival was detected using Kaplan-Meier curve and the mean survival time of patients who carried K-ras mutations were significantly lower than those without the mutation (Log rank test=12.7; p=0.0004). Conclusion: MDS patients bearing an mutated K-ras oncogene frequently showed poor response to treatment; leukemic progression of the disease and shorter overall survival, suggesting that an activated K-ras oncogene is a critical factor for prognostic evaluation; therapeutic decis
Effects of Different Soil Tillage Methods, Weed Control and Phosphorus Fertilizer Doses on Yield Components in Chickpea under Central Anatolian Conditions
Nihal Kayan,M. Sait Adak
Pakistan Journal of Biological Sciences , 2005,
Abstract: This research was carried out in Central Anatolian region (in Haymana, Turkey) throughout 2 years (2002-2003). The objective of this study was to determine the effects of different soil tillage methods, weed control and phosphorus fertilizer doses on yield and yield components of chickpea. The experimental design was split plot with three replications. In the research, two different soil tillage methods (moldboard plow and rotary tiller), two weed control methods ( hand weeding and herbicide application) and three phosphorus doses (30, 60 and 90 kg P2O5 ha-1) were used. According to the results, different soil tillage methods had effect on the number of plant at emergence. Tradational Tillage (TT) plots values had higher than Minimum Tillage (MT) values. Except harvest index, weed control methods had effect on all of the yield components. Hand weeding is the most effective method in weed control. When hand weeding isn`t possible in wide areas, herbicide application may advice as an alternative solution. Phosphorus fertilization may provide high yield in chickpea.
Effect of Different Soil Tillage, Weed Control and Phosphorus Fertilization on Weed Biomas, Protein and Phosphorus Content of Chickpea (Cicer arietinum L.)
Nihal Kayan,M. Sait Adak
Asian Journal of Plant Sciences , 2006,
Abstract: This research was carried out in Central Anatolian Region (Haymana, Turkey) throughout 2 years (2002 and 2003). The objective of this study was to determine the effects of different soil tillage methods, weed control and phosphorus fertilizer doses on yield and yield componenets of chickpea. The experimental design was split split plot with three replications. In the research, two different soil tillage methods (moldboard plow and rotary tiller), two weed control methods ( hand weeding and herbicide application) and three phosphorus doses (30, 60 and 90 kg P2O5 ha) were used. According to the results, different soil tillage methods and phosphorus fertilization did not have any effect on yield components. In addition to it, increasing levels of phosphorus had decreased the grains phosphorus content. Weed control methods had effect on dry weed biomass and grain yield. If weed control, by hand is not possible, herbicide application may advice as an alternative solution.
Ectopic (heterotopic) pancreas in the mesentery of the jejunum: Imaging findings  [PDF]
Nihal Uslu
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.24075

Ectopic pancreatic tissue in the mesentery of the jejunum is an entity that is seen very rarely. Most patients are asymptomatic and usually this is an incidental ?nding at autopsy or laparotomy. Most of the cases are clinically silent, but symptoms either might be due to the localization of the ectopic tissue or due to the complications including obstruction or bleeding. Surgery is not indicated unless complications occur, so diagnosis is very important for prevention of unnecessary surgery. Here, we present a case that had ectopic pancreatic tissue in the mesentery of the jejunum. We show the computed tomography and magnetic resonance imaging findings of this patient.

An entity mimicking inflammatory breast carcinoma: Granulomatous mastitis  [PDF]
Nihal Uslu
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.24067

Granulomatous mastitis (GM) is a chronic inflammatory breast disease. This pathology was first described by Kersler and Wolloch in 1972 [1]. It is an uncommon cause of a breast mass [2-5]. Awareness of this entity is crucial, because it can clinically and radiologically mimic breast carcinoma, fibroadenoma or fibrocystic changes [3]. It has several appearances radiologically also; biopsy still remains the only way for final diagnoses. Here we present a woman with a breast mass. Our aim is to show ultrasound, mammography and magnetic resonance imaging findings of GM by reviewing the literature.

Localization and Sorting of Mast Cells in Human Ovary;A Histological and Immunohistochemical Study
Sahar M Gamal, Nadia M Al- Rouby, and Mohammad A Ali
Egyptian Journal of Hospital Medicine , 2009,
Abstract: Background: In human, mast cells (MCs) are classified according to their proteases' content into tryptase-containing mast cells (MCT) and tryptase and chymase-containing mast cells (MCTC). In addition to phenotypic differences in MC subtypes, there is also functional distributional heterogeneity. The present study was carried out to determine the physiological distribution of mast cells in the different components of human ovary of different age groups. Mast cell sorting according to their proteases content was also attempted with special emphasis on the possible mechanism of their effects on ovarian functions. Material and methods: Archival blocks of human ovarian tissue from females with age ranging from 16 to 75 years were used. The specimens were divided into reproductive- and postmenopausal-age groups. Histological study using haematoxylin and eosin as well as Masson trichrome staining was performed. Immunostaining using monoclonal antibodies against tryptase and chymase was also carried out. Morphometric measurements in the form of mast cell count per high power field as well as optical density of positively immuno-stained mast cells in addition to measurement of area and area per cent were done. Obtained data were statistically analyzed for significance using student's T- test. Results: MCs were mainly found in the deep cortical stroma and in the vicinity of blood vessels. Occasionally, few cells were found in the corpora lutea. There were no immunostained MCs in the walls of the different ovarian follicles, corpora albicans or in the periphery of the ovarian cortical stroma. Statistical analysis revealed that the number of MCT was significantly higher than MCTC in the reproductive-age group in comparison to the postmenopausal-age group. The postmenopausal-age group demonstrated the presence of statistically significant more degranulated MCTC and high collagen content in comparison to the reproductive-age group. Conclusion: MC subtypes follow specific distribution pattern within the ovarian tissue in the different age groups which has an impact on different ovarian functions in many physiological and pathological situations.
Adsorption of methyl green dye onto multi-walled carbon nanotubes decorated with Ni nanoferrite
Mohamed Bahgat,Ahmed Ali Farghali,Waleed El Rouby,Mohamed Khedr,Mohassab Y. Mohassab-Ahmed
Applied Nanoscience , 2013, DOI: 10.1007/s13204-012-0127-3
Abstract: This research was carried out to evaluate the capability of multi-walled carbon nanotubes (CNTs) and NiFe2O4-decorated multi-walled carbon nanotubes (NiFe2O4-CNTs) toward waste water treatment relevant to organic dyes. CNTs were prepared via chemical vapor deposition method. NiFe2O4-CNTs were prepared by in-situ chemical precipitation of metal hydroxides followed by hydrothermal processing. The samples were characterized using XRD and TEM. The adsorption efficiency of CNTs and NiFe2O4-CNTs of methyl green dye at various temperatures was examined. The adsorbed amount increased with the CNTs and NiFe2O4-CNTs dosage. The linear correlation coefficients and standard deviations of Langmuir and Freundlich isotherms were determined. It was found that Langmuir isotherm fitted the experimental results well in both adsorption cases n of methyl green onto CNTs and NiFe2O4-CNTs. Kinetics analyses were conducted using pseudo first-order, second-order and the intraparticle diffusion models. The results showed that the adsorption kinetics was controlled by a pseudo second-order model for adsorption of methyl green onto CNTs and best controlled by pseudo first-order in case of NiFe2O4-CNTs. Changes in the free energy of adsorption (ΔG°), enthalpy (ΔH°), entropy (ΔS°), and the activation energy (E a) were determined. The ΔH°, ΔG° and E a values indicated that the adsorption of methyl green onto MWCNTs and NiFe2O4-MWCNTs was physisorption.
Polarographic Analysis of Quetiapine in Pharmaceuticals
El-Enany,Nahed; El-Brashy,Amina; Belal,Fathalla; El-Bahay,Nihal;
Portugaliae Electrochimica Acta , 2009,
Abstract: the voltammetric behaviour of quetiapine (qtp) was studied using direct current (dct), differential pulse (dpp) and alternating current (act) polarography. the drug manifests cathodic waves over the ph range of 6 - 11.8. the waves were characterized as being irreversible, diffusion-controlled with limited adsorption properties. at ph 8, the diffusion current-concentration relationship was rectilinear over the range of 8 - 44 μg/ml and 4 - 44 μg/ml using dct and dpp modes, respectively, with minimum detection limits (lod) of 0.06 μg/ml and 0.04 μg/ml using the dct and dpp modes, respectively. the diffusion-current constant (id) is 1.36 ± 0.04 (n = 10). the proposed method was successfully applied to the determination of the studied compound both in pure form and in formulations. the results obtained were favourably compared with those obtained using a reference method. a pathway for the electrode reaction was postulated.
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