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Search Results: 1 - 10 of 38607 matches for " Nideshda Ramírez-Uribe "
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History of Infection Prior to Hematopoietic Stem Cell Transplant in the Recipient as a Risk Factor to Develop Acute Graft versus Host Disease  [PDF]
Alberto Olaya-Vargas, Iván Castorena-Villa, Martin Pérez-García, Gerardo Hernández Lopéz-Hernández, Nideshda Ramírez-Uribe, Haydeé Salazar-Rosales
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.104026
Abstract: Background: Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). Objective: To determine if a history of prior infection in the allogeneic HSTC recipient is a risk factor to develop aGVHD. Methods: A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. Results: 27 patients developed aGVHD (36.4%). Median time to aGVHD presentation was 82 days (9 to 273 days). Most patients developed grade III aGVHD. Following the multivariate analysis peripheral blood > bone marrow (OR 12.3; p < 0.001), cell dose > 8.3 × 106/kg (OR 7.1; p = 0.05), peripheral blood (OR: 11.4; p < 0.001), infection 3 months prior to allogeneic transplant (OR: 4.5; p < 0.03) and CMV infection in the recipient (OR: 4.68; p < 0.03) were significant. Conclusions: Either bacterial infection or CMV infection in the recipient was significant risk factor within the aGVHD recipients; it is important to consider these factors for patients that are going to receive an allogeneic HSCT.
Low Dose Total Body Irradiation (600 cGy) as a Conditioning Regimen in Allogenic Hematopoietic Stem Cell Transplant in Children with Acute Lymphoblastic Leukemia  [PDF]
Alberto Olaya-Vargas, Martín Pérez-García, Nideshda Ramírez-Uribe, M. Angeles Del Campo-Martinez, Gerardo Lopez-Hernández, Montserrat Hernández-García, Jorge Amador-Zarco, Guadalupe Garcia-Vega, Yadira Melchor-Vidal, Marta Zapata-Tarres, Rocío Cárdenas-Cardos, Roberto Rivera-Luna
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.78061
Abstract: Total body irradiation (TBI) is conditioning regimen in children with acute lymphoblastic leukemia (ALL) with a very high risk of relapse or in those who have not achieved remission and have relapsed and subsequently received allogenic hematopoietic stem cell transplantation (HSCT). A retrospective evaluation of 33 ALL patients in full remission with an indication of HSCT was performed to evaluate overall survival (OS) and event-free survival (EFS). The inclusion criteria included a myeloablative conditioning regimen of TBI at a dose of 600 cGy. The observed OS at 5 years was 50%, and the EFS of 32% we observed difference in the EFS stem cell origin; the peripheral blood (PB) 60%, and the umbilical cord blood (UC) accounted for 40%. Overall, 45% had a documented chimerism. The OS at 5 years from patients with chimeras was 75%, while those without chimeras had an OS at 5 years of 25%. The mortality in the first 100 days was 24%. A total of 24.2% of children presented with acute graft versus-host disease (GVHD), while 33% had chronic GVHD. Currently, there is no general agreement among all international centers regarding the optimum TBI dose. Our study reports an acceptable range of adverse events with a relatively low dose of 600 cGy.
Los Mapas Conceptuales como Estrategia que Permite Mejorar el Proceso de Ense?anza Aprendizaje de la Neuroanatomía
Flórez-Uribe,Adriana Margarita; Ayala-Pimentel,Jaime Otoniel; Conde Cotes,Carlos Arturo;
International Journal of Morphology , 2011, DOI: 10.4067/S0717-95022011000100014
Abstract: the present study describes the implementation of conceptual maps as a pedagogical strategy that tends to transform the passive students into an active producer.the use of concept maps in groups encourages students to meaningful learning, increasing interest and attention in relevant concepts working in a cooperative way. the objective was to measure the improvement of academic performance of the student when implementing the strategy of conceptual maps as a pedagogical tool of students of morphophysiology ii at the universidad industrial de santander (uis) for teaching the functional anatomy of the nervous system. an analytic prospective with four transversal sections study was conducted in 130 students of medicine (ii semesters of 2006) bucaramanga, santander at 2006, who attended the course morphophysiology ii.for the first and the second section the students received master classes and for the third section the group was divided and the active method of concept maps was applied. the multiple corrected comparisons were made using the bonferroni test (p< 0.05) when the anova shows significant statistical differences. all student received master classes as a group. for other activities they were divided in 4 groups; a, b, c and d with 36, 40, 25 and 29 students respectively. it is important that at the third period the performance of the group was homogeneous, finding not difference between groups. an anova for all students in comparison of the 4 periods showed significant differences (f3,387: 39,116, p<0,001) where the comparison with bonferroni demonstrated that performance in the third period was significantly better than in the other periods. using concept maps as an strategy for actively constructing knowledge by students confirms that the process of learning is active and was reflected in the improvement of their performance.
Los Mapas Conceptuales como Estrategia que Permite Mejorar el Proceso de Ense anza Aprendizaje de la Neuroanatomía Concept Maps as a Strategy for Improving the Teaching Learning Process in Neuroanatomy
Adriana Margarita Flórez-Uribe,Jaime Otoniel Ayala-Pimentel,Carlos Arturo Conde Cotes
International Journal of Morphology , 2011,
Abstract: Los mapas conceptuales son una estrategia de ense anza aprendizaje que permite organizar los contenidos de una temática determinada facilitando su interpretación, comprensión y análisis. Su construcción en forma grupal incrementa la capacidad de los estudiantes de aprender de modo significativo debido al aumento del interés y la atención para integrar los conceptos más relevantes en forma cooperativa. El objetivo de este trabajo fue evaluar el rendimiento académico de los estudiantes que cursaron la asignatura morfofisiología II en la Universidad Industrial de Santander (UIS) al implementar el uso de los mapas conceptuales como herramienta pedagógica para la ense anza de la anatomía funcional del sistema nervioso. Se realizó un estudio de tipo prospectivo analítico con mediciones transversales en cuatro momentos en 130 estudiantes de medicina (II semestre 2006) que cursaban la asignatura morfofisiología II a quienes durante los dos primeros cortes se les transmitió la información en forma de cátedra magistral y para el tercer corte se dividieron en grupos de trabajo que utilizaron como método activo de ense anza los mapas conceptuales. Los resultados de sus exámenes académicos escritos se compararon utilizando la prueba de Bonferroni (p<0.05) cuando los ANOVA indicaron diferencias estadísticamente significativas. Los resultados demostraron que las calificaciones de las evaluaciones del tercer corte fueron significativamente mejores que las de los otros, lo que nos sugiere que la realización de mapas conceptuales en forma cooperativa ofrece ventajas al estudiante entre las que se encuentra la mejoría de su rendimiento académico. The present study describes the implementation of conceptual maps as a pedagogical strategy that tends to transform the passive students into an active producer.The use of concept maps in groups encourages students to meaningful learning, increasing interest and attention in relevant concepts working in a cooperative way. The objective was to measure the improvement of academic performance of the student when implementing the strategy of conceptual maps as a pedagogical tool of students of morphophysiology II at the Universidad Industrial de Santander (UIS) for teaching the functional anatomy of the nervous system. An analytic prospective with four transversal sections study was conducted in 130 students of medicine (II semesters of 2006) Bucaramanga, Santander at 2006, who attended the course morphophysiology II.For the first and the second section the students received master classes and for the third section the group was divid
TnaA, an SP-RING Protein, Interacts with Osa, a Subunit of the Chromatin Remodeling Complex BRAHMA and with the SUMOylation Pathway in Drosophila melanogaster
Juan Monribot-Villanueva, R. Alejandro Juárez-Uribe, Zoraya Palomera-Sánchez, Lucía Gutiérrez-Aguiar, Mario Zurita, James A. Kennison, Martha Vázquez
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062251
Abstract: Tonalli A (TnaA) is a Drosophila melanogaster protein with an XSPRING domain. The XSPRING domain harbors an SP-RING zinc-finger, which is characteristic of proteins with SUMO E3 ligase activity. TnaA is required for homeotic gene expression and is presumably involved in the SUMOylation pathway. Here we analyzed some aspects of the TnaA location in embryo and larval stages and its genetic and biochemical interaction with SUMOylation pathway proteins. We describe that there are at least two TnaA proteins (TnaA130 and TnaA123) differentially expressed throughout development. We show that TnaA is chromatin-associated at discrete sites on polytene salivary gland chromosomes of third instar larvae and that tna mutant individuals do not survive to adulthood, with most dying as third instar larvae or pupae. The tna mutants that ultimately die as third instar larvae have an extended life span of at least 4 to 15 days as other SUMOylation pathway mutants. We show that TnaA physically interacts with the SUMO E2 conjugating enzyme Ubc9, and with the BRM complex subunit Osa. Furthermore, we show that tna and osa interact genetically with SUMOylation pathway components and individuals carrying mutations for these genes show a phenotype that can be the consequence of misexpression of developmental-related genes.
Expresión de moléculas HLA-DR, coestimuladoras y TLR9 en células presentadoras de antígenos circulantes de pacientes con lupus eritematoso sistémico (LES)
Soraya Zorro,Liliana Arango,Oscar Uribe,Luis Ramírez
Iatreia , 2004,
Abstract: El LES es una enfermedad autoinmune sistémica con producción de autoanticuerpos anti dsDNA de manera Tdependiente1; por lo tanto, la participación de las células presentadoras de antígeno (APC), por las interacciones MHC:péptido-TCR, CD40-CD40L, CD80 y CD86 con CD28, es necesaria para el desencadenamiento de la respuesta autoinmune. En las APC, la regulación positiva de moléculas HLA-DR, CD40, CD80 y CD86 se da por estímulos endógenos (citoquinas) y exógenos (patógenos o sus productos)2. Dentro de éstos últimos están los dinucleótidos Citosina-Guanina hipometilados (CpG) presentes en DNA de procariotas que son reconocidos por el receptor TLR93. Sin embargo, los pacientes con LES presentan CpG circulantes de DNA propio, cuyo reconocimiento por TLR9 podría participar en la inducción de moléculas HLA-DR y coestimuladoras en las APC y por ende regular la activación de linfocitos T y B autorreactivos en estos pacientes.
Pseudoefoliative syndrome
Catalina Ramírez Uribe,Juan Camilo Parra,Juan Carlos Rueda
MedUNAB , 2007,
Abstract:
Evaluación de la inserción de catéter peritoneal por laparoscopia en pacientes con diálisis peritoneal
Ramírez Beltrán,Nelson; Morales Uribe,Carlos Hernando; Ramírez Morales,Carolina; Sánchez Vélez,Catalina;
Revista Colombiana de Cirugía , 2007,
Abstract: introduction: continuous or automated ambulatory peritoneal dialysis is an option for patients that for one or other individual or social reason can not undergo hemodialysis. success of the modality depends on the good function of the implanted catheter. infection and malfunction due to mechanical obstruction are the main complications. laparoscopy permits the secure and controlled implantation of the catheter in the pelvic cavity, as well as fixation of the greater omentum to the round ligament, thus preventing entrapment of the catheter by the omentum with subsequent mechanical outflow obstruction. objective: to evaluate the functioning and complications of the peritoneal dialysis catheter placed by the laparoscopic method with fixation in the pelvis and omentopexy. materials and methods: this is a descriptive and retrospective study on 109 patients older than 18 years, with terminal chronic renal insufficiency that underwent laparoscopic placement of the peritoneal catheter, covering the period january 2002 to june 2005 at clínica las américas, medellín, colombia. results: sixty patients (55%) presented complications in this series of peritoneal catheter placement by the laparoscopic technique. the most common complication was infection, in 58 patients (53.2%); two patients (1.8%) developed outflow obstruction; one (0.9%) had persistent leakage of the dialysate, and in one the catheter broke (0.9%). there were no cases of hemorrhage, visceral perforation, or hernia. the average period of use of the peritoneal dialysis catheter was 13 months (ds 11.7), and the average survival time of the catheter was 34.4 months (ci 95% 31-1-37.6). conclusions: laparoscopic placement of peritoneal dialysis catheters reduces the risk of catheter obstruction by displacement or by omental entrapment, and a reduced rate of complications such as hernias and bleeding. the rate of infectious complications is similar to those observed when the catheter is placed by the open technique.
Evaluación de la inserción de catéter peritoneal por laparoscopia en pacientes con diálisis peritoneal Evaluation of laparoscopic placement of peritoneal catheter in patients undergoing peritoneal dialysis
Nelson Ramírez Beltrán,Carlos Hernando Morales Uribe,Carolina Ramírez Morales,Catalina Sánchez Vélez
Revista Colombiana de Cirugía , 2007,
Abstract: Introducción. La diálisis peritoneal continua ambulatoria es una opción para pacientes que requieren diálisis y a quienes, por razones individuales o sociales, no se les puede realizar hemodiálisis. Su éxito depende del adecuado funcionamiento del catéter implantado. Las complicaciones de los catéteres son la infección y el mal funcionamiento por obstrucción. La colocación por vía laparoscópica permite la ubicación del catéter en la pelvis en forma segura y controlada, y la fijación del epiplón mayor al ligamento redondo evita la compresión del catéter por el epiplón con la consiguiente obstrucción. Objetivo. Evaluar el funcionamiento y las complicaciones de los catéteres de diálisis peritoneal colocados por laparoscopia con fijación del catéter en la pelvis y omentopexia. Materiales y métodos. Es un estudio descriptivo, retrospectivo, de 109 pacientes con insuficiencia renal crónica terminal a quienes se les colocó un catéter para diálisis peritoneal por laparoscopia, entre enero de 2002 y junio de 2005, en la Clínica las Américas, Medellín (Colombia). Resultados. Se presentaron complicaciones en 60 pacientes con el catéter de diálisis peritoneal (55%) colocados por vía laparoscópica. La complicación más frecuente fue la infección en 58 pacientes (53,2%); dos presentaron obstrucción (1,8%), 1 presentó fuga de líquido (0,9%) y hubo un caso de ruptura del catéter (0,9%). Ningún paciente presentó hemorragia, perforación de órgano abdominal o hernia en el tiempo de seguimiento. El tiempo promedio de uso del catéter de diálisis peritoneal fue de 13 meses (DE=11,7). El tiempo promedio de supervivencia fue de 34,4 meses (IC 95%: 31,1 - 37,6). Conclusiones. La técnica laparoscópica para la inserción de catéteres de diálisis peritoneal disminuye el riesgo de obstrucción del catéter por desplazamiento o por compresión del epiplón y presenta un menor número de complicaciones como hernia y sangrado. La frecuencia de complicaciones infecciosas es similar a la de la técnica quirúrgica abierta. Introduction: Continuous or automated ambulatory peritoneal dialysis is an option for patients that for one or other individual or social reason can not undergo hemodialysis. Success of the modality depends on the good function of the implanted catheter. Infection and malfunction due to mechanical obstruction are the main complications. Laparoscopy permits the secure and controlled implantation of the catheter in the pelvic cavity, as well as fixation of the greater omentum to the round ligament, thus preventing entrapment of the catheter by the omentum with subsequent mechanic
Nefropatía lúpica. Presentación clínica, clasificación y tratamiento
González Naranjo,Luis Alonso; Vásquez Duque,Gloria María; Uribe Uribe,Oscar; Ramírez Gómez,Luis Alberto;
Revista Colombiana de Reumatología , 2006,
Abstract: lupus nephritis (ln) is a major cause of morbility and mortality in patients with systemic lupus erythematosus (sle). similarly, kidney involvement is common in sle, occurring in up to 60% of affected adults during the course of their disease. recently, the classification of glomerulonephritis in sle has been modified; in this classification, it was proposed that class i and ii be used for purely mesangial involvement (i, mesangial immune deposits without mesangial hypercellularity; ii, mesangial immune deposits with mesangial hypercellularity); class iii for focal glomerulonephritis (involving < 50% of total number of glomeruli) with subdivisions for active and sclerotic lesions; class iv for diffuse glomerulonephritis (involving = 50% of total number of glomeruli) either with segmental (class iv-s) or global (class iv-g) involvement, and also with subdivions for active and sclerotic lesions; class v for membranous glomerulonephritis; and class vi for advanced sclerotic lesions. it is important that combinations of membranous and proliferative glomerulonephritis should be reported individually in the diagnosis line, as well as the diagnosis should also include notations for any concomitant vascular or tubolointersticial lesions, therefore, one of the main advantages of this classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and giving a basis for further clinicopathologic studies. otherwise, despite the development of new modalities of treatment in ln, cyclophosphamide remains the preferred initial treatment for severe forms of ln like proliferative and membranous glomerulonephritis associated with both, lesions of class iii or class iv; nevertheless, the optimal treatment remains challenging because of the adverse effects associated with cyclophosphamide like sustained amenorrhea, infertility, increased susceptibility to infection, bone marrow suppression,
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