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Search Results: 1 - 10 of 2997 matches for " Nicole Heussen "
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New ways in the biometrical education within the scope of the medicine study – individual qualification profiles
Heussen, Nicole,Hilgers, Ralf-Dieter
GMS Medizinische Informatik, Biometrie und Epidemiologie , 2008,
Abstract: By the revision of the 'Approbationsordnung für rzte' from June 27, 2002 the Medical faculties must offer compulsory elective courses. In addition, the science council has demanded the support of the scientific education of students and young researcher in medicine. Here we present our approach to consolidate both aspects and provide some ideas how to intensify and extend teaching within epidemiology, medical biometry and medical informatics (called Q1 course).
A new method to analyse the pace of child development: Cox regression validated by a bootstrap resampling procedure
Christian Denne, Sarah Maag, Nicole Heussen, Martin H?usler
BMC Pediatrics , 2010, DOI: 10.1186/1471-2431-10-12
Abstract: Neonates treated at Aachen University Hospital in 2000/2001 were identified retrospectively (n = 796). Outcome data, based on a structured interview, were available from 466 children, as were perinatal data. Factors possibly related to outcome were identified by bootstrap selection and then included into a multivariate Cox regression model. To evaluate if the parental assessment might change with the time elapsed since birth we studied five age cohorts of 163 normally developed children.Birth weight, gestational age, congenital cardiac disease and periventricular leukomalacia were related to outcome in the multivariate analysis (p < 0.05). Analysis of the control cohorts revealed that the parents' assessment of the ability of bladder control is modified by the time elapsed since birth.Combined application of the bootstrap resampling procedure and multivariate Cox regression analysis effectively identifies perinatal factors influencing the age at which distinct abilities are acquired. These were similar as known from previous cross sectional studies. Retrospective data acquistion may lead to a bias because the parental memories change with time. This recommends applying this statistical approach in larger prospective trials.During the past decades progress in intensive care medicine has markedly improved the prognosis of sick newborns. Despite this success, many children still face severe long-term medical educational and social problems as a result of a difficult perinatal period [1]. Numerous studies have focused on factors worsening neurodevelopmental outcome, for example identifying low APGAR scores, birth weight, umbilical artery pH and intraventricular hemorrhage (IVH) as infant-related factors as well as low social standing and drug abuse during pregnancy as maternal factors [2,3]. Most of these studies were cross sectional. None of them evaluated whether distinct risk factors influence the age at which distinct capabilities are acquired which would facilitate
Outcome after thoracoscopic ventral stabilisation of thoracic and lumbar spine fractures
Pfeifer Roman,Pishnamaz Miguel,Dombroski Derek,Heussen Nicole
Journal of Trauma Management & Outcomes , 2012, DOI: 10.1186/1752-2897-6-10
Abstract: Background and Purpose Thoracoscopic-assisted ventral stabilisation for thoracolumbar fractures has been shown to be associated with decreased recovery time and less morbidity when compared with open procedures. However, there are a limited number of studies evaluating late clinical and radiological results after thoracoscopic spinal surgery. Methods We performed an analysis of the late outcomes of thoracolumbar fractures after minimally invasive thoracoscopic ventral instrumentation. Between August 2003 and December 2008, 70 patients with thoracolumbar fractures (T5-L2) underwent ventral thoracoscopic stabilisation. Tricortical bone grafts, anterior plating systems (MACS-System), and cage implants were used for stabilisation. Outcomes measured include radiologic images (superior inferior endplate angle), Visual Analogue Scale (VAS), VAS Spine Score, quality of life scores SF-36 and Oswestry Disability Index (ODI). Results Forty seven patients (67%, 47 out of 70) were recruited for the follow up evaluation (2.2 ± 1.5 years). Lower VAS Spine scores were calculated in patients with intra- or postoperative complications (44.7 (± 16.7) vs. 65.8 (± 24.5), p=0.0447). There was no difference in outcome between patients treated with bone graft vs. cage implants. Loss of correction was observed in both bone graft and titanium cage groups. Interpretation The present study demonstrates diminished long-term quality of life in patients treated with thoracoscopic ventral spine when compared with the outcome of german reference population. In contrast to the other patients, those patients without intra-operative or post-operative complications were associated with improved outcome. The stabilisation method (bone graft versus spinal cage) did not affect the long-term clinical or radiographic results in this series.
Evaluation of a newly developed media-supported 4-step approach for basic life support training
Sa?a Sopka, Henning Biermann, Rolf Rossaint, Sebastian Knott, Max Skorning, J?rg C Brokmann, Nicole Heussen, Stefan K Beckers
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-37
Abstract: After baseline testing, 220 laypersons were either trained using the widely accepted method for resuscitation training (4-step approach) or using a newly created “media-supported 4-step approach”, both of equal duration. In this approach, steps 1 and 2 were ensured via a standardised self-produced podcast, which included all of the information regarding the BLS algorithm and resuscitation skills. Participants were tested on manikins in the same mock cardiac arrest single-rescuer scenario prior to intervention, after one week and after six months with respect to ECC-performance, and participants were surveyed about the approach.Participants (age 23?±?11, 69% female) reached comparable practical ECC performances in both groups, with no statistical difference. Even after six months, there was no difference detected in the quality of the initial assessment algorithm or delay concerning initiation of CPR. Overall, at least 99% of the intervention group (n?=?99; mean 1.5?±?0.8; 6-point Likert scale: 1?=?completely agree, 6?=?completely disagree) agreed that the video provided an adequate introduction to BLS skills.The “media-supported 4-step approach” leads to comparable practical ECC-performance compared to standard teaching, even with respect to retention of skills. Therefore, this approach could be useful in special educational settings where, for example, instructors’ resources are sparse or large-group sessions have to be prepared.Within cardiopulmonary resuscitation (CPR), external chest compressions (ECC) are the key element providing forward blood flow, thereby maintaining heart and brain viability. Thus, ECC are of primary importance for improving outcomes after in- or out-of-hospital cardiac arrest.Existing data about the ideal training methods for basic life support (BLS) are still insufficient; the duration of BLS training that is adequate remains unknown. Pedagogic training methods are thought to be the best, but specific auxiliary training methods that would
Improvement of Left Ventricular Function under Cardiac Resynchronization Therapy Goes along with a Reduced Incidence of Ventricular Arrhythmia
Christian Eickholt, Marcus Siekiera, Kiriakos Kirmanoglou, Astrid Rodenbeck, Nicole Heussen, Patrick Schauerte, Artur Lichtenberg, Jan Balzer, Tienush Rassaf, Stefan Perings, Malte Kelm, Dong-In Shin, Christian Meyer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048926
Abstract: Objectives The beneficial effects of cardiac resynchronization therapy (CRT) are thought to result from favorable left ventricular (LV) reverse remodeling, however CRT is only successful in about 70% of patients. Whether response to CRT is associated with a decrease in ventricular arrhythmias (VA) is still discussed controversially. Therefore, we investigated the incidence of VA in CRT responders in comparison with non-responders. Methods In this nonrandomized, two-center, observational study patients with moderate-to-severe heart failure, LV ejection fraction (LVEF) ≤35%, and QRS duration >120 ms undergoing CRT were included. After 6 months patients were classified as CRT responders or non-responders. Incidence of VA was compared between both groups by Kaplan-Meier analysis and Cox regression analysis. ROC analysis was performed to determine the aptitude of LVEF cut-off values to predict VA. Results In total 126 consecutive patients (64±11years; 67%male) were included, 74 were classified as responders and 52 as non-responders. While the mean LVEF at baseline was comparable in both groups (25±7% vs. 24±8%; P = 0.4583) only the responder group showed an improvement of LVEF (36±6% vs. 24±7; p<0.0001) under CRT. In total in 56 patients VA were observed during a mean follow-up of 28±14 months, with CRT responders experiencing fewer VA than non-responders (35% vs. 58%, p<0.0061). Secondary preventive CRT implantation was associated with a higher likelihood of VA. As determined by ROC analysis an increase of LVEF by >7% was found to be a predictor of a significantly lower incidence of VA (AUC = 0.606). Conclusions Improvement of left ventricular function under cardiac resynchronization therapy goes along with a reduced incidence of ventricular arrhythmia.
Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions
Sebastian Breuer, Katrin Pech, Armin Buss, Christoph Spitzer, Juris Ozols, Elly M Hol, Nicole Heussen, Johannes Noth, Franz-Werner Schwaiger, Andreas B Schmitt
BMC Neuroscience , 2004, DOI: 10.1186/1471-2202-5-15
Abstract: In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.It is well known that damaged nerve fibers in the peripheral nervous system (PNS) have the capacity for complete regeneration followed by the restoration of appropriate synaptic connectivity and full functional recovery. However, damaged nerve fibers in the central nervous system (CNS) only demonstrate an abortive sprouting response without any functional regeneration. Up to now, little is known about the molecular programs leading to these fundamental differences. To gain insight into the molecular differences, we have compared the differentially regulated genes of axotomized PNS neurons to those of axotomized CNS neurons by differential display polymerase chain reaction [1]. In the following study, we concentrate on one clone which corresponds to the 3' end of the rat stearoyl-Coenzyme A desaturase-1 (SCD-1).The first mammalian cDNA of this enzyme was isolated in 1986 from rat liver [2]. Subsequently, two different SCD isoforms (SCD-1 and SCD-2) were identified in mouse 3T3-L1 adipocytes [3,4]. Zheng et al. identified a third SCD isoform (SCD-3) which is exclusively present in skin [5] and most recently Miyazaki et al. identified a novel heart-specific isoform (SCD4)[6].Stearoyl-CoA desaturase is responsible for the rate limiting step in the ?9-cis desaturation of a spectrum of methylene-interrupted fatty acyl-CoA substrates [7]. One of the preferred substrates, stearoyl-CoA, is desaturated, resulting in oleoyl-CoA which is further converted into its corresponding fatty acid oleate. Beside its function as an energy store in the form of triacylglycerides and its presence in biological cell mem
Evaluation of Cystoid Change Phenotypes in Ocular Toxoplasmosis Using Optical Coherence Tomography
Yanling Ouyang, Uwe Pleyer, Qing Shao, Pearse A. Keane, Nicole Stübiger, Antonia M. Joussen, Srinivas R. Sadda, Florian M. Heussen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086626
Abstract: Purpose To present unique cystoid changes occurring in patients with ocular toxoplasmosis observed in spectral domain optical coherence tomography (OCT). Methods Forty-six patients (80 eyes) with a diagnosis of ocular toxoplasmosis, who underwent volume OCT examination between January 2005 and October 2012, were retrospectively collected. Review of clinical examination findings, fundus photographs, fluorescein angiograms (FA) and OCT image sets obtained at initial visits and follow-up. Qualitative and quantitative analyses of cystoid space phenotypes visualized using OCT. Results Of the 80 eyes included, 17 eyes (15 patients) demonstrated cystoid changes in the macula on OCT. Six eyes (7.5%) had cystoid macular edema (CME), 2 eyes (2.5%) had huge outer retinal cystoid space (HORC), 12 eyes (15%) had cystoid degeneration and additional 3 eyes (3.75%) had outer retinal tubulation due to age related macular degeneration. In one eye with HORC, the lesion was seen in the photoreceptor outer segment, accompanied by photoreceptor elongation and splitting. Three eyes presented with paravascular cystoid degeneration in the inner retina without other macular OCT abnormality. Conclusions In this study, different phenotypes of cystoid spaces seen in eyes with ocular toxoplasmosis using spectral domain OCT (SD-OCT) were demonstrated. CME presented as an uncommon feature, consistently with previous findings. Identification of rare morphological cystoid features (HORC with/without photoreceptor enlongation or splitting) on clinical examination had provided evidence to previous experimental models, which may also expand the clinical spectrum of the disease. Cystoid degeneration in the inner retina next to the retinal vessels in otherwise “normal” looking macula was observed, which may suggest more often clinical evaluation for those patients. Further studies are needed to verify the relevance of cystoid features seen on SD-OCT in assisting with the diagnosis and management of ocular toxoplasmosis.
Analytical Framework for Market-oriented DSR Flexibility Integration and Management  [PDF]
Shi You, Junjie Hu, Kai Heussen, Chunyu Zhang
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B259
Abstract:

Integration and management of the flexibility of Demand Side Resources (DSR) in today’s energy systems plays a significant role in building up a sustainable society. However, the challenges of understanding, predicating and handling the uncertainties associated this subject to a great extent hamper its development. In this paper, an analytical framework based on a multi-portfolio setup in presence of a deregulated power market is proposed to address such challenges by adopting the thinking in modern portfolio theory (MPT). A Numerical example that targets on analyzing the risk and return for various flexibility pricing strategies are presented to illustrate some features of the framework.

From Sméagol to Gollum: Mechanical Stress and Bone Remodelling  [PDF]
Nicole Pace
Open Journal of Orthopedics (OJO) , 2018, DOI: 10.4236/ojo.2018.84018
Abstract: This imaginary transformation from Sméagol to Gollum is a dramatization of the illusive repercussions of mechanical stress affecting bone. This paper presents the main ideas of mechanical stress and bone remodelling from a novel’s perspective. The object of this study is to provide evidence for new ways to explore bone’s functional adaptation to mechanical stress made through the copious interpretation and integration of new and existing literature. It tackles the underlying biology of bone cells and how they detect and react to strain stimuli. The different types of mechanical demands in daily activities are sifted through and any misconceptions found fallible in literature are refined. A personal experience of a stress fracture is reviewed to parallel the implications that lead to the incident with the findings on the link between mechanical stress and bone remodelling. Some factors regarding age, gender and ethnicity and the interplay with mechanical stress influencing bone remodelling are considered. Brief overviews of three new medical novelties in bone healing are outlined, hoping that these interventions of proper medical techniques can be a change for the better: one from Gollum to Sméagol rather than vice versa.
The Influence of Implicit Achievement Motive and Graphological Variables on Learning Variables  [PDF]
Nicole Gruber, Ludwig Kreuzpointner
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.612145
Abstract: There are several methods of implicit measurement. A very valid and wide spread assessment of motives by using the technique of projection is picture story exercises (PSE). Graphology, as theory of inferences on personality and motives by analyzing handwriting, is another one. The presented study examines the commons of the both measurement methods and their prediction of achievement behaviour. So, the achievement motive of 189 students was assessed using the PSE of Heckhausen (1963) and afterwards their handwriting was scored by a categorical system of Ploog (2013). Achievement related behaviour was operatively analyzed with self-reported learning time, learning behaviour and task-choice performance. It is shown that implicit motives measured by PSE are related with the criteria of task-choice performance. It is shown that both implicit motives measured by PSE and graphological variables deliver information about learning variables.
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