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Search Results: 1 - 10 of 30945 matches for " Ng Sok Peng and Jeffrey Hill "
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Generation of Active Bovine Terminal Deoxynucleotidyl Transferase (TdT) in E.coli
Wee Liang Kuan, Joma Joy, Ng Fui Mee, Kwek Zekui Perlyn, Then Siew Wen, Thuy Nguen, Joanne James, Elaine Chai, Horst Flotow, Sharon Crasta, Kelvin Chua, Ng Sok Peng and Jeffrey Hill
Biochemistry Insights , 2012, DOI: 10.4137/BCI.S5123
Abstract: A synthetic gene encoding bovine terminal deoxynucleotidyl transferase (TdT) was generated, cloned into an expression vector and expressed in E.coli. The effects of altering culture and induction conditions on the nature of recombinant protein production were investigated. This led to the expression of active recombinant bovine TdT in E.coli. After purification and characterisation, the activity of the enzyme was assessed in a biological assay for apoptosis. The process described in this report enables the economical production of TdT for high throughput applications.
Genome Wide Analysis of Chromosomal Alterations in Oral Squamous Cell Carcinomas Revealed over Expression of MGAM and ADAM9
Vui King Vincent-Chong, Arif Anwar, Lee Peng Karen-Ng, Sok Ching Cheong, Yi-Hsin Yang, Padmaja Jayaprasad Pradeep, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Zuraiza Mohamad Zaini, Narayanan Prepageran, Thomas George Kallarakkal, Anand Ramanathan, Nur Aaina Binti Mohd Mohayadi, Nurul Shielawati Binti Mohamed Rosli, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Rosnah Binti Zain
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054705
Abstract: Despite the advances in diagnosis and treatment of oral squamous cell carcinoma (OSCC), mortality and morbidity rates have not improved over the past decade. A major drawback in diagnosis and treatment of OSCC is the lack of knowledge relating to how genetic instability in oral cancer genomes affects oral carcinogenesis. Hence, the key aim of this study was to identify copy number alterations (CNAs) that may be cancer associated in OSCC using high-resolution array comparative genomic hybridization (aCGH). To our knowledge this is the first study to use ultra-high density aCGH microarrays to profile a large number of OSCC genomes (n = 46). The most frequently amplified CNAs were located on chromosome 11q11(52%), 2p22.3(52%), 1q21.3–q22(54%), 6p21.32(59%), 20p13(61%), 7q34(52% and 72%),8p11.23–p11.22(80%), 8q11.1–q24.4(54%), 9q13–q34.3(54%), 11q23.3–q25(57%); 14q21.3–q31.1(54%); 14q31.3–q32.33(57%), 20p13–p12.3(54%) and 20q11.21–q13.33(52%). The most frequently deleted chromosome region was located on 3q26.1 (54%). In order to verify the CNAs from aCGH using quantitative polymerase chain reaction (qPCR), the three top most amplified regions and their associated genes, namely ADAM5P (8p11.23–p11.22), MGAM (7q34) and SIRPB1 (20p13.1), were selected in this study. The ADAM5P locus was found to be amplified in 39 samples and deleted in one; MGAM (24 amplifications and 3 deletions); and SIRPB1 (12 amplifications, others undetermined). On the basis of putative cancer-related annotations, two genes, namely ADAM metallopeptidase domain 9 (ADAM9) and maltase-glucoamylase alpha-glucosidase (MGAM), that mapped to CNA regions were selected for further evaluation of their mRNA expression using reverse transcriptase qPCR. The over-expression of MGAM was confirmed with a 6.6 fold increase in expression at the mRNA level whereas the fold change in ADAM9 demonstrated a 1.6 fold increase. This study has identified significant regions in the OSCC genome that were amplified and resulted in consequent over-expression of the MGAM and ADAM9 genes that may be utilized as biological markers for OSCC.
The Utility of Diagnostic Imaging in Fish Bone Impaction  [PDF]
Shanesh Kumar, Casey Yu, Jason Toppi, Matthew Ng, Fiona Hill, Natalie Sist
Open Journal of Radiology (OJRad) , 2018, DOI: 10.4236/ojrad.2018.81006
Abstract: Objectives: The purpose of this pilot study was to obtain an Australian perspective on evaluating the utility of plain film radiography and computed tomography (CT) to rule out fish bone impaction in the upper aerodigestive tract in the emergency department (ED) setting. Methods: A retrospective multicentre cohort study was conducted. A total of 73 patients met the inclusion criteria. A subgroup of patients underwent CT. We studied the sensitivity and specificity of x-ray and CT along with other demographic variables to determine the likelihood of true fish bone impaction. Results: Out of the 73 patients, 28 patients had true bone impaction. The sensitivity for x-ray was 42.9% and specificity was 73.3%. The sensitivity of CT was 87.5% and specificity was 71.4%. We found a significant difference in the mean age of presentation for true bone and false bone impaction, P = 0.02. Conclusion: Due to the low sensitivity of x-ray we do not recommend the utilisation of plain film radiography to rule out bone impaction Advances in low dose radiation multidetector CT scanners may replace plain film radiography as a screening tool.
Anomaly mediated neutrino-photon interactions at finite baryon density
Harvey, Jeffrey A.;Hill, Christopher T.;Hill, Richard J.
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevLett.99.261601
Abstract: We propose new physical processes based on the axial vector anomaly and described by the Wess-Zumino-Witten term that couples the photon, Z-boson, and the omega-meson. The interaction takes the form of a pseudo-Chern-Simons term, $\sim \epsilon_{\mu\nu\rho\sigma}\omega^\mu Z^\nu F^{\rho\sigma}$. This term induces neutrino-photon interactions at finite baryon density via the coupling of the Z-boson to neutrinos. These interactions may be detectable in various laboratory and astrophysical arenas. The new interactions may account for the MiniBooNE excess. They also produce a competitive contribution to neutron star cooling at temperatures >10^9 K. These processes and related axion--photon interactions at finite baryon density appear to be relevant in many astrophysical regimes.
Standard Model Gauging of the WZW Term: Anomalies, Global Currents and pseudo-Chern-Simons Interactions
Jeffrey A. Harvey,Christopher T. Hill,Richard J. Hill
Physics , 2007, DOI: 10.1103/PhysRevD.77.085017
Abstract: The standard model $SU(2)_L\times U(1)_Y$ gauging of the Wess-Zumino-Witten term requires a modified counterterm when background fields, needed to generate the full set of currents, are introduced. The modified counterterm plays an essential role in properly defining covariant global currents and their anomalies. For example, it is required in order to correctly derive the gauge invariant baryon number current and its anomalous divergence. The background fields can also be promoted to a description of the physical spin-1 vector and axial-vector mesons in QCD and the counterterm leads to novel interactions. These are (pseudo-) Chern-Simons terms, such as $\epsilon^{\mu\nu\rho\sigma} \omega_\mu Z_\nu \partial_\rho A_\sigma$ and $\epsilon^{\mu\nu\rho\sigma} \rho^{\pm}_\mu W^{\mp}_\nu \partial_\rho A_\sigma$ that mediate new interactions between neutrinos and photons at finite baryon density.
Anomaly mediated neutrino-photon interactions at finite baryon density
Jeffrey A. Harvey,Christopher T. Hill,Richard J. Hill
Physics , 2007, DOI: 10.1103/PhysRevLett.99.261601
Abstract: We propose new physical processes based on the axial vector anomaly and described by the Wess-Zumino-Witten term that couples the photon, Z-boson, and the omega-meson. The interaction takes the form of a pseudo-Chern-Simons term, $\sim \epsilon_{\mu\nu\rho\sigma}\omega^\mu Z^\nu F^{\rho\sigma}$. This term induces neutrino-photon interactions at finite baryon density via the coupling of the Z-boson to neutrinos. These interactions may be detectable in various laboratory and astrophysical arenas. The new interactions may account for the MiniBooNE excess. They also produce a competitive contribution to neutron star cooling at temperatures >10^9 K. These processes and related axion--photon interactions at finite baryon density appear to be relevant in many astrophysical regimes.
Optimal Aerations in the Inverse Fluidized Bed Biofilm Reactor When Used in Treatment of Industrial Wastewaters of Various Strength  [PDF]
W?odzimierz Sokó?
Advances in Chemical Engineering and Science (ACES) , 2012, DOI: 10.4236/aces.2012.23046
Abstract: The aim of this work was the determination of the optimal aerations, and more specifically the corresponding optimal air velocities uopt, at which the largest COD removals were achieved in treatment of industrial wastewaters of various strength conducted in the inverse fluidized bed biofilm reactor. The largest COD removals were achieved at the following air velocities uopt and retention times ts, and (Vb/VR) = 0.55: i) for CODo = 72,780 mg/l at uopt = 0.052 m/s and ts = 80 h ; ii) for CODo = 62,070 mg/l at uopt = 0.042 m/s and ts = 65 h; iii) for CODo = 49,130 mg/l at uopt = 0.033 m/s and ts= 55 h ; iv) for CODo = 41,170 mg/l at uopt = 0.028 m/s and ts = 45 h; v) for CODo = 35,460 mg/l at uopt = 0.025 m/s and ts = 27.5 h; and vi) for CODo = 26,470 mg/l at uopt= 0.014 m/s and ts = 22.5 h. In the treatment operation conducted in a reactor optimally controlled at the above values of uopt, ts and (Vb/VR), the following decreases in COD were obtained: i) from 72,780 to 5410 mg/l; ii) from 62,070 to 3730 mg/l; iii) from 49,130 to 2820 mg/l; iv) from 41,170 to 1820 mg/l; v) from 35,460 to 1600 mg/l; and vi) from 26,470 to 1180 mg/l, that is, approximately a 93%, 94%, 95%, 96%, 95% and 96% COD reduction was attained, respectively.
THE CONDITIONS OF MALARIA TRANSMISSION IN KUALA PENYU DISTRICT, SABAH AND THE RESIDUAL EFFECTS OF SUMITHION, DDT AND MALATHION
Jeffrey L.K. Hill,Michael Macdonald
Bulletin of Health Research , 2012,
Abstract: During 1976 - 1977, the Sabah Malaria Control Programme carried out an extended field trial com-paring the residual effects of Summithiona, DDT and Malathionb against the primary vector of Sabah, An. balabacensis balabacensis Baisas in Kuala Penyu district. In the courseof this work and continuiting into 1978, a study was made of the conditions of increased malaria transmission in 3 areas four month after residual applications of Sumithion, DDT and Malathion. Since the findings relate to the south-western part of Sabah which suffers annual anticipated seasonal outbreaks of malaria they are of parti-cular epidemiological interest
Spatial shaping for generating arbitrary optical dipoles traps for ultracold degenerate gases
Jeffrey G. Lee,W. T. Hill III
Physics , 2014, DOI: 10.1063/1.4895676
Abstract: We present two spatial-shaping approaches -- phase and amplitude -- for creating two-dimensional optical dipole potentials for ultracold neutral atoms. When combined with an attractive or repulsive Gaussian sheet formed by an astigmatically focused beam, atoms are trapped in three dimensions resulting in planar confinement with an arbitrary network of potentials -- a free-space atom chip. The first approach utilizes an adaptation of the generalized phase-contrast technique to convert a phase structure embedded in a beam after traversing a phase mask, to an identical intensity profile in the image plane. Phase masks, and a requisite phase-contrast filter, can be chemically etched into optical material (e.g., fused silica) or implemented with spatial light modulators; etching provides the highest quality while spatial light modulators enable prototyping and realtime structure modification. This approach was demonstrated on an ensemble of thermal atoms. Amplitude shaping is possible when the potential structure is made as an opaque mask in the path of a dipole trap beam, followed by imaging the shadow onto the plane of the atoms. While much more lossy, this very simple and inexpensive approach can produce dipole potentials suitable for containing degenerate gases. High-quality amplitude masks can be produced with standard photolithography techniques. Amplitude shaping was demonstrated on a Bose-Einsten condensate.
catena-Poly[[[2-({6-[(pyrimidin-2-ylsulfanyl-κS)methyl]pyridin-2-yl-κN}methylsulfanyl)pyrimidine]copper(I)]-μ-thiocyanato-κ2N:S]
Rong Peng,Seik Weng Ng
Acta Crystallographica Section E , 2012, DOI: 10.1107/s160053681201063x
Abstract: The N-heterocyclic ligand in the title compound, [Cu(NCS)(C15H13N5S2)]n, coordinates to the CuI atom through its pyridine N-donor site, and adjacent metal atoms are bridged by the thiocyanate ion, forming a helical chain along the b axis. The geometry of the metal atom is tetrahedral owing to a somewhat long intramolecular Cu—S interaction of 2.5621 (9) .
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