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Search Results: 1 - 10 of 12931 matches for " Nephrotic Syndrome "
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Resolution of Late Steroid-Responsive Nephrotic Syndrome in a Patient with Alport Syndrome Treated with Atorvastatin  [PDF]
Jia-Feng Chang, Wei-Ning Lin, Chien-Chen Tsai
Open Journal of Pediatrics (OJPed) , 2015, DOI: 10.4236/ojped.2015.51003

Experimental and clinical studies have pointed out the lipid-induced renal damage, and statins may have pleiotropic effects on renoprotection. We reported a girl with X-linked Alport syndrome whose late steroid-responsive nephrotic syndrome (NS) was resolved by atorvastatin. She had been in a nephrotic condition despite of prednisone therapy 60 mg/day for 8 weeks. Renal biopsy dispicted extreme foamy appearance of tubular epithelial cells with detachment led to luminal obliteration. Atorvastatin was started on the ninth week of prednisone therapy due to severe hypercholesterolemia. Partial remission of NS was dramatically achieved with unchanged dosage of prednisone at the end of the twelfth week. Our case provides a pathology-based evidence to support the use of statins in profoundly hyperlipidemic patients with NS. In patients with NS and profound hyperlipidemia, early initiation of statin therapy is required in combination with immunosuppressive therapy.

Refractory Oedema of Nephrotic Syndrome in a Resource Poor Setting: A Case Presentation  [PDF]
Nneka Chioma Okoronkwo, Chukwuemeka Ngozi Onyearugha, Ikechukwu Frank Ogbonna
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.71003
Abstract: Background: Oedema, a constant feature of childhood nephrotic syndrome can be severe, enough to cause respiratory embarrassment. It can also be refractory to diuretic monotherapy. In such cases, combination of salt poor albumin (SPA) infusion and diuretics has remained the best treatment option. However, the cost of SPA has made it practically unavailable in resource-poor settings. It becomes a therapeutic dilemma when nephrotic syndrome patients of financially-constrained caregivers present with refractory anasarca in a resource-poor settings. Case review: We present a seven-year-old boy with relapsed steroid sensitive nephrotic syndrome who presented to Abia State University Teaching Hospital Aba, in respiratory distress with anasarca and a weight of 58 kilograms. SPA could not be accessed due to financial constraints. A decision to use fresh whole blood in the place of SPA, in combination with frusemide, achieved a lifesaving diuresis and regression of the anasarca. Conclusion: Whole blood is a good alternative for the treatment of refractory oedema in children with nephrotic syndrome in resource poor settings.
A rare complication of a rare disease: Amyloidosis in situs inversus  [PDF]
Abdullah Ozkok, Mirac Vural Keskinler, Erhan Eken, Ozge Caklili, Alihan Oral, Kubra Aydin Bahat, Omer Celal Elcioglu, Ali Bakan, Ali Riza Odabas, Osman Kostek
Open Journal of Internal Medicine (OJIM) , 2013, DOI: 10.4236/ojim.2013.32013
Abstract: A 31-year-old female admitted with productive cough and progressively increasing edema in her legs. Four years ago she had the diagnosis of situs inversus (SI) totalis. She had6.5 g/day proteinuria in 24-hour urine analysis. High resolution computed tomography revealed bronchiectatic areas in the left lung. In renal biopsy, kongo and amyloid AA antibody positivity was detected in arteriolar walls and mesangial areas. The patient is currently being followed with ramipril and colchicine treatments. Primary ciliary dyskinesia (PCD) and resultant SI totalis are very rare anomalies characterized by the total inversion of all organs and chronic bronchiectasis. There are very few reports on the association of SI totalis with nephrotic syndrome. Patients with SI totalis and chronic bronchiectasis have increased risk of AA amyloidosis and possibly end stage renal disease and thus these patients should be regularly followed with proteinuria and serum creatinine levels.
Hidden renal disease in a female patient with long-lasting isolated gestational proteinuria followed by hypertension  [PDF]
Kosuke Kawabata, Rina Akaishi, Ayako Nozaki, Osamu Sato, Kaoru Hanatani, Hisanori Minakami
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.39124

Background: The prevalence of asymptomatic renal scarring, such as a focal segmental glomerulosclerosis (FSGS), was suggested to be high in women who develop preeclampsia. FSGS is a risk factor for endstage renal disease. Objective: To document preeclamptic women with proteinuria that developed eight weeks prior to hypertension with confirmed FSGS postpartum. Case: A 20-year-old nulliparous Japanese woman with a negative dipstick test result at gestational week (GW) 18 exhibited proteinuria 1+ on dipstick test at GW 22. Proteinuria determined from the random urine protein to creatinine ratio (P/Cr, g/g) was increased from 3.7 at GW 26 to 4.6 and 8.9 at GW 28 and 30, respectively. She developed hypertension (142/66 mmHg) at GW 30. Due to increased edema, emergency cesarean section was performed at GW 33. She gave birth to an otherwise healthy female small-for-gestational-age infant, weighing 1290 g. Postpartum course was uneventful except for persisting proteinuria: P/Cr of 9.8 just before delivery decreased to 3.6 and 1.7 on postpartum weeks 9 and 17, respectively. Renal biopsy on postpartum week 13 revealed FSGS in this patient. Conclusion: Hidden FSGS may have manifested as preeclampsia in this patient. This case highlighted the need to determine the prevalence of asymptomatic FSGS among women who later develop preeclampsia.

Renal Amyloidosis Following Chronic Osteomyelitis in a Patient with Congenital Insensitivity to Pain and Anhidrosis  [PDF]
Sevgi Yavuz, Aydin Ece
Open Journal of Pediatrics (OJPed) , 2014, DOI: 10.4236/ojped.2014.43032
Abstract: Congenital insensitivity to pain and anhidrosis (CIPA) is a rare form of hereditary sensory and autonomic neuropathy. It is characterized by impaired perception of pain and temperature, anhidrosis and intellectual disability. Self mutilating behaviors lead to accidental injuries. The limb lesions are often infected and frequently progress to chronic osteomyelitis. In pediatrics, amyloidosis usually occurs secondary to chronic inflammatory diseases. The coexistence of amyloidosis and CIPA has not previously been reported in literature. A CIPA case complicated with nephrotic syndrome and renal amyloidosis following chronic osteomyelitis is presented here. This report emphasizes the importance of close follow-up of patients by urine analysis for the risk of developing amyloidosis particularly in the presence of chronic infections.
Study of Xanthine Oxidase Activity in Sera of Iraqi Children with Nephrotic Syndrome  [PDF]
Vyan Asad Qadir, Sardar Nouri Ahmed, Dler Rostum Ali
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.65014
Abstract: Introduction: To investigate the relationship of xanthine oxidase activity with nephrotic syndrome disorder in children, and the optimization of the enzyme activity conditions in the disorder. Material and methods: Sera of children with nephrotic syndrome (NS) (60 samples) were obtained from Central Child Teaching Al Karama Hospital (CCTAH), from 2nd Mar. 2013 to 28th Feb. 2014. Sera of the patients were assayed for xanthine oxidase (XO) activity using colorimetric absorbance technique. The obtained results were compared with the enzyme activity of normal children (70 samples) as control. Results and conclusions: The results revealed a significant (P < 0.001) elevation in XO activity in serum of nephrotic syndrome (0.12 ± 0.06 IU/L) compared with that of normal subjects (0.05 ± 0.009 IU/L), showing an elevation of (70%) in XO activity (about 2/3) that of normal group. Factors influencing XO activities were also studied and showed that XO activity is a pH dependent. Significant elevation (P < 0.001) was found in uric acid level in sera of NS patients (497.52 ± 3.21 μmol/L) compared with that in normal group (298.12 ± 1.70 μmol/L). Elevation was found in urea level in sera of NS patient (10.69 ± 7.55 mmol/L) compared with that of normal group (4.57 ± 1.27 mmol/L). It was appeared, there is a role of XO activity in the pathogenesis of endothelial injury during glomerular lesion in NS and that was confirmed by comparing XO activity and other related conditions with the activity of normal volunteers.
A Case Report of the Association Renal AA Amyloidosis and Thyroid Papillary Carcinoma  [PDF]
Dione Diomaye Jean Pierre, Jmahri Hind, En-Niya Fatima, Al Hamany Zitouna, Bouattar Tarik, Benamar Loubna, Bayahia Rabéa, Ouzeddoun Naima
Open Journal of Nephrology (OJNeph) , 2018, DOI: 10.4236/ojneph.2018.82008
Abstract: AA amyloidosis is often secondary to chronic inflammatory diseases but can rarely occur in patients with malignant neoplasms. A 33 years old woman with papillary carcinoma of thyroid was hospitalized in our department of Nephrology for nephrotic syndrome. Renal histology finds AA amyloidosis. To our knowledge, this is the first report of a patient with papillary carcinoma of thyroid and secondary (AA) amyloidosis with amyloid deposition in the kidneys causing nephrotic syndrome.
Recurrence of paraneoplastic membranous glomerulonephritis following chemoradiation in a man with non-small-cell lung carcinoma
Andrew R. Crawford,Lance Dworkin,Kara Leonard,Humera Khurshid
Rare Tumors , 2013, DOI: 10.4081/rt.2013.e16
Abstract: Membranous glomerulonephritis can occur as a rare paraneoplastic complication of human cancers. In this case report, we describe a patient who presented acutely with symptoms of the nephrotic syndrome including heavy proteinuria and anasarca. He was subsequently diagnosed with membranous glomerulonephritis, and soon afterwards was found to have stage IIIB non-small cell lung cancer. Following chemoradiation therapy, both the patient’s cancer and membranous glomerulonephritis dramatically improved. However, approximately 14 months following his initial presentation, the patient was found to have a recurrence of his nephrotic-range proteinuria which corresponded temporally with recurrence of his cancer. We present details of the case and a review of the relevant scientific literature.
Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria  [PDF]
Tajamul H. Shah, Ajaz N. Koul, Sonaullah Shah, Umar H. Khan, Parvaiz A. Koul, Fayaz A. Sofi, Mufti S., Rafi Ahmed Jan
Open Journal of Nephrology (OJNeph) , 2013, DOI: 10.4236/ojneph.2013.32017

Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count (eosinophilia) along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1-4], with no obvious cause for eosinophilia. The onset of symptoms is insidious in most of the cases and eosinophilia is detected incidentally. However, in others, the initial manifestations are severe and life-threatening due to the rapid evolution of cardiac or neurologic complications [5]. Renal involvement is rarely reported [6] in IHES. Herein we reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy.

Tromboembolismo pulmonar no síndrome nefrótico associado a trombofilia
Pereira,Joana Ramos; Leite,Filipa; Pio,Daniela; Morais,Lurdes; Costa,Teresa; Faria,Maria Sameiro; Barbot,José; Mota,Concei??o;
Nascer e Crescer - Revista do Hospital de Crian?as Maria Pia , 2011,
Abstract: introduction: children with nephrotic syndrome (ns) have an increased risk of thromboembolic complications. case report: the authors report a case of 12 year-old boy with steroid resistant nephrotic syndrome, treated with prednisone, cyclosporine, omeprazole, enalapril and acetylsalicylic acid. he was admitted for anasarca and poor renal perfusion, with initial good response to daily albumin infusions. by the fourth day of hospitalization he presented fever, chest pain, hemoptysis and worsening of dyspnea. computed tomography pulmonary angiography showed central and peripheral acute pulmonary thromboembolism, with multiple areas of pulmonary infarction and pleural effusion of small volume. screening for hereditary thrombophilia showed heterozygosity for the g20210a mutation in prothrombin gene and homozygosity for the thermolabile variant c677t of the methylenetetrahydrofolate reductase. conclusion: the thromboembolic complications in children with ns are rare and its diagnosis requires a high index of suspicion. screening for inherited thrombophilia is important to identify patients with ns and increased thrombotic risk.
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