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Search Results: 1 - 10 of 914 matches for " Neena Goyal "
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Role of Efflux Pumps and Intracellular Thiols in Natural Antimony Resistant Isolates of Leishmania donovani
Smita Rai, Bhaskar, Sudhir K. Goel, Upendra Nath Dwivedi, Shyam Sundar, Neena Goyal
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074862
Abstract: Background In view of the recent upsurge in the phenomenon of therapeutic failure, drug resistance in Leishmania, developed under natural field conditions, has become a great concern yet little understood. Accordingly, the study of determinants of antimony resistance is urgently warranted. Efflux transporters have been reported in Leishmania but their role in clinical resistance is still unknown. The present study was designed to elucidate the mechanism of natural antimony resistance in L. donovani field isolates by analyzing the functionality of efflux pump(s) and expression profiles of known genes involved in transport and thiol based redox metabolism Methodology/Principal Findings We selected 7 clinical isolates (2 sensitive and 5 resistant) in addition to laboratory sensitive reference and SbIII resistant mutant strains for the present study. Functional characterization using flow cytometry identified efflux pumps that transported substrates of both P-gp and MRPA and were inhibited by the calmodulin antagonist trifluoperazine. For the first time, verapamil sensitive efflux pumps for rhodamine 123 were observed in L. donovani that were differentially active in resistant isolates. RT-PCR confirmed the over-expression of MRPA in isolates with high resistance index only. Resistant isolates also exhibited consistent down regulation of AQP1 and elevated intracellular thiol levels which were accompanied with increased expression of ODC and TR genes. Interestingly, γ-GCS is not implicated in clinical resistance in L. donovani isolates. Conclusions/Significance Here we demonstrate for the first time, the role of P-gp type plasma membrane efflux transporter(s) in antimony resistance in L. donovani field isolates. Further, decreased levels of AQP1 and elevated thiols levels have emerged as biomarkers for clinical resistance.
Investigation of Tolerable Laser Linewidth for Different Modulation Formats in CO-OFDM Systems  [PDF]
Divya Dhawan, Neena Gupta
Optics and Photonics Journal (OPJ) , 2017, DOI: 10.4236/opj.2017.75009
Abstract: The ideal behavior of communication system requires a single frequency carrier. In optical communication system, light is used as a carrier. Practical laser source has a finite linewidth due to variations in the frequency of operation, hence, resulting in undesired phase perturbations in the signal whereas the ideal requirement is the delta function spectral shape at the carrier frequency. The spectral shape gets broadened due to phase noise and is modeled as lorentzian shape. Linewidth is a measure of stability of laser phase noise with time. Coherent Optical Orthogonal frequency division multiplexing (CO-OFDM) along with the spectrally efficient Quadrature Amplitude Modulation (QAM) formats is emerging as one of the best solutions for future high speed fiber transmission systems. Though the coherent, receivers have advantages in terms of sensitivity and selectivity, laser phase noise is the main limitation of such systems as the laser phase noise further causes common phase rotation of all the subcarriers per symbol and also results in inter carrier interference. QAM formats are also susceptible to laser phase noise. Phase noise in coherent systems is governed by laser linewidth. Hence, it is very important to investigate the impact of laser linewidth in CO-OFDM systems. This paper investigates the tolerable laser linewidths for different QAM formats in a 40 Gbps COOFDM system.
Hand dermatitis in beauticians in India
Khanna Neena
Indian Journal of Dermatology, Venereology and Leprology , 1997,
Abstract: One hundred and sixty-one beauticians and hairdressers (146 women and 15 men) were examined for the presence of hand dermatitis and those with hand eczema were patch tested with a battery of antigens standardised for beauticians. Forty-two (26.1%) subjects were found to have hand dermatitis and of these, in 31 (69.3%) the patch tests were positive; the following antigens elicited a positive response; paraphenylene diamine (35.5%), rubber antigens (22.6%), nickel (22.6%), shampoos (12.9%), ammonium thioglycollate (9.7%), ammonium persulphate (3.2%), henna mixture (3.2%) and detergents (6.5%). In addition, irritant reaction was seen in 7; in 5 patients it was to shampoos and in 2 to ammonium persulphate. Of the 8 patients who, on questioning, had a history of atopy, 7 (87.5%) had hand eczema, while 1 (12.5%) did not, and this difference was statistically significant (p < 0.001), suggesting that beauticians with a history of atopy were more likely to develop hand eczema.
Hairdyes and their toxicology
Vaswani Neena
Indian Journal of Dermatology, Venereology and Leprology , 1991,
Cosmetic treatment of hirsutism
Khanna Neena
Indian Journal of Dermatology, Venereology and Leprology , 1993,
Treatment of acne vulgaris with oral tetracyclines
Khanna Neena
Indian Journal of Dermatology, Venereology and Leprology , 1993,
Abstract: Forty four patients with moderately severe and severe acne were put on treatment with either tetracycline 1g daily (21 patients) or minocycline 100 mg daily (23 patients). Patients were assessed at 6 and 12 weeks by calculating the reduction of the acne lesion score. At 6 weeks with minocycline 47.6% of the patients showed a good response, with tetracycline none of the patients showed a comparable response and the difference in the 2 therapeutic groups was statistically significant (p< 0.01). However, at 12 weeks the response of acne was comparable with the 2 drugs. With tetracycline 70.4% patients and with minocycline 69.6% patients showed a good to excellent response. Similarly, at 6 weeks the mean reduction in acne lesion score was significantly better with minocycline than with tetracycline, but at 12 weeks the response was comparable with the 2 drugs.
Follow up of patients of acne vulgaris treated with tetracyclines
Khanna Neena
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract: Tetracyclines have been used extensively for the management of moderately severe to severe acne. In this study we studied the effect of withdrawal of tetracycline and minocycline on the course of acne. Ninety seven clinically controlled patients of acne vulgaris who had earlier taken tetracycline (1G daily) or minocycline (100 mg daily) were followed up at 4 weekly intervals for a period of 12 weeks after stopping all anti-acne therapy. At each visit the acne lesion score (ALS) was calculated. It was found that in the group of 48 patients who had previously received tetracyclines, 25% continued to improve at 12 weeks while 16.7% had relapsed. In the group of 49 patients who had earlier taken minocycline, 69.4% continued to improve and none had relapsed at 12 weeks. Similarly, when the mean acne lesion score of the 2 groups was compared at 12 weeks, it was found that response persisted in the group of acne patients who had been treated previously with minocycline and not in the group treated with tetracyclines.
Forest Ecology in India. Colonial Maharashtra 1850-1950
Rao Neena
Conservation & Society , 2008,
Joel Best, Stat-spotting: A Field Guide to Identifying Dubious Data
Neena Chappell
The Canadian Journal of Sociology , 2009,
The Role of Iron in Prion Disease and Other Neurodegenerative Diseases
Neena Singh
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004335
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