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Search Results: 1 - 10 of 742 matches for " Natasha Leporé "
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A Multivariate Surface-Based Analysis of the Putamen in Premature Newborns: Regional Differences within the Ventral Striatum
Jie Shi, Yalin Wang, Rafael Ceschin, Xing An, Yi Lao, Douglas Vanderbilt, Marvin D. Nelson, Paul M. Thompson, Ashok Panigrahy, Natasha Leporé
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066736
Abstract: Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures have been documented in these subjects, but little is known about surface deformation in these structures. For the first time, here we found regional surface morphological differences in the preterm neonatal ventral striatum. We performed regional group comparisons of the surface anatomy of the striatum (putamen and globus pallidus) between 17 preterm and 19 term-born neonates at term-equivalent age. We reconstructed striatal surfaces from manually segmented brain magnetic resonance images and analyzed them using our in-house conformal mapping program. All surfaces were registered to a template with a new surface fluid registration method. Vertex-based statistical comparisons between the two groups were performed via four methods: univariate and multivariate tensor-based morphometry, the commonly used medial axis distance, and a combination of the last two statistics. We found statistically significant differences in regional morphology between the two groups that are consistent across statistics, but more extensive for multivariate measures. Differences were localized to the ventral aspect of the striatum. In particular, we found abnormalities in the preterm anterior/inferior putamen, which is interconnected with the medial orbital/prefrontal cortex and the midline thalamic nuclei including the medial dorsal nucleus and pulvinar. These findings support the hypothesis that the ventral striatum is vulnerable, within the cortico-stiato-thalamo-cortical neural circuitry, which may underlie the risk for long-term development of frontal executive dysfunction, attention deficit hyperactivity disorder and attention-related learning disabilities in preterm neonates.
A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast
Nathalie Leporé, Denis L. J. Lafontaine
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024962
Abstract: Ribogenesis is a multistep error-prone process that is actively monitored by quality control mechanisms. How ribosomal RNA synthesis, pre-rRNA processing and nucleolar surveillance are integrated is unclear. Nor is it understood how defective ribosomes are recognized. We report in budding yeast that, in vivo, the interaction between the transcription elongation factor Spt5 and Rpa190, the largest subunit of RNA polymerase (Pol) I, requires the Spt5 C-terminal region (CTR), a conserved and highly repetitive domain that is reminiscent of the RNA Pol II C-terminal domain (CTD). We show that this sequence is also required for the interaction between Spt5 and Nrd1, an RNA specific binding protein, and an exosome cofactor. Both the Spt4-Spt5, and the Nrd1-Nab3 complexes interact functionally with Rrp6, and colocalize at the rDNA. Mutations in the RNA binding domain of Nrd1, but not in its RNA Pol II CTD-interacting domain, and mutations in the RRM of Nab3 led to the accumulation of normal and aberrant polyadenylated pre-rRNAs. Altogether these results indicate that Nrd1-Nab3 contributes to recruiting the nucleolar surveillance to elongating polymerases to survey nascent rRNA transcripts.
The Effects of Pre-Surgical Education on Patient Expectations in Total Knee Arthroplasties  [PDF]
Steven Furney, Natasha Montez
Open Journal of Preventive Medicine (OJPM) , 2015, DOI: 10.4236/ojpm.2015.512050
Abstract: As patients prepare for total-knee arthroplasty surgery, they have many expectations related to their long-term recovery and function. This research examined whether the use of a pre-surgical patient education class with an additional long-term expectation module addressing recovery during the first 12 months after surgery was more effective in modifying participant’s pre-surgical expectations than participants receiving the standard pre-surgical education class alone. Prior to the class each participant completed one disease-specific instrument, a general-health survey, and a total-knee replacement expectation survey. After the class, each participant once again completed the total-knee replacement survey. Included in the study were 42 participants who were enrolled in a pre-surgical education course that was randomized. The participants in the control group received the standard pre-surgical education addressing pre-surgical topics. The participants in the intervention group received the standard pre-surgical education plus an additional module that specifically addressed long-term recovery and function up to 12 months post surgery. The primary outcome of the data revealed that participants’ who received the standard pre-surgical education with the additional module and who had an educational level higher than highschool, had expectations that were able to be modified to coincide with the surgeons’ expectations.
Nephrotic Sydrome Can Be a Marker for Prostatic Carcinoma  [PDF]
Natasha Takova, Alexander Otsetov
Modern Research in Inflammation (MRI) , 2017, DOI: 10.4236/mri.2017.64004
Abstract: Paraneoplastic syndromes (PS) represent a large spectrum of symptoms, associated with malignant diseases. PS can be diagnosed in asymptomatic patients with occult carcinoma, clinically active cancer, and during clinical remission, suggesting a recurrence of the neoplasm. The underlying mechanisms of PS are not completely understood but several authors have suggested that the increased production of biologically active immune factors and cytokines from the neoplastic cells may underlie the etiology of PS. Although rare, the renal involvement of patients with prostatic carcinoma has been reported. The most common paraneoplastic-associated glomerulopathy in prostatic cancer is the membranoproliferative glomerulonephritis with nephrotic syndrome (NS). In this review, we aimed to discuss the incidence of nephrotic syndrome secondary to prostatic carcinoma, its challenging diagnosis, clinical manifestation, and treatment.
Single Dilepton Production at $e^+e^-$, $eγ$ and $γγ$ Colliders
N. Leporé,B. Thorndyke,H. Nadeau,D. London
Physics , 1994, DOI: 10.1103/PhysRevD.50.2031
Abstract: We calculate the cross sections for the single production of doubly-charged dileptons, both scalar and vector, at $e^+e^-$, $e\gamma$ and $\gamma\gamma$ colliders at $\sqrt{s}=500$ GeV and 1 TeV. The $e\gamma$ mode is by far the most promising -- dileptons whose coupling is as weak as $O(10^{-4})\alpha_{em}$ can be observed, for masses virtually up to the kinematic limit. Dileptons of mass up to $\sqrt{s}$ can also be seen in $e^+e^-$ and $\gamma\gamma$ colliders, for couplings of order $\alpha_{em}$. In all three colliders, most of the cross section comes from events in which the only particles detected are $e^-e^-$, the decay products of the dilepton, yielding an unmistakeable experimental signature.
Perceptions of cultural competency of undergraduate nursing students  [PDF]
Diane Von Ah, Natasha Cassara
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.32024

Purpose: The purpose of this study was to examine the level of cultural competence of undergraduate nursing students at a large Midwestern University. Background: Developing cultural competence of nurses is critical to meet the needs of our growing diverse society. Methods: A convenience sample of 150 undergraduate nursing students completed a one-time questionnaire assessing students’ cultural competence. Results: Nursing students’ rated their overall knowledge and comfort moderate to poor with only 28% rated themselves as very comfortable and 15% as very skillful in providing culturally competent care. Students rated their knowledge and comfort highest in taking a family history, whereas, the lowest scores were related to pregnancy and childbirth, death and dying, and organ donation in other cultures. Conclusions: Findings suggest that nursing students feel inadequately prepared to provide culturally competent care.

Barriers and Facilitators to Community Mobility for Assistive Technology Users
Natasha Layton
Rehabilitation Research and Practice , 2012, DOI: 10.1155/2012/454195
Abstract: Mobility is frequently described in terms of individual body function and structures however contemporary views of disability also recognise the role of environment in creating disability. Aim. To identify consumer perspectives regarding barriers and facilitators to optimal mobility for a heterogeneous population of impaired Victorians who use assistive technology in their daily lives. Method. An accessible survey investigated the impact of supports or facilitators upon actual and desired life outcomes and health-related quality of life, from 100?AT users in Victoria, Australia. This paper reports upon data pertaining to community mobility. Results. A range of barriers and enablers to community mobility were identified including access to AT devices, environmental interventions, public transport, and inclusive community environs. Substantial levels of unmet need result in limited personal mobility and community participation. Outcomes fall short of many principles enshrined in current policy and human rights frameworks. Conclusion. AT devices as well as accessible and inclusive home and community environs are essential to maximizing mobility for many. Given the impact of the environment upon the capacity of individuals to realise community mobility, this raises the question as to whether rehabilitation practitioners, as well as prescribing AT devices, should work to build accessible communities via systemic advocacy. 1. Introduction Getting around at the home and in the community is a core activity, central to much human participation and therefore of key interest to rehabilitation practitioners. Identifying the constraints and supports which consumers perceive as impacting their current and desired life outcomes will both inform the work of rehabilitation practitioners and identify any barriers usually beyond the gaze of rehabilitation practice [1]. 1.1. Mobility Mobility, defined by the Oxford Dictionary of English [2] as the capacity to move, is a core element of human capacity. Independent mobility, preferably without the need for assistive technology (AT), is viewed as a key outcome measure, alongside communication and self-care, in the rehabilitation literature [3]. Health-related quality-of-life measures also regard the capacity to independently mobilize as a key indicator for quality of life [4, 5]. The extent of mobility will depend upon both the capacity of the person and the nature of the environments in which the person operates. A tension exists in considering the relationship between the person and the environment in which mobility takes
Weighted Hardy and Potential Operators in Morrey Spaces
Natasha Samko
Journal of Function Spaces and Applications , 2012, DOI: 10.1155/2012/678171
Abstract: We study the weighted →-boundedness of Hardy-type operators in Morrey spaces ?,(?) (or ?,(?1
Parameter depending almost monotonic functions and their applications to dimensions in metric measure spaces
Natasha Samko
Journal of Function Spaces and Applications , 2009, DOI: 10.1155/2009/929041
Abstract: In connection with application to various problems of operator theory, we study almost monotonic functions w(x, r) depending on a parameter x which runs a metric measure space X, and the so called index numbers m(w, x), M(w, x) of such functions, and consider some generalized Zygmund, Bary, Lozinskii and Stechkin conditions. The main results contain necessary and sufficient conditions, in terms of lower and upper bounds of indices m(w, x) and M(w, x) , for the uniform belongness of functions w(·, r) to Zygmund-Bary-Stechkin classes. We give also applications to local dimensions in metric measure spaces and characterization of some integral inequalities involving radial weights and measures of balls in such spaces.
The use of private-sector contracts for primary health care: theory, evidence and lessons for low-income and middle-income countries
Bulletin of the World Health Organization , 2000, DOI: 10.1590/S0042-96862000000600014
Abstract: contracts for the delivery of public services are promoted as a means of harnessing the resources of the private sector and making publicly funded services more accountable, transparent and efficient. this is also argued for health reforms in many low- and middle-income countries, where reform packages often promote the use of contracts despite the comparatively weaker capacity of markets and governments to manage them. this review highlights theories and evidence relating to contracts for primary health care services and examines their implications for contractual relationships in low- and middle-income countries.
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