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Search Results: 1 - 10 of 1672 matches for " Natalie Veronika Freytag "
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The Wnt Pathway Target Gene CCND1 Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480  [PDF]
Annica Vlad-Fiegen, Natalie Veronika Freytag, Susanne Dorn, Oliver Müller, Sonja Eberth
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.412017
Abstract: Mutations leading to constitutive activation of the Wnt pathway and its target genes are frequently observed in cancer. The Wnt pathway promotes cell proliferation and increasing evidence supports its role also in cancer cell metabolism. This study aims to elucidate the role of the Wnt/β-catenin target gene CCND1 in these processes in colorectal cancer. We analyzed whether knock-down of CCND1 affects cell cycle progression and energy metabolism in a colorectal cancer cell line. Down-regulation of CCND1 led to retardation of the cell cycle. The proportion of cells in the G0 phase increased, while the amount of cells in the S- and G2/M phase decreased. Interestingly, knock-down of CCND1 changed the perinuclear localization of mitochondria into a homogeneous distribution within the cytosol. In addition CCND1 knock-down led to an increase of the intracellular ATP level indicating that cyclin D1 reduced mitochondrial activity. Our findings suggest that in addition to its role in cell cycle regulation, the Wnt target gene CCND1 regulates mitochondrial localization and inhibits mitochondrial activity in colorectal cancer cells.
Saskatchewan Doukhobor Russian: A Disappearing Language  [PDF]
Veronika Makarova
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.23012
Abstract: This paper introduces the history and surveys some features of Saskatchewan Doukhobor Russian, a near-extinct variety of the Russian language spoken in the Canadian prairie province of Saskatchewan. The paper also outlines the reasons for the language loss in Saskatchewan.
Intercultural interaction and "situational places": a perspective for urban cultural geography within and beyond the performative turn
T. Freytag
Social Geography (SG) & Discussions (SGD) , 2010, DOI: 10.5194/sg-5-49-2010
Abstract: In the context of sustained growth in European city tourism, competing travel destinations develop marketing strategies that include measures to attract an increasing number of repeat visitors. This paper explores the case of Paris in order to provide a better understanding of the specific motivations, interests and activities of leisure tourists who had previously stayed in the capital of France. Drawing on Pierre Bourdieu's concept of "distinction" it is argued that repeat visitors tend to differentiate themselves from other tourists. On the basis of substantive field work in Paris, a set of repeat visitor practices is presented that include strategies to avoid spatial concentrations of major tourist spots in order to participate in Parisian everyday life. Moreover, it is suggested to conceptualize the encounters between repeat visitors and tourism destinations as a lifelong relationship, which can be renewed and reproduced through further visits and virtual encounters. The distinct characteristics of repeat visitor practices have substantial implications for the organization of tourism in the city and the relationships between first-time tourists, repeat visitors and the local population.
Making a difference: tourist practices of repeat visitors in the city of Paris
T. Freytag
Social Geography Discussions , 2008,
Abstract: In the context of sustained growth in European city tourism, competing travel destinations develop marketing strategies that include measures to attract an increasing number of repeat visitors. This paper explores the case of Paris in order to provide a better understanding of the specific motivations, interests and activities of leisure tourists who had previously stayed in the capital of France. Drawing on Pierre Bourdieu's concept of "distinction" it is argued that repeat visitors tend to differentiate themselves from other tourists. On the basis of substantive field work in Paris, a set of repeat visitor practices is presented that include strategies to avoid spatial concentrations of major tourist spots in order to participate in Parisian everyday life. Moreover, it is suggested to conceptualize the encounters between repeat visitors and tourism destinations as a lifelong relationship, which can be renewed and reproduced through further visits and virtual encounters. The distinct characteristics of repeat visitor practices have substantial implications for the organization of tourism in the city and the relationships between first-time tourists, repeat visitors and the local population.
Does central bank independence reflect monetary commitment properly? Methodical considerations
Andreas Freytag
PSL Quarterly Review , 2001,
Abstract: Central bank independence (CBI) has attracted much attention in economics and politics in recent years. The concept is based on the political economy literature onmonetary policy. In this paper, we argue that CBI is an incomplete approximation to legal monetary commitment. We first discuss the nature and criteria ofcommitment, then show the shortcomings of the most important indices of CBI before we introduce an alternative measure of legal monetary commitment. This measure is more comprehensive and includes more aspects of commitment than the indices of CBI. A first empirical comparison of this index and a leading CBI index strengthens the argument.
Crystallization in the Three-Component Systems Rb2SO4-MSO4-H2O (M = Mg, Co, Ni, Cu, Zn) at 298 K  [PDF]
Veronika Karadjova, Donka Stoilova
Journal of Crystallization Process and Technology (JCPT) , 2013, DOI: 10.4236/jcpt.2013.34022
Abstract:

The crystallization in the three-component systems Rb2SO4-MSO4-H2O (M = Mg, Co, Ni, Cu, Zn) is studied by the method of isothermal decrease of supersaturation. It has been established that isostructural double compounds,

Rb2M(SO4)2·6H2O (M = Mg, Co, Ni, Cu, Zn),\"\" , crystallize from the ternary solutions within wide

concentration ranges. The infrared spectra are discussed with respect to the normal vibrations of the sulfate ions and water molecules. The unit-cell group theoretical treatment of the double salts is presented. The extent of energetic distortions of \"\" guest ions (about 2 mol%) matrix-isolated in the respective selenates, \"\" (M' = K, Rb, \"\"; M\" = Mg, Co, Ni, Cu, Zn), is commented.

La bibliotecología y las ciencias de la información en Alemania después de la reunificación
phill Jurgen Freytag
ACIMED , 1993,
Abstract: Se abordan brevemente la problemática de los cambios operados en el territorio alemán y sus implicaciones para la actividad científico-informativa. Se dan a conocer algunas interioridades relacionadas con los efectos que dichos cambios han traído consigo para el documentalista, el bibliotecario y el profesional dedicado a la actividad editorial. Se brindan diversos ejemplos de instituciones de Información y publicaciones que han desaparecido o han sufrido transformaciones y se ofrecen al respecto algunos criterios con carácter perspectivo.
Transformaciones sociales y desarrollo de las fuentes de información
Jürgen Freytag
ACIMED , 1995,
Abstract:
Stellar Envelope Convection calibrated by Radiation Hydrodynamics Simulations: Influence on Globular Clusters Isochrones
Bernd Freytag,Maurizio Salaris
Physics , 1999, DOI: 10.1086/311912
Abstract: One of the largest sources of uncertainty in the computation of globular cluster isochrones and hence in the age determination of globular clusters is the lack of a rigorous description of convection. Therefore, we calibrated the superadiabatic temperature gradient in the envelope of metal-poor low-mass stars according to the results from a new grid of 2D hydrodynamical models, which cover the Main Sequence and the lower Red Giant Branch of globular cluster stars. In practice, we still use for computing the evolutionary stellar models the traditional mixing length formalism, but we fix the mixing length parameter in order to reproduce the run of the entropy of the deeper adiabatic region of the stellar envelopes with effective temperature and gravity as obtained from the hydro-models. The detailed behaviour of the calibrated mixing length depends in a non-trivial way on the effective temperature, gravity and metallicity of the star. Nevertheless, the resulting isochrones for the relevant age range of galactic globular clusters have only small differences with respect to isochrones computed adopting a constant solar calibrated value of the mixing length. Accordingly, the age of globular clusters is reduced by 0.2 Gyr at most.
3D hydrodynamical simulations of evolved stars and observations of stellar surfaces
A. Chiavassa,B. Freytag
Physics , 2014,
Abstract: Evolved stars are among the largest and brightest stars and they are ideal targets for the new generation of sensitive, high resolution instrumentation that pro- vides spectrophotometric, interferometric, astrometric, and imaging observables. The interpretation of the complex stellar surface images requires numerical simulations of stellar convection that take into account multi-dimensional time-dependent radiation hydrodynamics with realistic input physics. We show how the evolved star simulations are obtained using the radiative hydrodynamics code CO5BOLD and how the accurate observables are computed with the post-processing radiative transfer code Optim3D. The synergy between observations and theoretical work is supported by a proper and quantitative analysis using these simulations, and by strong constraints from the obser- vational side.
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