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Search Results: 1 - 10 of 3186 matches for " Narasimha Reddy Parine "
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Association of Single Nucleotide Polymorphisms in Wnt Signaling Pathway Genes with Breast Cancer in Saudi Patients
Mohammad Saud Alanazi, Narasimha Reddy Parine, Jilani Purusottapatnam Shaik, Huda A. Alabdulkarim, Sana Abdulla Ajaj, Zahid Khan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059555
Abstract: Breast cancer is a complex heterogeneous disease involving genetic and epigenetic alterations in genes encoding proteins that are components of various signaling pathways. Candidate gene approach have identified association of genetic variants in the Wnt signaling pathway genes and increased susceptibility to several diseases including breast cancer. Due to the rarity of somatic mutations in key genes of Wnt pathway, we investigated the association of genetic variants in these genes with predisposition to breast cancers. We performed a case-control study to identify risk variants by examining 15 SNPs located in 8 genes associated with Wnt signaling. Genotypic analysis of individual locus showed statistically significant association of five SNPs located in β-catenin, AXIN2, DKK3, SFRP3 and TCF7L2 with breast cancers. Increased risk was observed only with the SNP in β-catenin while the other four SNPs conferred protection against breast cancers. Majority of these associations persisted after stratification of the cases based on estrogen receptor status and age of on-set of breast cancer. The rs7775 SNP in exon 6 of SFRP3 gene that codes for either arginine or glycine exhibited very strong association with breast cancer, even after Bonferroni's correction. Apart from these five variants, rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively. This is the first study to utilize pathway based approach to identify association of risk variants in the Wnt signaling pathway genes with breast cancers. Confirmation of our findings in larger populations of different ethnicities would provide evidence for the role of Wnt pathway as well as screening markers for early detection of breast carcinomas.
Association between PARP-1 V762A Polymorphism and Breast Cancer Susceptibility in Saudi Population
Mohammad Alanazi, Akbar Ali Khan Pathan, Zainul Arifeen, Jilani P. Shaik, Huda A. Alabdulkarim, Abdelhabib Semlali, Mohammad D. Bazzi, Narasimha Reddy Parine
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0085541
Abstract: Genetic aberrations of DNA repair enzymes are known to be common events and to be associated with different cancer entities. Aim of the following study was to analyze the genetic association of rs1136410 (Val762Ala) in PARP1 gene with the risk of breast cancer using genotypic assays and insilico structural predictions. Genotypic analysis of individual locus showed statistically significant association of Val762Ala with increased susceptibility to breast cancer. Protein structural analysis was performed with Val762Ala variant allele and compared with the predicted native protein structure. Protein prediction analysis showed that this nsSNP may cause changes in the protein structure and it is associated with the disease. In addition to the native and mutant 3D structures of PARP1 were also analyzed using solvent accessibility models for further protein stability confirmation. Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population.
Familial Eosinophilic Granulomatosis with Polyangiitis  [PDF]
Abdurhman S. Al Arfaj, Mohammad Al Anazi, Najma Khalil, Akbar Ali Khan Pathan, Narsimha Reddy Parine
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2017, DOI: 10.4236/ojra.2017.73013
Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is an uncommon ANCA associated vasculitic disorder characterized by systemic necrotizing vasculitis of small vessels occurring exclusively among patients with bronchial asthma and tissue eosinophilia. Familial EGPA is extremely rare. Only two case reports have been published so far. We present a Saudi family with 3 cases of EGPA and almost three-fourths of family members affected by asthma. We explored genetic basis of EGPA in this family and found that genes were mutated in four affected siblings suggesting genetic involvement in susceptibility to EGPA.
Role of acupuncture in the treatment of `Incurable′ retinal diseases
Reddy N,Fouzdar Narasimha
Indian Journal of Ophthalmology , 1983,
Simultaneous Determination of Atorvastatin and Glimepiride by LC-MS/MS in Human Plasma and Its Application to a Pharmacokinetic Study  [PDF]
Kishore Kumar Hotha, Narasimha Reddy Yarramu, Thriveni Kandibedala, Vijaya Bharathi Dasari, Venkateswarlu Vobalaboina
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.38074
Abstract: The aim of the proposed research work was to develop and validate a simple, selective high sensitive and high-throughput assay for the simultaneous estimation of Atorvastatin and Glimepiride in human plasma using liquid chromatography tandem mass spectrometry (LC-MS/MS). Atorvastatin–Glimepiride combines a competitive inhibitor of HMG-CoA reductase and a sulfonylurea anti-diabetic drug. The purpose of this study was to develop single method for Atorvastatin and Glimepiride in plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) that would result into a simultaneous estimation of Atorvastatin and Glimepiride avoiding acid –lactone inter conversions right from sample collections to analysis on the LC-MS/MS. Sample collection procedure optimized for Atorvastatin holds good for Glimepiride, hence resulting into a simultaneous estimation of Atorvastatin and Glimepiride. Liquid-liquid extraction and liquid chromatography coupled to positive ion mode tandem mass spectrometry was used to develop the method and was validated according to US FDA guidelines. The calibration curves for two analytes were linear (R2 ≥ 0.9950, n = 4) over the concentration range of 0.2 - 30 ng/mL for Atorvastatin and 1 - 250 ng/mL for Glimepiride. Mean extraction recoveries 80.34 ± 9.43 for Atorvastatin and 88.19 ± 7.13 for Glimepiride. Intra- and inter-run mean percent accuracy was between 85% - 115% and percent imprecision was ≤15%. Stability studies revealed that Atorvastatin and Glimepiride were stable in plasma during bench top (10.5 h at room temperature), in Injector (47.5 h), at the end of three successive freeze and thaw cycles and long term at -65℃ ± 15℃ for 114 days. The method was successfully applied to the study of pharmacokinetics of Atorvastatin and Glimepiride in healthy volunteers. Simultaneous estimation of Atorvastatin and Glimepiride is cost effective, reduces analysis cycle time, enables effective utilization of resources and reduces bleeding burden on human volunteers.
Venkateswarlu Malisetty,Ramana Reddy Yerradoddi,Narasimha Jatoth
International Journal of Science, Environment and Technology , 2013,
Efficacy of Family Intervention in Acquired Head-Injury Cases in India
N Krishna Reddy,Mysore Narasimha Vranda
Disability, CBR & Inclusive Development , 2012, DOI: 10.5463/dcid.v23i3.120
Abstract: Purpose: In India, there are few studies on interventions for families of persons with acquired or traumatic brain injuries. This study aimed to test the efficacy of the Family Intervention Package (FIP) with caregivers of persons with head injuries. Method: The study was carried out at the Neuro-Surgery Department of the National Institute for Mental Health and Neuro Sciences (NIMHANS), Bangalore, India. Ninety persons with severe head injuries and their caregivers were included in the study using the socio-demographic schedule and family interaction pattern scale. Results: The findings revealed that the Family Intervention Package (FIP) was effective in bringing about changes in the functioning of persons with head injuries, and interactions among their families in the experimental group, as compared to the control group. Conclusion: The multi-disciplinary team dealing with persons with head injury need to recognise the importance of multi-component FIP for this group and their families. The current FIP should be made a part of treatment in clinical settings. doi: 10.5463/dcid.v23i3.120
Digital simulation of FM-ZCS-quasi resonant converter fed DD servo drive using Matlab Simulink
Kattamuri Narasimha Rao,Chinna Vyza Veera Reddy
Serbian Journal of Electrical Engineering , 2009, DOI: 10.2298/sjee0902227k
Abstract: This paper deals with digital simulation of FM-ZCS-quasi resonant converter fed DC servo drive using Matlab Simulink. Quasi Resonant Converter (QRC) is fast replacing conventional PWM converters in high frequency operation. The salient feature of QRC is that the switching devices can be either switched on at zero voltage or switched off at zero current, so that switching losses are zero ideally. Switching stresses are low, volumes are low and power density is high. This property imparts high efficiency and high power density to the converters. The output of QRC is regulated by varying the switching frequency of the converter. Hence it is called Frequency modulated Zero current/zero voltage switching quasi resonant converter. The present work deals with simulation of DC Servo motor fed from ZCS-QRC using Matlab. Simulation results show that the ZCS-QRC's have low total harmonic distortion. The ZCS-QRC operating in half wave and full wave modes are simulated successfully. .
A Facile Stereoselective Total Synthesis of (R)-Rugulactone
B. Narasimha Reddy,R. P. Singh
ISRN Organic Chemistry , 2014, DOI: 10.1155/2014/767954
Abstract: An efficient and novel synthesis of (R)-rugulactone has been achieved employing Sharpless asymmetric epoxidation of allyl alcohols followed by selective hydride reduction of epoxy alcohols and olefin cross metathesis reactions. 1. Introduction The 6-alkyl and aryl substituted α-pyrones (6-arylalkyl-5,6-dihydro-2H-pyran-2-ones) possess important biological properties such as antitumor, antiviral, antifungal, and anti-inflammatory [1–12]. These properties arise as a result of Michael acceptor property of α-pyrones towards the amino acid residues of the receptors. The biological assays of 6-arylalkyl-5,6-dihydro-2H-pyran-2-one, (R)-rugulactone (1), which has been extracted from the evergreen tree Cryptocarya rugulosa [13] of Lauraceae family, have been found to inhibit the nuclear factor (NF- B) activation pathway occurring in different types of cancers [14–18]. Due to the attractive biological activity of (R)-rugulactone (1) (Figure 1), several total syntheses have already been reported in the literature [19–25]. In those reported syntheses the chiral center was created by different means: by Jacobsen’s hydrolytic kinetic resolution of epoxides [19], by Keck’s asymmetric allylation [21], by proline catalyzed α-aminoxylation [22] of aldehydes, by enzymatic resolution of racemic homoallylic alcohols [23], and by using a chiral pool [24, 25]. In this communication, we describe the stereoselective synthesis of (R)-rugulactone starting from inexpensive starting materials. The Sharpless asymmetric epoxidation of allyl alcohols followed by selective hydride reduction affords 1, 3-diols with high stereoselectivity. These chiral 1, 3-diols are versatile synthetic intermediates for a variety of biologically active molecules [26–28]. The retrosynthetic strategy of our synthesis is depicted in Scheme 1, which involves Grubb’s cross metathesis between compounds 11 and 12. Scheme 1: Retrosynthesis of ( R)-rugulactone. Figure 1: ( R)-Rugulactone ( 1). 2. Materials and Methods 2.1. General Information Solvents were purified and dried by standard procedures before use. Optical rotations were measured using sodium D line on a JASCO-181 digital polarimeter. IR spectra were recorded on Thermo Scientific-Nicolet 380 FT-IR Instrument. 1H NMR and 13C NMR spectra were recorded on Brucker AC-200 spectrometer. Elemental analysis was carried out on a Carlo Erba CHNS-O analyzer. Full experimental details, 1H and 13C NMR spectra, can be found in Supplementary Material available online at http://dx.doi.org/10.1155/2014/767954. 2.2. ((3S)-3-(2-(Benzyloxy)ethyl)oxirane-2-yl)methanol, 4
Designing ISP-friendly Peer-to-Peer Networks Using Game-based Control
Vinith Reddy,Younghoon Kim,Srinivas Shakkottai,A. L. Narasimha Reddy
Computer Science , 2009,
Abstract: The rapid growth of peer-to-peer (P2P) networks in the past few years has brought with it increases in transit cost to Internet Service Providers (ISPs), as peers exchange large amounts of traffic across ISP boundaries. This ISP oblivious behavior has resulted in misalignment of incentives between P2P networks--that seek to maximize user quality--and ISPs--that would seek to minimize costs. Can we design a P2P overlay that accounts for both ISP costs as well as quality of service, and attains a desired tradeoff between the two? We design a system, which we call MultiTrack, that consists of an overlay of multiple \emph{mTrackers} whose purpose is to align these goals. mTrackers split demand from users among different ISP domains while trying to minimize their individual costs (delay plus transit cost) in their ISP domain. We design the signals in this overlay of mTrackers in such a way that potentially competitive individual optimization goals are aligned across the mTrackers. The mTrackers are also capable of doing admission control in order to ensure that users who are from different ISP domains have a fair chance of being admitted into the system, while keeping costs in check. We prove analytically that our system is stable and achieves maximum utility with minimum cost. Our design decisions and control algorithms are validated by Matlab and ns-2 simulations.
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