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Search Results: 1 - 10 of 1493 matches for " Naoki Shitsukawa "
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The Wheat Plastochron Mutant, fushi-darake, Shows Transformation of Reproductive Spikelet Meristem into Vegetative Shoot Meristem  [PDF]
Chikako Tahira, Naoki Shitsukawa, Yusuke Kazama, Tomoko Abe, Koji Murai
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.412A1005
Abstract:

In wheat plants at the vegetative growth stage, the shoot apical meristem (SAM) produces leaf primordia. When reproductive growth is initiated, the SAM forms an inflorescence meristem (IM) that differentiates a series of spikelet meristem (SM) as the branch. The SM then produces a series of floret meristem (FM) as the branch. To identify the mechanisms that regulate formation of the reproductive meristems in wheat, we have investigated a leaf initiation mutant, fushi-darake (fdk) which was developed by ion beam mutagenesis. The morphological traits were compared in wild type (WT) and fdk mutant plants grown in the experimental field. WT plants initiated leaves from SAM at regular intervals in spiral phyllotaxy, while fdk plants had 1/2 alternate phyllotaxy with rapid leaf emergence. The fdk plants have increased numbers of nodes and leaves compared with WT plants. The time interval between successive leaf initiation events (plastochron) was measured in plants grown in a growth chamber. The fdk plants clearly show the rapid leaf emergence, indicating a shortened plastochron. Each tiller in fdk plants branches at the upper part of the culm. The fine structure of organ formation in meristems of fdk plants was examined by scanning electron microscopy (SEM). The SEM analysis indicated that fdk plants show transformation of spikelet meristems into vegetative shoot meristems. In conclusion, the fdk mutant has a heterochronic nature, i.e., both

Non-invasive assessment of hepatic fibrosis by tissue strain imaging in chronic hepatitis C patients  [PDF]
Naoki Hotta
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68A2003
Abstract: The development of fibrosis in hepatitis C patients is associated with increased rates of liver cancer. Assessing hepatic fibrosis during interferon treatment for chronic hepatitis C is thus an important factor in treatment planning. Complications such as bleeding may occur in association with liver biopsy and there are also some reports of sampling error [1,2]. In recent years, however, a number of studies looking at noninvasive means of assessing hepatic fibrosis have appeared in the literature [3-5]. The present study was conducted to determine whether it would be possible to apply an easily performed technique of myocardial examination to hepatic fibrosis. We have already documented our findings for strain rate imaging used to differentiate the normal condition, chronic hepatitis and cirrhosis of the liver identified by diagnostic imaging and haematology data [6]. In this study, patients identified by liver biopsy were investigated, and a comparative investigation with several fibrosis markers was carried out.
Carnitine Deficiency and Improvement of Muscle Cramp by Administration of Carnitine in Patients with Liver Cirrhosis  [PDF]
Naoki Hotta
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.45036
Abstract:

Aim: We measured carnitine levels in patients with carnitine including dialysis patients, and examined whether administration of L-carnitine improved muscle symptoms. Methods: We measured carnitine levels in 27 patients with liver cirrhosis who were receiving treatment in our hospital, and administered L-carnitine (600 mg - 1800 mg) to patients having muscle cramps for approximately one month and examined the presence/absence of the symptom. We measured carnitine concentration before and after dialysis, before dialysis after the administration to eight dialysis patients, before and after the administration to 19 nondialytic patients. Results: The total carnitine levels before the dialysis of dialysis patients were an average of 42.2 μmol/L and fell to 17.7 μmol/L after more dialysis, but it was increased to 155 μmol/L after the administration of L-carnitine. In the nondialytic patients, the total carnitine levels were significantly increased from 71.7 μmol/L to 101.7 μmol/L after the administration of L-carnitine (P = 0.038). For symptomatic patients, significant improvement of muscle clamps was observed in the L-carnitine administrated group when compared with the non-administrated group (P = 0.0002). Conclusions: Total carnitine levels were low even before dialysis in the dialysis patients with liver cirrhosis in particular and they further decreased after the dialysis. Administration of L-carnitine increased the total carnitine levels and improved the symptom. Based on these results, we conclude that L-carnitine is useful for carnitine deficiency in patients with liver cirrhosis.

 

Noninvasive Assessment of Liver Disease—Measurement of Hepatic Fibrosis Using Shear Wave Elastography (SWE)  [PDF]
Naoki Hotta
Open Journal of Medical Imaging (OJMI) , 2015, DOI: 10.4236/ojmi.2015.53014
Abstract: The evaluation of liver fibrosis is said to be one of the factors of the liver cancer development. The noninvasive testing is considered for abdominal echography, MRI, a blood marker in various ways. We announce the evaluation as an article by liver fibrosis using the probe for the heart before, too. This time is shear wave elastography using the echo probe for the abdomen (SWE). We used and examined it in normal, chronic hepatitis patients with cirrhosis. We tried it, but, in the patients with cirrhosis, there was no examination in the change in a value after ascites time and ascitic drainage. The future examination thinks about a comparison with the liver biopsy, the comparison with the liver fibrosis marker. Also, we think that a malignancy and the benign differentiation should be possible for a liver tumor.
The Use of Castor Oil for Bowel Preparation for Colon Capsule Endoscopy  [PDF]
Naoki Hotta
Open Journal of Medical Imaging (OJMI) , 2016, DOI: 10.4236/ojmi.2016.64010
Abstract: Colon capsule endoscopy was approved for reimbursement under the national health insurance system of Japan in 2014. At our hospital, specialized mainly in renal, hepatic, and diabetic diseases, we have been performing colon capsule endoscopy since December 2014. Dialysis patients are potentially susceptible to bleeding because of the fragile intestine, impaired platelet function, or oral administration of nonsteroidalanti inflammatory drugs (NSAIDs) or anticoagulants. For this reason, detailed examination by capsule endoscopy appears to be useful. However, the capsule excretion rate after recommended bowel preparation reportedly ranges from 70% to 90%, and administration of boosters is also necessary. For dialysis patients, liquid loading is a problem. In this study, we evaluated the efficacy of bowel preparation with castor oil for improving the capsule excretion rate. In all 20 patients (including four dialysis patients), both capsule transit time and duration of capsule endoscopy were shortened. The results are presented and briefly discussed in this report.
Implementability by a Canonical Indirect Mechanism of an Optimal Two-Dimensional Direct Mechanism  [PDF]
Naoki Kojima
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.72016
Abstract: The present paper investigates the multi-dimensional mechanism design in which buyers have taste and budget as their private information. The paper shows an easy proof of a two-dimensional optimal direct mechanism by a one-dimensional indirect mechanism: A canonical mechanism in the traditional one-dimensional setting, i.e., function of one variable, the buyers taste. It also sheds light on where the difficulty lies implementability of a general direct mechanism—not optimal—by a canonical mechanism.
Two-Dimensional Mechanism Design and Implementability by an Indirect Mechanism  [PDF]
Naoki Kojima
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.76107
Abstract: This paper studies the problem on two-dimensional mechanism design where the buyer’s taste and budget are his private information. The paper investigates the problem by the method of dimension-reduction, i.e., by focusing only on the buyer’s budget and constructing an indirect mechanism: function of one variable, the buyer’s budget. It is an approach quite antipodal to that by Kojima [1] where he focused on the buyer’s taste instead of his budget. It is shown that the seller does not lose any money by adopting the indirect mechanism of this paper. In other words, the seller’s revenue-maximizing direct mechanism is implemented by such an indirect mechanism
Usefulness of Castor Oil for Bowel Preparation for Colon Capsule Endoscopy in the Patients on Dialysis  [PDF]
Naoki Hotta
Open Journal of Medical Imaging (OJMI) , 2017, DOI: 10.4236/ojmi.2017.74024
Abstract: Since Colon capsule endoscopy (CCE) was approved for reimbursement under the national health insurance system of Japan in January 2014. Dialysis patients are potentially susceptible to bleeding because of the fragile intestine, impaired platelet function, or oral administration of nonsteroidal antiinflammatory drugs (NSAIDs) or anticoagulants. Increasing experience with CCE different bowel preparation regimens have been used with variable results. The patient on dialysis has moisture restrictions. We experienced the case of the half a dose of the previous protocol by a method using the castor oil. In this study, we evaluated the efficacy of bowel preparation with castor oil for improving the capsule excretion rate. In 23 of 24 (95.8%) patients capsule transit time and duration of capsule endoscopy were shortened. The results are presented and briefly discussed in this report.
The Use of Elobixibat and Lactulose for Bowel Preparation for Colon Capsule Endoscopy  [PDF]
Naoki Hotta
Open Journal of Medical Imaging (OJMI) , 2018, DOI: 10.4236/ojmi.2018.84012
Abstract: Colon capsule endoscopy was approved for reimbursement under the national health insurance system of Japan in 2014. We decreased quantity of the castor oil and examined an intestinal irrigation degree using Elobixibat and lactulose that could maintain a discharge rate at 100% at a discharge rate and discharge time.
Efficacy and Safety of Glecaprevir/Pibrentasvir in Combination Therapy in Chronic Hemodialysis Patients with Genotype 2 Hepatitis C Virus Infection  [PDF]
Naoki Hotta
Open Journal of Gastroenterology (OJGas) , 2019, DOI: 10.4236/ojgas.2019.91001
Abstract: Background: Glecaprevir (nonstructural protein 3/4A protease inhibitor) and Pibrentasvir (nonstructural protein 5A inhibitor) (G/P), a coformulated once-daily, all oral, ribavirin (RBV)-free, direct-antiviral regimen, was evaluated for safety and efficacy in chronic hemodialysis patients with genotype 2 hepatitis C virus infection. Methods: In this prospective, observational, single-center study at Masuko Memorial Hospital, between November 2017 and December 2018, a total of 8 HD patients with an HCV infection genotype 2 received G/P combination therapy. Age was an average of 67.1 (61 - 75) years and there were four men and two women. It was FIB4 INDX an average of 2.67 (1.5 - 3.34) before the start of therapy. It was quantity of HCV RNA an average of 4.43 (2.1 - 6.5). HCV RNA levels were measured by real-time RCR-based method (COBAS AmpiPrep/COBAS TaqMan HCV Test. 4 cases 12 weeks were 2 cases eight weeks for dosing period. Patients were excluded if they had evidence of hepatocellular carcinoma. This study was approved by the ethics committee of our hospital, while we obtained written consent from the participants after providing a thorough explanation of the contents and methods of this study. Results: 6 patients were available for total dose internal use. As for the HCV RNA of the fourth week, (100%) HCV RNA became negative after administration start of therapy. Rapid virologic response (RVR) achieved all cases. 5 patients achieved 12-week sustained virologic response (SVR12) and were following up the 1 patient. The itching appeared in two cases (33%), but there was symptom improvement in nalfurafine hydrochloride use treatment, and treatment continuation was possible. Conclusion: It is thought that G/P can be given to the HD patients’ safety, but we will accumulate a case in future, and it is thought to be necessary to examine utility and safety.
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