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Search Results: 1 - 10 of 201107 matches for " Nancy N. Diehl "
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Evaluation of the Role of SNCA Variants in Survival without Neurological Disease
Michael G. Heckman, Alexandra I. Soto-Ortolaza, Nancy N. Diehl, Minerva M. Carrasquillo, Ryan J. Uitti, Zbigniew K. Wszolek, Neill R. Graff-Radford, Owen A. Ross
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042877
Abstract: Background A variety of definitions of successful aging have been proposed, many of which relate to longevity, freedom from disease and disability, or preservation of high physical and cognitive function. Many behavioral, biomedical, and psychological factors have been linked with these various measures of successful aging, however genetic predictors are less understood. Parkinson's disease (PD) is an age-related neurodegenerative disorder, and variants in the α-synuclein gene (SNCA) affect susceptibility to PD. This exploratory study examined whether SNCA variants may also promote successful aging as defined by survival without neurological disease. Methods We utilized 769 controls without neurological disease (Mean age: 79 years, Range: 33–99 years) and examined the frequency of 20 different SNCA variants across age groups using logistic regression models. We also included 426 PD cases to assess the effect of these variants on PD risk. Results There was a significant decline in the proportion of carriers of the minor allele of rs10014396 as age increased (P = 0.021), from 30% in controls younger than 60 to 14% in controls 90 years of age or older. Findings were similar for rs3775439, where the proportion of carriers of the minor allele declined from 32% in controls less than 60 years old to 19% in those 90 or older (P = 0.025). A number of SNCA variants, not including rs10014396 or rs3775439, were significantly associated with susceptibility to PD. Conclusions In addition to its documented roles in PD and α-synucleinopathies, our results suggest that SNCA has a role in survival free of neurological disease. Acknowledging that our findings would not have withstood correction for multiple testing, validation in an independent series of aged neurologically normal controls is needed.
Evaluation of Serum Calcium as a Predictor of Biochemical Recurrence following Salvage Radiation Therapy for Prostate Cancer
Jennifer L. Peterson,Steven J. Buskirk,Michael G. Heckman,Alexander S. Parker,Nancy N. Diehl,Katherine S. Tzou,Nitesh N. Paryani,Stephen J. Ko,Larry C. Daugherty,Laura A. Vallow,Thomas M. Pisansky
ISRN Oncology , 2013, DOI: 10.1155/2013/239241
Abstract: Background. Previous reports have shown a positive association between serum calcium level and prostate cancer mortality. However, there is no data regarding whether higher serum calcium levels are associated with increased risk of biochemical recurrence (BCR) following salvage radiation therapy (SRT) for prostate cancer. Herein, we evaluate the association between pretreatment serum calcium levels and BCR in a cohort of men who underwent SRT. Methods. We evaluated 165 patients who underwent SRT at our institution. Median dose was 65.0?Gy (range: 54.0–72.4?Gy). We considered serum calcium as both a continuous variable and a 3-level categorical variable (low [≤9.0?mg/dL], moderate [>9.0?mg/dL and ≤9.35?mg/dL], and high [>9.35?mg/dL]) based on sample tertiles. Results. We observed no evidence of a linear association between serum calcium and BCR (relative risk (RR): 0.96, ). Compared to men with low calcium, there was no significantly increased risk of BCR for men with moderate (RR: 0.94, ) or high (RR: 1.08, ) serum calcium levels. Adjustment for clinical, pathological, and SRT characteristics in multivariable analyses did not alter these findings. Conclusion. Our results provide evidence that pretreatment serum calcium is unlikely to be a useful tool in predicting BCR risk following SRT. 1. Introduction Approximately, one-third of men treated with a radical prostatectomy (RP) for prostate cancer will have biochemical recurrence (BCR) within 10 years, and in two-thirds of these men on active surveillance, metastatic disease develops within 10 years [1]. Salvage external beam radiation therapy (SRT) appears to positively affect this natural history when it is initiated early in the course of postoperative BCR [2–4]. A key clinical issue centers on the need to predict which patients with a detectable serum prostate-specific antigen (PSA) after RP have local recurrence versus micrometastatic disease. Accurate means of distinguishing these two groups of men would allow for better selection of patients as candidates for local SRT. We developed and published a scoring algorithm based on readily available clinicopathologic features to help predict which men will experience BCR after SRT and thus provide a guide for clinicians when counseling patients [2]. More recently, we evaluated RP specimens for the ability of specific tumor-based biomarkers (e.g., Ki-67 and B7-H3) to predict which men will respond to SRT [5–7]. Based on our reports, information on clinicopathologic features and tumor-based biomarkers can assist in the appropriate selection of men as good
Oxygen depletion in the gulf of Mexico adjacent to the Mississippi river
Rabalais,Nancy N;
Gayana (Concepción) , 2006, DOI: 10.4067/S0717-65382006000300015
Abstract: the seasonal formation of a bottom-water layer severely depleted in dissolved oxygen has become a perennial occurrence on the louisiana continental shelf adjacent to the mississippi river system. dramatic changes have occurred in this coastal ecosystem in the last half of the 20th century as the loads of dissolved inorganic nitrogen tripled. there are increases in primary production, shifts in phytoplankton community composition, changes in trophic interactions, and worsening severity of hypoxia. the river-influenced continental shelf is representative of similar ecosystems in which increased nutrient flux to the coastal ocean has resulted in eutrophication and subsequently hypoxia. the hypoxic conditions (dissolved oxygen less than 2 mg l-1) cover up to 22,000 km2 of the seabed in mid-summer. dissolved oxygen concentrations seldom decrease to anoxia, but are often below 1 mg l-1 and down to 0.5 mg l-1. the biogeochemical processes of oxic versus suboxic conditions in the water column and sediments of the louisiana shelf are similar to other areas of oxygen deficiency. however, the suboxic conditions in the gulf of mexico are less persistent in time and space, and anoxia at the seabed is not common or long-lasting.
Factores de virulencia de Mycobacterium tuberculosis
Maulén,Nancy P;
Revista médica de Chile , 2011, DOI: 10.4067/S0034-98872011001200012
Abstract: mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. immunodeficiency caused by malnutrition, senescence or co-infection with hivenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. the increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. the understanding of the mechanisms of transmission, pathogenesis and virulence of m. tuberculosis is important. the analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. environmental stimuli such as ph, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. the molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.
Oxygen depletion in the gulf of Mexico adjacent to the Mississippi river El agotamiento del oxígeno en la porción adyacente al río Misisipi en el golfo de México
Nancy N Rabalais
Gayana (Concepción) , 2006,
Abstract: The seasonal formation of a bottom-water layer severely depleted in dissolved oxygen has become a perennial occurrence on the Louisiana continental shelf adjacent to the Mississippi River system. Dramatic changes have occurred in this coastal ecosystem in the last half of the 20th century as the loads of dissolved inorganic nitrogen tripled. There are increases in primary production, shifts in phytoplankton community composition, changes in trophic interactions, and worsening severity of hypoxia. The river-influenced continental shelf is representative of similar ecosystems in which increased nutrient flux to the coastal ocean has resulted in eutrophication and subsequently hypoxia. The hypoxic conditions (dissolved oxygen less than 2 mg L-1) cover up to 22,000 km2 of the seabed in mid-summer. Dissolved oxygen concentrations seldom decrease to anoxia, but are often below 1 mg L-1 and down to 0.5 mg L-1. The biogeochemical processes of oxic versus suboxic conditions in the water column and sediments of the Louisiana shelf are similar to other areas of oxygen deficiency. However, the suboxic conditions in the Gulf of Mexico are less persistent in time and space, and anoxia at the seabed is not common or long-lasting. En el Golfo de México existe un área extensa donde el agua del fondo es deficiente en oxígeno durante ciertas estaciones del a o. En esta área las descargas de nutrientes del Río Misisipi han aumentado desde los a os 50. El fenómeno de hypoxia alcanza grandes extensiones y es persistente de mayo a septiembre en la mayoría de los a os, pudiendo alcanzar un área de hasta 22,000 km2 a mediados del verano. Aunque la hypoxia es rara en este sistema, es común que ocurran extensos periodos en los que la concentración de oxígeno disuelto cae por debajo de 1 mg L-1, e incluso hasta 0.5 mg L-1, lo cual afecta los procesos bentónicos y a la diversidad.
Troubled Waters of the Gulf of Mexico
Nancy N. Rabalais
Oceanography , 2011,
Abstract: The gusher has ended, but before it did, an estimated 206 million gallons of crude oil and methane gas escaped from the Macondo well in lease block Mississippi Canyon 252. We know it better as the BP Deepwater Horizon oil spill that resulted from a series of mechanical and safety failures leading to an explosion, the deaths of 11 workers, and the largest accidental oil spill in history. The well was in the northern Gulf of Mexico in 1500 m of water, not the deepest in this petroleum production fron-tier, but in an otherwise blue-water, pristine ocean home to deep-water corals and pods of sperm whales, and one of two spawning areas for Atlantic bluefin tuna. Satellite images of black oil at the surface marred this picture as the oil continued to spew from the ocean bottom and spread into the northern Gulf of Mexico. Innumerable lives were affected—from microbes to humans—and the world was transfixed by the continuous images of oil and gas blowing from the Gulf bottom while technology raced to catch up with Mother Nature.
Factores de virulencia de Mycobacterium tuberculosis Virulence factors of Mycobacterium tuberculosis
Nancy P Maulén
Revista médica de Chile , 2011,
Abstract: Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.
Mobility training using a bionic knee orthosis in patients in a post-stroke chronic state: a case series
Byl Nancy N
Journal of Medical Case Reports , 2012, DOI: 10.1186/1752-1947-6-216
Abstract: Introduction An emerging area of neurorehabilitation is the use of robotic devices to enhance the efficiency and effectiveness of lower extremity physical therapy post-stroke. Many of the robotic devices currently available rely on computer-driven locomotive algorithms combined with partial bodyweight-supported treadmill training that drive reflex stepping with minimal patient intention during therapy. In this case series, we examined the effect of task-oriented mobility training in patients in a post-stroke chronic state using a novel, wearable, mobile, intention-based robotic leg orthosis. Case presentation Three individuals, all of whom had reached a plateau with conventional bodyweight-supported treadmill training, participated in task-oriented mobility therapy (1.5 hours, two to four times per week for four weeks) with a robotic leg orthosis under supervision by a physical therapist. Participant 1 was a 59-year-old Caucasian man, who had an ischemic left stroke six years previously with resultant right hemiparesis. Participant 2 was a 42-year-old Caucasian woman with left hemiparesis after a right stroke 15 months previously. Participant 3 was a 62-year-old Caucasian woman with a history of a right middle cerebral artery aneurysm with third degree sub-arachnoid hemorrhage 10 years ago. Immediately after training, all participants demonstrated improved gait speed (10 meter walk), stride length and walking endurance (6 minute walk) compared with baseline measurements. Improvements were maintained one month after training. Timed up and go and five times sit-to-stand were maintained for all three participants, with only one individual remaining outside the safety performance norm. Conclusions Lower extremity training integrating an intention-based robotic leg orthosis may improve gait speed, endurance and community levels of participation in select patients in a post-stroke chronic state after plateauing within a bodyweight-supported treadmill training program. The wearable, mobile assistive robotic device safely supplemented supervised physical therapy including mobility and balance skill training.
Humanismo y valores en la formación del profesional de la educación. El componente humanista y la formación de maestros cubanos
Nancy Chacón Arteaga
Ciencia y Sociedad , 2000,
Abstract:
Consideraciones de seguridad en el dise?o de un consultorio odontológico
León Martínez,Nancy;
Acta Odontológica Venezolana , 2009,
Abstract: it?s very important to know the human and technological needs of the users in order to properly the physical planning of spaces which will provide the setting of a dental health care facility. the dental personnel required of the physical environment that enhance health and security at work.
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