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Liposomal daunorubicin and dexamethasone as a treatment for multiple myeloma: the DD Protocol
Dulley, Frederico Luiz;Saboya, Rosaura;Hungria, Vania Tietsche de Moraes;Bueno, Nadjanara Dorna;Mello, Fernando Gomes de;Frota, Maria Tereza;Chiattone, Carlos Sergio;Barros, José Carlos;Mori, Nair Sumie;Sturaro, Daniel;Macedo, Maria Cristina Martins de Almeida;Silva, Roberto Luiz da;Melo, Leila Maria Magalh?es Pessoa de;Souza, Cármino Antonio;
Sao Paulo Medical Journal , 2005, DOI: 10.1590/S1516-31802005000600003
Abstract: context and objective: liposomal daunorubicin has been used to treat hematological malignancies, including multiple myeloma (mm). the goal was to evaluate efficacy, side-effects and toxicity of liposomal daunorubicin and dexamethasone ("dd protocol"). design and setting: prospective study at sírio-libanês, s?o camilo, brasil and alem?o oswaldo cruz hospitals. methods: twenty consecutive patients with active mm received four cycles of liposomal daunorubicin intravenously for two hours (25-30 mg/m2/day) on three consecutive days per month, with oral dexamethasone (10 mg every six hours) on four consecutive days three times a month. results: the male/female ratio was 1:1 and median age 60. nine patients were stage iia, ten iiia and one iiib. the median from diagnosis to starting dd was 13 months. all patients received four cycles, except one. fifteen had already received chemotherapy before dd. responses of > 50% reduction in serum monoclonal paraprotein were observed in six patients after first cycle (30%), six after second (30%) and four after third (20%), while four (20%) did not obtain this. initially, 17 patients (85%) had anemia: 12 (70%) achieved correction. progressive disease was observed in three patients (15%), while one had minimal response, four (20%) partial and 12 (60%) complete. hematological toxicity was acceptable: three patients (15%) had neutrophils < 1,000/mm3; none had thrombocytopenia. gastrointestinal toxicity was mild: nausea (10%), anorexia (15%) and no vomiting. conclusions: this treatment has mild toxicity and good response rate. it may therefore be feasible before autologous bone marrow transplantation.
4-(hidroximetil)-benzenossulfonato de potássio: metabólito inédito isolado da alga marinha Bostrychia tenella (Rhodomelaceae, ceramiales)
Felício, Rafael de;Debonsi, Hosana Maria;Yokoya, Nair Sumie;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000400025
Abstract: chemical investigation of the dichloromethane/methanol extract of the marine alga bostrychia tenella has led to the isolation of two aromatic compounds, the new sulfate metabolite potassium 4-(hydroxymethyl)-benzenosulfonate (1) and the compound 1-methoxyphenethyl alcohol (2), described previously as a synthetic product. their structures were determined by spectroscopic methods including nmr, ms, ir and by comparison with literature data.
Adoptability of Peer Assessment in ESL Classroom  [PDF]
Sumie Matsuno
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.88091
In ESL class, a teacher in charge of the class usually evaluates all the students’ performances, where using peer assessment may be a good way to confirm or modify the teacher assessment. In this study, whether peer assessment can be adopted in class is considered using FACET analysis. Since this is a regular small English class in Japan, the participants are 18 ESL university students and one teacher. First, one misfitting rater is eliminated and all the other raters including the teacher are included as assessors. The rater measurement report shows that, after eliminating one rater, no raters are misfits. The FACET map shows that most of them, including the teacher, are lenient raters. In addition, only a few unexpected responses are detected. Overall, this study concludes that peer assessment can be reasonably used as additional assessment in class.
Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular
Pracchia, Luís Fernando;Buccheri, Valeria;Menezes, Yara de;Siqueira, Sheila A. C.;Mori, Nair Sumie;Chamone, Dalton Alencar Fisher;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2005, DOI: 10.1590/S1676-24442005000500012
Abstract: background: nodular sclerosis (ns), a frequent histological subtype of hodgkin?s lymphoma (hl), presents great variability in its cellular composition. in the 80's, researchers of the british national lymphoma investigation (bnli) proposed a histological-based subclassification for ns hl. they identified two histological grades - ns hl grade i (ns hl i) and ns hl grade ii (ns hl ii) - and reported that ns ii patients had a lower survival rate in comparison with ns i patients. others studies, however, did not reproduce these findings. objective: evaluate the prognostic significance of the bnli grading system. material and method: we retrospectively studied 69 ns hl patients. more than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for ns i and ns ii patients. results: thirty-five cases (51%) were classified as ns i and 34 (49%) as ns ii. we did not observe significant differences in the distribution of other prognostic factors between the two ns grades. the complete remission rate after initial therapy was 85.7% in the ns i group and 82.4% in the ns ii group (p = 0.75). the predicted 5-year overall survival rate was 67% in the ns i patients and 83.5% in the ns ii patients (p = 0.13). the predicted 5-year disease free survival rate for nsi and nsii patients was 85.2% and 87%, respectively (p = 0.72). conclusion: the histological bnli grading system was not associated with the prognosis of this uniformly treated ns lh population.
Predictors of dying at home for patients receiving nursing services in Japan: A retrospective study comparing cancer and non-cancer deaths
Sumie Ikezaki, Naoki Ikegami
BMC Palliative Care , 2011, DOI: 10.1186/1472-684x-10-3
Abstract: A retrospective national survey of a random sample of 2,000 out of the 5,224 VNS was made in January 2005. Questionnaires were mailed to VNS asking the respondents to fill in the questionnaire for each patient who had died either at home or at the hospital from July to December of 2004. Logistic regression analysis was respectively carried out to examine the factors related to dying at home for cancer and non-cancer patients.We obtained valid responses from 1,016 VNS (50.8%). The total number of patients who had died in the selected period was 4,175 (cancer: 1,664; non-cancer: 2,511). Compared to cancer patients, non-cancer patients were older and had more impairment in activities of daily living (ADL) and cognitive performance, and a longer duration of care. The factor having the greatest impact for dying at home was that of both the patient and the family expressing such preferences [cancer: OR (95% CI) = 57.00 (38.79-83.76); non-cancer: OR (95% CI) = 12.33 (9.51-15.99)]. The Odds ratio was greater compared with cases in which only the family had expressed such a preference and in which only the patient had expressed such a preference. ADL or cognitive impairment and the fact that their physician was based at a clinic, and not at a hospital, had modest effects on dying at home.Dying at home was more likely when both the patient and the family had expressed such preferences, than when the patient alone or the family alone had done so, in both cancer and non-cancer patients. Health care professionals should try to elicit the patient's and family's preferences on where they would wish to die, following which they should then take appropriate measures to achieve this outcome.How end-of-life care should appropriately be provided has been a major policy issue [1-3]. Many factors have to be considered in deciding what is "appropriate", including the patient's condition and preferences [4-6], the situation of the family [6,7], and the services available [8-10]. If the pat
Acidentes de motocicleta no Município de S?o Paulo, SP, Brasil: 2. análise da mortalidade
Koizumi,Maria Sumie;
Revista de Saúde Pública , 1985, DOI: 10.1590/S0034-89101985000600006
Abstract: this is a descriptive study of official data on motorcycle accidents with victim (3,390) which occurred, during 1982, in s. paulo city. there were 4,480 casualties and 166 of them died within 180 days of the event. the death rate was close to 2/100,000 inhabitants and the male/female ratio was 6:1. in relation to the kind of injury, the findings demonstrated the most frequent diagnoses were skull fracture, thoracic and abdominal injuries and leg fractures. death on the scene of the accident or within twenty-four hours of the accident accounted for 62.35% of deaths. motorcyclist and passenger deaths occurred more rapidly than those of the pedestrians.
Perfil da pesquisa de enfermagem em terapia intensiva no Brasil
Koizumi, Maria Sumie;
Revista da Escola de Enfermagem da USP , 1997, DOI: 10.1590/S0080-62341997000300009
Abstract: this is an analyses about critical care nursing research production and publication, as well as, the nursing research's profile in brazil focusing the research producer, the research product and the customer of this product.
Acidentes de motocicleta no município de S?o Paulo, SP (Brasil): 1. caracteriza??o do acidente e da vítima
Koizumi,Maria Sumie;
Revista de Saúde Pública , 1985, DOI: 10.1590/S0034-89101985000500011
Abstract: this is a descriptive study of official data on those motorcycle accidents with casualties riders and/or pedestrians (3,390) which occurred during 1,982 in s. paulo city, brazil. there were 4,480 casualties and 166 of these died within 180 days of the event. these accidents were more frequent and serious than those involving any other kind of motor vehicle. the casualties were, in their majority, males aged between 15 and 24, and two-thirds of this population were motorcyclists. the results of a study of the accidents themselves demonstrated that the peak occurred at weekends and there was no significant variations with regard to months or times of day.
Padr?o das les?es nas vítimas de acidentes de motocicleta
Koizumi,Maria Sumie;
Revista de Saúde Pública , 1992, DOI: 10.1590/S0034-89101992000500002
Abstract: an analysis of the injury patterns presented by inpatients of a government teaching hospital, known as one of the emergency centers of s. paulo city, brazil, is given the majority of victims are young, male adults and most of them were later discharged from the hospital. in relation to the injuries the majority of the patients were classified as being of minor injury grade (iss between 1 and 9) and the most frequent injuries were extremity and pelvic fractures, surface trauma, traumatic brain injury and extremity and pelvic dislocations. besides extremity and pelvic fractures, the victims who died showed abdominal organ injury and traumatic brain injury and the iss was over 20. head injury patients who had a high glasgow coma scale score had a low iss and vice-versa.
Elevated pancreatic enzymes, IgM, soluble interleukin-2 receptor in anti-GADab(+) type 1 diabetes
Hidekatsu Yanai,Sumie Moriyama
World Journal of Diabetes , 2011, DOI: 10.4239/wjd.v2.i5.75
Abstract: Type 1 diabetes can be classified into immune-mediated diabetes (type 1A) and idiopathic diabetes, which lacks immunological evidence for beta cell autoimmunity (type 1B). Type 1A diabetes is characterized by the presence of the anti-glutamic acid decarboxylase antibody (anti-GADab). Fulminant type 1 diabetes is classified as type 1B diabetes, and characterized by the absence of anti-GADab, flu-like symptoms, and elevated serum exocrine pancreatic enzymes. We report a type 1 diabetic patient who showed flu-like symptoms, elevated serum exocrine pancreatic enzymes, and an extremely high-titer of anti-GADab, manifesting the characteristics of both type 1A and fulminant type 1 diabetes.
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