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Search Results: 1 - 10 of 179084 matches for " Naiara Correa Nogueira de;Noronha "
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Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com cancer de mama: estudo caso-controle
Linhares, José Juvenal;Silva, Ismael Dale Cotrim Guerreiro da;Souza, Naiara Correa Nogueira de;Noronha, Emmanuelle Coelho;Ferraro, Odair;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2005, DOI: 10.1590/S0100-72032005000800007
Abstract: purpose: to analyze the correlation between progins polymorphism and breast cancer. methods: a case-control study was carried out from april to october 2004. the genotypes of 50 women with breast cancer and 49 healthy women were analyzed. the 306-base pair alu insertion polymorphism in the g intron of progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. the control and experimental groups were compared regarding genotypes using the statistical epi-info 6.0 program and for frequencies the exact fisher test or c2 test were used. p value smaller p than 5% was considered to be significant. results: in relation to progins we found in the studied population a prevalence of 62 (62.6%) wild homozygous, 35 (35.3%) heterozygous individuals and two (2.1%) cases with the presence of the mutation. regarding progins polymorphism, significance was not evidenced when cases and controls were compared, as related to homozygosis (62 vs 65.3%), heterozygosis (36 vs 34,6%) or the mutation (2.0 vs 2.1%), with p=0.920 (or=1.01), 0.891 (or=1.06), and 0.988 (or=1.10), respectively. conclusions: the results show that single-gene progins polymorphism does not confer a substantial risk of breast cancer to its carriers.
Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
JOSé JUVENAL LINHARES,ISMAEL DALE COTRIM GUERREIRO DA SILVA,NAIARA C NOGUEIRA DE SOUZA,EMMANUELLE COELHO NORONHA
Biological Research , 2005,
Abstract: Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X2 or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.
Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
LINHARES,JOSé JUVENAL; GUERREIRO DA SILVA,ISMAEL DALE COTRIM; NOGUEIRA DE SOUZA,NAIARA C; COELHO NORONHA,EMMANUELLE; FERRARO,ODAIR; DE CARVALHO,CRISTINA VALLETA; CHADA BARACAT,EDMUND; FARAH BARACAT,FAUSTO;
Biological Research , 2005, DOI: 10.4067/S0716-97602005000200017
Abstract: due to the conflicting results regarding the association between breast cancer and the gstm1 null mutation, our aim was to research this association in a brazilian population and correlations with smoking, reproductive history and several clinical pathologies. a case-control study was performed on 105 women with breast cancer and 278 controls. extraction of dna was accomplished according to the protocol of the gfx? kit and polymorphism analysis by the pcr technique. the control and experimental groups were compared and statistical analysis assessed by x2 or fisher's exact test. the deletion in the gstm1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. in the control group, the null mutation was present in 104 (37.4%) women. upon comparison of the two groups, no statistically significant difference of the gstm1 gene was observed, with an odds ratio (or) of 0.74, 95%, confidence interval (ci) 0.45 - 1.20, p = 0.277. the results conclusively show that single gene gstm1 polymorphisms do not confer a substantial risk of breast cancer to its carriers. furthermore, in this study no correlation was found between gsts and smoking, reproductive history and several clinical pathologies with respect to cancer risk.
Increased Risk of Acute Myeloid Leukemia in Patients with CYP1A1 Polymorphisms  [PDF]
Luís Arthur Flores Pelloso, Ismael Dale Cotrim Guerreiro da Silva, Naiara C?rrea Nogueira de Souza, Mihoko Yamamoto, Maria de Lourdes L. Ferrari Chauffaille
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.45111
Abstract:

Acute Myeloid Leukemia (AML) is a group of genetically diverse hematopoietic malignancies arising from cell progenitors developing in the myeloid pathway or from primitive stem cells. Genetic susceptibility of AML may account for an increased risk of AML due to partial metabolism of or biocativation of carcinogens. Chemical compounds are metabolized by a two-tiered phase detoxifying system. Polymorphisms in these pathways may lead to DNA damage and development of AML. We determined the frequencies of carcinogen metabolism gene polymorphisms (CYP1A1, del{GSTM1} and del{GSTT1}) in a case control-study based on polymorphism analysis. Fifty-eight consecutively AML patients (median age 62 years) and 174 sex and age-matched control group were assessed by a PCR-RFLP assay. There were 51 de novo and 7 secondary AML. CYP1A1*2A and CYP1A1*2C polymorphisms were more frequent in CG than AML p < 0.001 and in contrast, CYP1A1*3 and CYP1A1*4 were more frequent in AML than CG p <

Angiotensin-(1 - 7) and Human Chorionic Gonadotropin (hCG) Modulate the Nuclear Transcription Factors or Nuclear Receptors Genes in the Tumorigenic Undifferentiated Breast Cancer Cell Line SKBR3  [PDF]
Isidoro Binda Neto, Samuel Marcos Ribeiro de Noronha, Silvana Aparecida Alves Correa de Noronha, Maria Del Carmen Garcia Molina Wolgien, Alexandre Jesus Barros, Clovis Ryiuchi Nakaie, Suma Imura Shimuta, Gil Facina, Ismael Dale Cotrim Guerreiro da Silva
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47A011
Abstract:

Breast cancer is the most common cancer among women. Angiotensin-(1 - 7) [Ang-(1 - 7)] has been correlated with cancer antiproliferative and apoptotic effects, similar properties of the human Chorionic Gonadotrofin (hCG). The aims of this work are to evaluate the role of Ang-(1 - 7) and of hCG in modulating the expression of Nuclear Receptors and Coregulators related genes in the tumorigenic breast cell line SK-BR3. Three experimental groups were created: control, hCG and hCG + Ang-(1 - 7). Cells were treated for 11 days and then had their RNA extracted. Samples were loaded into PCR Array plates containing 84 genes relate to Nuclear Receptors and Coregulators pathways. Gene expression data were used to construct canonical pathways (MetacoreTM). hCG and hCG + Ang-(1 - 7) treatments markedly modulate the expression of Nuclear Receptors and Coregulators related genes. hCG differentially expressed 17% of the genes, being 29% upregulated and 71% downregulated. Meanwhile, hCG + Ang-(1 - 7) changed the expression of 30% of the genes on the plate, among these genes 56% were upregulated and 44% downregulated. Among these differentially expressed genes, we highlight Esr1, Nr2f2, and Nr2f1, Esr1, Hdac5, and Nr4A1 (>4 fold). Finally MetaCore analysis based on Gene Ontology (GO) generated six networks for hCG and ten networks for the

Leptin Signaling Modulates Expression of Polycomb and Trithorax Complexes in the Brain of Fat Tissue Implanted Polycystic Ovarian Sindrome Mice  [PDF]
Eduardo Henrique da Silva Freitas, Samuel Marcos Ribeiro de Noronha, Maria Nazareth Gamboa Ritto, Carlos Fernandes Baptista, Ismael Dale Cotrim Guerreiro da Silva, Silvana Aparecida Alves Correa-Noronha, Ivaldo da Silva
American Journal of Molecular Biology (AJMB) , 2014, DOI: 10.4236/ajmb.2014.44020
Abstract: The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-Lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31; Smarca1/?17; Dnmt3b/4.7; Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.
Uranium Metabolism Associated with Ontogenetic Growth of Birds—Case Studies with Broilers and Ducks  [PDF]
Joao Dias de Toledo Arruda-Neto, Guacyara Tenorio Cavalcante, Guilherme de Paula Nogueira, Tulio Eduardo Rodrigues, Luiz Eduardo Correa Fonseca, Mitiko Saiki, Godofredo Camara Genofre
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.59090
Abstract:

Cobb broilers and domestic ducks, both one-day-old, were treated using ration doped with 20 ppm of uranyl nitrate. Uranium concentrations in the tibia (μg-U/g-bone) were measured by neutron activation analysis as function of the animals’ age, from the neonatal period to maturity. Results show that Uranium and Calcium qualitatively follow the same metabolic pathway, and that adult ducks incorporate on average ten times more Uranium than broilers. Data interpretation shows that the Uranium clearance rate in broilers is substantially higher than that in ducks, suggesting that metabolic characteristics favoring Calcium retention in bone may hinder the elimination of Uranium in ducks. The need for further comparative biochemistry studies between Galliformes and Anseriformes is addressed.

Psoríase eritrodérmica refratária em crian?a com excelente resposta ao etanercepte
Fraga, Naiara Abreu de Azevedo;Paim, Maria de Fátima;Follador, Ivonise;Ramos, Andréia Nogueira;Rêgo, Vitória Regina Pedreira de Almeida;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000700038
Abstract: psoriasis affects 0.12% to 0.71% of all children. erythrodermic psoriasis is an uncommon but serious disorder, occurring in less than 1.5% of cases. tumor necrosis factor-alpha blockers (tnf-α) are a new class of drugs used to treat moderate to severe psoriasis refractory to conventional therapies. etanercept is a tnfα receptor fusion protein, approved by the fda for treating juvenile rheumatoid arthritis. we present the case of a 7-year-old suffering from plaque psoriasis since 8 months old which evolved into erythroderma refractory to cyclosporine and methotrexate. patient responded excellently to etanercept, with no adverse side effects
Mechanisms and role of microRNA deregulation in cancer onset and progression
Palmero, Edenir Inês;Campos, Silvana Gisele P de;Campos, Marcelo;Souza, Naiara C Nogueira de;Guerreiro, Ismael Dale C.;Carvalho, Andre L.;Marques, Marcia Maria C.;
Genetics and Molecular Biology , 2011, DOI: 10.1590/S1415-47572011000300001
Abstract: micrornas are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. mature micrornas (mirnas) are single-stranded rna molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. these molecules typically reduce the stability of mrnas, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. microrna targeting is mostly achieved through specific base-pairing interactions between the 5' end ('seed' region) of the mirna and sites within coding and untranslated regions (utrs) of mrnas; target sites in the 3' utr diminish mrna stability. since mirnas frequently target hundreds of mrnas, mirna regulatory pathways are complex. calin and croce were the first to demonstrate a connection between micrornas and increased risk of developing cancer, and meanwhile the role of micrornas in carcinogenesis has definitively been evidenced. it needs to be considered that the complex mechanism of gene regulation by micrornas is profoundly influenced by variation in gene sequence (polymorphisms) of the target sites. thus, individual variability could cause patients to present differential risks regarding several diseases. aiming to provide a critical overview of mirna dysregulation in cancer, this article reviews the growing number of studies that have shown the importance of these small molecules and how these micrornas can affect or be affected by genetic and epigenetic mechanisms.
Enfermedad periodontal en oncológicos: Factor indicativo de exodoncias?
Audrey Cristina Bueno,Allyson Nogueira Moreira,Cláudia Silami de Magalh?es,Vladimir R.A.S. Noronha
Acta Odontológica Venezolana , 2010,
Abstract: En este estudio se verificó las indicaciones de exodoncias en pacientes con cáncer en región de cabeza e cuello, que serán sometidos a radioterapia, en el servicio de Oncología de la Facultad de Odontología da Universidad Federal de Minas Gerais. Fueran evaluadas 114 historias clínicas y radiografías panorámicas y periapicales y fueran divididos de acuerdo con las indicaciones de exodoncias. Estas indicaciones fueron por caries, enfermedad periodontal, asociaciones de caries y periodontitis, falta de soporte para prótesis, diente incluidos, dientes extruidos, y en algunos casos dientes con indicaciones de extracciones exclusivamente por causa de la radioterapia. Los resultados mostraron que la mayor parte de indicaciones de exodoncias fueron debido a caries (21,05%) y enfermedades periodontales (26,31%). Debido a la predisposición a la pérdida de inserción periodontal y al riesgo de su progresión, pacientes que serán sometidos a la radioterapia de cabeza y cuello deberán ser evaluados en relación a la condición periodontal y a las indicaciones de exodoncia. Este estudio mostró que el diagnóstico de la enfermedad periodontal fue el principal factor relacionado con la indicación de exodoncias previamente al tratamiento oncológico The aim of this study was to describe the indication of the exodontias in patients with head embedded tooth, extruded tooth and some cases when indication is because of radiotherapy. The results show that caries (21, 05%) and periodontitis (26, 31%) were the biggest indications of exodontias in these patients. Due to a tendency of attachment loss and bone destruction and the risk of progression, patients that will be under head and neck radiotherapy should be evaluated on the periodontal status e tooth extraction indications. This study shows that the diagnosis of periodontal disease was the main indication to teeth extractions previous to oncological treatment
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