oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 2 )

2019 ( 175 )

2018 ( 245 )

2017 ( 247 )

Custom range...

Search Results: 1 - 10 of 191340 matches for " Nadjanara D.;Seber "
All listed articles are free for downloading (OA Articles)
Page 1 /191340
Display every page Item
O transplante de medula óssea alogênico e autogênico na leucemia mielóide aguda: análise de 80 pacientes
Bueno Nadjanara D.
Revista Brasileira de Hematologia e Hemoterapia , 2003,
Abstract:
Estudo retrospectivo do tratamento de leucemia mielóide aguda com o transplante de medula óssea: a experiência brasileira
Hamerschlak, Nelson;Barton, Débora;Pasquini, Ricardo;Sarquis, Yana N.;Ferreira, Eurípedes;Moreira, Frederico R.;Colturato, Vergilio A. R.;Souza, Carmino A.;Voltarelli, Júlio;Piron-Ruiz, Lilian;Setúbal, Daniela C.;Zanichelli, Maria A.;Castro, Cláudio G. de;Bueno, Nadjanara D.;Seber, Adriana;Rotolo, Marco A.;Silla, Lucia M. R.;Bittencourt, Henrique;Souza, Mair P.;Vigorito, Afonso C.;Brandalise, Silvia R.;Maiolino, Angelo;Nucci, Márcio;Coelho, érika;Ostronoff, Maurício;Sim?es, Belinda;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000100005
Abstract: data from the international bone marrow transplant registry (ibmtr) contribute for the improvement of bone marrow transplant (bmt) worldwide. we studied the brazilian experience in bmt for aml to compare this with international data. we performed a retrospective study by sending questionnaires to 16 bmt centers regarding clinical and treatment variables. statistical analyses concerning autologous bmt (autobmt) and allogeneic bmt (allobmt) were performed using the kaplan-meier method and the log-rank test. all p-values were two-tailed. we collected data from 731 patients (205 autobmt and 526 allobmt). median overall survival (os) for autobmt patients was longer than allobmt patients (1035 vs. 466 days, p=0.0012). allobmt stem cell source (scs): 73% bone marrow stem cell (bmsc), 23% peripheral blood stem cells (pbsc) and 4% umbilical cord blood. among the autobmt patients, the scs was 63% pbsc, 22% bmsc and 15% both. the scs did not impact on os. there was no difference in os between different fab classifications in the allobmt group, but in the autobmt the m3 patients had longer survival. as expected, the main cause of mortality among autobmt patients was related to disease relapse (60%), while in the allobmt, to infection (38%). in both groups we found longer os in first complete remission (1cr) compared to second (2cr) and other (p<0.0001), and longer os in de novo aml than in secondary. in the allobmt group we found more patients with advanced disease (60%), while in the autobmt group, we found more m3 patients (24%), which could explain the difference in os. most of our results are in accordance with ibmtr data. one should consider the fact that this is a retrospective study and our findings should be analysed with caution.
The intraplate Euphrates fault system-Palmyrides mountain belt junction and relationship to Arabian plate boundary tectonics
D. Alsdorf,M. Barazaugi,R. Litak,D. Seber
Annals of Geophysics , 1995, DOI: 10.4401/ag-4113
Abstract: We interpret seismic data and well logs to indicate that the Euphrates graben, intersecting orthogonally with the Palmyride mountains, is an intraplate transtensional feature that probably developed in response to plate boundary stress created by a latest Cretaceous convergence event along the present-day northern boundary of the Arabian plate. The principal stress direction is proposed to lie generally parallel to the graben; hence, it may have formed as a tear in the Arabian crust while, as previously documented, the Palmyride region under- went shortening and uplift. Arabian plate boundary tectonism as well as shorteningin the Palmyrides were pe- riodically active during the entire Cenozoic, especially in Neogene and Quaternary time. However, the normal fault motions that formed the Euphrates graben were not active within the study area after the end of the Cre- taceous, and were most active during the Campanian-Maastl.ichtian. A broad, Cenozoic depression overlying the Euphrates graben and most of Eastern Syria is possibly related to the Mesopotamian foredeep that devel- oped in response to the nearby Zagros continental collision zone during Neogene and Quaternary time. Cenozoic strike-slip faults lie between the Euphrates graben and the Palmyrides belt and may kinematically separate the Palmyrides from the Euphrates system.
O transplante de células-tronco hematopoéticas na infancia: situa??o atual e perspectivas
Seber, Adriana;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000035
Abstract: hematopoietic stem cell transplantation is a treatment option for a large number of children with malignant and non-malignant diseases. the objective of this article is to present the current status of hematopoietic stem cell transplantation in the treatment of malignant hematological diseases in pediatrics, including results in brazil, and future perspectives.
Strategical Behavior of Firms and Excise Tax Payment (Revenue Maximization, Profit Maximization, Love, Respect and Trust)
Akin Seber,Andac Arslan
International Journal of Economics and Finance , 2012, DOI: 10.5539/ijef.v4n3p164
Abstract: In this paper, we analyze the effect on price and quantity traded of a commodity of an excise tax payment under different conditions. First, we analyze the effect of the tax payment as in traditional analysis, where the firm considers tax as a “bad” to be avoided. Next, we propose a new approach for sharing the payment for the firm. Finally, we develop a new philosphical and psychological analysis wehere tax payment may be considered as a “good” to be happily provided by the firm rather than a “bad” that needs totally to be avoided.
Scalable Purification and Characterization of the Anticancer Lunasin Peptide from Soybean
Lauren E. Seber, Brian W. Barnett, Elizabeth J. McConnell, Steven D. Hume, Jian Cai, Kati Boles, Keith R. Davis
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035409
Abstract: Lunasin is a peptide derived from the soybean 2S albumin seed protein that has both anticancer and anti-inflammatory activities. Large-scale animal studies and human clinical trials to determine the efficacy of lunasin in vivo have been hampered by the cost of synthetic lunasin and the lack of a method for obtaining gram quantities of highly purified lunasin from plant sources. The goal of this study was to develop a large-scale method to generate highly purified lunasin from defatted soy flour. A scalable method was developed that utilizes the sequential application of anion-exchange chromatography, ultrafiltration, and reversed-phase chromatography. This method generates lunasin preparations of >99% purity with a yield of 442 mg/kg defatted soy flour. Mass spectrometry of the purified lunasin revealed that the peptide is 44 amino acids in length and represents the original published sequence of lunasin with an additional C-terminal asparagine residue. Histone-binding assays demonstrated that the biological activity of the purified lunasin was similar to that of synthetic lunasin. This study provides a robust method for purifying commercial-scale quantities of biologically-active lunasin and clearly identifies the predominant form of lunasin in soy flour. This method will greatly facilitate the development of lunasin as a potential nutraceutical or therapeutic anticancer agent.
Bussulfano e melfalano como regime de condicionamento para o transplante autogênico de células-tronco hematopoéticas na leucemia mielóide aguda em primeira remiss?o completa
Bueno, Nadjanara D.;Dulley, Frederico L.;Saboya, Rosaura;Amigo Filho, José U.;Piron-Ruiz, Lílian;Sturaro, Daniel;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000500005
Abstract: twenty-two consecutive patients with acute myeloid leukemia in first complete remission submitted to autologous hematopoietic stem cells transplantation conditioned with busulfan and melphalan were evaluated between 1993 and 2006. the overall survival, according to the kaplan-meier curve, was 57.5% at 36 months, with a "plateau" at 20 months after transplant. factors such as gender, french-american-british (fab) classification of acute myeloid leukemia, induction therapy, intensive consolidation, remission after the first cycle of induction and source of cells had no impact on survival. one patient with poor prognosis before the procedure died a year after transplantation. nine patients died, eight by relapse and one because of bleeding. death before 100 days occurred for two patients, one due to relapse and the other bleeding caused by refractory thrombocytopenia related to the procedure. in conclusion, the conditioning regiment with busulfan and melphalan is a valid option compared to the other conditioning regimens, with an excellent overall survival.
O transplante de medula óssea na leucemia mielóide aguda: análise de 80 pacientes transplantados no complexo do Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo
Bueno, Nadjanara D.;Saboya, Rosaura;Martins, Maria Cristina;Silva, Roberto L.;Chamone, Dalton A. F.;Rocha, Isamara F.;Sturaro, Daniel;Dulley, Frederico L.;
Revista Brasileira de Hematologia e Hemoterapia , 2004, DOI: 10.1590/S1516-84842004000200004
Abstract: the patients records of eighty consecutive patients with acute myeloid leukemia (aml) submitted to allogeneic (allo bmt) and autologous (auto bmt) bone marrow transplantation (bmt) between 1989 and 2001 were assessed. forty percent were alive in the end of the study; 37.9% of allogeneic patients and 45.4% of autologous. factors such as gender, the french-american-british aml classification, induction treatment, number of infused cells and the conditioning regiment did not have any impact in survival. patients with aml from m1 to m4, and who were consolidated with high doses of arabinoside had better a survival rate (p=0.0148). patients in their first complete remission also had better survival both with allogeneic and autologous bmt, with respective survival rates of 52.6% and 69.2%. acute graft-versus-host disease (gvhd) had an impact when it was compared the absence, grade i/ii with iii/iv giving a p-value of 0.0285. infection was the most frequent cause of death in allogeneic bmt. in autologous bmt relapse was the principal cause of death. toxicity related to the procedure occurred in 38.9% of patients who died in allogeneic bmt and 16.7% in autologous bmt. in univariant cox analyses for prognostic factors, the disease status and acute gvhd were significant, but this significance was lost in the multiple variant analyses (p-value = 0.069).
Simplified flow cytometric assay to detect minimal residual disease in childhood with acute lymphoblastic leukemia
Delbuono, Elizabete;Maekawa, Yumi H.;Latorre, Maria do Rosário D. O.;Seber, Adriana;Petrilli, Antonio Sergio;Braga, Josefina A. P.;Lee, Maria Lúcia M.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000400010
Abstract: the detection of minimal residual disease (mrd) is an important prognostic factor in childhood acute lymphoblastic leukemia (all) providing crucial information on the response to treatment and risk of relapse. however, the high cost of these techniques restricts their use in countries with limited resources. thus, we prospectively studied the use of flow cytometry (fc) with a simplified 3-color assay and a limited antibody panel to detect mrd in the bone marrow (bm) and peripheral blood (pb) of children with all. bm and pb samples from 40 children with all were analyzed on days (d) 14 and 28 during induction and in weeks 24-30 of maintenance therapy. detectable mrd was defined as > 0.01% cells expressing the aberrant immunophenotype as characterized at diagnosis among total events in the sample. a total of 87% of the patients had an aberrant immunophenotype at diagnosis. on d14, 56% of the bm and 43% of the pb samples had detectable mrd. on d28, this decreased to 45% and 31%, respectively. the percentage of cells with the aberrant phenotype was similar in both bm and pb in t-all but about 10 times higher in the bm of patients with b-cell-precursor all. moreover, mrd was detected in the bm of patients in complete morphological remission (44% on d14 and 39% on d28). mrd was not significantly associated to gender, age, initial white blood cell count or cell lineage. this fc assay is feasible, affordable and readily applicable to detect mrd in centers with limited resources.
Síndrome mielodisplásica na infancia
Lopes, Luiz F.;Lorand-Metze, Irene;Mendes, Wellington L.;Seber, Adriana;Melo, Ligia N.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000300016
Abstract: the brazilian cooperative study group on pediatric myelodysplastic syndromes (gcb-smd-ped) started in january 1997 with the goal of studying under 18-year-old patients with mds or suspected mds from all over the country. some primary or secondary disorders are incorrectly called mds. because of this the gcb-smd-ped is a referral group in the country to review and also to give diagnostic support (morphology, genetics, etc.). some groups still use the fab classification but two new classifications for pediatric cases have been published: one from the sick children's hospital, university of toronto, canada the "ccc classification" (category, cytology and cytogenetic), and the who pediatric classification by hasle et al. our proposal here is to present data from the 173 pediatric cases which were referred to the gcb-smd-ped from 15 states (41 centers). from 1983 to 1997, 51 pediatric cases were registered as retrospective cases and from january 1998 to february 2003, 122 prospective cases were registered. from these 173 cases, 93 where confirmed as mds. in 36.5% of them there was a transformation into acute leukemia with 82.3% as aml and 17.7% as all. the follow up showed that 54.8% died, 5.4% had spontaneous remission and 16.1% were in treatment with no chemotherapy (just transfusion or conservative approach). infections were the primary cause of death (58.8%). additionally, in this article the diagnostic approach according to classical or molecular genetics is shown with a review of literature for bone marrow transplantation in pediatric cases and other aspects which are different from the approach offered to adult patients with mds.
Page 1 /191340
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.