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Search Results: 1 - 10 of 189 matches for " Nadezhda Malomanova "
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Performance of the Genotype? MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian Federation
Vladyslav Nikolayevskyy, Yanina Balabanova, Tatyana Simak, Nadezhda Malomanova, Ivan Fedorin, Francis Drobniewski
BMC Clinical Pathology , 2009, DOI: 10.1186/1472-6890-9-2
Abstract: We performed an evaluation of the GenoType? MTBDRplus assay (HAIN Lifescience GmbH, Germany) on a total of 168 sputum specimens from individual patients at a public health laboratory in Central Russia, as a model of a middle income site in a region with high levels of drug resistance. Phenotypic drug resistance tests (DST) were performed on cultures derived from the same sputum specimens using the BACTEC 960 liquid media system.Interpretable GenoType? MTBDRplus results were obtained for 154(91.7%) specimens with readability rates significantly higher in sputum specimens graded 2+ and 3+ compared to 1+ (RR = 1.17 95%CI 1.04–1.32). The sensitivity and specificity of the assay for the detection of rifampicin (RIF) and isoniazid (INH) resistance and MDR was 96.2%, 97.4%, 97.1% and 90.7%, 83.3%, 88.9% respectively. Mutations in codon 531 of the rpoB gene and codon 315 of the katG gene dominated in RIF and INH resistant strains respectively. Disagreements between phenotypical and molecular tests results (12 samples) could be explained by the presence of rare mutations in strains circulating in Russia and simultaneous presence of resistant and sensitive bacilli in sputum specimens (heteroresistance).High sensitivity, short turnaround times and the potential for screening large numbers of specimens rapidly, make the GenoType? MTBDRplus assay suitable as a first-line screening assay for drug resistant TB.Emergence of multidrug resistance tuberculosis (MDRTB, i.e. resistance to at least rifampicin (RIF) and isoniazid (INH) in conjunction with increasing rates of HIV infection worldwide makes the rapid detection of TB drug resistance a key factor in patients' management and care. Rapid (within 1–2 days) diagnosis of MDRTB in clinical specimens allows the commencement of an appropriate TB treatment regimen earlier and helps to prevent transmission of drug resistant TB bacilli.The WHO estimates current MDRTB rates in new and previously treated cases globally at 2.9% and 15.3% re
Survival of Civilian and Prisoner Drug-Sensitive, Multi- and Extensive Drug- Resistant Tuberculosis Cohorts Prospectively Followed in Russia
Yanina Balabanova,Vladyslav Nikolayevskyy,Olga Ignatyeva,Irina Kontsevaya,Clare M. Rutterford,Anastasiya Shakhmistova,Nadezhda Malomanova,Yulia Chinkova,Svetlana Mironova,Ivan Fedorin,Francis A. Drobniewski
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020531
Abstract: A long-term observational study was conducted in Samara, Russia to assess the survival and risk factors for death of a cohort of non-multidrug resistant tuberculosis (non-MDRTB) and multidrug resistant tuberculosis (MDRTB) civilian and prison patients and a civilian extensive drug-resistant tuberculosis (XDRTB) cohort.
An Integrated Approach to Rapid Diagnosis of Tuberculosis and Multidrug Resistance Using Liquid Culture and Molecular Methods in Russia
Yanina Balabanova, Francis Drobniewski, Vladyslav Nikolayevskyy, Annika Kruuner, Nadezhda Malomanova, Tatyana Simak, Nailya Ilyina, Svetlana Zakharova, Natalya Lebedeva, Heather L. Alexander, Rick O'Brien, Hojoon Sohn, Anastasia Shakhmistova, Ivan Fedorin
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0007129
Abstract: Objective To analyse the feasibility, cost and performance of rapid tuberculosis (TB) molecular and culture systems, in a high multidrug-resistant TB (MDR TB) middle-income region (Samara, Russia) and provide evidence for WHO policy change. Methods Performance and cost evaluation was conducted to compare the BACTEC? MGIT? 960 system for culture and drug susceptibility testing (DST) and molecular systems for TB diagnosis, resistance to isoniazid and rifampin, and MDR TB identification compared to conventional Lowenstein-Jensen culture assays. Findings 698 consecutive patients (2487 sputum samples) with risk factors for drug-resistant tuberculosis were recruited. Overall M. tuberculosis complex culture positivity rates were 31.6% (787/2487) in MGIT and 27.1% (675/2487) in LJ (90.5% and 83.2% for smear-positive specimens). In total, 809 cultures of M. tuberculosis complex were isolated by any method. Median time to detection was 14 days for MGIT and 36 days for LJ (10 and 33 days for smear positive specimens) and indirect DST in MGIT took 9 days compared to 21 days on LJ. There was good concordance between DST on LJ and MGIT (96.8% for rifampin and 95.6% for isoniazid). Both molecular hybridization assay results correlated well with MGIT DST results, although molecular assays generally yielded higher rates of resistance (by approximately 3% for both isoniazid and rifampin). Conclusion With effective planning and logistics, the MGIT 960 and molecular based methodologies can be successfully introduced into a reference laboratory setting in a middle incidence country. High rates of MDR TB in the Russian Federation make the introduction of such assays particularly useful.
The Relationship of SmokingOpioidAntidepressant Use and History of Spine Surgery  [PDF]
Walid Mohammad, Zaytseva Nadezhda
International Journal of Clinical Medicine (IJCM) , 2010, DOI: 10.4236/ijcm.2010.11003
Abstract: Introduction: In a recent paper, smoking was shown to be an independent predictor of longterm continued opioid use in spine patients (Krebs et al. 2010). In this paper, we study the interaction of smoking with opioid and antidepressant use and the relationship with prior spine surgery and future spine surgery. Methods: Data on smoking, opioid and antidepressant use were retrospectively collected from 758 spine surgery inpatients [lumbar microdiskectomy (LMD), anterior cervical decompression and fusion (ACDF) and lumbar decompression and fusion (LDF)]. Interaction with history of previous spine surgery and return for additional spine surgery was studied. Followup ranged from one to four years. Results: Significant correlation was detected between smoking and opioid use and between opioid and antidepressant use. History of previous spine surgery correlated with antidepressant use and return for additional spine surgery. Additional spine surgery correlated with opioid use and history of previous spine surgery. Smoking LMD patients on both opioids and antidepressants and smoking ACDF patients on antidepressants who have a history of prior spine surgery were more likely to return for additional spine surgery. However, in the LDF group, smoking patients on antidepressants without previous spine surgery were more likely to come for another spine surgery. Conclusion: Smokingantidepressantopioid use could be predictive of return for additional spine surgery during the followup years especially if a history of prior spine surgery was reported. Further research is needed on the implications of such an association.
Extra Investigation Might Be Necessary in High-Risk CT-Negative Cerebrovascular Cases  [PDF]
Mohammad Sami Walid, Nadezhda Zaytseva
Neuroscience & Medicine (NM) , 2013, DOI: 10.4236/nm.2013.42017

Cerebrovascular accidents occur in elderly patients in whom neurodegenerative changes increase the risk of vascular permeation and concomitant intracranial bleeding. In rare cases, intracerebral massive hemorrhage happens in hospitalized patients with apparently stable clinical picture. We report two cases illustrating this phenomenon, discuss the possible pathomechanism involved in those tragic incidents and suggest possible prevention measures for these patients. A negative CT image in a patient with neurological symptoms, especially who are on warfarin with or without considerably elongated coagulation time, may be subject to a sudden intracranial hemorrhage. Microvascular abnormalities might be detected on perfusion CT imaging and should therefore be performed in all CT negative patients with close observation for 24 hours before contemplating discharge.

Crop Water Supply and its Relation to Yield of Spring Wheat in the South of Russian Plain
Nadezhda Shumova
Journal of Hydrology and Hydromechanics , 2009, DOI: 10.2478/v10098-009-0003-3
Abstract: The proposed method to estimate water supply of spring wheat crop is based on the ratio of the water amount extracted by plants under actual conditions of growth (transpiration) to cover needs for maximum (potential) yield (potential transpiration). Estimates of spatial, inter- and intra-annual water supply variability of the spring wheat crop in basic agricultural zones are given. Dependence of the spring wheat yield on water supply is presented.
Nadezhda Egorova
Sovremennye Issledovania Social?nyh Problem , 2012,
Abstract: Methods of relay race technical preparation of athletics freshmen in the course of Physical Training classes in higher education institutions on activ game base are represented in this paper.
The myth-making in the media
Shulga Nadezhda
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: The article considers the system of functioning of the myths in the mass political consciousness. Identified methods of influence of mass media by means of mythological elements in the mass consciousness. The main emphasis is on the methods of implementation of political myths in the media.
Irkutsk Development Regulation before the Revolution: Basic Provisions Регулирование застройки дореволюционного Иркутска: основные положения
Nadezhda Bubis
Project Baikal , 2010,
“To sell the motherland”: the characters of Vasily Shukshin stories and a potential brand of Altai krai (Russia) Продать родину : герои Василия Шукшина и потенциальный бренд Алтайского края
Nadezhda Zamyatina
Cultural Geography & Geohumanities , 2012,
Abstract: The potential brand and symbols of Altai krai (Russia) are analyzed through Internet search engines. The new brand based on the stories by Vasily Shukshin (native of the region) is suggested. The focus in regional branding is thought to be shifted towards the typical characters of his stories interpreted in modern conditions. В статье по данным поисковых систем в Интернете анализируется известность потенциального бренда Алтайского края, его возможные символы. Предлагается создание бренда региона на основе использования творчества местного уроженца В.М. Шукшина. При этом обосновывается использование в брендинге не столько жизни и творчества самого писателя, сколько характеров героев его произведений, которые могут творчески трактоваться с учётом современных условий.
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