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Search Results: 1 - 10 of 154375 matches for " Nabil H. Omar "
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The Impact of Human Parvovirus B19 Co-Infection on Liver Function of HCV Infected Patients  [PDF]
Mohamed Nabil, Mohammed H. Saiem Al-Dahr, Waleed Abu Al-Soud, Omar Alfaruok
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.91003
Abstract: Background: Human Parvovirus B19 is most known for causing disease in the pediatric population but can also affect adults. Human co-infection with Parvovirus B19 could deteriorate the prognosis of patient with chronic ill-ness.

Objectives: This paper attempts to determine the prevalence of Parvovirus B19 in HCV infected patients and to evaluate the impact of Parvovirus B19 on liver enzymes activity of Hepatitis C patients. Study Design: The study population includes 74 chronic HCV (patient group) and 49 cases without viral hepatitis (control group). Nucleic acid of Parvovirus B19 was detected in Serum samples by nested polymerase chain reaction (nested-PCR) method. Results: Parvovirus B19-DNA infection was detected in 28.0% of chronic HCV patients. Parvovirus B19-HCV co-infection caused increasing in Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) activity than in B19-negative HCV patients. Conclusion: We conclude that Parvovirus B19 acted synergistically with HCV by increasing the levels alanine ami-notransferase (ALT) and Aspartate aminotransferase (AST).

Pulmonary Hypertension Induced by Thalidomide (and Derivatives) in Patients with Multiple Myeloma: A Systematic Review  [PDF]
Abdulqadir J. Nashwan, Nader I. Al-Dewik, Hisham M. Al Sabah, Mohamed A. Yassin, Shehab F. Mohamed, Nabil H. Omar, Dana B. Mansour
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.713094
Abstract: Thalidomide is widely used in the treatment of multiple myeloma (MM). In recent years, several cases of pulmonary hypertension have been reported following treatment with thalidomide. The aim of this review was to evaluate the published literature on multiple myeloma patients with pulmonary hypertension following thalidomide treatment. A literature search was performed between 2000 and 2016. A total of 7 eligible studies were identified and deemed eligible, including 11 cases—approximately 37% (4 cases) with IgA (k), 27% (3 cases) with IgG (λ) MM, 27% (3 cases) with IgG (k) MM, and one case (9%) with primary plasma cell leukemia (PPCL). The vast majority of cases—82% (9 cases)—are associated with thalidomide, while only 18% (2 cases) are related to thalidomide derivatives (lenalidomide and pomalidomide). In conclusion, pulmonary hypertension induced by thalidomide or derivatives in multiple myeloma (MM) patients is related to a multifactorial etiology including the pathophysiology of the disease, thromboembolic events, preexisted cardiovascular conditions, comorbidities, and combination with other chemo- or bio-therapeutic agents. MM patients should be evaluated for signs and symptoms underlying cardiopulmonary disease before initiating, and during treatment with thalidomide.
Calculation of Open Water Evaporation as a Climate Parameter  [PDF]
Nabil H. Swedan
Journal of Water Resource and Protection (JWARP) , 2018, DOI: 10.4236/jwarp.2018.108043
Abstract: Calculation of open water evaporation is important for hydrology, industry, agriculture, environment, and other fields. The available methods of calculating evaporation are based on field or laboratory experiments and should not be used for scale-up to open water evaporation for similitude relationships cannot be correctly obtained. The methods are thus unjustified scientifically. In addition, surface evaporation is not a local phenomenon that is a function of independent meteorological parameters. These are in fact dependent parameters, and the solar energy exchanged with the surface of the earth is the only independent variable for open water evaporation. Contrary to the existing methods, meteorological records and measurements are therefore not required. Many parts of the world do not have full or partial records available. For these, the available methods are likely not to be useful. In addition, future meteorological records or measurements cannot be made available for evaporation projection in a warming world. This may well place a limit on using the existing methods. The work presented in this manuscript reveals a new understanding of evaporation as a climate parameter instead and can be calculated as such. Minimal to no meteorological records or measurements may be required. The advantages of the proposed method are scientific justification, simplicity, accuracy, versatility, low to virtually no cost, and can be used to map present and future evaporation in a short period of time.
Synthesis and Characterization of Hybrid Materials Consisting of n-octadecyltriethoxysilane by Using n-Hexadecylamine as Surfactant and Q0 and T0 Cross-Linkers
Ismail Warad,Omar Abd-Elkader H,Saud Al-Resayes,Ahmad Husein,Mohammed Al-Nuri,Ahmed Boshaala,Nabil Al-Zaqri,Taibi Ben Hadda
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13056279
Abstract: Novel hybrid xerogel materials were synthesized by a sol-gel procedure. n -octadecyltriethoxysilane was co-condensed with and without different cross-linkers using Q0 and T0 mono-functionalized organosilanes in the presence of n-hexadecylamine with different hydroxyl silica functional groups at the surface. These polymer networks have shown new properties, for example, a high degree of cross-linking and hydrolysis. Two different synthesis steps were carried out: simple self-assembly followed by sol-gel transition and precipitation of homogenous sols. Due to the lack of solubility of these materials, the compositions of the new materials were determined by infrared spectroscopy, 13C and 29Si CP/MAS NMR spectroscopy and scanning electron microscopy.
Crizotinib in non-small cell lung cancer  [PDF]
Nawfel Mellas, Fatimzahra Hijri, Zineb Benbrahim, Omar El Mesbahi, Nabil Ismaili
Modern Chemotherapy (MC) , 2014, DOI: 10.4236/mc.2014.31002
Abstract:

Chemotherapy and targeted therapy remain the cornerstone of treatment of locally advanced and metastatic non-small cells lung cancer (NSCLC). Given the intrinsic chemoresistance of tumor cells, new treatment options have been developped. The knowledge of the molecular mechanisms of tumor biology, and signal transduction pathways activating cancer cells led to the identification of a new targeted therapy such as Crizotinib. The small molecule Crizotinib is a selective inhibitor of the receptor tyrosine kinase ALK (anaplastic lymphoma kinase) and its oncogenic variants (ALK fusion gene and some mutations of ALK). Phases I and II trials showed the efficacy of Crizotinib in the treatment of locally advanced and metastatic NSCLC expressing ALK. Thereafter, randomized Phase III trial confirmed the significant superiority of Crizotinib versus standard chemotherapy in terms of progression free survival and objective response with good tolerance; therefore, it has been approved by the Food and Drug Administration (FDA) as the standard treatment for locally advanced and metastatic ALK-positive NSCLC.

Diagnostic and prognostic value of plasma level of microRNA-92a in acute myeloid leukemia  [PDF]
Nabil El-Halawani, Nahla Hamed, Mohamed Eldafrawi, Zeinab Mourad, Amani Sorour, Omar Ghallab
American Journal of Molecular Biology (AJMB) , 2014, DOI: 10.4236/ajmb.2014.41001
Abstract:

Background: MicroRNAs (miRNAs) are short noncoding RNAs of ~21 to 23 nucleotides in length that post-transcriptionally regulate mRNA expression. Highthroughput methodologies have shown deregulated miRNA expression in an increasing number of human cancers. MiRNA expression patterns have been found to distinguish tumors of different developmental origin, even better than traditional mRNA expression profiling. Aim: To assess the plasma level of microRNA-92a in adult acute myeloid leukemia and to correlate it with prognostic factors and therapeutic response. Patients and Methods: This study was carried out on fifty AML patients as well as fifty healthy subjects as control. Conventional cytogenetics was performed on patients group only while measurement of the plasma level of miRNA-92a using TaqMan quantitative RT-PCR with miRNA-638 as endogenous reference for standardization and FLT3/ITD mutation was performed on patients and controls. Results: The differences in the ratio or relative quantitation (RQ) of plasma miRNa-92a to miRNA-638 in patients group to the control group have confirmed statistical significance. Also there was significant negative correlation between RQ of miRNA-92a and white blood count in patient group. Patients who achieved a response after induction chemotherapy had a mean RQ of miRNA-92a higher than non-responder with statistical significance. With regard to cytogenetics, favorable risk cytogenetics had meant RQ of miRNA-92a that was comparable to intermediate risk cytogenetics. While poor risk cytogenetics had a mean RQ which is significantly lower than both favorable and intermediate risk cytogenetics. Summary/Conclusions: Our data suggest the potential importance of the microRNA-92a as noninvasive cancer biomarkers helping in diagnosis, clinical prediction and therapeutic response.

Automatic Test Data Generation for Java Card Applications Using Genetic Algorithm  [PDF]
Saher Manaseer, Warif Manasir, Mohammad Alshraideh, Nabil Abu Hashish, Omar Adwan
Journal of Software Engineering and Applications (JSEA) , 2015, DOI: 10.4236/jsea.2015.812057
Abstract: The main objective of software testing is to have the highest likelihood of finding the most faults with a minimum amount of time and effort. Genetic Algorithm (GA) has been successfully used by researchers in software testing to automatically generate test data. In this paper, a GA is applied using branch coverage criterion to generate the least possible set of test data to test JSC applications. Results show that applying GA achieves better performance in terms of average number of test data?generations, execution time, and percentage of branch coverage.
Low Voltage Ride through Control Capability of a Large Grid Connected PV System Combining DC Chopper and Current Limiting Techniques  [PDF]
Ronald Ntare, Nabil H. Abbasy, Karim H. M. Youssef
Journal of Power and Energy Engineering (JPEE) , 2019, DOI: 10.4236/jpee.2019.71004
Abstract: This paper presents the development and performance capability of a comprehensive Low voltage ride through (LVRT) control scheme that makes use of both the DC chopper and the current limiting based on the required reactive power during fault time. The study is conducted on an 8.5 MW single stage PV power plant (PVPP) connected to the Rwandan grid. In the event of fault disturbance, this control scheme helps to overcome the problems of excessive DC-link voltage by fast activation of the DC chopper operation. At the same instance, AC current is limited to the maximum rating of the inverter as a function of the injected reactive current. This helps overcome AC-over- current that may possibly lead to damage or disconnection of the inverter. The control scheme also ensures voltage support and power balance through the injection of reactive current as per grid code requirements. Selected simulations using MATLAB are carried out in the events of different kinds of fault caused voltage dips. Results demonstrate the effectiveness of the proposed LVRT control scheme.
A Note on the Size-Sensitive Packing Lemma
Nabil H. Mustafa
Computer Science , 2015,
Abstract: We show that the size-sensitive packing lemma follows from a simple modification of the standard proof, due to Haussler and simplified by Chazelle, of the packing lemma.
Synthesis, Characterization and Antimicrobial Screening Mixed-Ligand Cu(II) and Zn(II) Complexes; DNA Binding Studies on Cu(II) Complex  [PDF]
Omar H. Al-Obaidi
Open Journal of Inorganic Non-metallic Materials (OJINM) , 2012, DOI: 10.4236/ojinm.2012.24007
Abstract: Several mixed ligand Cu(II), Zn(II) complexes using (benzylidenethiourea) (obtained by the condensation of benzaldehyde and thiourea) as the primary ligand and (acetamide or thioacetamide) as an additional ligand were synthesized and characterized analytically and spectroscopically, magnetic susceptibility and molar conductance measurements ,as well as by UV-Vis. and IR spectroscopy. The interaction of the complexes with calf thymus (CT)DNA was studied using absorption spectra, while the concentration of DNA in gel electrophoresis remained constant at 10 μl. They exhibit absorption hypochromicity increased during the binding of the complexes to calf thymus DNA. The complexes show enhanced antimicrobial activities complexes with the free ligand. A theoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.
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