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Search Results: 1 - 10 of 37735 matches for " Na Guo "
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The Hematopoietic and Immunomodulatory Effect of rhIL-12 for Liver Cancer  [PDF]
Xiaojing Gong, Na Guo, Lingqin Wan, Xifeng Jia, Yishan Wang
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2016, DOI: 10.4236/ijmpcero.2016.51004
Abstract: Purpose: To explore the effect of rhIL-12 on the number of the blood cells and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells in liver cancer patients following radiation therapy. Methods: We selected forty liver cancer patients who carried out by cyber knife (the patients were given 5 Gy every time for 5 times continuously) to observe the size of the tumor. After thirty hours, rhIL-12 was injected into the liver cancer patients via subcutaneous at the concentration of 50 ng/kg, 100 ng/kg, 200 ng/kg and 300 ng/kg in different patients, respectively. And there were ten patients in the four groups, respectively. The twenty patients who were selected from the hospital without rhIL-12 treatment were used as controls. All the blood cells were collected from different groups on day 0, hour 12, day 7, day 14, day 21 and day 28 after rhIL-12 treatment, respectively. The full number of blood cells in every group was analyzed by ELISA. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were detected by Flow Cytometry. After one month with rhIL-12 treatment, ECOG and WHO were used to evaluate the prognosis of liver cancer. Results: In present study, we found that the number of blood cells was significantly decreased on day 0 - day 3, while recovered from day 7 - day 14 and down-regulated on day 21 after rhIL-12 treatment. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells was elevated with any concentration of rhIL-12. Furthermore, results showed that number of white blood cells was obviously higher than in patients without rhIL-12 treatment (P < 0.05). However, there was no significant difference of erythrocyte and platelet, between groups treated with rhIL-12 and control groups. In addition, the immune cells including CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were reduced on day 0 - day 3, recovered from day 7, and then decreased from day 21 in rhIL-12 treatment groups related to control groups (P < 0.05). Furthermore, studies showed that five patients developed symptoms of fever, bilirubin increased and liver dysfunction with the dose of 300 ng/kg. So we found that the safe and well-tolerated human dose of 200 ng/kg is within this efficacious range based on exposure parameters through the research. Higher ECOG and WHO scores were observed in rhIL-12 treatment groups compared to control groups (P = 0.025, P = 0.044, respectively). Conclusion: Our results suggested that rhIL-12 could recover the liver cancer induced aberrant blood cell number and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells , which may be an effective method to
Evaluation of Magnetic Resonance Imaging Findings and Short-Term Outcome in Brain Metastatic Tumors after CyberKnife Treatment  [PDF]
Jiashou Hu, Hongzi Tian, Na Guo, Di Wang, Jinfeng Sun
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2016, DOI: 10.4236/ijmpcero.2016.51010
Abstract: Objective: To evaluate the treatments’ outcomes in brain metastatic tumors after CyberKnife treatment according to magnetic resonance imaging (MRI) findings and improvement of symptoms. Methods: A retrospective analysis of CyberKnife treatment; 63 cases of patients with brain metastases; the use of CyberKnife treatment; short-term outcome evaluation after treatment and the MRI findings and measured before treatment and underwent diffusion-weighted imaging MRI scan of apparent diffusion coefficient (ADC) values. Results: 3 months after CyberKnife treatment and effectiveness were 82.5% and 96.8% respectively; 6 months and one year survival rates were 82.5% and 55.6% respectively; the median survival time was 16 months. MRI of 52 patients (67 lesions) ADC values after treatment increased to some extent than before treatment. There are 38 lesions volume to shrink or disappear, no enhancement or slight enhancement in the lesion, no edema zone; 27 lesions does not change in volume, no edema (18 lesions significantly weakened the degree of enhancement; 6 lesions showed no obvious change enhancement; 3 lesions showed ring enhancement, internal cystic); 2 lesions volume were larger, heterogeneous enhancement, peripheral edema. Conclusion: CyberKnife is an effective method for treating brain metastatic tumor. MRI can accurately evaluate tumor lesions after treatment.
Test Method of Laser Detection Sensitivity Based on Every Pulse Measurement and Rearrangement  [PDF]
Hao Guo, Na Ma, Hongpeng Zhao, Mei Yao
Optics and Photonics Journal (OPJ) , 2017, DOI: 10.4236/opj.2017.78B006
Abstract:
It is very important to accurately measure the detection sensitivity of laser receiving equipment. Based on the traditional test method of detection probability curve, a new test method is proposed which works through measuring laser pulse one by one. Accurate measurement systems were constructed to improve the accuracy of laser energy measurement and energy regulation. A new data processing method of detection probability curve is put forward, which based on subsection statistics. The new data processing method in effect reduces the light source instability from 6.57% to 0.67%. These works improve the test accuracy of laser receiving detection sensitivity. It is a great support for the accurate evaluation of key technical indices of laser receiving equipment, which subsequently are done by models and simulation.
Thoughts about Foreign Language Teaching Planning Reform in Military Academies  [PDF]
Meng Li, Guo Li, Xinshe Qi, Na Wang
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.73040
Abstract:
In the process of transition from general foreign language teaching to military foreign language teaching, the main challenge facing the foreign language teaching reform in military academies is how to define and test the new foreign language teaching objectives scientifically. The paper points out that it is the key to solve the dilemma of foreign language teaching in military academies to grasp the special requirements of the application of military foreign language ability and integrate it systematically into the whole process of talent training. This study can provide a reference for the reform of foreign language teaching in military academies and provide some enlightenment for the reform of foreign language teaching reform in local colleges and universities.
The (1+1)-dimensional spatial solitons in media with weak nonlinear nonlocality

Ding Na,Guo Qi,

中国物理 B , 2009,
Abstract: We study the propagation of (1+1)-dimensional spatial soliton in a nonlocal Kerr-type medium with weak nonlocality. First, we show that an equation for describing the soliton propagation in weak nonlocality is a nonlinear Schr?dinger equation with perturbation terms. Then, an approximate analytical solution of the equation is found by the perturbation method. We also find some interesting properties of the intensity profiles of the soliton.
Formation Process and Properties of Phytic Acid Conversion Coatings on Magnesium  [PDF]
Jian-Rui Liu, Yi-Na Guo, Wei-Dong Huang
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2011, DOI: 10.4236/jsemat.2011.11003
Abstract: A chromium-free conversion coating treatment for magnesium by phytic acid solution was studied. The formation process of phytic acid conversion coating was studied through measuring the open circuit potential (OCP) and weight change of the pure magnesium in the different conversion treatment time. The morphologies and compositions of the coatings were determined by SEM and EDS respectively. The conversion coating has the multideck structure with netlike morphology which is similar to the chromate conversion coating, and is mainly composed of Mg, P, O and C. The contents of C and P and the size of the cracks in different layers decrease from the external layer to the inner layer. The hydroxyl groups and phosphate carboxyl groups in the coating which have the similar properties to organic paintcoat are beneficial to the combination of substrate and organic paintcoat. The formation mechanism and thickness variation of the conversion coatings are also discussed.
Responses to Comments of Weis
Na Guo, Carlo A Marra, Fawziah Marra
Health and Quality of Life Outcomes , 2010, DOI: 10.1186/1477-7525-8-6
Abstract: We thank Weis and Pasipanodya for their valuable and insightful comments on our published manuscript, Measuring health-related quality of life in tuberculosis: a systemic review [1]. However, we want to address their question regarding our statement "A validated tuberculosis-specific quality of life instrument was not located". When we searched for a "validated tuberculosis-specific quality of life instrument" for our literature review, there were two requirements that we had determined apriori. Firstly, the quality of life (QoL) instrument had to be originally designed and tailored specifically to assess a tuberculosis (TB) population; and secondly, the involved QoL instrument had to be validated in various TB populations.Subjective measurements, such as QoL, are always prone to inherent biases. Validation is an important process involving the accumulation of evidences to provide a sound scientific basis to support the inferences of their psychometric properties. In addition, the quality of validation evidences is very important. Although there is no rule of thumb when validating a QoL instrument, a number of considerations should be taken into account - for example reliability, validity and responsiveness, representative samples of the targeted population, appropriate analysis techniques, and controls over plausible confounding factors [2].Through our literature review, we only found one QoL instrument, the DR-12 [3], which was designed specifically for use in TB infected populations. However, as we stated in our manuscript [1], it has only been used once in a sample of active TB patients and the validation was not done in a systematic fashion. More applications with better validation methods are needed to further establish the psychometric properties of the DR-12.Finally, we agree with Weis and Pasipanodya that item banking is a promising direction for QoL measurements. Item banking is a large collection of items that are measuring the same health construct and c
Measuring health-related quality of life in tuberculosis: a systematic review
Na Guo, Fawziah Marra, Carlo A Marra
Health and Quality of Life Outcomes , 2009, DOI: 10.1186/1477-7525-7-14
Abstract: A systematic literature search from 1981 to 2008 was performed through a number of electronic databases as well as a manual search. Eligible studies assessed multi-dimensional quality of life in people with tuberculosis disease or infection using standardized instruments. Results of the included studies were summarized qualitatively.Twelve original studies met our criteria for inclusion. A wide range of quality of life instruments were involved, and the Short-Form 36 was most commonly used. A validated tuberculosis-specific quality of life instrument was not located. The findings showed that tuberculosis had a substantial and encompassing impact on patients' quality of life. Overall, the anti-tuberculosis treatment had a positive effect of improving patients' quality of life; their physical health tended to recover more quickly than the mental well-being. However, after the patients successfully completed treatment and were microbiologically 'cured', their quality of life remained significantly worse than the general population.Tuberculosis has substantially adverse impacts on patients' quality of life, which persist after microbiological 'cure'. A variety of instruments were used to assess quality of life in tuberculosis and there has been no well-established tuberculosis-specific instrument, making it difficult to fully understand the impact of the illness.The assessment of patient reported outcomes (PROs) has become more accepted and valued in the disease management and outcome evaluation. Health-related quality of life (HRQL) is a complex type of PRO that evaluates health status. HRQL broadly describes how well individuals function in daily lives and their own perception of well-being in physical, psychological, and social aspects [1,2]. Although traditional clinical and biological indicators are often intrinsically related to patients' quality of life, they fail to represent one's self-perceived function and well-being in everyday life settings. It is known tha
A Distributed Routing Algorithm with Traffic Prediction in LEO Satellite Networks
Gao Zihe,Guo Qing,Na Zhenyu
Information Technology Journal , 2011,
Abstract: These recent years, Low Earth Orbit (LEO) satellite networks, which have global coverage and short round-trip delays, have been playing an increasingly important role. As fast speed, frequent handover and time-varying topology, to develop specialized and efficient routing algorithm is a huge challenge in LEO satellite networks. A Distributed Routing Algorithm with Traffic Prediction (TPDRA) is proposed in this study. TPDRA solves the linearly inseparable problem of satellite traffic prediction in higher dimensionality space and finds the optimal path for data packets through mobile agents. TPDRA consists of two parts, traffic prediction and routing decision. In traffic prediction module, the upcoming traffic from terrestrial is forecasted using Radial Basis Function neural network. In routing decision module, mobile agents traverse the whole satellite networks and collect the routing information. The final routing decision factor is not only depending on the current state of satellite networks, but also related to the future state of satellite nodes. Simulation shows that, compared with ACO, TPDRA has better transmission delay as well as intensive performance for congestion.
Cyclooxygenase-2 gene silence induces apoptosis of human hepatocellular carcinoma cells
Dan GUO,Na-na CHEN,Shu-guang WU,Lin-sheng LEI
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective To specifically silence COX-2 gene expression in cultured human hepatocellular carcinoma cells HepG2 by construction and transfection of COX-2 hairpin RNA (shRNA) expression vectors, and investigate the effects of knocking COX-2 down on cell proliferation and apoptosis. Methods The inserted sequences coding shRNA homologous to COX-2 gene were designed and COX-2 shRNA expression vectors were constructed and transfected into HepG2 cells with Lipofectamine 2000. The inhibitory efficiency of COX-2 shRNA was determined by detection of COX-2 mRNA levels in transfected cells using semi-quantitative RT-PCR. Cell viability was analyzed by cell counting kit-8 (CCK-8) assay. Indexes of apoptotic cells and cell cycle distribution were analyzed by flow cytometry. Western blotting was used to detect the changes of protein levels of COX-2 and Bcl-2 in HepG2 cells. Results Plasmid sequencing indicated the successful construction of two shRNA expression vectors. The expressive levels of COX-2 mRNA in HepG2 cells transfected with two COX-2 shRNA expression vectors decreased to 41.66% and 77.79%, respectively, of that in cells transfected with control scrambled shRNA expression vector. The vector which efficiently suppressed the expression of COX-2 mRNA was transfected into HepG2 cells, and G418 was used to select a population of cells which may stably express the shRNA. The expression of COX-2 mRNA decreased by 75.30% and the cell viability decreased by 29.33% in cells which stably expressed COX-2 shRNA. Flow cytometry analysis showed a higher proportion of apoptotic cells in COX-2 shRNA group than in untransfected and scrambled shRNA groups (17.83% vs4.47% and 4.63%). The proportion of cells in G0/G1 phase was 73.93%, 57.63% and 61.2%, while in S phase was 13.43%, 26.90% and 26.03%, respectively, in COX-2 shRNA group, untransfected and scrambled shRNA groups. Western blotting revealed that the protein levels of COX-2 and Bcl-2 in HepG2 cells which expressed COX-2 shRNA reduced to 31.25% (P < 0.01) and 54.93% (P < 0.01) of scrambled shRNA expression vector respectively. Conclusion Recombinant expression vector pSilencer 2.1-U6-COX-2 shRNA may efficiently silence COX-2 gene expression, inhibit cell proliferation, promote apoptosis, arrest cell cycle and decrease the Bcl-2 protein level in human hepatocellular carcinoma cells HepG2.
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