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Search Results: 1 - 10 of 197986 matches for " N;Lalaoui "
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General characterization of venom from the Moroccan snakes Macrovipera mauritanica and Cerastes cerastes
Oukkache, N;Lalaoui, M;Ghalim, N;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2012, DOI: 10.1590/S1678-91992012000400009
Abstract: ophidian envenomation accidents constitute a serious public health problem in many countries around the globe. over 5 million such accident cases occur each year causing more than 100,000 deaths. in africa, more than 20,000 deaths per year are registered while 400,000 envenomation victims retain severe and permanent functional sequelae. in morocco, snakebites are frequent and of greater severity in children. they occur mostly in rural areas. the incidence of these bites remains poorly understood and vastly underestimated. the epidemiological data are not well known due to the absence of a national registry, whereas a significant proportion of envenomations receive only traditional treatment methods in non-medical intensive care. this prompted us to investigate the enzymatic and biological properties of venom biochemical constituents from two of the most dangerous snake venoms in morocco: cerastes cerastes (cc) and macrovipera mauritanica (mm). also, we studied the immune cross-reactivity of cc and mm venoms in comparison to that of another important dangerous moroccan viper, bitis arietans (ba), to identify the best candidates (venom or a mixture of venoms) for producing the most efficient and protective antivenom. in the present study, we report a preliminary venom characterization of cc and mm and the cross-reactivity that may exist between their venoms and ba. these venoms are known to be highly toxic and contain several proteins that differ by molecular weights. interestingly, both cc and mm venoms are characterized by intense hemorrhagic and phospholipase a2 activities and their ability to degrade the α and γ chains of fibrinogen. they display very low proteolysis through the casein test. after injection into mice, cc and mm induce myonecrosis in skeletal muscles, which most likely reflects direct action of myotoxins and indirect action of hemorrhagic molecules present in these venoms. in mice, this myonecrosis diminishes serum creatine phosphokinase (cpk) leve
Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants
Akroum Souad,Bendjeddou Dalila,Satta Dalila,Lalaoui Korrichi
International Journal of Green Pharmacy , 2010,
Abstract: Flavonoids are well-known for their many therapeutic and pharmaceutical effects. In this study, we tested the antibacterial activity of 11 flavonoids extracted from some medicinal plants by the agar diffusion method. Then, we measured their antioxidant activity using the DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay and we also tested their acute toxicity effect on mice. The results showed that apigenin-7-O-glucoside was more active against the Gram-positive bacteria and quercetin was more active against the Gram-negative ones. Also, quercetin and diosmin showed the best antioxidant activity. Quercetin, apigenin-7-O-glucoside, luteolin-7-O-glucoside and luteolin-3′-O-glucuronide gave the best acute toxicity values. It can be concluded that quercetin was the most interesting compound for all the tested activities. Also, we observed that the presence or the absence of substitutions in flavonoids influenced significantly the results obtained, whereas the substitution type had a low impact.
Textilome abdominal: à propos d’un cas
I Serghini, A El Fikri, JS Lalaoui, M Zoubir, M Boui, M Boughanem
Pan African Medical Journal , 2011,
Abstract: Le textilome est une complication postopératoire très rare mais bien connue. Il peut s’agir d’un corps étranger composé de compresse(s) ou champ(s) chirurgicaux laissés au niveau d’un foyer opératoire. La découverte du textilome abdominale est généralement tardive. L’anamnèse est donc essentielle pour diagnostic vu que la clinique n’est pas concluante. La clinique associe des troubles chroniques du transit à des syndromes sub-occlusifs, le cliché d’abdomen sans préparation est peu contributif. L’échographie est fiable. La tomodensitométrie permet un diagnostic topographique précis. Certaines équipes proposent des explorations par IRM. Nous rapportons un cas de textilome intra abdominale, chez une patiente opérée 6 mois auparavant d’un fibrome utérin.
Management of undiagnosed pheochromocytoma with acute appendicitis
Mustapha Bensghir, Abderhmane Elwali, Salim Lalaoui, Noureddine kamili, Hassan Alaoui, Jawad Laoutid, Hicham Azendour, Hicham Balkhi, Charqui Haimeur, Mohamed Atmani
World Journal of Emergency Surgery , 2009, DOI: 10.1186/1749-7922-4-35
Abstract: Letter to editor:Pheochromocytoma is a rare catecholamine-secreting tumor. A proportion of patients are diagnosed at the time of incidental surgery, when induction of anaesthesia may precipitate an hypertensive crisis. In this situation, mortality is close to 80% [1]. The authors report a case of an undiagnosed pheochromocytoma patient with an acute appendicitis.A 17 years old man was scheduled for acute appendicitis. The patient's cardiovascular examination was normal, arterial blood pressure was 135/65 mmHg and heart rate was 85 beats/min. A crush-induction (Propofol 3 m/kg, célocurine 1 mg/kg) was used. Anaesthesia was maintained with sevoflurane in a mixture of nitrous oxide and oxygen. Five minutes after resection the appendicitis, just as washing the abdominal cavity, the blood arterial pressure abruptly increased up to 210/110 mmHg and heart rate increased to 200 beats/min. Anaesthesia was deepened. Medication errors were ruled. There was no skeletal muscle rigidity and the body temperature was 37°c. EtCO2 and airway pressure had not changed and kaliemia was 4.5 mmol/L. An arterial catheter was placed to be able to rapidly detect and treat any hypertension crisis. The arterial pressure continued to rise to 220/120. Heart rate varied from 100 to 140 beats/min. The diagnosis of pheochromocytoma was suspected. The anaesthesiologist and surgeon decided to interrupt the surgery. IV incremental dose of nicardipine and esmolol were given and resulted in arterial pressure of 125/50 mmHg and heart rate of 70 beats/min. Once the patient stabilized, closing the fascia and the skin was effected. Infusion of nicardipine was started and adjusted according to the blood pressure. In intensive care unit, aggressive therapy included nicardipine, propanolol and hydration was continued. After extubation the pression was stabilized by nicardipine 6 mg per hour and propanolol 40 mg twice per day. Abdominal injected computerized tomography showed a unilateral suprarenal mass. Measu
TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Najoua Lalaoui,Aymeric Morlé,Delphine Mérino,Guillaume Jacquemin,Elisabetta Iessi,Alexandre Morizot,Sarah Shirley,Bruno Robert,Eric Solary,Carmen Garrido,Olivier Micheau
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019679
Abstract: TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightly controlled by two antagonistic receptors, TRAIL-R3 and TRAIL-R4, both devoid of a functional death domain, an intracellular region of the receptor, required for the recruitment and the activation of initiator caspases. Upon TRAIL-binding, TRAIL-R4 forms a heteromeric complex with the agonistic receptor TRAIL-R2 leading to reduced caspase-8 activation and apoptosis.
Implementation of a Higher Quality dc Power Converter  [PDF]
N. N. Barsoum
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.22012
Abstract: Many single and three-phase converters are well developed, and covered up in most of electric markets. It is used in many applications in power systems and machine drives. However, an exact definite output signal from the dc side still not recognized. The waveforms of output voltage and current demonstrate an imperfect dc signal and constitute losses, harmonic distortion, low power factor, and observed some ripples. An approximately perfect rectifier bridge is the aim of this research. Perhaps it gives the ability to identify the parameters of the converter to obtain, as much as possible, a perfect dc signal with less ripple, high power factor and high efficiency. Design is implemented by simulation on Power Simulator PSIM, and practically, a series regulator LM723 is applied to provide regulating output voltage. Comparisons of both simulation and hardware results are made to observe differences and similarities.
Estimation of Sensitivity of the DS/AHP Method While Solving Foresight Problems with Incomplete Data  [PDF]
N. Pankratova, N. Nedashkovskaya
Intelligent Control and Automation (ICA) , 2013, DOI: 10.4236/ica.2013.41011

The paper provides mathematical analysis of sensitivity of different combination rules in the DS/AHP method when an alternative is added to the set of decision alternatives while solving foresight problems. Different cases of rank reversals are defined and two sets of conditions for these cases using the method DS/AHP are considered. Rank reversals are illustrated when the DS/AHP method is used to solve practical problem of critical technologies of energy conservation and power efficiency evaluation in Ukraine. It is shown that the DS/AHP method is not sensitive to exclusion (or addition) of an irrelevant decision alternative from (or to) the set of decision alternatives.

Computation of the Genetic Code: Full Version  [PDF]
N. N. Kozlov
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.510008
Abstract: One of the problems in the development of mathematical theory of the genetic code (summary is presented in [1], the detailed—to [2]) is the problem of the calculation of the genetic code. Similar problem in the world is unknown and could be delivered only in the 21st century. One approach to solving this problem is devoted to this work. For the first time a detailed description of the method of calculation of the genetic code was provided, the idea of which was first published earlier [3]), and the choice of one of the most important sets for the calculation was based on an article [4]. Such a set of amino acid corresponds to a complete set of representation of the plurality of overlapping triple gene belonging to the same DNA strand. A separate issue was the initial point, triggering an iterative search process all codes submitted by the initial data. Mathematical analysis has shown that the said set contains some ambiguities, which have been founded because of our proposed compressed representation of the set. As a result, the developed method of calculation was reduced to two main stages of research, where at the first stage only single-valued domains were used in the calculations. The proposed approach made it possible to significantly reduce the amount of computation at each step in this complex discrete structure.
The Study of the Secrets of the Genetic Code  [PDF]
N. N Kozlov
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.67007
Abstract: The disclosure of many secrets of the genetic code was facilitated by the fact that it was carried out on the basis of mathematical analysis of experimental data: the diversity of genes, their structures and genetic codes. New properties of the genetic code are presented and its most important integral characteristics are established. Two groups of such characteristics were distinguished. The first group refers to the integral characteristics for the areas of DNA, where genes are broken down in pairs and all 5 cases of overlap, allowed by the structure of DNA, were investigated. The second group of characteristics refers to the most extended areas of DNA in which there is no genetic overlap. The interrelation of the established integral characteristics in these groups is shown. As a result, a number of previously unknown effects were discovered. It was possible to establish two functions in which all the over-understood codons in mitochondrial genetic codes (human and other organizations) participate, as well as a significant difference in the integral characteristics of such codes compared to the standard code. Other properties of the structure of the genetic code following from the obtained results are also established. The obtained results allowed us to set and solve one of the new breakthrough problems—the calculation of the genetic code. The full version of the solution to this problem was published in this journal in August 2017.
Guidelines for Optimization of the Absorber Layer Energy Gap for High Efficiency Cu(In,Ga)Se2 Solar Cells  [PDF]
N. Severino, N. Bednar, N. Adamovic
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.64015
Abstract: This work investigates in-depth the effects of variation of the compositional ratio of the absorber layer in Cu(In,Ga)Se2 (CIGS) thin-film solar cells. Electrical simulations were carried out in order to propose the most suitable gallium double-grading profile for the high efficiency devices. To keep the model as close as possible to the real behavior of the thin film solar cell a trap model was implemented to describe the bulk defects in the absorber layer. The performance of a solar cell with a standard CIGS layer thickness (2 μm) exhibits a strong dependence on the front grading height (decreasing band gap toward the middle of the CIGS layer). An absolute gain in the efficiency (higher than 1%) is observed by a front grading height of 0.22. Moreover, simulation results show that the position of the plateau (the region characterized by the minimum band gap) should be accurately positioned at a compositional ratio of 20% Ga and 80% In, which corresponds to the region where a lower bulk defect density is expected. The developed model demonstrates that the length of the plateau is not playing a relevant role, causing just a slight change in the solar cell performances. Devices with different absorber layer thicknesses were simulated. The highest efficiency is obtained for a CIGS thin film with thicknesses between 0.8 and 1.1 μm.
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