oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 486 )

2018 ( 706 )

2017 ( 701 )

2016 ( 1059 )

Custom range...

Search Results: 1 - 10 of 475628 matches for " N.C.V.;Damasceno "
All listed articles are free for downloading (OA Articles)
Page 1 /475628
Display every page Item
Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients
Moreira, N.C.V.;Damasceno, R.S.;Medeiros, C.A.M.;de Bruin, P.F.C.;Teixeira, C.A.C.;Horta, W.G.;de Bruin, V.M.S.;
Brazilian Journal of Medical and Biological Research , 2008, DOI: 10.1590/S0100-879X2008001000017
Abstract: we have tested the hypothesis that restless leg syndrome (rls) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (ms). the diagnosis of rls used the four minimum criteria defined by the international restless legs syndrome study group. fatigue was assessed by the fatigue severity scale (fss >27), quality of sleep by the pittsburgh sleep quality index (psqi >6), excessive daytime sleepiness by the epworth sleepiness scale (ess >10) and clinical disability by the expanded disability status scale (edss). forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. edss varied from 0 to 8.0 (3.6 ± 2.0). rls was detected in 12 cases (27%). patients with rls presented greater disability (p = 0.01), poorer sleep (p = 0.02) and greater levels of fatigue (p = 0.03). impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). fatigue was present in 32 subjects (73%) and was associated with clinical disability (p = 0.000) and sleep quality (p = 0.002). age, gender, disease duration, ms pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of rls. fatigue was best explained by clinical disability and poor sleep quality. awareness of rls among health care professionals may contribute to improvement in ms management.
Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats
Baracho, N.C.V.;Sim?es-e-Silva, A.C.;Khosla, M.C.;Santos, R.A.S.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000900016
Abstract: in the present study we evaluated the nature of angiotensin receptors involved in the antidiuretic effect of angiotensin-(1-7) (ang-(1-7)) in water-loaded rats. water diuresis was induced in male wistar rats weighing 280 to 320 g by water load (5 ml/100 g body weight by gavage). immediately after water load the rats were treated subcutaneously with (doses are per 100 g body weight): 1) vehicle (0.05 ml 0.9% nacl); 2) graded doses of 20, 40 or 80 pmol ang-(1-7); 3) 200 nmol losartan; 4) 200 nmol losartan combined with 40 pmol ang-(1-7); 5) 1.1 or 4.4 nmol a-779; 6) 1.1 nmol a-779 combined with graded doses of 20, 40 or 80 pmol ang-(1-7); 7) 4.4 nmol a-779 combined with graded doses of 20, 40 or 80 pmol ang-(1-7); 8) 95 nmol cgp 42112a, or 9) 95 nmol cgp 42112a combined with 40 pmol ang-(1-7). the antidiuretic effect of ang-(1-7) was associated with an increase in urinary na+ concentration, an increase in urinary osmolality and a reduction in creatinine clearance (ccr: 0.65 ± 0.04 ml/min vs 1.45 ± 0.18 ml/min in vehicle-treated rats, p<0.05). a-779 and losartan completely blocked the effect of ang-(1-7) on water diuresis (2.93 ± 0.34 ml/60 min and 3.39 ± 0.58 ml/60 min, respectively). cgp 42112a, at the dose used, did not modify the antidiuretic effect of ang-(1-7). the blockade produced by losartan was associated with an increase in ccr and with an increase in sodium and water excretion as compared with ang-(1-7)-treated rats. when ang-(1-7) was combined with a-779 there was an increase in ccr and natriuresis and a reduction in urine osmolality compared with rats treated with ang-(1-7) alone. the observation that both a-779, which does not bind to at1 receptors, and losartan blocked the effect of ang-(1-7) suggests that the kidney effects of ang-(1-7) are mediated by a non-at1 angiotensin receptor that is recognized by losartan.
Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats
Baracho N.C.V.,Sim?es-e-Silva A.C.,Khosla M.C.,Santos R.A.S.
Brazilian Journal of Medical and Biological Research , 1998,
Abstract: In the present study we evaluated the nature of angiotensin receptors involved in the antidiuretic effect of angiotensin-(1-7) (Ang-(1-7)) in water-loaded rats. Water diuresis was induced in male Wistar rats weighing 280 to 320 g by water load (5 ml/100 g body weight by gavage). Immediately after water load the rats were treated subcutaneously with (doses are per 100 g body weight): 1) vehicle (0.05 ml 0.9% NaCl); 2) graded doses of 20, 40 or 80 pmol Ang-(1-7); 3) 200 nmol Losartan; 4) 200 nmol Losartan combined with 40 pmol Ang-(1-7); 5) 1.1 or 4.4 nmol A-779; 6) 1.1 nmol A-779 combined with graded doses of 20, 40 or 80 pmol Ang-(1-7); 7) 4.4 nmol A-779 combined with graded doses of 20, 40 or 80 pmol Ang-(1-7); 8) 95 nmol CGP 42112A, or 9) 95 nmol CGP 42112A combined with 40 pmol Ang-(1-7). The antidiuretic effect of Ang-(1-7) was associated with an increase in urinary Na+ concentration, an increase in urinary osmolality and a reduction in creatinine clearance (CCr: 0.65 ± 0.04 ml/min vs 1.45 ± 0.18 ml/min in vehicle-treated rats, P<0.05). A-779 and Losartan completely blocked the effect of Ang-(1-7) on water diuresis (2.93 ± 0.34 ml/60 min and 3.39 ± 0.58 ml/60 min, respectively). CGP 42112A, at the dose used, did not modify the antidiuretic effect of Ang-(1-7). The blockade produced by Losartan was associated with an increase in CCr and with an increase in sodium and water excretion as compared with Ang-(1-7)-treated rats. When Ang-(1-7) was combined with A-779 there was an increase in CCr and natriuresis and a reduction in urine osmolality compared with rats treated with Ang-(1-7) alone. The observation that both A-779, which does not bind to AT1 receptors, and Losartan blocked the effect of Ang-(1-7) suggests that the kidney effects of Ang-(1-7) are mediated by a non-AT1 angiotensin receptor that is recognized by Losartan.
Renal actions of angiotensin-(1-7)
Sim?es-e-Silva A.C.,Baracho N.C.V.,Passaglio K.T.,Santos R.A.S.
Brazilian Journal of Medical and Biological Research , 1997,
Abstract: The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance
Efeitos do período de jejum entre o nascimento e o alojamento de pintos de corte e da adi??o de óleo à ra??o sobre o desenvolvimento do trato gastrintestinal e concentra??o de lipase
Can?ado, S.V.;Bai?o, N.C.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2002, DOI: 10.1590/S0102-09352002000600011
Abstract: the objective of the present work was to evaluate the efects of the fasting periods (zero, 24 and 48 hours) between hatching and housing of broiler chicks and the addition of oil to the feed, on the alometric growth of the digestive organs and lipase concentration in the pancreas and small intestine. in the experiment, 720 male broiler chicks were raised from one to 15 days of housing. the evaluations of development of the digestive organs were done on days zero, three, six, nine, 12 and 15 of age. the evaluations of the lipase concentrations in the pancreas were done on days zero, three, six, nine, 12 and 15, and in the small intestine on days zero, three and six. a factorial 3 x 2 (three periods of fasting and two types of ration) experimental design was used. the alometric growth of the digestive organs was greater for the broilers not submitted to fasting, and the greatest rates of alometric growth were observed on the first days of life, showing a faster growth of the digestive organs at this stage. although there was some lipase storage in the pancreas, in the small intestine the concentration was low and increased with age. the content of lipase in the intestine varied with the concentration of lipid in the diet.
Efeito do período de jejum entre o nascimento e o alojamento e da adi??o de óleo à ra??o sobre o desempenho de pintos de corte e digestibilidade da ra??o
Can?ado, S.V.;Bai?o, N.C.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2002, DOI: 10.1590/S0102-09352002000600012
Abstract: in order to evaluate the effects of three fasting periods (zero, 24 and 48 hours) between hatching and housing of broiler chicks and the addition of oil to the feed, 360 male broiler chicks were used, raised during a period ranging from 1 to 21 days in cages designed for collecting feces. the performance and digestibility of the feed ration were evaluated. a factorial 3 x 2 (three periods of fasting and two types of ration) experimental design was used. it was concluded that the fasting birds had better results at 21 days when compared with not fasting birds. the interval between hatching and housing did not have a clear effect on the coefficients of apparent digestibility of the dry mater, crude protein and ether extract of the feed, while the birds which were fed with the diet containing oil showed higher coefficients of apparent digestibility for the ether extract of the feed.
Efeito do período de jejum entre o nascimento e o alojamento e da adi o de óleo à ra o sobre o desempenho de pintos de corte e digestibilidade da ra o
Can?ado S.V.,Bai?o N.C.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2002,
Abstract: Com o objetivo de verificar os efeitos de três períodos de jejum (zero, 24 e 48 horas) entre o nascimento e o alojamento e da adi o de óleo à ra o sobre o desempenho de pintos de corte e a digestibilidade da ra o, foram utilizados 360 aves de corte machos, criados de um a 21 dias em gaiolas metálicas próprias para coleta de excretas. O delineamento experimental foi em arranjo fatorial 3 x 2 (três períodos de jejum e dois tipos de ra o). As aves submetidas ao jejum apresentaram melhor desempenho aos 21 dias quando comparadas com as n o submetidas ao jejum. O intervalo entre o nascimento e o alojamento n o teve efeito sobre os coeficientes de digestibilidade aparente da matéria seca, da proteína bruta e do extrato etéreo da ra o, enquanto que as aves que se alimentaram com dieta contendo óleo apresentaram maior coeficiente de digestibilidade aparente do extrato etéreo.
Efeitos do período de jejum entre o nascimento e o alojamento de pintos de corte e da adi o de óleo à ra o sobre o desenvolvimento do trato gastrintestinal e concentra o de lipase
Can?ado S.V.,Bai?o N.C.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2002,
Abstract: Os objetivos deste trabalho foram determinar o efeito de três períodos de jejum (zero, 24 e 48 horas) entre o nascimento e o alojamento de pintos e da adi o de óleo à ra o sobre o crescimento alométrico dos órg os digestivos e estudar a atividade da lipase no pancreas e intestino delgado. Foram utilizados 720 pintos de corte machos, criados de um a 15 dias de alojamento. As avalia es do crescimento dos órg os digestivos foram feitas nos dias zero, três, seis, nove, 12 e 15 de idade. As avalia es da concentra o de lipase no pancreas foram feitas nos dias zero, três, seis, nove, 12 e 15, e no intestino delgado nos dias zero, três e seis. O delineamento experimental foi em arranjo fatorial 3 x 2 (três períodos de jejum e dois tipos de ra o). O crescimento alométrico dos órg os digestivos foi maior para as aves alojadas ao nascimento e a maior taxa de crescimento alométrico foi observada nos primeiros dias de vida, demonstrando crescimento mais acelerado dos órg os digestivos nesta fase. Embora tenham sido encontradas reservas de lipase no pancreas, ao nascimento as concentra es de lipase no intestino foram baixas e aumentaram com a idade. O conteúdo de lipase no intestino variou com a concentra o de óleo na dieta.
Preliminary Studies on Two Vegetable Oil Based Self Emulsifying Drug Delivery System (SEDDS) for the Delivery of Metronidazole, A Poorly Water Soluble Drug
N.C. Obitte,H. Ezeiruaku,V.I. Onyishi
Journal of Applied Sciences , 2008,
Abstract: A preliminary evaluation was carried out on metronidazole-loaded Self Emulsifying Drug Delivery System (SEDDS) using two vegetable oils-Palm Kernel Oil (PKO) and Palm Oil (PO). Purification of oils, drug solubility in the oils, pre/post formulation isotropicity tests, emulsification times and release studies of metronidazole from the SEDDS were carried out. Results indicated solubility values of 4.441 and 4.654%w/w, respectively for metronidazole in PKO and PO. Preformulation isotropicity test revealed that out of the 24 batches evaluated 10 of the SEDDS formulations containing different oil: surfactant ratios and PKO:PO admixtures were found to be isotropic after 5 h. However when the SEDDS were loaded with metronidazole there was a reduction in the number (to 7) of formulations that maintained isotropicity and stability after 72 h. All the batches had emulsification times of less than two minutes except batch 4D with oil:surfactant concentration of 50:50. The release profile showed that most of the formulations released 50% of drug in less than 8 min and 85% of drug in less than 30 min. We therefore conclude that SEDDS containing the two vegetable oils are potential alternatives when immediate release and delivery of metronidazole is the primary motivation.
Resistência vs susceptibilidade a piretróides em Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae): há vencedor?
Oliveira, Eugênio E.;Guedes, Raul N.C.;Corrêa, Alberto S.;Damasceno, Bruno L.;Santos, Camila T.;
Neotropical Entomology , 2005, DOI: 10.1590/S1519-566X2005000600015
Abstract: studies on insecticide resistance evolution usually associate the phenomenon with an adaptative cost to the individual carrying this trait. our objective was to verify if insecticide resistance in a population of sitophilus zeamais motschulsky incurs in fitness cost under an insecticide-free environment. two populations of the species (a susceptible and a pyrethroid resistant population) were submitted to competition against each other for two consecutive generations in the absence of insecticide. a factorial bivariated derivated from an additive series was used in the experimental design with two initial density levels (lower, with 50 individuals of one population and a crescent series of individuals from 0 to 50 from the other population; and higher, with 100 individuals of a population and a crescent series of individuals from 0 to 100 from the other). the total number of adult insects, mortality by deltamethrin and insect body mass for each treatment were recorded. adaptative disadvantage was not found on the resistant population compared with the susceptible population in an insecticide-free environment since both populations showed similar growth rate. this finding brings about practical complications for insecticide resistance management in this species because management strategies based on the interruption of pyrethroid use aiming their future reintroduction may not achieve the desired effects. this may take place because even after a long period without insecticide use, the resistant populations may still maintain themselves as such since there is no perceptible adaptative disadvantage associated with this trait.
Page 1 /475628
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.