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Search Results: 1 - 10 of 198267 matches for " N. Manoharan "
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Safety and Risk Associated with Nanoparticles - A Review  [PDF]
Vinita Vishwakarma, Subhranshu Sekhar Samal, N. Manoharan
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2010, DOI: 10.4236/jmmce.2010.95031
Abstract: The emerging field of nanotechnology has created risk for environment and human health. Nanoparticles are not a recent discovery. It has existed for many years. Today synthesis of nanoparticles takes place for many applications in various field of science, technology, medicine, colloid technologies, diagnostics, drug delivery, health impacts, food, personal care applications etc. In spite of this, toxicology of nanoparticles is poorly understood as there are no sufficient methods to test nanoparticles for health, safety and environmental impacts, especially in the size range lower than 50nm.
Holographic Measurements of Anisotropic Three-Dimensional Diffusion of Colloidal Clusters
Jerome Fung,Vinothan N. Manoharan
Physics , 2013, DOI: 10.1103/PhysRevE.88.020302
Abstract: We measure all nonzero elements of the three-dimensional (3D) diffusion tensor D for clusters of colloidal spheres to a precision of 1% or better using digital holographic microscopy. We study both dimers and triangular trimers of spheres, for which no analytical calculations of the diffusion tensor exist. We observe anisotropic rotational and translational diffusion arising from the asymmetries of the clusters. In the case of the three-particle triangular cluster, we also detect a small but statistically significant difference in the rotational diffusion about the two in-plane axes. We attribute this difference to weak breaking of threefold rotational symmetry due to a small amount of particle polydispersity. Our experimental measurements agree well with numerical calculations and show how diffusion constants can be measured under conditions relevant to colloidal self-assembly, where theoretical and even numerical prediction is difficult.
Dasatinib-Induced Hepatic Dysfunction  [PDF]
Arumugam Manoharan
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.41003

A 53-year-old man with chronic myeloid leukaemia developed significant hepatic dysfunction when treatment was changed from imatinib (because of drug-induced rash) to dasatinib. Liver function tests returned to normal 77 days after cessation of therapy and have remained normal despite recommencement of dasatinib. Although the pathogenesis for the significant hepatic dysfunction is unclear, this case illustrates the reversibility of this event with dose interruption and that dasatinib can be safely recommenced for ongoing treatment.

Study of Acoustic Emission Sensor Techniques for Monitoring Machining Processes
S. Sundaram,P. Senthilkumar,N. Manoharan
Journal of Engineering and Applied Sciences , 2012,
Abstract: Condition monitoring of machining process denotes a control system that measures certain output variables, which are in turn used to control speed and or feed. The popular process variables that have been used to monitor the machining process are force, torque, cutting temperature, vibration amplitude and horsepower. However, this study deals with the application of the Acoustic Emission (AE) sensor for monitoring the machining processes. The application of this AE technique to machining processes started only two decades back and prior to that only very little work had been done in this field. Hence, a presentation has been made to highlight the works of various investigators from 1999-2005 using acoustic emission as a tool in monitoring machining process. The research done in monitoring machining processes using AE Techniques have been grouped into mainly 2 categories of monitoring Via, Turning, Milling and they are discussed accordingly. Some trails to take full advantage of the AE sensor for tool condition monitoring will be conducted relating to the sensor mounting and the signal processing. As a practical solution for the AE sensor mounting, for example, the coolant stream is successfully used as a medium for transmitting the AE wave in the case of milling processes monitoring. The sensor has mounted in the coolant pump nozzle l with other necessary drives so that the AE signal can be transmitted to the outside of the cutter by radio. By applying these methods, it has become possible to take the AE signal from the rotating tools. In terms of AE, signal processing for identifying an emerging technique for in process monitoring of various machining process.
Testing the Foundations of Classical Entropy: Colloid Experiments
Michael E. Cates,Vinothan N. Manoharan
Physics , 2015, DOI: 10.1039/C5SM01014D
Abstract: Defining the entropy of classical particles raises a number of paradoxes and ambiguities, some of which have been known for over a century. Several, such as Gibbs' paradox, involve the fact that classical particles are distinguishable, and in textbooks these are often `resolved' by appeal to the quantum-mechanical indistinguishability of atoms or molecules of the same type. However, questions then remain of how to correctly define the entropy of large poly-atomic particles such as colloids in suspension, of which no two are exactly alike. By performing experiments on such colloids, one can establish that certain definitions of the classical entropy fit the data, while others in the literature do not. Specifically, the experimental facts point firmly to an `informatic' interpretation that dates back to Gibbs: entropy is determined by the number of microstates that we as observers choose to treat as equivalent when we identify a macrostate. This approach, unlike some others, can account for the existence of colloidal crystals, and for the observed abundances of colloidal clusters of different shapes. We also address some lesser-known paradoxes whereby the physics of colloidal assemblies, which ought to be purely classical, seems to involve quantum mechanics directly. The experimental symptoms of such involvement are predicted to be `isotope effects' in which colloids with different inertial masses, but otherwise identical sizes and properties, show different aggregation statistics. These paradoxes are caused by focussing one's attention on some classical degrees while neglecting others; when all are treated equally, all isotope effects are found to vanish.
Intelligent Controller for UPQC Using Combined Neural Network  [PDF]
Ragavan Saravanan, Subramanian Manoharan
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.76057
Abstract: The Unified Power Quality Conditioner (UPQC) plays an important role in the constrained delivery of electrical power from the source to an isolated pool of load or from a source to the grid. The proposed system can compensate voltage sag/swell, reactive power compensation and harmonics in the linear and nonlinear loads. In this work, the off line drained data from conventional fuzzy logic controller. A novel control system with a Combined Neural Network (CNN) is used instead of the traditionally four fuzzy logic controllers. The performance of combined neural network controller compared with Proportional Integral (PI) controller and Fuzzy Logic Controller (FLC). The system performance is also verified experimentally.
Optimization of cultural conditions for production of chitinase by Bacillus laterosporous MML2270 isolated from rice rhizosphere soil
V Shanmugaiah, N Mathivanan, N Balasubramanian, PT Manoharan
African Journal of Biotechnology , 2008,
Abstract: A total of 39 chitinolytic bacteria were isolated from 77 rhizosphere soil samples collected from different crop fields in Tamil Nadu state, India. Among them, a strain designated as MML2270, which produced highest chitinolytic activity in primary and secondary screening in colloidal chitin agar was selected and later identified as Bacillus laterosporous. The production of chitinase by B. laterosporous was optimized using different growth media, substrate concentrations, pH, temperature and incubation period. The maximum chitinase production was observed in yeast nitrogen based medium (YNB) amended with 0.3% colloidal chitin at pH 8.0 and 35°C after four days of inoculation. Under this optimized growth condition, B. laterosporous MML2270 produced a total chitinase activity of 59.05 units/ml as against only 19.7 units/ml in the initial YNB medium stage, which is a three-fold increase.
Lens induced glaucomas - visual results and risk factors for final visual acuity
Prajna N,Ramakrishnan R,Krishnadas R,Manoharan N
Indian Journal of Ophthalmology , 1996,
Abstract: Lens induced glaucomas are a common occurence in India. An attempt was made to understand the clinical modes of presentation and post operative visual results in 93 patients with lens induced glaucoma, 49 phacomorphic and 44 phacolytic, attending our institute during 1994. All these patients were subjected to a planned extracapsular cataract extraction. Forty four percent had a posterior chamber intraocular lens implantation following surgery. Fifty seven percent eyes with phacomorphic glaucoma and 61% with phacolytic glaucoma recovered visual acuity of 6/12 or better. There was no significant difference in the final visual acuity between those patients who had an intraocular lens implanted and those who did not (P=0.18). Univariate analysis was performed for selected risk factors such as age, sex and duration of glaucomatous process as predictors of final visual acuity and odds ratios with 95% confidence intervals were calculated. Patients with age more than 60 years (OR=2.7, 95% CI=1.04 - 6.93) and in whom the glaucoma was present for more than 5 days (OR=3.1, 95% CI=1.21 - 8.13) had a significantly higher risk of poor visual outcome post-operatively.
Effect of vesicular arbuscular mycorrhizal fungus on the physiological and biochemical changes of five different tree seedlings grown under nursery conditions
PT Manoharan, M Pandi, V Shanmugaiah, S Gomathinayagam, N Balasubramanian
African Journal of Biotechnology , 2008,
Abstract: The symbiotic association between certain plants and microorganisms plays an important role in soil fertilization, and improves their growth and mineral nutrition. The symbiotic association between vesicular arbuscular mycorrhizal (VAM) fungi and roots provides a significant contribution to plant nutrition and growth. VAM mycelium in soil results in greater efficiency of nutrient absorption particularly for slowly diffusing mineral ions, especially phosphorous. The present investigation aims at studying the effects of VAM fungi on the physiological changes of the selected tree seedlings viz., Cassia siamea, Delonix regia, Erythrina variegata, Samanea saman and Sterculia foetida. The chlorophyll a, chlorophyll b, total chlorophyll, carotenoid, protein, nitrate, nitrogen, phosphorus and potassium content increased in VAM fungus treated seedlings compared with non-mycorrhizal tree seedlings. The total soluble sugars and soluble starch contents in the leaves of all the selected tree species in the present study showed a decrease in mycorrhizal seedlings than non-mycorrhizal seedlings.
Flank Wear Monitoring in Coated Carbide Tool Using Ae Signal Analysis, Cutting Force, Motor Current and Acceleration Due to Tool Vibration
S. Sundaram,P. Senthilkumar,A. Kumaravel,N. Manoharan
International Journal of Systems Signal Control and Engineering Application , 2012,
Abstract: Wear of a cutting tool in a machining operation is highly undesirable because it severely degrades the quality of machined surfaces and causes undesirable and unpredictable changes in the work geometry. From a process automation point of view, it is therefore necessary that an intelligent sensing system be devised to detect the progress of tool wear during cutting operations so that worn tools can be identified and replaced in time. As a non-destructive sensing methodology, Acoustic Emission (AE) based techniques offer some advantages over force or power based tool monitoring techniques because of the close relationship between the generation of the emission signal and the fracture or wear phenomenon in machining. The generation of the AE signals directly in the cutting zone makes them very sensitive to changes in the cutting process. Acoustic Emission Techniques (AET) is a relatively recent entry into the field of non-destructive evaluation (NDE) which has particularly shown very high potential for material characterization and damage assessment in conventional as well as nonconventional processes. This method has also been widely used in the field of metal cutting to detect process changes like tool wear etc. In this research work the results obtained from the analysis of Acoustic Emission sensor employs to predict flank wear in turning of C45 steel of 250 BHN hardness using Polycrystalline diamond (PCD) insert. Machining trails were conducted in 5 H.P all geared lathe to obtain the data. The observations noted during the experimental work are analyzed for correlations between the tool wear and the AE parameters.
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