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Search Results: 1 - 10 of 544207 matches for " N. M. Nseka "
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The Atherogenic Dyslipidemia Ratio Log (Tg)/Hdl-C Was Not Associated with Urinary Albumin Excretion Rate (Uaer) and Increased Cardiovascular Risk in Black Patients with Type 2 Diabetes  [PDF]
M. F. Kajingulu, B. F. Lepira, I. N. F. Mbutiwi, J. R. R. Makulo, E. Bieleli, M. N. Nseka
World Journal of Cardiovascular Diseases (WJCD) , 2016, DOI: 10.4236/wjcd.2016.61003
Abstract: Objective: The objective is to assess the relationship of Log (TG)/HDL-c as surrogate estimate of atherogenic dyslipidemia with urinary albumin excretion rate and cardiovascular risk among black patients with type 2 diabetes. Patients and methods: A post-hoc analysis of data from 181 type 2 diabetes patients enrolled in a cross-sectional study of urinary albumin excretion rate seen at a tertiary healthcare. Microalbuminuria and macroalbuminuria were defined as ACR 30 - 299.9 mg/g and ACR ≥ 300 mg/g, respectively. Quartiles of Log (TG)/HDL-c were used as surrogate estimates of atherogenic dyslipidemia. Cardiovascular risk was assessed using WHO chart for estimation of CV risk in low and middle income countries. Comparisons across Log (TG)/HDL-c quartiles were performed using one way ANOVA and Chi square for trend as appropriate. P < 0.05 defined the level of statistical significance. Results: A high prevalence (69%) of atherogenic dyslipidemia (AD) was observed in the present case series of Black Africans with type 2 diabetes. Average total cholesterol levels showed significant (p = 0.010) trends towards lower values across quartiles of Log (TG)/ HDL-c. No significant trends were observed for average UAER and cardiovascular risk across quartiles of Log (TG)/HDL-c. Conclusion: Log (TG)/HDL-c as a surrogate estimate of atherogenic failed to predict cardiovascular risk in the present case series of black patients with type 2 diabetes.
Sickle Cell Trait, Hemoglobin Levels and Anemia among Black Patients with Predialysis Chronic Kidney Disease: A Post Hoc Analysis  [PDF]
F. B. Lepira, T. K. Mukendi, F. I. N. Mbutiwi, J. R. Makulo, E. K. Sumaili, P. K. Kayembe, N. M. Nseka
World Journal of Cardiovascular Diseases (WJCD) , 2016, DOI: 10.4236/wjcd.2016.68029
Abstract: Objective: To assess the relationship between SCT, hemoglobin levels and anemia in CKD black patients. Method: A post-hoc analysis of data from 188 patients, enrolled in a cross-sectional study of sickle cell trait (SCT) and chronic kidney disease (CKD), was performed to assess the relationship between SCT, hemoglobin (Hb) levels and anemia defined as Hb < 12 g/dl in men and <11 g/dl in women. Student t test, Mann Whitney and Chi square test were used as appropriate for different comparisons. P < 0.05 defined the level of statistical significance. Results: SCT (HbAS) and normal hemoglobin (HbAA) were present in 39 (21%) and 149 (79%) CKD patients, respectively. Despite similar estimated GFR (eGFR) and age, HbAS patients had significantly lower Hb levels (8.8 ± 1.8 vs 10 ± 2.2 g/dl; p = 0.001) and a higher proportion of anemia (95% vs 72%, p = 0.001). In multiple linear regression analysis, eGFR, BMI, SBP and SCT emerged as independent determinants of Hb levels. The presence of SCT was associated with 1.185 g/dl decrease in Hb levels. Conclusion: In the present case series, SCT was associated with lower Hb levels suggesting its potential contribution to the pathogenesis of CKD-associated anemia.
Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study  [PDF]
P. I. Mboliasa, F. B. Lepira, J. R. Makulo, A. Nkodila, E. K. Sumaili, J. B. Bukabau, V. M. Mokoli, A. L. Longo, C. V. Zinga, F. M. P. Kanjingulu, Y. M. Nlandu, Y. M. Engole, M. M. Mukendi, E. M. Kadima, C. K. Ilunga, P. M. Ekulu, N. M. N. Nseka
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.83021
Abstract: Background: Although systemic hypertension is rarely seen in steady state sickle cell disease (SCD), relative hypertension has been reported to be associated with an increased risk of cardiovascular and renal complications. Objective: To determine the prevalence of BP patterns and assess factors associated with relative hypertension insickle cell anemia (SCA) adult patients. Methods: Clinical data and office BP were obtained from 103 consecutive steady-state SCA adult patients (mean age 26 ± 7.9 years, 66% females, 22.3% on hydroxyurea) attending four healthcare centers providing SCD-specific care in Kinshasa. Seated BP was measured using an automated electronic device. Three consecutive blood pressure measurements were taken with 2 minutes interval between readings and the average of the 2 last readings was considered for the analyses. Normal BP, relative hypertension and systemic hypertension were defined as BP < 120/70 mmHg, 120 - 139/70 - 89 mmHg and ≥140/90 mmHg, respectively. Results: Normal BP, relative hypertension and systemic hypertension were observed in 56 (54%), 43(42%) and 4 (4%) of SCA patients, respectively. In multivariate analysis, factors associated with relative hypertension were leg ulcer (aOR 2.05; 95%CI 1.77 -
High prevalence of undiagnosed chronic kidney disease among at-risk population in Kinshasa, the Democratic Republic of Congo
Ernest K Sumaili, Eric P Cohen, Chantal V Zinga, Jean-Marie Krzesinski, Nestor M Pakasa, Nazaire M Nseka
BMC Nephrology , 2009, DOI: 10.1186/1471-2369-10-18
Abstract: In a cross-sectional study, 527 people from primary and secondary health care areas in the city of Kinshasa were studied from a random sample of at-risk out-patients with hypertension, diabetes, obesity, or HIV+. We measured blood pressure (BP), blood glucose level, proteinuria, body mass index, and estimated glomerular filtration rate (eGFR by MDRD equation) using calibrated creatinine levels based on one random measurement. The associations between health characteristics, indicators of kidney damage (proteinuria) and kidney function (<60 ml/min/1.73 m2) were also examined.The prevalence of CKD in this study was 36%, but only 12% were aware of their condition. 4% of patients had stage 1 CKD, 6% stage 2, 18% stage 3, 2% stage 4, and 6% had stage 5. 24 hour quantitative proteinuria (>300 mg/day) was found in 19%. In those with the at-risk conditions, the % of CKD was: 44% in patients with hypertension, 39% in those with diabetes; 16% in the obese and 12% in those who were HIV+. 82% of those with a history of diabetes had elevated serum glucose levels at screening (≥ 126 mg/dl). Only 6% of individuals with hypertension having CKD had reduced BP to lower than 130/80 mmHg. In multivariate analysis, diabetes, proteinuria and hypertension were the strongest determinants of CKD 3+.It appears that one out of three people in this at-risk population has undiagnosed CKD and poorly controlled CKD risk factors. This growing problem poses clear challenges to this developing country. Therefore, CKD should be addressed through the development of multidisciplinary teams and improved communication between traditional health care givers and nephrology services. Attention to CKD risk factors must become a priority.Chronic Kidney Disease (CKD) is a worldwide health problem [1]. Indeed, the incidence and prevalence of CKD has increased in recent years in both developed and developing countries [2] including in Sub-Saharan Africa (SSA) [3]. In SSA, CKD affects mainly young adults in their
Chronic kidney disease among high school students of Kinshasa
Justine B Bukabau, Jean Robert R Makulo, Nestor M Pakasa, Eric P Cohen, Fran?ois B Lepira, Nazaire M Nseka, Patrick K Kayembe, Ernest K Sumaili
BMC Nephrology , 2012, DOI: 10.1186/1471-2369-13-24
Abstract: In an epidemiological cross sectional study, a random sample of 524 pupils (263 boys, mean age of 18.7 ± 1.4 years) from school environment of Kinshasa were studied. Recorded parameters of interest were anthropometric, proteinuria, serum creatinine and estimated glomerular filtration rate (eGFR) according to the Schwartz formula using uncalibrated creatinine levels from one random measurement. CKD was defined as the presence of kidney damage (daily proteinuria ≥ 300 mg) and/or reduced kidney function (eGFR < 60 ml/min/1.73 m2). Concordances between eGFR according to Schwartz, Cockcroft-Gault (C-G) indexed for BSA and modification of diet in renal disease (MDRD) study equations were computed using the kappa coefficient.The prevalence of CKD by the Schwartz formula was 1.5%. By stage, 0.8% had CKD stage 1 (proteinuria with normal eGFR) and 0.8% had CKD stage 3 (eGFR, 30 to 59 ml/min/1.73 m2). The prevalence of proteinuria ≥ 300 mg/day was 1% (one case had 2.7g/day). Agreement between eGFR according to Schwartz formula and the MDRD formula was excellent (kappa: 88.8%). Although correlations between all formulas were excellent (0.99; 0.87, and 0.89), agreement was poor between eGFR according to Schwartz and C-G indexed BSA equation (kappa: 52.7%) and, poorer with C-G unadjusted for BSA (kappa: 26.9%).In the large African city of Kinshasa, 2% of high school students have CKD. This high prevalence rate emphasizes the need for appropriate detection and prevention measures in this vulnerable young age population group.
Epidemiology, clinical, immune, and molecular profiles of microsporidiosis and cryptosporidiosis among HIV/AIDS patients
Wumba R, Longo-Mbenza B, Menotti J, Mandina M, Kintoki F, Situakibanza NH, Kakicha MK, Zanga J, Mbanzulu-Makola K, Nseka T, Mukendi JP, Kendjo E, Sala J, Thellier M
International Journal of General Medicine , 2012, DOI: http://dx.doi.org/10.2147/IJGM.S32344
Abstract: emiology, clinical, immune, and molecular profiles of microsporidiosis and cryptosporidiosis among HIV/AIDS patients Original Research (1567) Total Article Views Authors: Wumba R, Longo-Mbenza B, Menotti J, Mandina M, Kintoki F, Situakibanza NH, Kakicha MK, Zanga J, Mbanzulu-Makola K, Nseka T, Mukendi JP, Kendjo E, Sala J, Thellier M Published Date July 2012 Volume 2012:5 Pages 603 - 611 DOI: http://dx.doi.org/10.2147/IJGM.S32344 Received: 28 March 2012 Accepted: 12 April 2012 Published: 19 July 2012 Roger Wumba,1 Benjamin Longo-Mbenza,2 Jean Menotti,3,4 Madone Mandina,5 Fabien Kintoki,5 Nani Hippolyte Situakibanza,1,5 Marie Kapepela Kakicha,6 Josue Zanga,1 Kennedy Mbanzulu-Makola,1 Tommy Nseka,1 Jean Pierre Mukendi,1 Eric Kendjo,7 Jean Sala,1 Marc Thellier7,8 1Department of Tropical Medicine, Infectious and Parasitic Diseases, Department of Parasitology, University Clinic of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Congo; 2Faculty of Health Sciences, Walter Sisulu University, Eastern Cape, South Africa; 3Laboratory of Parasitology and Mycology, Saint-Louis Hospital, Public Assistance-Hospitals of Paris, Paris, France; 4Faculty of Medicine, Lariboisière-Saint-Louis, University of Paris VII, Paris, France; 5Department of Internal Medicine, University Clinic of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Congo; 6Department of Pediatrics, University Clinic of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Congo; 7National Center for Malaria Research, AP-HP, CHU Pitie Salpêtrière, Paris, France; 8Laboratory of Parasitology and Mycology, Pitié Salpêtrière Hospital, Public Assistance-Hospitals of Paris, Pierre and Marie Curie University, Paris, France Background: The objective of this study was to determine the prevalence of intestinal parasites, with special emphasis on microsporidia and Cryptosporidium, as well as their association with human immunodeficiency virus (HIV) symptoms, risk factors, and other digestive parasites. We also wish to determine the molecular biology definitions of the species and genotypes of microsporidia and Cryptosporidium in HIV patients. Methods: In this cross-sectional study, carried out in Kinshasa, Democratic Republic of the Congo, stool samples were collected from 242 HIV patients (87 men and 155 women) with referred symptoms and risk factors for opportunistic intestinal parasites. The analysis of feces specimen were performed using Ziehl–Neelsen stainings, real-time polymerase chain reaction (PCR), immunofluorescence indirect monoclonal antibody, nested PCR-restriction fragment length polymorphism, and PCR amplification and sequencing. Odds ratio (OR) and 95% confidence intervals were used to quantify the risk. Results: Of the 242 HIV patients, 7.8%, 0.4%, 5.4%, 0.4%, 2%, 10.6%, and 2.8% had Enterocytozoon bieneusi, Encephalitozoon intestinalis, Cryptosporidium spp., Isospora belli, pathogenic intestinal protozoa, nonpathogenic intestinal protozoa, and hel
The Oleic Acid Composition Effect on the Carboxymethyl Cellulose Based Biopolymer Electrolyte  [PDF]
M. N. Chai, M. I. N. Isa
Journal of Crystallization Process and Technology (JCPT) , 2013, DOI: 10.4236/jcpt.2013.31001
Abstract:

Biopolymer electrolyte based on carboxymethyl cellulose has been prepared by doping with different concentration of oleic acid via solution casting technique. Fourier Transform Infrared spectroscopy was used to study the complexation between the salt and polymer. New peak was observed at 1710, 2850, 2920 cm-1. X-ray diffraction study reveals the amorphous nature of the biopolymer electrolyte. Impedance study shows the highest ionic conductivity, σ, was found to be 2.11 × 10-5 S·cm-1 at room temperature (303 K) for sample containing 20 wt.% of oleic acid and the biopolymer electrolyte obeys Arrhenius behaviour.

An Empirical Investigation into the Effect of Financial Sector Development on Consumption and Inflation in Nigeria: 1986-2012  [PDF]
M. N. G. Omofa
Open Journal of Business and Management (OJBM) , 2017, DOI: 10.4236/ojbm.2017.51002
Abstract: Private consumption expenditure is one of the largest components of aggregate expenditure in Nigeria. It constitutes about 72% of GDP over the period understudy. It is therefore an important aspect of the macro-economy of any nation. In the same vein inflation has been a persistent evil affecting the economy of Nigeria. So they are both required to have a deep understanding of how macro-economy functions. The determinants of these two aggregates can therefore not be divorced from the activities in the financial sector. Hinging on the Keynesian absolute income consumption hypothesis, the paper used 3 SLS to estimate the two macroeconomic equations. The results showed that money supply, market capitalization and exchange rate had positive impact on personal consumption expenditure. However, it is only market capitalization that is not statistically significant. All the financial variables used—money supply, interest rate and exchange rate had positive relationship with the general price level. However it was only exchange rate that was not statistically significant. The paper concluded that shocks in the financial sector explained the variations in personal consumption and inflation. It was therefore recommended that interest rate and exchange rate should not be absolutely left to the dictate of the market forces. Government should intervene occasionally as the case may demand. Conducive environment that will make activities in the capital market should be encouraged.
An Assessment of the Effect of Financial Sector Development on Growth and Unemployment in Nigeria: 1986-2012  [PDF]
M. N. G. Omofa
Open Journal of Business and Management (OJBM) , 2017, DOI: 10.4236/ojbm.2017.51004
Abstract: Parts of the major macroeconomic objectives of any nation are attaining high growth and employment rates. However these constitute major challenges in Nigeria as economic growth has either remained stunted or stagnant and unemployment rate very high. The financial sector is expected to push up the real sector thereby lowering unemployment rate. It is within this supply leading hypothesis that this work is situated. The 3 Stage Least Square method was used in estimating the Growth and Unemployment macroeconomic equations. The results showed that interest rate and exchange rate have effects on growth but only exchange rate was statistically significant. This seems to suggest that there is a disconnection between the Nigerian money market and the real sector. However interest rate and exchange rate were significant in influencing the rate of unemployment in Nigeria. The goodness of fits for each of the two equations was high. The simulation results showed that the shock in the financial sector has serious implications for the economic growth and unemployment. The work therefore suggests that interest rate and exchange rate should not be left absolutely to the dictate of the market forces. Occasionally government should intervene in these markets as the time requires.
Influence of Angle Ply Orientation on Tensile Properties of Carbon/Glass Hybrid Composite  [PDF]
M. N. GuruRaja, A. N. HariRao
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2013, DOI: 10.4236/jmmce.2013.15036
Abstract: Hybrid composites are considered materials of great potential for engineering applications. One advantage of hybrid composite materials for the designer is that the properties of a composite can be controlled to a considerable extent by the choice of fibers and matrix and by adjusting the orientation of the fiber. The scope for this tailoring of the properties of the material is much greater, however, when different kinds of fiber orientations are incorporated in the same resin matrix. For the study of potential of these materials, in this work specimens were prepared with different angle ply ori entation of carbon/glass hybrid with epoxy resin as an adhesive. Three orientations viz 0°/90°, 45°/45° and 30°/60° were considered for studies. Mechanical properties such as tensile strength, tensile modulus, & peak load of the hybrid com posites were determined as per ASTM standards. Vacuum bagging technique was adopted for the fabrication of hybrid specimens. It was observed that angle ply orientation at 0°/90° showed significant increase in tensile properties as compared to other orientation. Scanning electron micrographs of fractured surfaces were used for a qualitative evaluation of interfacial properties of woven carbon-glass hybrid composites. These results indicated that carbon-glass hybrid composites offered the merits of synthetic fibers.
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