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Search Results: 1 - 10 of 21155 matches for " Myoung-Ok Kim4 "
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Proteome analysis of developing mice diastema region
Young-Mi Chae1, Young-Joo Jin1, Hyeng-Soo Kim2, Gi-Jeong Gwon1, Wern-Joo Sohn1,2, Sung-Hyun Kim3, Myoung-Ok Kim4, Sanggyu Lee2, Jo-Young Suh5 & Jae-Young Kim1*
BMB Reports , 2012,
Abstract: Different from humans, who have a continuous dentition ofteeth, mice have only three molars and one incisor separatedby a toothless region called the diastema in the hemimandibular arch. Although tooth buds form in the embryonicdiastema, they regress and do not develop into teeth. In thisstudy, we evaluated the proteins that modulate the diastemaformation through comparative analysis with molar-formingtissue by liquid chromatography-tandem mass spectroscopy(LC-MS/MS) proteome analysis. From the comparative andsemi-quantitative proteome analysis, we identified 147 up- and173 down-regulated proteins in the diastema compared to themolar forming proteins. Based on this proteome analysis, weselected and evaluated two candidate proteins, EMERIN andRAB7A, as diastema tissue specific markers. This studyprovides the first list of proteins that were detected in themouse embryonic diastema region, which will be useful tounderstand the mechanisms of tooth development.
Tobacco mosaic virus Movement Protein Enhances the Spread of RNA Silencing
Hannes Vogler,Myoung-Ok Kwon,Vy Dang,Adrian Sambade,Monika Fasler,Jamie Ashby,Manfred Heinlein
PLOS Pathogens , 2008, DOI: 10.1371/journal.ppat.1000038
Abstract: Eukaryotic cells restrain the activity of foreign genetic elements, including viruses, through RNA silencing. Although viruses encode suppressors of silencing to support their propagation, viruses may also exploit silencing to regulate host gene expression or to control the level of their accumulation and thus to reduce damage to the host. RNA silencing in plants propagates from cell to cell and systemically via a sequence-specific signal. Since the signal spreads between cells through plasmodesmata like the viruses themselves, virus-encoded plasmodesmata-manipulating movement proteins (MP) may have a central role in compatible virus:host interactions by suppressing or enhancing the spread of the signal. Here, we have addressed the propagation of GFP silencing in the presence and absence of MP and MP mutants. We show that the protein enhances the spread of silencing. Small RNA analysis indicates that MP does not enhance the silencing pathway but rather enhances the transport of the signal through plasmodesmata. The ability to enhance the spread of silencing is maintained by certain MP mutants that can move between cells but which have defects in subcellular localization and do not support the spread of viral RNA. Using MP expressing and non-expressing virus mutants with a disabled silencing suppressing function, we provide evidence indicating that viral MP contributes to anti-viral silencing during infection. Our results suggest a role of MP in controlling virus propagation in the infected host by supporting the spread of silencing signal. This activity of MP involves only a subset of its properties implicated in the spread of viral RNA.
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,*
BMB Reports , 2012,
Abstract: The role of peroxiredoxin (Prx) I as an erythrocyte antioxidantdefense in red blood cells (RBCs) is controversial. Here weinvestigated the function of Prx I by using Prx I– – and Prx I/II– –mice. Prx I– – mice exhibited a normal blood profile. However,Prx I/II– – mice showed more significantly increased Heinz bodyformation as compared with Prx II– – mice. The clearance rate ofHeinz body-containing RBCs in Prx I– – mice decreasedsignificantly through the treatment of aniline hydrochloride (AH)compared with wild-type mice. Prx I deficiency decreased thephagocytic capacity of macrophage in clearing Heinz bodycontainingRBCs. Our data demonstrate that Prx I deficiency didnot cause hemolytic anemia, but showed that further increasedhemolytic anemia symptoms in Prx II– – mice by attenuatingphagocytic capacity of macrophage in oxidative stress damagedRBCs, suggesting a novel role of Prx I in phagocytosis ofmacrophage.
Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells
Dongbum Kim1, Min Chul Park1, Byoung Kwon Park1, Sanghoon Kwon2, Joon-Ho Choi3, Hyun-Jong Kim4, Soo-Young Choi5, Jinseu Park5, Younghee Lee6 & Hyung-Joo Kwon1,2,*
BMB Reports , 2012,
Abstract: We evaluated the expression of the costimulatory moleculesCD80 and CD83 and major histocompatibility (MHC) class IIinduced by 2,4-dinitrofluorobenzene (DNFB) in the RAW264.7 macrophage cell line. In contrast to the previously reportedeffect of DNFB on dendritic cells, CD86 expression didnot change. Furthermore, we observed that the CD83 expressionlevel transiently increased and then decreased.Induction of CD80 and MHC class II molecule expression anda decrease in CD83 expression by DNFB in vitro were alsoconfirmed in splenocytes of BALB/c and NC/Nga mice.However, DNFB did not influence CD83 expression in peritonealCD11b+ cells from BALB/c or NC/Nga mice. Detailedin vivo experiments and further studies on the possible contributionof CD11b+ cells to induce atopic dermatitis (AD)would be helpful to attain a better understanding of ADpathogenesis.
The Effect of Smartwork Environment on Organizational Commitment and Innovative Behavior in the Global Financial Service Industry  [PDF]
Myong Ok Kim, Sooyeon Shin
Journal of Service Science and Management (JSSM) , 2015, DOI: 10.4236/jssm.2015.81014
Abstract: This study analyzed how smartwork environment perceived by employees in global financial service industry (GFSI) influences their organizational commitment and innovative behavior. Data were collected through a questionnaire survey from 147 respondents randomly selected from seven global financial service firms in Seoul, Korea, where all three types of smartwork setting (working at home, mobile office, and smartwork center) are utilized. We found that no specific characteristic of smartwork environment (presenteeism, IT complexity, security risks, task interdependence) was significantly related to organizational commitment. For innovative behavior, only IT complexity and security risks of smartwork environment appeared to be significantly related. Contrary to our expectations, it was found that the negative emotion and stress of employees as to the complexity of IC technology and IT security risks can actually inspire their innovative behavior.
Korea’s Construction Business Informatization Overview and Future Plans  [PDF]
Myoung Bae Seo, Nam Gon Kim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B003
Abstract: South Korea’s construction industry won orders worth USD 58 billion in 2011, and as such, it has achieved a remarkable growth. However, despite such an impressive quantitative growth, value-added quality growth has been very slow. Thus, the Ministry of Land, Transport and Marine Affairs (MLTM) is pushing ahead with the construction informatization initiative (Construction Continuous Acquisition & Life-cycle Support - CALS) in order to systematically manage a wide range of construction information by stage and to enhance the efficiency of construction costs. This study aims to review the country’s construction CALS to explore a construction development direction. 
Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene
Mijeong Cha1, Sang Hee Shim1, Sung Hong Kim2, Ok Tae Kim3, Se-Weon Lee4, Suk-Yoon Kwon5 & Kwang-Hyun Baek1,*
BMB Reports , 2012,
Abstract: Paclitaxel is produced by various species of yew trees and hasbeen extensively used to treat tumors. In our research, ataxadiene synthase (TS) gene from Taxus brevifolia was used totransform the roots of cultured ginseng (Panax ginseng C.A.Meyer) to produce taxadiene, the unique skeletal precursor totaxol. The TS gene was successfully introduced into theginseng genome, and the de novo formation of taxadiene wasidentified by mass spectroscopy profiling. Without any changein phenotypes or growth difference in a TS-transgenic ginsengline, the transgenic TSS3-2 line accumulated 9.1 μg taxadieneper gram of dry weight. In response to the treatment of methyljasmonate for 3 or 6 days, the accumulation was 14.6 and15.9 μg per g of dry weight, respectively. This is the first reportof the production of taxadiene by engineering ginseng rootswith a taxadiene synthase gene.
Instability of planar vortices in two-dimensional easy-plane Heisenberg model with distance-dependent interactions
Myoung Won Cho,Seunghwan Kim
Physics , 2003, DOI: 10.1103/PhysRevB.70.024405
Abstract: It is known that magnetic vortices in two dimensional Heisenberg models with easy-plane anisotropy exhibit an instability depending on the anisotropy strength. In this paper, we study the statistic behavior of the two-dimensional easy-plane Heisenberg models with distance-dependent interactions, $J_{xy}(r)$ and $J_z(r)$ for in-plane and out-of-plane components. We develop analytical and numerical methods for accurate determination of critical anisotropy, above which out-of-plane vortices are stable. In particular, we explore the vortex formation of the Gaussian-type interaction model and determine the critical anisotropy accurately for square, hexagonal and triangular lattices.
Understanding visual map formation through vortex dynamics of spin Hamiltonian models
Myoung Won Cho,Seunghwan Kim
Physics , 2003, DOI: 10.1103/PhysRevLett.92.018101
Abstract: The pattern formation in orientation and ocular dominance columns is one of the most investigated problems in the brain. From a known cortical structure, we build spin-like Hamiltonian models with long-range interactions of the Mexican hat type. These Hamiltonian models allow a coherent interpretation of the diverse phenomena in the visual map formation with the help of relaxation dynamics of spin systems. In particular, we explain various phenomena of self-organization in orientation and ocular dominance map formation including the pinwheel annihilation and its dependency on the columnar wave vector and boundary conditions.
General representation of collective neural dynamics with columnar modularity
Myoung Won Cho,Seunghwan Kim
Quantitative Biology , 2004,
Abstract: We exhibit a mathematical framework to represent the neural dynamics at cortical level. Our description of neural dynamics with columnar and functional modularity, named fibre bundle representation (FBM) method, is based both on neuroscience and informatics, whereas they correspond with the conventional formulas in statistical physics. In spite of complex interactions in neural circuitry and various cortical modification rules per models, some significant factors determine the typical phenomena in cortical dynamics. The FBM representation method reveals them plainly and gives profit in building or analyzing the cortical dynamic models. Not only the similarity in formulas, the cortical dynamics can share the statistical properties with other physical systems, which validated in primary visual maps. We apply our method to proposed models in visual map formations, in addition our suggestion using the lateral interaction scheme. In this paper, we will show that the neural dynamic procedures can be treated through conventional physics expressions and theories.
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