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Search Results: 1 - 10 of 45458 matches for " Myeong-Jin Kim "
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Characterization of Incidental Liver Lesions: Comparison of Multidetector CT versus Gd-EOB-DTPA-Enhanced MR Imaging
Yong Eun Chung, Myeong-Jin Kim, Yeo-Eun Kim, Mi-Suk Park, Jin Young Choi, Ki Whang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066141
Abstract: As a result of recent developments in imaging modalities and wide spread routine medical checkups and screening, more incidental liver lesions are found frequently on US these days. When incidental liver lesions are found on US, physicians have to make a decision whether to just follow up or to undergo additional imaging studies for lesion characterization. In order to choose the next appropriate imaging modality, the diagnostic accuracy of each imaging study needs to be considered. Therefore, we tried to compare the accuracy of contrast-enhanced multidetector CT (MDCT) and Gd-EOB-DTPA-enhanced MRI for characterization of incidental liver masses. We included 127 incidentally found focal liver lesions (94 benign and 33 malignant) from 80 patients (M:F = 45:35) without primary extrahepatic malignancy or chronic liver disease. Two radiologists independently reviewed Gd-EOB-DTPA-enhanced MRI and MDCT. The proportion of confident interpretations for differentiation of benign and malignant lesions and for the specific diagnosis of diseases were compared. The proportion of confident interpretations for the differentiation of benign and malignant lesions was significantly higher with EOB-MRI(94.5%–97.6%) than with MDCT (74.0%–92.9%). In terms of specific diagnosis, sensitivity and accuracy were significantly higher with EOB-MRI than with MDCT for the diagnosis of focal nodular hyperplasia (FNH) and focal eosinophilic infiltration. The diagnoses of the remaining diseases were comparable between EOB-MRI and MDCT. Hence, our results suggested that Gd-EOB-MRI may provide a higher proportion of confident interpretations than MDCT, especially for the diagnosis of incidentally found FNH and focal eosinophilic infiltration.
Comparison of CT and MRI for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma
Young Chul Kim, Mi-Suk Park, Seung-Whan Cha, Yong Eun Chung, Joon Suk Lim, Kyung Sik Kim, Myeong-Jin Kim, Ki Whang Kim
World Journal of Gastroenterology , 2008,
Abstract: AIM: To determine the accuracy of computed tomography (CT) and magnetic resonance (MR) for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma.METHODS: Two radiologists independently evaluated CT and MR imaging of 31 patients who had undergone lymphadenectomy (9 metastatic and 22 non-metastatic paraaortic nodes). Receiver operating characteristic (ROC) curve analysis was performed using a five point scale to compare CT with MRI. To re-define the morphologic features of metastatic nodes, we evaluated CT scans from 70 patients with 23 metastatic paraaortic nodes and 47 non-metastatic ones. The short axis diameter, ratio of the short to long axis, shape, and presence of necrosis were compared between metastatic and non-metastatic nodes by independent samples t-test and Fisher’s exact test. P < 0.05 was considered statistically significant.RESULTS: The mean area under the ROC curve for CT (0.732 and 0.646, respectively) was slightly higher than that for MRI (0.725 and 0.598, respectively) without statistical significance (P = 0.940 and 0.716, respectively). The short axis diameter of the metastatic lymph nodes (mean = 9.2 mm) was significantly larger than that of non-metastatic ones (mean = 5.17 mm, P < 0.05). Metastatic nodes had more irregular margins (44.4%) and central necrosis (22.2%) than non-metastatic ones (9% and 0%, respectively), with statistical significance (P < 0.05).CONCLUSION: The accuracy of CT scan for the characterization of paraaortic nodes is not different from that of MRI. A short axis-diameter (> 5.3 mm), irregular margin, and presence of central necrosis are the suggestive morphologic features of metastatic paraaortic nodes.
Paraaortic lymph node metastasis in patients with intra-abdominal malignancies: CT vs PET
Mi-Jung Lee, Mi Jin Yun, Mi-Suk Park, Seung Hwan Cha, Myeong-Jin Kim, Jong Doo Lee, Ki Whang Kim
World Journal of Gastroenterology , 2009,
Abstract: AIM: To compare the diagnostic accuracy of computed tomography (CT) and positron emission tomography (PET) for the preoperative detection of paraaortic lymph node (PAN) metastasis in patients with intra-abdominal malignancies.METHODS: Sixty-six patients with intra-abdominal malignancies who underwent both CT and PET before lymphadenectomy were included in this study. Histopathologically, 13 patients had metastatic PAN, while 53 had non-metastatic PAN. The CT criteria for metastasis were: short diameter of > 8 mm, lobular or irregular shape, and/or combined ancillary findings, including necrosis, conglomeration, vessel encasement, and infiltration. The PET criterion was positive fluorodeoxyglucose (FDG) uptake. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of both modalities were compared with the pathologic findings, and the false positive and false negative cases with both CT and PET were analyzed.RESULTS: The sensitivity, specificity, PPV, NPV, and accuracy of CT were 61.5%, 84.9%, 50%, 90% and 80.3%, respectively. For PET, the percentages were 46.2%, 100%, 100%, 88.3%, and 89.4%. Additionally, there were 8 false positive CT cases (8/53, 15.1%) and zero false positive PET cases. Of the 13 metastatic PANs, there were 5 false negative CT scans (38.5%) and 7 (53.9%) false negative PET scans.CONCLUSION: For detecting PAN metastasis, CT is more sensitive than PET, while PET is more specific.
18F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma: A Preliminary Study
Sung Jun Ahn, Mi-Suk Park, Kyung Ah Kim, Jun Yong Park, InSeong Kim, Won Joon Kang, Seung-Koo Lee, Myeong-Jin Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071571
Abstract: Objectives Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI). Materials and Methods Twenty-one patients with advanced HCC underwent 18F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUVmax) from 18F-FDG-PET, variables of the volume transfer constant (Ktrans) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman’s correlation analysis. The influence of portal vein thrombosis on SUVmax and variables of Ktrans and ADC was evaluated by Mann-Whitney test. Results SUVmax showed significant negative correlation with Ktransmax (ρ = ?0.622, p = 0.002). However, variables of ADC showed no relationship with variables of Ktrans or SUVmax (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and Ktrans (p>0.05). Conclusion In this study, SUV was shown to be correlated with Ktrans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study
Je Sung You, Hye-Jeong Lee, Yong Eun Chung, Hye Sun Lee, Myo Jeong Kim, Sung Phil Chung, Myeong-Jin Kim, Incheol Park, Ki Whang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084870
Abstract: In contrast to patients with underlying cancer or chronic disease, injury patients are relatively young, and can be expected to live their natural lifespan if injuries are appropriately treated. Multiple and repeated diagnostic scans might be performed in these patients during admission. Nevertheless, radiation exposure in injury patients has been overlooked and underestimated because of the emergent nature of such situations. Therefore, we tried to assess the cumulative effective dose (cED) of injury patients in the emergency department. We included patients who visited the emergency department (ED) of a single tertiary hospital due to injury between February 2010 and February 2011. The cED for each patient was calculated and compared across age, sex and injury mechanism. A total of 11,676 visits (mean age: 28.0 years, M:F = 6,677:4,999) were identified. Although CT consisted of only 7.8% of total radiologic examinations (n=78,025), it accounted for 87.1% of the total cED. The mean cED per visit was 2.6 mSv. A significant difference in the cED among injury mechanisms was seen (p<0.001) and patients with traffic accidents and fall down injuries showed relatively high cED values. Hence, to reduce the cED of injury patients, an age-, sex- and injury mechanism-specific dose reduction strategy should be considered.
Depigmentation Effect of Kadsuralignan F on Melan-A Murine Melanocytes and Human Skin Equivalents
Myeong-Jin Goh,Hae-Kwang Lee,Liang Cheng,De-Yun Kong,Jae-Ho Yeon,Quan-Quan He,Jun-Cheol Cho,Yong Joo Na
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14011655
Abstract: The development of melanogenic inhibitors is important for the prevention of hyperpigmentation, and, recently, consideration has been given to natural materials or traditionally used ingredients such as Chinese medicine. The aim of this study is the evaluation of a new anti-melanogenic candidate, kadsuralignan F, from the natural plant Kadsura coccinea, as well as the determination of mechanisms of melanogenesis inhibition at a molecular level. Kadsuralignan F significantly reduced melanin synthesis in a dose-dependent manner in a murine melanocyte cell line and human skin equivalents. There was no direct inhibition on mushroom tyrosinase or cell-extract tyrosinase activity, and mRNA expression of tyrosinase and other melanogenic genes such as tyrosinase-related protein-1 (trp-1) or trp-2 were not affected by kadsuralignan F. Interestingly, the protein level of tyrosinase was dramatically downregulated with kadsuralignan F treatment. We found that a decrease of tyrosinase protein by kadsuralignan F was fully recovered by MG132, a proteasome inhibitor, but not by chloroquine, a lysosome inhibitor. In this study, we found that kadsuralignan F, a lignan from an extract of Kadsura coccinea, has an inhibitory activity on melanin synthesis through tyrosinase degradation. These findings suggest that kadsuralignan F can be used as an active ingredient for hyperpigmentation treatment.
Design of DC-DC Converter for Flash Memory IPs  [PDF]
Li-yan Jin, Woo-Young Jung, Ji-Hye Jang, Min-Sung Kim, Myeong-Seok Kim, Heon Park, Pan-Bong Ha, Young-Hee Kim
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.51B026
Abstract: A DC-DC converter for flash memory IPs performing erasing by the FN (Fowler-Nordheim) tunneling and programming by the CHEI (channel hot electron injection) is designed in this paper. For the DC-DC converter for flash memory IPs using a dual voltage of VDD (=1.5V±0.15V)/VRD (=3.1V±0.1V), a scheme of using VRD (Read Voltage) instead of VDD is proposed to reduce the pumping stages and pumping capacitances of its charge pump circuit. VRD (=3.1V±0.1V) is a regulated voltage by a voltage regulator with an external voltage of 5V, which is used as the WL activation voltage in the read mode and an input voltage of the charge pump. The designed DC-DC converter outputs positive voltages of VP6V (=6V), VP8V (=8V) and VP9V(=9V); and a negative voltage of  VM8V (=-8V) in the write mode.
Preparation of Nanosized - Particles Using a Microwave Pretreatment at Mild Temperature
Hyun Soo Kim,No-Kuk Park,Tae Jin Lee,Myeong-Heon Um,Misook Kang
Advances in Materials Science and Engineering , 2012, DOI: 10.1155/2012/920105
Abstract: This study investigated the effect of microwave pretreatment to reduce the growth temperature of α-Al2O3. The microwave pre-treating of the synthesized powders at 1,000°C produced rhombohedral structured α-Al2O3 with high specific surface area and dispersion; however the structure accumulated among the particles was seen above 1,200°C when the microwave did not pretreated. 1. Introduction Alumina is an advanced ceramic with wide applications in electrical insulating, microelectronics, polishing, and various material matrixes, depending on the structural diversity. Particularly, the α-Al2O3 powder has considerable potential for a wide range of applications like sapphire crystal growth, electronics, semiconductors, and catalysts, because of having excellent thermal conductivity and resistance, and larger strength and hardness. In general, aluminum hydroxide at 500°C to form γ-alumina which then transforms to δ-alumina and θ-alumina before becoming α-Al2O3 in the range of 1,200–1,400°C, depending on the procedure [1–3]. However, little research is presently being conducted on the synthesis of α-Al2O3 because the high formation temperature makes it more difficult to create a structure at a lower temperature. Recently several studies on the preparation of α-Al2O3 have tried to lower the formation temperature by using additives [4, 5]. It has been suggested that the metal-organic-derived alumina could lower the transformation temperature of α-Al2O3. Such studies are continuing, but without evident success as yet. In this study, we tried to synthesize a special α-Al2O3 powder at lower temperature than the ordinary temperatures in previous papers [1–3]. As an idea, the microwave pretreatment is introduced in this study. Xie et al. [6] reported the densification and grain growth of alumina by microwave processing; microwave heating showed enhanced densification processing and short sintering time as compared to conventional heating. Ebadzadeh and Asadian [7] also represented that nanosized alumina powder was obtained through microwave heating (2.45?GHz and 900?W) for different times. The γ-Al2O3 was the main phase for powder samples heated for 4 and 6?min. When heating was extended to 8?min, weak peaks of α-Al2O3 also appeared. For heating times longer than 10?min, α-Al2O3 was the only crystalline phase present. Microwave instrument used in this paper has high efficiency that the input energy is converted to heat more than 90%. Thus, the reaction mixture as a whole is heated evenly, which eventually results in shortening of reaction time [8]. 2. Experimental
Comparative Genomics Reveals Adaptation by Alteromonas sp. SN2 to Marine Tidal-Flat Conditions: Cold Tolerance and Aromatic Hydrocarbon Metabolism
Renukaradhya K. Math, Hyun Mi Jin, Jeong Myeong Kim, Yoonsoo Hahn, Woojun Park, Eugene L. Madsen, Che Ok Jeon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035784
Abstract: Alteromonas species are globally distributed copiotrophic bacteria in marine habitats. Among these, sea-tidal flats are distinctive: undergoing seasonal temperature and oxygen-tension changes, plus periodic exposure to petroleum hydrocarbons. Strain SN2 of the genus Alteromonas was isolated from hydrocarbon-contaminated sea-tidal flat sediment and has been shown to metabolize aromatic hydrocarbons there. Strain SN2's genomic features were analyzed bioinformatically and compared to those of Alteromonas macleodii ecotypes: AltDE and ATCC 27126. Strain SN2's genome differs from that of the other two strains in: size, average nucleotide identity value, tRNA genes, noncoding RNAs, dioxygenase gene content, signal transduction genes, and the degree to which genes collected during the Global Ocean Sampling project are represented. Patterns in genetic characteristics (e.g., GC content, GC skew, Karlin signature, CRISPR gene homology) indicate that strain SN2's genome architecture has been altered via horizontal gene transfer (HGT). Experiments proved that strain SN2 was far more cold tolerant, especially at 5°C, than the other two strains. Consistent with the HGT hypothesis, a total of 15 genomic islands in strain SN2 likely confer ecological fitness traits (especially membrane transport, aromatic hydrocarbon metabolism, and fatty acid biosynthesis) specific to the adaptation of strain SN2 to its seasonally cold sea-tidal flat habitat.
Concomitant renal insufficiency and diabetes mellitus as prognostic factors for acute myocardial infarction
Chang Seong Kim, Joon Seok Choi, Jeong Woo Park, Eun Hui Bae, Seong Kwon Ma, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Soo Wan Kim, other Korea Acute Myocardial Infarction Registry Investigators
Cardiovascular Diabetology , 2011, DOI: 10.1186/1475-2840-10-95
Abstract: From November 2005 to August 2008, 9905 patients (63 ± 13 years; 70% men) with AMI were enrolled in a nationwide prospective Korea Acute Myocardial Infarction Registry (KAMIR) and were categorized into 4 groups: Group I (n = 5700) had neither diabetes nor renal insufficiency (glomerular filtration rate [GFR] ≥ 60 ml/min/1.73 m2), Group II (n = 1730) had diabetes but no renal insufficiency, Group III (n = 1431) had no diabetes but renal insufficiency, and Group IV (n = 1044) had both diabetes and renal insufficiency. The primary endpoints were major adverse cardiac events (MACE), including a composite of all cause-of-death, myocardial infarction, target lesion revascularization, and coronary artery bypass graft after 1-year clinical follow-up.Primary endpoints occurred in 1804 (18.2%) patients. There were significant differences in composite MACE among the 4 groups (Group I, 12.5%; Group II, 15.7%; Group III, 30.5%; Group IV, 36.5%; p < 0.001). In a Cox proportional hazards model, after adjusting for multiple covariates, the 1-year mortality increased stepwise from Group III to IV as compared with Group I (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.34-2.86; p = 0.001; and HR, 2.42; 95% CI, 1.62-3.62; p < 0.001, respectively). However, Kaplan-Meier analysis showed no significant difference in probability of death at 1 year between Group III and IV (p = 0.288).Renal insufficiency, especially in association with diabetes, is associated with the occurrence of composite MACE and indicates poor prognosis in patients with AMI. Categorization of patients with diabetes and/or renal insufficiency provides valuable information for early-risk stratification of AMI patients.Renal dysfunction and diabetes mellitus are established risk factors for long-term adverse prognosis in patients with cardiovascular disease. Any degree of preexisting renal dysfunction should be considered a potent, independent risk factor for cardiovascular complication after acute myocardial i
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