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Search Results: 1 - 10 of 224 matches for " Muthu Periasamy "
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High gender -specific susceptibility to curare- a neuromuscular blocking agent
Santosh K Maurya,Muthu Periasamy,Naresh C Bal
Biological Research , 2013,
Abstract: Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, but at higher doses it is known to be lethal. However, the exact dose of curare initiating muscle relaxation vs. lethal effect has not been fully characterized in mice. In this study we carefully examined the dose-response for achieving muscle inactivity over lethality in both male and female mice (C57BL6/J). The most striking finding of this study is that female mice were highly susceptible to curare; both the EDm and LDm were at least 3-fold lower than male littermates. This study shows that gender-specific differences can be an important factor when administering skeletal muscle relaxants, particularly curare or other analogous agents targeted to the neuromuscular junction.
Guidelines Based Software Engineering for Developing Software Components  [PDF]
Muthu Ramachandran
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.51001
Abstract: Software guidelines have been with us in many forms within Software Engineering community such as knowledge, experiences, domain expertise, laws, software design principles, rules, design heuristics, hypothesis, experimental results, programming rules, best practices, observations, skills, algorithms have played major role in software development. This paper presents a new discipline known as Guidelines Based Software Engineering where the aim is to learn from well-known best practices and documenting newly developed and successful best practices as a knowledge based (could be part of the overall KM strategies) when developing software systems across the life cycle. Thereby it allows reuse of knowledge and experiences.
Localized Coverage Connectivity Based on Shape and Area Using Mobile Sensor Robots in Wireless Sensor Networks  [PDF]
Rajaram Pichamuthu, Prakasam Periasamy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78171
Abstract: A wireless sensor network (WSN) is spatially distributing independent sensors to monitor physical and environmental characteristics such as temperature, sound, pressure and also provides different applications such as battlefield inspection and biological detection. The Constrained Motion and Sensor (CMS) Model represents the features and explain k-step reach ability testing to describe the states. The description and calculation based on CMS model does not solve the problem in mobile robots. The ADD framework based on monitoring radio measurements creates a threshold. But the methods are not effective in dynamic coverage of complex environment. In this paper, a Localized Coverage based on Shape and Area Detection (LCSAD) Framework is developed to increase the dynamic coverage using mobile robots. To facilitate the measurement in mobile robots, two algorithms are designed to identify the coverage area, (i.e.,) the area of a coverage hole or not. The two algorithms are Localized Geometric Voronoi Hexagon (LGVH) and Acquaintance Area Hexagon (AAH). LGVH senses all the shapes and it is simple to show all the boundary area nodes. AAH based algorithm simply takes directional information by locating the area of local and global convex points of coverage area. Both these algorithms are applied to WSN of random topologies. The simulation result shows that the proposed LCSAD framework attains minimal energy utilization, lesser waiting time, and also achieves higher scalability, throughput, delivery rate and 8% maximal coverage connectivity in sensor network compared to state-of-art works.
Exercise Protects against Diet-Induced Insulin Resistance through Downregulation of Protein Kinase Cβ in Mice
Xiaoquan Rao, Jixin Zhong, Xiaohua Xu, Brianna Jordan, Santosh Maurya, Zachary Braunstein, Tse-Yao Wang, Wei Huang, Sudha Aggarwal, Muthu Periasamy, Sanjay Rajagopalan, Kamal Mehta, Qinghua Sun
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081364
Abstract: Physical exercise is an important and effective therapy for diabetes. However, its underlying mechanism is not fully understood. Protein kinase Cβ (PKCβ) has been suggested to be involved in the pathogenesis of obesity and insulin resistance, but the role of PKCβ in exercise-induced improvements in insulin resistance is completely unknown. In this study, we evaluated the involvement of PKCβ in exercise-attenuated insulin resistance in high-fat diet (HFD)-fed mice. PKCβ-/- and wild-type mice were fed a HFD with or without exercise training. PKC protein expression, body and tissue weight change, glucose and insulin tolerance, metabolic rate, mitochondria size and number, adipose inflammation, and AKT activation were determined to evaluate insulin sensitivity and metabolic changes after intervention. PKCβ expression decreased in both skeletal muscle and liver tissue after exercise. Exercise and PKCβ deficiency can alleviate HFD-induced insulin resistance, as evidenced by improved insulin tolerance. In addition, fat accumulation and mitochondrial dysfunction induced by HFD were also ameliorated by both exercise and PKCβ deficiency. On the other hand, exercise had little effect on PKCβ-/- mice. Further, our data indicated improved activation of AKT, the downstream signal molecule of insulin, in skeletal muscle and liver of exercised mice, whereas PKCβ deficiency blunted the difference between sedentary and exercised mice. These results suggest that downregulation of PKCβ contributes to exercise-induced improvement of insulin resistance in HFD-fed mice.
Dual Authentication Hashing for Security Enhancement in MANET  [PDF]
L. Raja, Dr. P. S. Periasamy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.74030
Abstract: Mobile Ad hoc Network (MANET) is a collection of mobile hosts with wireless interfaces that form a temporary network without the aid of any fixed infrastructure or centralized administration. A MANET is a type of ad hoc network that can change locations and configure itself on the fly. The dynamic and cooperative behaviour of ad hoc networking without any centralized or unified controlling authority for authentication and monitoring is sensitive to attacks that damage or exploit the cooperative behaviour of ad hoc routing. Routing attacks lead to the most disastrous damage in MANET. The main objective of this paper is to enhance the security against routing attacks in MANETs. Intrusion detection based on DAHT (Dual Authentication Hash Technique) entirely depends on the end to end communication between the source and destination is employed here. The proposed technique identifies the misbehaving nature of current node and the previous node where it receives the information. DAHT is simulated with various parameters in NS2. The results obtained are compared with existing mechanism. The results show that malicious detection, overhead reduction and delay are better when compared to the existing system that is employed in protecting the routing information.
Improved Quantification of Glomerular Filtration Rate and Differential Renal Function of Ectopic Kidneys in a Dual Head Gamma Camera  [PDF]
Gopal Sonai Muthu, Sujata Mitra
Open Journal of Medical Imaging (OJMI) , 2014, DOI: 10.4236/ojmi.2014.41003
Abstract: Introduction: Tc-99m Di-ethylene Tri-amine Penta Acetic Acid (DTPA) renogram is an accepted method to measure Glomerular Filtration Rate (GFR) of the kidneys. The depth and position of ectopic kidneys may vary. This may lead to variation in tissue attenuation and error in the computed GFR and Differential Renal Function (DRF) of each kidney. Objective: The present study was undertaken in patients with ectopic kidneys to improve the accuracy of GFR and DRF calculation in a renogram with single injection of Tc-99m DTPA on a dual head gamma camera. Materials and Method: The study was conducted on 55 patients with ectopic kidneys. Images were acquired on a dual head gamma camera simultaneously in anterior and posterior views. Both anterior and posterior image datasets were used to compute the GFR of the ectopic kidney by Gates method. Depth correction of the ectopic kidney was done using the lateral view image. Total GFR was calculated as the sum of the anterior dataset ectopic kidney GFR and the posterior dataset normal kidney GFR. DRF was calculated again, by using the anterior dataset GFR of the ectopic kidney and posterior dataset for normal kidneys. The total GFR calculated by our method was compared to the patient’s eGFR (based on serum creatinine, age and sex). Result: The GFR calculated by anterior data set in the ectopic kidney was significantly higher than that calculated by posterior dataset (p < 0.001). Similarly, the differential GFR of the ectopic kidney was higher when the anterior dataset was used (p
Reactive oxygen species—Control and management using amphiphilic biosynthetic hydrogels for cardiac applications  [PDF]
Gnanaprakasam Thankam Finosh, Muthu Jayabalan
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.412150

The reactive oxygen species (ROS) originated from endogenous and exogenous sources play a dominant role in the initiation and propagation of several diseases. It is therefore an urgent need to explore substances capable of encountering the ROS and resist the damage caused by ROS. The present paper deals with various aspects of generation and implications of ROS in the management of myocardial infarction. The use of biosynthetic amphiphilic biodegradable hydrogels in the control and management of ROS in myocardial infarction was studied using a biosynthetic hydrogel (PA-PEGDA) comprising poly(propylene fumarate)-co-alginate copolymer cross-linked with calcium and polyethylene glycol diacrylate (PEGDA). The effect of ROS on the cell growth was studied using H2O2 as model ROS molecule. The present hydrogel resists the penetration of ROS in the cell which was evident from the live/dead assay, increased intra cellular GSH levels when compared with the H2O2 treated positive and curcumin treated negative control cells. The Comet assay reveals genomic integrity of the cells exposed to the present hydrogel. The hydrogel is a promising injectable material for the management of myocardial infarction and ischemia. 

Nanoparticles based on PLGA and its co-polymer: An overview
Muthu M
Asian Journal of Pharmaceutics , 2009,
Abstract: Poly (D, L-lactide-co-glycolide) (PLGA) is approved by the Food and Drug Administration for drug delivery use. The polymeric nanoparticles based on PLGA and its co-polymer are designed for controlled and targeted drug delivery. Also, PLGA and its co-polymer are important in designing nanoparticles with desired characteristics such as biocompatibility, biodegradation, particle size, surface properties, drug release and targetability. This review focuses on the polymer literature, methods for preparation of nanoparticles and recent studies on the nanoparticles based on PLGA and its co-polymer for the conventional and targeted delivery of drugs by various routes.
Automated Improvement for Component Reuse
Muthu Ramachandran
Computer Science , 2005,
Abstract: Software component reuse is the key to significant gains in productivity. However, the major problem is the lack of identifying and developing potentially reusable components. This paper concentrates on our approach to the development of reusable software components. A prototype tool has been developed, known as the Reuse Assessor and Improver System (RAIS) which can interactively identify, analyse, assess, and modify abstractions, attributes and architectures that support reuse. Practical and objective reuse guidelines are used to represent reuse knowledge and to do domain analysis. It takes existing components, provides systematic reuse assessment which is based on reuse advice and analysis, and produces components that are improved for reuse. Our work on guidelines has been extended to a large scale industrial application.
Diversity of Millipedes in Alagar Hills Reserve Forest in Tamil Nadu, India
Periasamy Alagesan,Baluchamy Ramanathan
International Journal of Biodiversity , 2013, DOI: 10.1155/2013/715460
Abstract: Millipede diversity and abundance were analysed at sites lying between 250 and 650 meters above mean sea level in Alagar Hills of Eastern Ghats, Tamil Nadu, India. Millipede abundance and diversity peaked at midelevations influenced by favourable niche and food resources. Diversity of millipedes indicates the influence of local habitat and food resource availability. In the present study, millipede species, Harpaphe haydeniana, Xenobolus carnifex, Arthrosphaera magna, Aulacobolus newtoni, and Spinotarsus colosseus, are present at midelevation (450?MSL). Abundance of millipedes at 450?m elevation is due to moderate canopy and litter, which support understorey vegetation like herbs and shrubs. 1. Introduction Biodiversity offers several direct and indirect economic benefits to humankind [1]. The interest in diversity especially over the past few years has focused on how diversity influences ecosystems and ecological processes [2]. Ninety-five percent of experimental studies support a positive relationship between diversity and ecosystem functioning [3–5]. The biotic diversity tends to play a significant role by enriching the soil, maintaining water and climatic cycles, and converting waste materials into nutrients. Soil macrofauna makes an important contribution to soil fertility by promoting the stability and productivity of forest ecosystems, mainly due to their influence on soil process such as litter decomposition and nutrient dynamics [6]. Furthermore, elevation is merely a surrogate for a suite of biotic and abiotic factors that influence species richness [7]. Therefore, identifying ecologically meaningful causal factors is essential in order to explain variation in species richness along elevation gradients [8]. Millipedes belong to class Diplopoda, a highly diverse group of terrestrial organisms with over 12,000 described species and an estimated 80, 000 species yet to be described [9, 10]. Among soil Arthropods, millipedes act as primary destructors of plant debris and play a crucial role in soil formation processes. Many millipedes can also serve as indicators of environmental conditions and improve the structure content of organic matter and nutrient elements of soil [11, 12]. Gadagkar et al. [13] studied species richness and diversity of ant populations from different localities in Western Ghats, India. Diversity of forest litter-inhabiting ants along an elevation gradient in the Wayanad region of the Western Ghats is studied by Sabu et al. [14]. Bharti and Sharma [15] observed the diversity and abundance of ants along an elevational gradient
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