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Search Results: 1 - 10 of 19401 matches for " Musa Al Harbi "
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Neuroblastoma in Saudi Children: A Single Center Experience (2006-2014)  [PDF]
Zaid Al Naqib, Atif A. Ahmed, Musa Al Harbi, Fahad Al Manjomi, Zaheer Ullah Khan, Awatif Alanazi, Othman Mosleh, Walid Ballourah, Mohammed Rayis
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.610098
Abstract: Introduction: Neuroblastoma is the most common extracranial solid tumor in childhood and survival rate has improved during the last few decades. Only a few studies, related to Neuroblastoma in Saudi Arabian children, have been performed. We report epidemiologic data and our clinical experience from the department of Pediatric Hematology Oncology (PHO), King Fahad Medical City (KFMC), Riyadh, Saudi Arabia. Method: A retrospective observational study of all patients, with diagnosis of Neuroblastoma, who attended PHO-KFMC from July 2006 to June 2014 was performed. The survival periods (overall survival and disease-free survival) and the final outcomes for patients treated and followed at KFMC were recorded. The survival data were statistically correlated with the clinical, pathological and biological features of patients and tumors and compared to national and international cohorts. Results: Eight-year data were available for the 42 patients of which 22 (52.4%) were male and 20 (47.6%) were females. Age at diagnosis ranged 0 - 91 months with a mean and median of 26.3 and 18.5 months respectively. 16 (38.1%) patients were under one year and 26 (61.9%) above 1 year of age. The event-free survival (EFS) and overall survival (OS) rates were 66.5% and 71.5% respectively. EFS and OS among those who were <1 year age at presentation was 75% and 82%, whereas ≥1 yr age group had 59% and 62% survival rates respectively. Patients with tumors in the adrenal had considerably lower EFS (59%) and OS (63%); in comparison to patients with tumors sites other than the adrenal who had EFS and OS of 85% and 89% respectively. Both EFS and OS survival rates at the end of follow-up interval were 100.0%, in the low and intermediate risk groups. In contrast, patients in the high risk group had EFS and OS rates of 44% and 48% respectively. This difference was statistically significant (p < 0.05). Conclusion: Our results are very encouraging and comparable with known published international cohorts, and reveal an excellent outcome for stage 1, 2, 3 & 4 s. The prognosis for advanced (stage 4) disease remains rather poor. A collaborative Saudi-wide effort, with an emphasis on research in detecting clinical and biologic characteristics of aggressive disease and tailoring therapy, is needed.
Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children & Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)  [PDF]
Nahla Ali Mobark, Suha A. Tashkandi, Wafa Al Shakweer, Khalid Al Saidi, Suha A. Fataftah, Mohammed M. Al Nemer, Awatif Alanazi, Mohammed Rayis, Walid Ballourah, Othman Mosleh, Zaheer Ullah, Fahad El Manjomi, Musa Al Harbi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64033
Abstract:

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature

Self-Similar Solution of Heat and Mass Transfer of Unsteady Mixed Convection Flow on a Rotating Cone Embedded in a Porous Medium Saturated with a Rotating Fluid  [PDF]
Saleh M. Al-Harbi
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.210166
Abstract: A self-similar solution of unsteady mixed convection flow on a rotating cone embedded in a porous medium saturated with a rotating fluid in the presence of the first and second orders resistances has been obtained. It has been shown that a self-similar solution is possible when the free stream angular velocity and the angular velocity of the cone vary inversely as a linear function of time. The system of ordinary differential equations governing the flow has been solved numerically using an implicit finite difference scheme in combination with the quasi-linearization technique. Both prescribe wall temperature and prescribed heat flux conditions are considered. Numerical results are reported for the skin friction coefficients, Nusselt number and Sherwood number. The effect of various parameters on the velocity, temperature and concentration profiles are also presented here.
Crystallization Kinetics of Melt-Blended Low-Density Phthalic Anhydride with a Low-Tg Tin-Phosphate  [PDF]
Laila M. Al-Harbi
Open Journal of Polymer Chemistry (OJPChem) , 2014, DOI: 10.4236/ojpchem.2014.43005
Abstract:

Polyamide prepared by the reaction of ethylene diamine with different ratios between 1,6-glyconic acid and phthalic anhydride. The differential scanning calorimetry (DSC) is used to study the nonisothermal and isothermal crystallization of low density polyamides in phosphate glass (Pglass)-polymer hybrid blends. The % crystallinity decreased as the Pglass volume increased. The half-life (t1/2) for crystallization decreased as the propagation rate constant rose for both the polymer matrices with increasing Pglass concentrations. The results show that the Pglass is improved nucleating agent for formation of the Pglass-polymer hybrids up to 35% Pglass and the energy necessary to break decreased. The stability of the reaction of ethylene diamine with phthalic anhydride and glyconic acid was qualitatively investigated using molecular orbital calculations.

Evaluation for Science Courses in the Middle Stage of Education in the Kingdom of Saudi Arabia Based on Light of the Next Generation Science Standards NGSS  [PDF]
Ali Saad Matar Al Harbi
Journal of Human Resource and Sustainability Studies (JHRSS) , 2019, DOI: 10.4236/jhrss.2019.72012
Abstract: The current study is aimed at evaluating the science courses in the middle stage of education in the Kingdom of Saudi Arabia in the light of the Next Generation Science Standards NGSS.
Predictors of Glycemic Control among Patients with Type 2 Diabetes in Najran Armed Forces Hospital: A Pilot Study  [PDF]
Imed Harrabi, Fawaz Al Harbi, Saad Al Ghamdi
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.42021
Abstract:

Background: Diabetes mellitus is a serious condition with potentially devastating complications that affects all age groups worldwide. The purposes of this study are to describe the glycemic control levels and to determine the associated factors of poor glycemiccontrol among type 2 diabetes patients followed in Najran Armed Forces Hospital. Methods:We conducted a retrospective analysis of administrative data from adult patients with diabetes type 2 followed in NAFH clinics. To be included in the pilot study, patients needed to meet the following criteria: 1) Be identified as having diabetes type 2 using algorithms employed by disease management oasis program; 2) Be at least aged 18; 3) Be male or female; 4) Have Fasting Plasma Glucose (FPG) and HbA1c measured at least twice during the last year. Both univariate and multivariate approaches of logistic regression were applied to determine factors associated with poor glycemic control. Results: Data from a total of 100 patients were analyzed. There were 22% of patients that achieved glycemic control. The risk factors associated with poor glycemic control were being female, age < 65 years old and those who had not achieved the target total cholesterol. Conclusion: The findings of this study showed that diabetic control is suboptimal. This study provides factors that predict poor glycemic control. With this information, sub-groups with high risk of disease morbidity were identified. Barriers that prevent these patients from meeting their goals must be explored to improve health outcomes.

Treatment-resistant depression: therapeutic trends, challenges, and future directions
Al-Harbi KS
Patient Preference and Adherence , 2012, DOI: http://dx.doi.org/10.2147/PPA.S29716
Abstract: eatment-resistant depression: therapeutic trends, challenges, and future directions Review (3662) Total Article Views Authors: Al-Harbi KS Published Date May 2012 Volume 2012:6 Pages 369 - 388 DOI: http://dx.doi.org/10.2147/PPA.S29716 Received: 05 January 2012 Accepted: 21 February 2012 Published: 01 May 2012 Khalid Saad Al-Harbi Medical College, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia Background: Patients with major depression respond to antidepressant treatment, but 10%–30% of them do not improve or show a partial response coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate. The aim of this paper is to review the therapeutic options for treating resistant major depressive disorder, as well as evaluating further therapeutic options. Methods: In addition to Google Scholar and Quertle searches, a PubMed search using key words was conducted, and relevant articles published in English peer-reviewed journals (1990–2011) were retrieved. Only those papers that directly addressed treatment options for treatment-resistant depression were retained for extensive review. Results: Treatment-resistant depression, a complex clinical problem caused by multiple risk factors, is targeted by integrated therapeutic strategies, which include optimization of medications, a combination of antidepressants, switching of antidepressants, and augmentation with non-antidepressants, psychosocial and cultural therapies, and somatic therapies including electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, deep brain stimulation, transcranial direct current stimulation, and vagus nerve stimulation. As a corollary, more than a third of patients with treatment-resistant depression tend to achieve remission and the rest continue to suffer from residual symptoms. The latter group of patients needs further study to identify the most effective therapeutic modalities. Newer biomarker-based antidepressants and other drugs, together with non-drug strategies, are on the horizon to address further the multiple complex issues of treatment-resistant depression. Conclusion: Treatment-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients with the disorder.
Treatment-resistant depression: therapeutic trends, challenges, and future directions
Al-Harbi KS
Patient Preference and Adherence , 2012,
Abstract: Khalid Saad Al-HarbiMedical College, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi ArabiaBackground: Patients with major depression respond to antidepressant treatment, but 10%–30% of them do not improve or show a partial response coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate. The aim of this paper is to review the therapeutic options for treating resistant major depressive disorder, as well as evaluating further therapeutic options.Methods: In addition to Google Scholar and Quertle searches, a PubMed search using key words was conducted, and relevant articles published in English peer-reviewed journals (1990–2011) were retrieved. Only those papers that directly addressed treatment options for treatment-resistant depression were retained for extensive review.Results: Treatment-resistant depression, a complex clinical problem caused by multiple risk factors, is targeted by integrated therapeutic strategies, which include optimization of medications, a combination of antidepressants, switching of antidepressants, and augmentation with non-antidepressants, psychosocial and cultural therapies, and somatic therapies including electroconvulsive therapy, repetitive transcranial magnetic stimulation, magnetic seizure therapy, deep brain stimulation, transcranial direct current stimulation, and vagus nerve stimulation. As a corollary, more than a third of patients with treatment-resistant depression tend to achieve remission and the rest continue to suffer from residual symptoms. The latter group of patients needs further study to identify the most effective therapeutic modalities. Newer biomarker-based antidepressants and other drugs, together with non-drug strategies, are on the horizon to address further the multiple complex issues of treatment-resistant depression.Conclusion: Treatment-resistant depression continues to challenge mental health care providers, and further relevant research involving newer drugs is warranted to improve the quality of life of patients with the disorder.Keywords: treatment-resistant depression, antidepressants, biomarkers, therapeutic options, somatic therapies
Healthcare Providers’ Perceptions towards Health Information Applications at King Abdul-Aziz Medical City, Saudi Arabia
Abeer Al-Harbi
International Journal of Advanced Computer Sciences and Applications , 2011,
Abstract: The purpose of this study was to assess the perceptions of healthcare providers towards health information technology applications in King Abdul-Aziz Medical City (KAMC) in terms of benefits, barriers, and motivation to use these applications. Data Collection: The study population consists of all healthcare providers working at KAMC. A sample size of 623 was drawn from a population of 7493 healthcare providers using convenience random sampling method. Of 623 questionnaires distributed, 377 were returned, giving a response rate of 60.5 percent. Measurement A self-administered questionnaire was developed based on extended literature review. The questionnaire comprised 25 statements measuring benefits, barriers, and motivation to use health information applications to be responded on a five-point Likert-scale. In addition, the questionnaire included questions on demographic and organizational variables. Results: The results show that the majority of healthcare providers had good knowledge and skills in information technology, as most of them use KAMC health information applications regularly and/or had training courses in the field. The results indicated that training has a significant positive effect on health providers' IT knowledge and skills. The majority of healthcare providers perceived that the information technology applications in KAMC are valuable and beneficial to both patients and KAMC. However, the healthcare providers were split over the barriers to HIT use in KAMC. As for drivers, the results showed that healthcare providers generally would be motivated to use IT applications in KAMC by provision of new applications and training, contribution in change hospital's work procedures, and provision of technical support. Finally, the results showed the perceptions of healthcare providers on benefits, barriers and motives were influenced by gender, occupation and training. However, the effect of these variables on healthcare providers towards benefits, barriers and motives of IT use were inconsistent. Conclusion: Despite the perceived benefits and motives of health information applications, there were many barriers identified by healthcare providers. These were insufficient number of computers, frequent system down, and the use of computerized systems is time consuming. Furthermore, there were significant differences in the perceptions of healthcare providers towards benefits, barriers, and motives to health information technology with respect gender, occupation, and training.
Faith and fate in medical practice
Al-Harbi Ali
Saudi Journal of Kidney Diseases and Transplantation , 2008,
Abstract:
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