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Search Results: 1 - 10 of 8672 matches for " Multiple organ dysfunction "
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A Case of Leptospirosis With Multiple Organ Dysfunction
Mesut Okur,Cihangir Akgün,Mehmet Sel?uk Bekta?,Avni Kaya
Cocuk Enfeksiyon Dergisi , 2010,
Abstract: Leptospirosis is a zoonotic infection caused by a spirochete of the genus Leptospira, which may affect both humans and animals and is common worldwide. The disease may lead to distinct clinical pictures in humans varying from subclinical infection to multiple organ dysfunction and even death. In this paper, we presented a 8-year-old male patient admitted with the complaints of fever, malaise, fatigue and night sweating, who had been feeding a pet rabbit in the house, and who had jaundice of the sclera and skin, a rash, gastrointestinal bleeding and hepatosplenomegaly found on examination. He developed encephalopathy, bleeding diathesis, hepatic and renal failure; and was diagnosed with leptospirosis based on the clinical symptoms and laboratory tests. After 14-days of therapy with crystallized penicillin and intensive supportive treatment, the neurological and hematological anomalies improved as well as the renal and hepatic dysfunction. In conclusion, we would like to emphasize that the probability of leptospirosis should be considered in children presenting with jaundice, encephalopathy, multiple organ dysfunction and bleeding diathesis if there are any environmental risk factors.
Preguntas y respuestas sobre el Da?o Múltiple de órganos: Reflexiones acerca de la temática
Montero González,Teresita; Hurtado de Mendoza Amat,José;
Revista Cubana de Medicina Militar , 2010,
Abstract: the organ multiple damage is the morphological expression of systemic inflammatory response triggered by many causal factors and the clinically it is expressed with the multiple organ dysfunction syndrome, which could be diagnosed after a detailed necropsy study. although both terms are well clinically and morphologically characterized there are confusions related to the use of both naming and in other features related to this subject, in which are involved pathologists, intensive care professionals, surgeons and other specialists. the aim of present paper was to clarify the controversial features related to organ multiple damage using questions and answers and to reflect in this respect. different features on thus subject were discussed clearing up the basis supporting the organ multiple damage diagnosis being necessary a necropsy with high quality, from a macroscopic study up to a microscopic one, collection of all the morphologic alterations founded and its assessment in each study patient and quantifying the changes noted to estimate the mark system and finally to value its place in the chronopathognomy of the deceased.
Unusual fatal multiple-organ dysfunction and pancreatitis induced by a single wasp sting
Azad, C;Parmar, VR;Jat, KR;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2011, DOI: 10.1590/S1678-91992011000100015
Abstract: acute onset of multiple organ dysfunction syndrome (mods) is a well-known complication following multiple wasp stings. however, mods after a single wasp sting has been rarely reported in children and acute pancreatitis have probably never been observed before. herein we describe the case of a 12-year-old boy who had urticaria and abdominal pain after a single wasp sting. the child gradually developed mods while his abdominal complaints were worsening. despite aggressive supportive management, the child did not survive. afterward, the cause of the acute abdomen was finally diagnosed as acute pancreatitis. both mods and pancreatitis following a single wasp sting are very unusual. thus, although pancreatitis is rarely manifested, it should be suspected after a wasp sting if there are predominant abdominal symptoms.
Survey of cases with sepsis & septic shock in the pediatric intensive care unit of Children's Hospital Medical Centre
Salmanzadeh S,Kadivar M
Tehran University Medical Journal , 1999,
Abstract: Sepsis is the systemic response to severe infection in critically ill patients. Sepsis, septic syndrome & septic shock represent the increasingly severe stages of the same disease. Despite the remarkable improvements in outcome, sepsis & septic shock remain an important cause of morbidity & mortality in children. This is a retrospective study among the patients who were admitted in the pediatric intensive care unit (PICU) of Children's Hospital Medical Center from Farvardin 1371 till Esfand 1375. During this period 4018 children were admitted in the PICU, 138 of these patients (3.4%) had the initial diagnosis of sepsis or septic shock. The age of these patients were from 3 months to 14 years (mean of 23.5 months). The male to female ratio was 2.1:1. Out of these 138 patients only 16 cases (11.6%) had sepsis and the others (88.4%) had criterias of severe sepsis or septic shock. Multiple Organ Dysfunction (MOD) were found in 96 cases (69.3%). Diarrhea was the most common primary disease that resulted in sepsis or septic shock. Only 20.3% of the cultures were positive, among which E-Coli was the most in 8.7%, Staphylococcus aureus in 5.7%, Klebsiella in 2.9% and pseudomonas in 1.4%. 66.7% of these patients expired, the mortality rates of the patients with severe sepsis or septic shock that concommitantely had MOD were higher than the other (P<0.0005). So it may be better if children with clinical diagnosis of sepsis be hospitalized in an intensive care unit or at minimum in a facility that can closely monitor these patients during the initial stabilization period.
成功救治妊娠合并脑炎继发多脏器功能障碍综合征一例
A Case of the Successful Treatment of a Pregnancy Woman Was Complicated Byencephalitis and Multiple Organ Dysfunction Syndromes
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张京晓, 刘海波, 尹永杰
Asian Case Reports in Emergency Medicine (ACREM) , 2013, DOI: 10.12677/ACREM.2013.11003
Abstract:
年轻女性,妊娠20周,因发热、寒战3天入院,入院后因血小板减少入我院血液科,次日出现抽搐,第3日出现意识障碍转入ICU,化验检查提示患者存在死胎、呼吸衰竭、休克、肝损伤、肾损伤、胃肠功能及凝血功能障碍等,诊断为:脑炎、多器官功能障碍综合征、休克、死胎,经机械通气,持续心电监护,CVP监测,抗休克、激素冲击、抗癫痫,亚低温治疗,纠正凝血功能,多器官功能支持及早期营养支持治疗,第5天诱导分娩出1女性死婴,经20余天治疗后,患者神志清楚,四肢肌力3~4级,可正常饮食各项化验指标基本恢复正常,痊愈出院。
A young pregnancy women suffered from fever for 3 days and came to our hospital. After admission to the hematology department because of thrombocytopenia, in the third day coma appears and she was deliveried to ICU department. Our lab finding suggests that the patient presented respiratory failure, shock, liver injury, renal injury, ga-strointestinal dysfunction and coagulation dysfunction. Consider of that, the diagnosis was encephalitis, multiple organ dysfunction syndrome, shock, and stillbirth. Then we give her the treatment including the mechanical ventilation, mon-itoring CVP, fluid resuscitation, large dose glucocorticoid injection, and mild hypothcrmia, sedation, coagulating, organ support and early nutrition support therapy. And on the 5th day, a dead female baby was delivered, after more than 20 days treatment, the patient was clear. Muscle power was 3-4 level in the four limbs, lab finding returns to normal, the patient was discharged.
Síndrome de disfun??o de múltiplos órg?os induzida por sepse: estudo experimental em ratos
Lima, Jo?o Batista de Area;Skare, Thelma Larocca;Malafaia, Osvaldo;Ribas-Filho, Jurandir Marcondes;Michaelis, Tiago;Ribas, Fernanda Marcondes;Macedo, Rodrigo de Almeida Coelho;
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S?o Paulo) , 2011, DOI: 10.1590/S0102-67202011000200002
Abstract: background: the leading cause of death in patients with sepsis in surgery is syndrome of multiple organ dysfunction. thus, experimental models that simulate organic changes of sepsis in humans are required. aim: to present two models that induce the syndrome of multiple organ dysfunction and to compare, the changes induced, by intravenous injection of lipopolysaccharide or cell 36ue of viable escherichia coli in relation to mortality and survival, level of lipopolysaccharide, release of tumor necrosis factor alpha ; hematological, liver and kidney function. method: the study lasted seven days and it was used on it 50 male wistar rats divided into three groups: control, lipopolysaccharide and escherichia coli. the experimental groups were inoculated and divided into two subgroups, with inocuation with 24 or 48 hours. on the seventh day were proceeded blood collection and histopathologic analysis of liver, kidneys and lungs. results: there was a survival of ten animals in the control group; zero in bacteria group of 24 hours and six in 48 hours; ten of lipopolysaccharide in 24 hours and six in 48 hours. in the experimental groups, levels of endotoxin, tumor necrosis factor alpha, leukocytes, platelets, renal and liver levels were higher than the control group. there were histopathological changes in the bacterial group. conclusion: the two models of sepsis induced multiple organ dysfunction syndrome; yet the administration 36ue endotoxin every 48 hours could be utilized in advantage over the other for not induce death in significant numbers during the period of seven days.
Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock: A prospective pilot study
Ruiz-Rodríguez,J.C.; Caballero,J.; Ruiz-Sanmartin,A.; Ribas,V.J.; Pérez,M.; Bóveda,J.L.;
Medicina Intensiva , 2012, DOI: 10.1016/j.medin.2011.11.024
Abstract: objective: to evaluate procalcitonin clearance as a prognostic biomarker in septic shock. design: prospective, observational pilot study. setting: intensive care unit. patients: patients admitted to the icu due to septic shock and multiorgan dysfunction. interventions: serum concentrations of procalcitonin were determined within 12h of onset of septic shock and multiorgan dysfunction (coinciding with admission to the icu), and the following extractions were obtained after 24, 48 and 72h in patients who survived. data collected: demographic data, acute physiology and chronic health evaluation ii score, and sequential organ failure assessment score, data on the primary focus of infection, and patient outcome (icu mortality). results: procalcitonin clearance was higher in survivors than in non-survivors, with significant differences at 24h (73.9 [56.4-83.8]% vs 22.7 [-331-58.4], p<0.05) and 48h (81.6 [71.6-91.3]% vs -7.29 [-108.2-82.3], p<0.05). the area under the roc curve was 0.74 (95%ci, 0.54-0.95, p<0.05) for procalcitonin clearance at 24h, and 0.86 (95%ci, 0.69-1.0, p<0.05) at 48h. conclusions: icu mortality was associated to sustained high procalcitonin levels, suggesting that procalcitonin clearance at 48h may be a valuable prognostic biomarker.
Síndrome de disfunción múltiple de órganos en neonatología: Comparación de dos períodos
Capelli,Carola; Salafia,Daniela; Bellani,Patricia; de Sarasqueta,Pedro;
Archivos argentinos de pediatr?-a , 2005,
Abstract: introduction. multiple organ system dysfunction (mosd) syndrome is an important cause of morbidity and mortality in pediatric and neonatal intensive care units. we studied the clinical course and the outcome of mosd in neonates admitted to a neonatal intensive care unit. our objective was to analyze the changes observed in the mosd in two different periods (1997-2002). population, material and methods. we prospectively evaluated two groups of 100 consecutive neonates admitted to the neonatal intensive care at the "hospital prof. dr. j. p. garrahan" between july 1st and december 31er 1997 (first period) and december 1st - july 31st 2002 (second period). organ system dysfunction was analyzed regarding its global rate, causes, presenting time, severity, compromise of different organs and intervening factors in its final outcome. we defined multiple organ system dysfunction as the failure of two or more systems or organs during a period longer than 24 hours. the dysfunction criteria for each organ were defined as in a previous study in order to compare both periods. results. we observed an increase in frequency (n= 60) but a lower mortality rate in the second period (15%) (p <0.05). there was a higher frequency of progression to organ dysfunction in congenital cardiac and digestive defects in the second period. a similar pattern of high frequency of progression and presentation of organ dysfunction after the admission was observed in both periods. mortality was related to the number of organ or systems affected. conclusions. there were important changes in multiple organ dysfunction in both periods. the frequency was higher and the mortality was lower in the second period. both periods showed a high frequency of progression or presentation of organ systemic dysfunction after admission. mortality was related to the number of organs and systems affected. a change in the definition of neonatal multiple organ systemic disfunction is proposed due to a probable overdiagnosis
Multiple organ dysfunction syndrome associated with Mycoplasma pneumoniae infection
Zhai, Shu-Bo;Cao, Dian-Bo;Xu, Hui-;Li, Xin-Xiang;Yang, Si-Rui;
Brazilian Journal of Microbiology , 2012, DOI: 10.1590/S1517-83822012000100025
Abstract: in this study, we report one case of a three-year-old boy infected with mycoplasma pneumonia (mp) and presenting concomitant multiple organ damage of the heart, kidney, lung and liver, among others, together with a brief review for the diagnosis and treatment of mp infection with multiple organ dysfunction syndrome (mods).
Síndrome pulmonar por hantavírus com disfun??o de múltiplos órg?os: relato de caso
Moreno, Marcelo Spegiorin;Castel?o, Ricardo Condi;Braga, Rodrigo Teno Castilho;Lobo, Suzana Margareth;
Revista Brasileira de Terapia Intensiva , 2007, DOI: 10.1590/S0103-507X2007000400016
Abstract: background and objectives: hantavirus infection is a zoonose with worldwide distribution. the transmission is related to the intimal contact with rodents. it causes two syndromes: hemorrhagic fever with renal syndrome (hfrs), endemic in asia and europe and the hantavirus pulmonary syndrome (hps), found in the american continent, including brazil, with high mortality rates. the aim of this study is to report a case of hps with multiple organ failure, managed with early goal-directed therapy guided by flow and tissue perfusion parameters. case report: a 36 year-old male had fever with progressive dispnea, severe hypoxia and acute respiratory failure. diffuse interstitial alveolar infiltrates were seen in the chest x-ray. he developed multiple organ dysfunction syndromes (pulmonary, renal, coagulation, cardiovascular and metabolic). treatment and invasive hemodynamic monitoring with pulmonary artery catheter was early instituted. the most important laboratory findings were thrombocytopenia, elevated hematocrit and hemoglobin concentrations, elevated liver enzymes, elevated lactate dehydrogenase and a positive sorology for hantavirus (elisa igm positive). organ dysfunctions reverted to normal and he was discharged after 21 days in hospital. conclusions: an early and adequate resuscitation with goal-directed therapy enabled the reversion of the multiple organ failure syndromes and a favorable outcome, despite the severity of the disease.
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