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Search Results: 1 - 6 of 6 matches for " Mulewu Ngandu Hypolitte "
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Risk Factors of Low Birth Weight in Mbujimayi City, Democratic Republic of Congo  [PDF]
Kanyiki Katala Moise, Banza Ndala Deca Blood, Mukendi Mukendi Jean René, Ciamala Mukendi Paul, Mukendi Ntumba Kennedy, Kaya Tompa Brigitte, Ilunga Bimpa Cedric, Kolela Kolela Alain, Mulewu Ngandu Hypolitte, Kabamba Nzaji Michel
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103501
The objective of this study was to identify and explain the factors influencing the birth of underweight children in the city of Mbuji-Mayi. Methods: This is not a paired case-control study of births registered from 1 to June 30, 2015 in maternity hospitals in three health zones selected for this study, cases are all children born with low weight and witnesses are all children born with a normal weight is 2500 g and more. The significance level was set at p < 0.05. Results: The proportion of LBW was 14.5%. The risk factors identified in this study are: Unmarried women [ORa = 2.92 (1.41 to 5.61)], not Luba Tribal origin [ORa = 1.71 (1.02 to 2.872)], anemia of pregnancy [ORa = 2.92 (1.79 to 4.75)], the non-attendance of the CPN [ORa = 1.92 (1.16 to 3.17)], preterm labor [ORa = 3, 11 (1.79 to 5.41)], diabetic mothers [ORa = 3.44 (1.91 to 6.21)], the history of malaria [ORa = 2 (1.23 to 3.26) ], multiparity [ORa = 2 (1.23 to 3.26)] and threatened abortion histories [ORa = 6.17 (2.82 to 13.52)] had statistical significantly associated with links é FPN.
Mutual Health Insurance and Access to Care in the Health Zone of Kabinda, Kasai-Oriental, Democratic Republic of Congo (DRC)  [PDF]
Cibangu Kazadi Richard, Bilonda Mpiana Alphonsine, Kabengele Mpinga Emmanuel, Mulewu Ngandu Hippolyte, Ciamala Mukendi Paul, Kanyiki Katala Moise, Kapitena Mangola Dominique, Tshimungu Kandolo Félicien
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103568
In the Democratic Republic of Congo, a large part of the population now lives in a context of extreme poverty and suffers from serious health problems. Deprived of social protection, these people see themselves therefore in the financial inability to access quality health care. This study aims to analyze the different characteristics of members of the mutual health insurance and compare with non-members. The following observations were made: Of those surveyed, 97.7% and 91.4% of members were not members resorted average 4 times to health services during the last 6 months prior to the survey, a statistically significant difference was observed (p = 0.027). The survey data showed that a significant proportion of members and non-members (62.5% vs 66.4%; p = 0.36) had resorted to self-medication. For non-members, the rate of self-medication and traditional therapy were higher. Lack of money is mentioned by members and non-members as a problem limiting access to health care (38.3% vs 69.5%; p < 0.0001).
Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission
Nobubelo K Ngandu, Cathal Seoighe, Konrad Scheffler
Virology Journal , 2009, DOI: 10.1186/1743-422x-6-164
Abstract: Here, we set out to determine the extent of adaptation of HIV-1 to three well-characterized HLA alleles during the initial exposure of the virus to the human cytotoxic immune responses following transmission from chimpanzee. We generated a chimpanzee consensus sequence to approximate the virus sequence that was initially transmitted to the human host and used a method based on peptide binding affinity to HLA crystal structures to predict peptides that were potentially targeted by the HLA alleles on this sequence. Next, we used codon-based phylogenetic models to quantify the average selective pressure that acted on these regions during the period immediately following the zoonosis event, corresponding to the branch of the phylogenetic tree leading to the common ancestor of all of the HIV-1 sequences. Evidence for adaptive evolution during this period was observed at regions recognised by HLA A*6801 and A*0201, both of which are common in African populations. No evidence of adaptive evolution was observed at sites targeted by HLA-B*2705, which is a rare allele in African populations.Our results suggest that the ancestral HIV-1 virus experienced a period of positive selective pressure due to immune responses associated with HLA alleles that were common in the infected human population. We propose that this resulted in permanent escape from immune responses targeting unconstrained regions of the virus.Phylogenetic analysis indicates that the human immunodeficiency virus type 1 (HIV-1) originated from simian immunodeficiency virus infecting chimpanzees (SIVcpz) through a chimpanzee-to-human zoonotic transmission [1-4]. Until recently [5], the natural hosts of the virus, the chimpanzee, have been thought to remain asymptomatic throughout infection despite high viral loads [6-8] In humans, however, an increase in viral load is usually associated with progression to the acquired immuno-deficiency syndrome (AIDS) and subsequently death [9-13]. The causes of the difference in
Hospital Hygiene Maternity Hospital Public Lubumbashi Democratic Republic of Congo  [PDF]
Kaj Fran?oise Malonga, Hendrick Lukuke Mbutshu, Jean-Jacques Lunda Ngandu, Mukengeshayi Abel Ntambue, Michel Makoutode
Open Journal of Preventive Medicine (OJPM) , 2017, DOI: 10.4236/ojpm.2017.74007
Abstract: Introduction: Public hospitals in the DRC are of significant disrepair, while there is a strong link between the failure of hospital hygiene and the incidence of nosocomial infections. We have conducted a study with the objective of evaluating the structural-functional conditions of hospital hygiene maternity wards of public hospitals in Lubumbashi. Methodology: It was a descriptive cross-sectional study and structural-functionalist whose population consisted of nurses responsible for 7 of 12 maternity hospitals which were selected based on the inclusion criteria. The observation with an observation guide and maintenance using a questionnaire we used to collect data. Results: The results showed that hospital hygiene conditions in maternity wards of public hospitals in Lubumbashi are not good because almost all maternity services and surgery are not always water in the taps (14.3%). The bins were a means for care units, no coding system exists to distinguish the type of waste. The medical waste are mixed and the other waste are burned in the open or in makeshift incinerator with other types of waste. Conclusion: These maternity wards have poor hygiene, staff responsible for this sector did not follow any training in this area. There is need to regulate the sector and train them.
Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences
Nobubelo K Ngandu, Konrad Scheffler, Penny Moore, Zenda Woodman, Darren Martin, Cathal Seoighe
Virology Journal , 2008, DOI: 10.1186/1743-422x-5-160
Abstract: We modelled site-to-site variation in the synonymous substitution rate across coding regions of the HIV-1 genome. Synonymous substitution rates were found to vary significantly within and between genes. Surprisingly, regions of the genome that encode proteins in more than one frame had significantly higher synonymous substitution rates than regions coding in a single frame. We found evidence of strong purifying selection pressure affecting synonymous mutations in fourteen regions with known functions. These included an exonic splicing enhancer, the rev-responsive element, the poly-purine tract and a transcription factor binding site. A further five highly conserved regions were located within known functional domains. We also found four conserved regions located in env and vpu which have not been characterized previously.We provide the coordinates of genomic regions with markedly lower synonymous substitution rates, which are putatively under the influence of strong purifying selection pressure at the nucleotide level as well as regions encoding proteins in more than one frame. These regions should be excluded from studies of positive selection acting on HIV-1 coding regions.Several statistical models of codon evolution have been developed and applied to protein-coding sequences from viral and other pathogens [1-4]. The primary application of these models has been the detection of evidence of diversifying selection acting on protein coding DNA sequences. Within maximum likelihood or Bayesian frameworks these models can be used to identify specific sites at which adaptive mutations have occurred. In the context of virus infections this information can be especially useful for identifying immune escape and drug resistance mutations [3,5,6].Positive selection is frequently inferred by comparing the rate of non-synonymous substitutions per non-synonymous site (dN) to the rate of synonymous substitutions per synonymous site (dS). The ratio of these two rates is often rep
Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo  [PDF]
Daddy Kabamba Numbi, Dophie Tshibuela Beya, Guelord Mukiapini Luzolo, Passy Kimena Nyota, Placide Cyanga Ngandu, Mamy Ngole Zita, Gustave Ilunga Ntita, Donatien Kayembe Nzongola-Nkasu, Jérémie Muwonga Masidi, Mireille Nganga Nkanga, Justin Mboloko Esimo, Arsène Mputu Lobota, Jean Bosco Kasiam Onkin, Baudouin Buassa-bu-Tsumbu, Cathy Ali Risasi, Fons Verdonck, Bernard Spitz, Jean Pierre Elongi Moyene
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.911145
Abstract: Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women; 65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age. All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations
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