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Search Results: 1 - 10 of 6985 matches for " Muhammad Zeeshan "
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Assessment of Rock Mass Quality and Deformation Modulus by Empirical Methods along Kandiah River, KPK, Pakistan  [PDF]
Mian Sohail Akram, Kamran Mirza, Muhammad Zeeshan, Muhammad Asad Jabbar
Open Journal of Geology (OJG) , 2018, DOI: 10.4236/ojg.2018.810057
Abstract: The pivotal aim of this study is to evaluate the rock mass characterization and deformation modulus. It is vital for rock mass classification to investigate important parameters of discontinuities. Therefore, Rock Mass Rating (RMR) and Tunneling quality index (Q) classification systems are applied to analyze 22 segments along proposed tunnel routes for hydropower in Kandiah valley, Khyber Pakhtunkhwa, Pakistan. RMR revealed the range of fair to good quality rocks, whereas Q yielded poor to fair quality rocks for investigated segments of the rock mass. Besides, Em values were acquired by empirical equations and computer-aided program RocLab, and both methods presented almost similar variation trend of their results. Hence, the correlations of Em with Q and RMR were carried out with higher values of the regression coefficient. This study has scientific significance to initially understand the rock mass conditions of Kandiah valley.
Demand and Response in Smart Grids for Modern Power System  [PDF]
Muhammad Qamar Raza, Muhammad Usman Haider, S. Muhammad Ali, Muhammad Zeeshan Rashid, Farooq Sharif
Smart Grid and Renewable Energy (SGRE) , 2013, DOI: 10.4236/sgre.2013.42016

Micro-grid plays a vital role in fulfilling the increasing demand by using distributed renewable energy resources. Demand and response technique can be broadly classified under the setup DR deployed (e.g. ISO’s/RTO’s). Demand response program can be implemented to improve power system quality, reliability and increasing demand. In modern power industry, strategic player can take more benefit from more emphasized DR study in terms of social benefit (uninterrupted power supply to consumers) and economy. This paper proposes the distributed micro-grid control and implemented control setup implemented demand response algorithm, which provides better power system reliability. This paper presents contingencies control demand and response for micro-grid. The main advantage of implementation of demand and response algorithms in Micro-grids provides reliable power supplies to consumers. The proposed micro-grid TCP/IP setup provides a chance to respond the contingencies to recover the shed to active condition. Micro-grid controller implements demand and response algorithm reasonable for managing the demand of the load and intelligent load scheme in case of blackout.

Qualitative and Quantitative Estimation of Hydroquinone in Skin Whitening Cosmetics  [PDF]
Saima Siddique, Zahida Parveen, Zeeshan Ali, Muhammad Zaheer
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.23042
Abstract: Hydroquinone has been used for decades as a skin lightening agent. Its use in cosmetics has been banned as a result of skin problems including contact dermatitis and ochronosis. A total of 22 samples of different skin whitening cosmetics were collected from local market. They were analyzed by using thin layer chromatography and HPLC for qualitative and quantitative determination of their hydroquinone contents. The hydroquinone was extracted from samples by using 96% ethanol and was subjected to TLC analysis. Eleven out of 22 samples were found to contain hydroquinone. The HPLC analysis showed the concentration of hydroquinone ranged from 0.002% to 0.092% in the cosmetic samples.
Homeobox leucine zipper proteins and cotton improvement  [PDF]
Muzna Zahur, Muhammad Ahsan Asif, Nadia Zeeshan, Sajid Mehmood, Muhammad Faheem Malik, Abdul R. Asif
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.410A3003

Transcription factors play key roles in plant development and stress responses through their interaction with cis-elements and/or other transcription factors. Homeodomain associated leucine zipper proteins (HD-Zip) constitute a family of transcription factors that are characterized by the presence of a DNA-binding domain closely linked with leucine zipper motif functioning in dimer formation. This type of association is unique to plants and considered as an excellent candidate to activate developmental responses to altering environmental conditions. Cotton is the most important fiber plant with a lot of local and commercial uses in the world. HD-Zip proteins not only have key roles in different stages of vascular and inter-fascicular fiber differentiation of cotton but also are suggested to have an important role against abiotic stress that is one of the key factors limiting cotton productivity. Plants have developed various strategies to manage stress conditions through a combination of metabolic, physiological and morphological adaptations. These adaptive changes rely largely on alterations in gene expression. Therefore, transcriptional regulators play a crucial role in stress tolerance. Being a transcription factor HD-Zip might be a useful target for genetic engineering to generate multiple stress tolerance in susceptible plants. In the following chapter, we discussed how the HD-Zip proteins would play a useful role for cotton development both in fiber production and stress adaptation.

Geotechnical Investigation and Prediction of Rock Burst, Squeezing with Remediation Design by Numerical Analyses along Headrace Tunnel in Swat Valley, Khyber Pakhtunkhwa, Pakistan  [PDF]
Mian Sohail Akram, Kamran Mirza, Muhammad Zeeshan, Muhammad Ali, Luqman Ahmed
Open Journal of Geology (OJG) , 2018, DOI: 10.4236/ojg.2018.810058
Abstract: This study illustrates the classification of the rock mass and evaluation of rock squeezing, rock burst potential, deformation modulus along the proposed tunnel alignment of small hydropower in Swat Valley, Khyber Pakhtunkhwa (KP), Pakistan. The field and laboratory studies were conducted to classify the rock mass by using geomechanical classification systems i.e. Rock Mass Rating (RMR), tunneling quality index (Q), Rock Mass Index (RMi). The empirical relations classified the ground as non-squeezing and minor to non-squeezing conditions, respectively. Whereas, other methods depict minor to medium bursting potential along chainage 1+000 to 4+000 m, while results along chainage 2+400 - 2+800 m present medium to high bursting potential. Furthermore, numerical analyses were carried out by RS3 for elastic and plastic conditions in order to assess the total displacement of each section in unsupported and supported conditions. The results gave maximum displacement along chainage 2+400 - 2+800 m (19.2 mm in unsupported and 16mm in supported condition) and minimum displacement along chainage 0+876 - 1+000 m (1.4 mm in unsupported and 1.3 mm in supported condition). Hence, the estimated support by empirical methods has been optimized by using numerical analyses for the stability of rock mass along the tunnel.
Influence of Seedling Age and Nitrogen Rates on Productivity of Rice (Oryza sativa L.): A Review  [PDF]
Muhammad Mahran Aslam, Muhammad Zeeshan, Ayesha Irum, Muhammad Umair Hassan, Saif Ali, Rashid Hussain, Pia Muhammad Adnan Ramzani, Muhammad Farhan Rashid
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.69135
Abstract: Rice is an important crop and the food security of the world is strongly associated with it as it is the staple food of half of the world’s population. Among various agro-management practices seedling age and nitrogen rates significantly affected its growth, development and yield components. Rice cultivars performed differently when transplanted in field at varying seedling ages depending upon their genetic makeup and adoptability to certain environmental conditions. Seedling age plays an important role in yield contributing parameters like number of productive tillers, panicle length, filled grains panicle-1 and 1000-kernel weight leading to higher paddy yield in different rice cultivars and hybrids. Nitrogen is required in huge quantity in rice production as it is an important constituent of plant parts and processes. Paddy yield increases significantly with the increase in nitrogen rate but after a certain limit yield starts decreasing. Keeping in view the significance of seedling age and nitrogen rates in different rice cultivars and hybrids, an effort has been made to review some research work already conducted and will be helpful to the researchers and scientists to plan future strategies.
Efficient Non-Viral Reprogramming of Myoblasts to Stemness with a Single Small Molecule to Generate Cardiac Progenitor Cells
Zeeshan Pasha, Husnain Kh Haider, Muhammad Ashraf
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023667
Abstract: The current protocols for generation of induced pluripotent stem (iPS) cells involve genome integrating viral vectors which may induce tumorgenesis. The aim of this study was to develop and optimize a non-viral method without genetic manipulation for reprogramming of skeletal myoblasts (SMs) using small molecules. Methods and Results SMs from young male Oct3/4-GFP+ transgenic mouse were treated with DNA methyltransferase (DNMT) inhibitor, RG108. Two weeks later, GFP+ colonies of SM derived iPS cells (SiPS) expressing GFP and with morphological similarity of mouse embryonic stem (ESCs) were formed and propagated in vitro. SiPS were positive for alkaline phosphatase activity, expressed SSEA1, displayed ES cell specific pluripotency markers and formed teratoma in nude mice. Optimization of culture conditions for embryoid body (EBs) formation yielded spontaneously contracting EBs having morphological, molecular, and ultra-structural similarities with cardiomyocytes and expressed early and late cardiac markers. miR profiling showed abrogation of let-7 family and upregulation of ESCs specific miR-290-295 cluster thus indicating that SiPS were similar to ESCs in miR profile. Four weeks after transplantation into the immunocompetent mice model of acute myocardial infarction (n = 12 per group), extensive myogenesis was observed in SiPS transplanted hearts as compared to DMEM controls (n = 6 per group). A significant reduction in fibrosis and improvement in global heart function in the hearts transplanted with SiPS derived cardiac progenitor cells were observed. Conclusions Reprogramming of SMs by DNMT inhibitor is a simple, reproducible and efficient technique more likely to generate transgene integration-free iPS cells. Cardiac progenitors derived from iPS cells propagated extensively in the infarcted myocardium without tumorgenesis and improved cardiac function.
Static Filtered Skin Detection
Rehanullah Khan,Zeeshan Khan,Muhammad Aamir
International Journal of Computer Science Issues , 2012,
Abstract: A static skin filter defines explicitly (using a number of rules) the boundaries the skin cluster has in a color space. Single or multiple ranges of threshold values for each color space component are created and the image pixel values falling within these range(s) for all the chosen color components are defined as skin pixels. In this paper, we investigate and evaluate static skin filters for skin segmentation. As a contribution, two new static skin filters for the IHLS and CIELAB color spaces are developed. The two new static filters and four state-of-the-art static filters in YCbCr, HSI, RGB and normalized RGB color spaces are evaluated on the two datasets DS1 and DS2, on the basis of F-measure. Experimental results reveal the feasibility of the developed static skin filters. We also found that since the static filters use static boundaries, any shift of skin color ranges from the static boundaries will result in varying performance. Therefore, the F-measure rankings of the color spaces are different for the datasets DS1 and DS2.
Reversal of Ischemic Cardiomyopathy with Sca-1+ Stem Cells Modified with Multiple Growth Factors
Ning Li, Zeeshan Pasha, Muhammad Ashraf
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093645
Abstract: Background We hypothesized that bone marrow derived Sca-1+ stem cells (BM Sca-1+) transduced with multiple therapeutic cytokines with diverse effects will induce faster angiomyogenic differentiation in the infarcted myocardium. Methods and Results BM Sca-1+ were purified from transgenic male mice expressing GFP. Plasmids encoding for select quartet of growth factors, i.e., human IGF-1, VEGF, SDF-1α and HGF were prepared and used for genetic modification of Sca-1+ cells (GFSca-1+). Scramble transfected cells (ScSca-1+) were used as a control. RT-PCR and western blotting showed significantly higher expression of the growth factors in GFSca-1+. Besides the quartet of the therapeutic growth factors, PCR based growth factor array showed upregulation of multiple angiogenic and prosurvival factors such as Ang-1, Ang-2, MMP9, Cx43, BMP2, BMP5, FGF2, and NGF in GFSca-1+ (p<0.01 vs ScSca-1+). LDH and TUNEL assays showed enhanced survival of GFSca-1+ under lethal anoxia (p<0.01 vs ScSca-1+). MTS assay showed significant increased cell proliferation in GFSca-1+ (p<0.05 vs ScSca-1+). For in vivo study, female mice were grouped to receive the intramyocardial injection of 15 μl DMEM without cells (group-1) or containing 2.5×105 ScSca-1+ (group-2) or GFSca-1+ (group-3) immediately after coronary artery ligation. As indicated by Sry gene, a higher survival of GFSca-1+ in group-3 on day4 (2.3 fold higher vs group-2) was observed with massive mobilization of stem and progenitor cells (cKit+, Mdr1+, Cxcr4+ cells). Heart tissue sections immunostained for actinin and Cx43 at 4 weeks post engraftment showed extensive myofiber formation and expression of gap junctions. Immunostaining for vWF showed increased blood vessel density in both peri-infarct and infarct regions in group-3. Infarct size was attenuated and the global heart function was improved in group-3 as compared to group-2. Conclusions Administration of BM Sca-1+ transduced with multiple genes is a novel approach to treat infarcted heart for its regeneration.
Advances in lignocellulosic biotechnology: A brief review on lignocellulosic biomass and cellulases  [PDF]
Tanzila Shahzadi, Sajid Mehmood, Muhammad Irshad, Zahid Anwar, Amber Afroz, Nadia Zeeshan, Umer Rashid, Kalsoom Sughra
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.53031

From the last few decades, there has been an increasing research interest in the value of lignocellulosic biomass. Lignoellulosic biomass is an inexpensive, renewable abundant and provides a unique natural resource for large-scale and cost-effective bio-energy collection. In addition, using lignocellulosic materials and other low-cost biomass can significantly reduce the cost of materials used for ethanol production. Therefore, in this background, the rapidly evolving tools of biotechnology can lower the conversion costs and also enhance a yield of target products. In this context, a biological processing presents a promising approach to converting lignocellulosic materials into energy-fuels. The present summarized review work begins with an overview on the physio-chemical features and composition of major agricultural biomass. The information is also given on the processing of agricultural biomass to produce industrially important enzymes, e.g., ligninases or cellulases. Cellulases provide a key opportunity for achieving tremendous benefits of biomass utilization.

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