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An Experience of Short-Term Results of Laparoscopic Inguinal Hernioplasty Using 3D Mesh in a Developing Country  [PDF]
Iqbal Saleem Mir, Alfer Ah Nafae, Aijaz Ahmed Malyar, Muntakhab Nafae, Yawar Watali, Mudasir Farooq, Shahnawaz Bashir Bhat, Sheikh Viqar
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.61010
Background: The experience of short term results of laparoscopic inguinal hernia repair using 3D mesh in a developing country is reviewed. Methods: From January 2012 to February 2014, 53 patients underwent laparoscopic inguinal hernioplasty. A retrospective case series of 53 consecutive patients undergoing TEP/TAPP by a single surgical team was followed prospectively with a focused physical examination and interview. 4 out of 53 patients had recurrent hernia following open repairs and 49 had primary hernias. Data collected included operative time, intraoperative bleeding, intraoperative difficulties, immediate postoperative pain, chronic groin pain, recurrence, sensory disturbance, activity or occupational limitation and personal satisfaction. Results: All the patients were male aged 32 to 75 years with a mean age of 53.5 years. Mean operative time was 37.4 minutes; intraoperative dissection, blood loss were less; and immediate postoperative pain was negligible as assessed by VAS. There was no mortality or major morbidity. Mean follow-up was 12 months (2 to 18 months). Follow-up was completed by interview and physical examination. Hernia was not found to recur during the follow up period. Chronic pain occurred in 2 patients (3.7%), which was mild in nature. Ninety-seven percent of patients were satisfied with their repair and would or had recommended TEP/TAPP to others using 3D Mesh. Conclusions: Short-term results of TEP/TAPP hernia repair using 3D mesh demonstrated to be an effective and safe procedure with low prevalence of chronic pain that is generally of a mild, infrequent nature. It was also concurred that there is decrease in operative time. Manipulation of mesh was significantly reduced. Intraoperative bleeding and use of post operative analgesia was reduced considerably. There was no recurrence, however the cost of the mesh increased the overall cost of the procedure acting as a limiting factor in a developing country.
Impact of Modification Made in Re-UCP on Software Effort Estimation  [PDF]
Mudasir Manzoor Kirmani, Abdul Wahid
Journal of Software Engineering and Applications (JSEA) , 2015, DOI: 10.4236/jsea.2015.86028
Abstract: This research work evaluates the performance of Re-UCP model and compares the results with the UCP and e-UCP method of software effort estimation. In this research work, an attempt has been made to highlight the accuracy of results by using MRE (Magnitude of Relative Error), MMRE (Mean Magnitude Relative Error), MdMRE (Median of Magnitude Relative Error) tools to check the error rate and PRED (20) and PRED (10) method to find out the predictability of accuracy of Re-UCP software effort estimation method. The observations made from the results are based on the comparison of Re-UCP, e-UCP and UCP models of software effort estimation.
Preliminary Studies on Plants with Anthelmintic Properties in Kashmir—The North-West Temperate Himalayan Region of India  [PDF]
Khurshid A. Tariq, Mudasir A. Tantry
Chinese Medicine (CM) , 2012, DOI: 10.4236/cm.2012.32017
Abstract: There is a growing interest in traditional uses of plants for health care among different communities especially in the developing countries. Kashmir valley is a temperate agro-climatic zone of north-west temperate Himalayan region of India and is blessed with a diverse variety of medicinal flora. The traditional uses of plants against parasitic infections in human beings and their live-stock is a common practice in the valley as most of the populations are rural and conventional veterinary drugs are very expensive and therefore unaffordable. This study is an ethno-botanical survey of those plant species traditionally used as anthelmintic that may warrant scientific validation for efficacy. The survey utilized well structured questionnaire and detailed discussions and recorded 44 plant species belonging to 37 genera and 26 families claimed as traditional anthelmintics in different preparations and forms. Out of these some plant species like Artemisia absinthium (tethwen) and Achillea millifolium (pahel-ghassa) were scientifically validated for their claimed anthelmintic action against gastrointestinal nematode infections in sheep. A few of other plants like Allium sativum (rohun), Myrsine africana have been scientifically validated for their claim by other people in various parts of the world. These plants together with other species reported in this study could be further scientifically evaluated for in vitro and in vivo anthelmintic activity against a diverse variety of parasitic groups in host and non host animals. That will lay a foundation and set a targeted platform for pharmacological studies and development of novel anthelmintic products to fill a gap in the anthelmintic drug industry, which is facing the crisis of anthelmintic resistance to conventional anthelmintic drugs.
Status and strategies in breeding for rust resistance in wheat  [PDF]
Mudasir Hafiz Khan, Asifa Bukhari, Zahoor Ahmad Dar, Syed Mudasir Rizvi
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.46042

Wheat along with rice and maize is fulfilling half of the calories demands of the world. Global Wheat production has increased tremendously since green revolution in 1960’s and helped in minimizing hunger and malnutrition. Developing countries, which consume 60% of the global wheat production, have shown a higher yield increase than the developed countries in the past [1]. It was driven by the hunger prevalence in these countries and was attributable to the introduction of high yielding and rusted resistant semi dwarf varieties developed under the collaborative efforts of International and National research systems during the last 50 years. Whereas, climate change and the emergence of new pests and diseases are threatening the food sustainability. The evolution of new races of disease pathogens like stem rust (Ug 99) is of serious concern. In order to feed the ever increasing population we have to increase wheat production at the rate 1.6% which can be achieved by developing high yielding varieties having a good tolerance level for biotic and abiotic stresses.

Mudasir Mohamad,Roheena Jan
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The matrix type Transdermal drug delivery system of aceclofenac was prepared by film casting technique employing mercury as the substrate. Stability studies for optimized formulations were carried out according to ICH guidelines. The optimized formulations were subjected to accelerated stability studies. Sufficient replicates of formulation were prepared, packed in aluminium foil and stored in petri dishes at temperature of 40± 0.5°C, 50± 0.5°C and 60± 0.5°C for 60 days. Samples were withdrawn at intervals of 15, 45 and 60 days and analyzed for drug content by HPLC method. The shelf life of formulations of aceclofenac were determined by accelerated stability studies on the basis of first order degradation kinetics and t0.9 (the time required to degrade 10 % of drug at 25°C). The shelf life was found to be 1.158yrs.
Breeding Strategies for Improving Rice Yield—A Review  [PDF]
Mudasir Hafiz Khan, Zahoor Ahmad Dar, Sher Ahmad Dar
Agricultural Sciences (AS) , 2015, DOI: 10.4236/as.2015.65046
Abstract: An increase in productivity is always one of the main goals of any crop breeding program including rice. However, many goals can be identified for this crop varying in importance from region to region, country to country, and even within a given country. Increase in grain yield potential is the major goal of almost all rice breeders programs. The major impacts are related to the development of new strategies to increase the genetic grain yield potential of the varieties. Rice breeders have been very successful in improving the crop. Some milestones are the contribution to the green revolution with the semi-dwarf varieties, the new rice plant type and hybrid rice. The main breeding method used to improve rice is the pedigree, but development of hybrids and population improvement are added to the breeder’s portfolio. Breeders have been taking advantage of biotechnology tools to enhance their breeding capacity; however, many programs are still struggling on how to integrate them into the breeding programs and how to balance the allocation of resources between conventional and modern tools.
Evaluating the Importance of Apoptotic Index, Mitotic Index and Turnover Index in Premalignant and Malignant Lesions of Cervix  [PDF]
Subhash Bhardwaj, Farooq Ahmed Wani
Open Journal of Pathology (OJPathology) , 2015, DOI: 10.4236/ojpathology.2015.52005
Abstract: Aim: To evaluate the premalignant and malignant lesions of the uterine cervix on light microscopy for apoptosis. To calculate and correlate the apoptotic index (AI), mitotic index (MI) and turnover index of the lesions. Materials and methods: A 2-year retrospective (November 2007 to October 2009) and 1-year prospective study (November 2009 to October 2010). A total of 95 cases of premalignant and malignant lesions of cervix were studied. The hematoxylin-eosin stained slides were screened for apoptosis under oil immersion lens. Apoptotic index (AI) was calculated as the number of Apoptotic cells and Apoptotic bodies, expressed as percentage of total no. of tumour cells counted in each case. Mitotic index (MI) was calculated by counting mitosis among 1000 tumour cells. Turnover index (TOI) was obtained by adding MI and AI, i.e., (TOI = MI + AI). After calculating, all these indices were correlated with different grades of the cervical lesions. Results: Premalignant lesions were divided into four subgroups. On statistical analysis, it was found that the difference in the apoptotic indices and turnover indices in all the four subgroups was not statistically significant. However for mitotic indices, significant statistical difference was found in Subgroup II (mild dysplasia vs. moderate dysplasia) with a p value of 0.03 and in subgroup IV (squamous metaplasia vs. moderate/severe dysplasia) with a p value of 0.0005. Within the malignant group, we compared well differentiated with less well differentiated subgroup. Statistical analysis revealed a significant difference in TOI between the two subgroups of malignant tumours (p = 0.04). Statistical comparison between premalignant and malignant group of lesions showed a highly significant difference between the AI, MI and TOI with p value of 0.0001. Conclusion: We conclude that proliferative and apoptotic indices are useful in distinguishing between benign and malignant lesions of the cervix. Proliferative activity of a lesion is a reliable indicator of its malignant potential and together with apoptotic count gives an idea about the net growth of a tumour.
Treating Schizophrenia with DOTS in Developing Countries: Author's Reply
Saeed Farooq
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040285
Leptochloa fusca cultivation for utilization of salt - affected soil and water resources in Cholistan Desert
Ahmad, Farooq;
Sociedade & Natureza , 2010, DOI: 10.1590/S1982-45132010000100010
Abstract: in the cholistan desert, 0.44 million hectares are salt - affected low lying and clayey in nature locally known as 'dhars', where rainwater as well as saline groundwater could be utilized for growing salt tolerant grasses like leptochloa fusca as forage during summer. l. fusca is a promising candidate grass for economic utilization and better management of sodic, high ph, saline soil and saline water resources of the cholistan desert. l. fusca is known to be a versatile, halophytic, primary colonizer, easily propagatable, perennial, nutritive and palatable forage plant species. the grass has the good biomass producing potential and can grow equally well both under upland and submerged saline soil environment.
Runoff farming in reducing rural poverty in Cholistan desert
Ahmad, Farooq;
Sociedade & Natureza , 2008, DOI: 10.1590/S1982-45132008000100012
Abstract: the proposed study strives to provide an overall picture for establishing a relationship of indigenous rainwater harvesting technology and its impact in poverty alleviation. the topographic form and the soil characteristics of cholistan is the best catchment area for rainwater harvesting. different profiles point out that the area is very poorly drained, capable of generating maximum runoff after absorbing minimum water. water intake characteristics of fine textured soils show that infiltration rate is low to very low. findings show that there is direct relationship between water availability and poverty reduction. study also sheds light on both strengths and limitations of the indigenous technology on reducing rural poverty and recommends using this technology along with modern water harvesting techniques.
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