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Prognostic Aspects of Lupus Nephritis at Aristide Le Dantec University Hospital in Dakar  [PDF]
Mbengue Mansour, Faye Maria, Cissé Mouhamadou Moustapha, Lemrabott Tall Ahmed, Fall Khodia, Keita Alex, Faye Moustapha, Ba Bakary, Diagne Seynabou, Keita Niakhaleen, Ba Mamadou Aw, Dieng Ameth, Motula Latou Lot, Niang Abdou, Diouf Boucar, Ka El Hadji Fary
Open Journal of Nephrology (OJNeph) , 2018, DOI: 10.4236/ojneph.2018.84014
Abstract: Introduction: Kidney injury is common in the course of lupus and affects the functional and vital prognosis. The risk of progression to end-stage renal failure can reach 40% to 60%. Thus we carried out this work for the purpose of an evaluation of the renal and vital prognosis and to deduce the factors of poor prognosis. Patients and method: This was a retrospective, descriptive and analytical study conducted over a period of 10 years from January 1, 2007 to December 31, 2016, performed in the Nephrology Department of Aristide Le Dantec Hospital in Dakar. Patients with lupus nephritis were included. The studied parameters were epidemiological, clinical, paraclinical and progression. We had done a crossover of the patients to look for the factors of poor renal and vital prognosis. Results: Out of 93 cases of lupus patients, 64 were included, a prevalence of 69%. The mean age of the patients was 31.97 ± 10.44 years old. There were 81% women and 19% men, a sex ratio of 0.23. Class III was found in 24 cases (37.5%), Class IV in 20 cases (31.25%), Class V in 15 cases (23.4%), Class II in 4 cases (6.25%) and Class I in 1 case (1.6%). The combination of corticosteroids and immunosuppressants was used in 56.25% of cases. After a follow-up of six months, 19 patients were in complete remission, 21 had resistance and 9 had partial remission. Of the 21 patients who had resistance, 8 were in chronic renal failure. Death was observed in 5 patients and the causes were in 3 patients: pulmonary embolism, bacterial meningitis and pulmonary tuberculosis. The cause of death was unknown in 2 patients. The factors of poor renal prognosis were lymphopenia, the presence of anti-native DNA antibodies, nephrotic syndrome, microscopic hematuria, tubular atrophy and interstitial fibrosis. Risk factors affecting renal survival were the presence of native anti-DNA antibodies, microscopic hematuria, leukocyturia and the presence of a proliferative class. The factors of poor prognosis were renal failure, lymphopenia, nephrotic syndrome, glomerular sclerosis, arteriosclerosis, interstitial infiltration and tubular atrophy. Conclusion: The risk conferred by nephropathy is greater for proliferative glomerulonephritis; it is also correlated with the presence of persistent nephrotic syndrome or severe renal failure.
Flexofytol, a Purified Curcumin Extract, in Fibromyalgia and Gout: A Retrospective Study  [PDF]
Thierry Appelboom, Christian Mélot MsciBiost
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2013, DOI: 10.4236/ojra.2013.32015

Flexofytol is a recently-purified curcumin extract administered as a food supplement with the indication for being “able to improve musculoskeletal flexibility and preserve articular function”. It is now marketed in Belgium, frequently used with success in daily clinical practice according to pharmacists, and also prescribed by general practitioners and rheumatologists for various painful conditions. The objective of this retrospective study was to evaluate the potential efficacy of the compound in fibromyalgia and gout from our practice from 2011-2012. Accordingly, the medical files of 116 patients (83 with a follow-up of 1 to 12 months) with fibromyalgia or gout who were treated with Flexofytol were analysed to determine whether they had benefited from this therapy or had experienced undesirable effects. Flexofytol provided a benefit in acute gout crisis and fibromyalgia. Interestingly, the clinical improvement was rapid (within 24 - 48 h), with good efficacy in gout. The benefit of Flexofytol was on different manifestations of pain rather than on the sleep disorders of fibromyalgia. Except for some occasional difficulties with tablet swallowing and transient diarrhoea, the treatment was well tolerated. In conclusion, Flexofytol appears to be an alternative to conventional treatment for fibromyalgia and gout.

Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis  [PDF]
Jiangang Qu, Christian Mélot, Thierry Appelboom
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2015, DOI: 10.4236/ojra.2015.54018
Abstract: To evaluate the potential benefit of Synofit—an association of Curcumin, Perna canaliculus green-mussels and blackcurrant leaf extracts, a real life open study was performed among 86 adult out patients suffering from Fibromyalgia (n = 22), low back pain (n = 33) or knee osteoarthritis (n = 31) who accepted to take 3 tablets a day during 1 week then 2 capsules of Synofit during 2 months in addition to their conventional therapy (mainly analgesics and anti-inflammatory) and then to report their evaluation of this complementary treatment. Statistical analysis included paired t test and when possible Wilcoxon signed rank test. Accordingly, the intermediate analysis showed that already within 4 weeks of treatment, an improvement quoted as “light” was statistically reported in patients with low back pain and knee osteoarthritis but not among those with fibromyalgia on pain, physical condition, global assessment of a benefit, quality of life but not on joint stiffness (although joint stiffness considered for the whole group was statistically improved). The limited number of patients and time duration of the study and the absence of double blind controlled study do not allow concluding on the efficacy but these preliminary analyses obtained from an intermediate analysis are encouraging for further studies.
Synofit Premium in Refractory Low Back Pain: A Retrospective Observational Study  [PDF]
Jiangan Qu, Christian Mélot, Thierry Appelboom
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2017, DOI: 10.4236/ojra.2017.72011
Abstract: In this retrospective observational study, information about pain and quality of life was collected for analysis from medical records of 85 patients with chronic low back pain who were treated for 3 months with Synofit? Premium (2 - 3 capsules daily), a liquid mixture of green-lipped mussel from New Zealand, blackcurrant leaf, and curcuma extract. Within the first 6 weeks of therapy, a significant clinical benefit was observed for relief from pain, need for pain-relieving drugs, and the interference of pain with personal care and lifting. This benefit was more pronounced at 3 months. The mixture was well tolerated without significant side effects. Adherence was estimated to be “good” to “very good.” Patients assessed global improvement and efficacy as “sufficient” to “good.” Based on this study, the mode of action of Synofit? Premium appears mainly to be analgesic, as reported by patients, and allows them to reduce the consumption of other pain-relieving substances and improve their quality of life. In conclusion, Synofit? Premium holds potential as a promising candidate alternative therapy for relief of low back pain and likely other painful rheumatic conditions, with almost no or minor side effects.
Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes  [PDF]
Anissa Messaaoui, Sylvie Tenoutasse, Christian Mélot, Harry Dorchy
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.41009

Background: Increased glomerular filtration rate (GFR) commonly develops in early diabetes and is closely correlated with the development of diabetic nephropathy. Objective: The aim was to study the relationship between GFR, C-peptide level and other parameters at diagnosis of Type 1 diabetes. Methods: We determined GFR, Cpeptide level, glycated hemoglobin (HbA1c), body mass index (BMI) SDS and loss of weight at diagnosis of Type 1 diabetes in 495 children (231 females). Linear and multiple regression analysis was used to test for the associations between GFR and other parameters. Results: In the 495 patients, GFR median (interquartile range) was increased vs normal values (p = 0.0001). GFR was significantly negatively correlated with age (p < 0.001) and C-peptide level (p = 0.001), and positively correlated with weight loss (p = 0.02). The multiple regression analysis showed that age (p = 0.001) and C-peptide level (p = 0.05) were independently and negatively related to GFR. Conclusions: This study shows that, at onset of Type 1 diabetes, higher the GFR, younger the age and lower the C-peptide level are. The role of this hyperfiltration in the development of later nephropathy and the putative preventive effect of C-peptide administration need to be evaluated.

Information and Communication Technologies and Poverty Reduction in Developing Countries : the Case of Sub Saharan Africa countries
Lot Tcheeko,Marcellin Ndong Ntah
Journal of Systemics, Cybernetics and Informatics , 2006,
Abstract: There is a growing interest in using Information and Communication Technologies (ICTs) to support poverty reduction efforts and strategies in the framework of the Millennium Development Goals (MDGs). These interest ended up revealing how much the Poverty Reduction Strategy Papers (PRSPs) of many african nations have underestimated the importance of ICTs as a development tool. The fact that so little was mentionned about the use of ICTs for poverty alleviation and creation of employment highlighted the confusion, and uncertainty of decision makers. At the country level, ICT is still to be effectively integrated into national poverty alleviation and development strategies. The question then is how ICTs can help achieve those objectives. How can ICTs be used as tools to fight against poverty? Poverty is widely recognized as multidimensional, encompassing food security, health, education, rights, security and dignity, amongst others as stressed by Bachelor and al in a model showing the intricate linkages between ICTs and most PRSP goals. The link between ICTs and poverty reduction strategy is therefore not that obvious. Although, researchers and development partners involved in poverty alleviation recognize more easily the linkage between ICT and poverty reduction strategies. In any case, it is a prerequisite to have a conducive environment and country readiness for ICTs implementation. Unfortunately, in many Sub-Saharan Africa countries, there is not yet a clear and effective policy and strategy for the use of ICT.
Digenes: genetic algorithms to discover conjectures about directed and undirected graphs
Romain Absil,Hadrien Mélot
Computer Science , 2013,
Abstract: We present Digenes, a new discovery system that aims to help researchers in graph theory. While its main task is to find extremal graphs for a given (function of) invariants, it also provides some basic support in proof conception. This has already been proved to be very useful to find new conjectures since the AutoGraphiX system of Caporossi and Hansen (Discrete Math. 212-2000). However, unlike existing systems, Digenes can be used both with directed or undirected graphs. In this paper, we present the principles and functionality of Digenes, describe the genetic algorithms that have been designed to achieve them, and give some computational results and open questions. This do arise some interesting questions regarding genetic algorithms design particular to this field, such as crossover definition.
On price of symmetrisation
Absil Romain,Hadrien Mélot
Computer Science , 2013,
Abstract: We introduce the price of symmetrisation, a concept that aims to compare fundamental differences (gap and quotient) between values of a given graph invariant for digraphs and the values of the same invariant of the symmetric versions of these digraphs. Basically, given some invariant our goal is to characterise digraphs that maximise price of symmetrisation. In particular, we show that for some invariants, as diameter or domination number, the problem is easy. The main contribution of this paper is about (partial) results on the price of symmetrisation of the average distance. It appears to be much more intricate than the simple cases mentioned above. First, we state a conjecture about digraphs that maximise this price of symmetrisation. Then, we prove that this conjecture is true for some particular class of digraphs (called bags) but it remains open for general digraphs. Moreover, we study several graph transformations in order to remove some configurations that do not appear in the conjectured extremal digraphs.
Autoimmune Thyroid, Celiac and Addison’s Diseases Related to HLA-DQ Types in Young Patients with Type 1 Diabetes in Belgium  [PDF]
Anissa Messaaoui, Sylvie Tenoutasse, Bart Van der Auwera, Christian Mélot, Harry Dorchy
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2012, DOI: 10.4236/ojemd.2012.24011
Abstract: Objective: To define the prevalence of auto antibodies (Ab) to different organs in young patients with type 1 diabetes (type 1DM). Methods: Ab to thyroid, celiac and adrenal disease was analyzed in 831 type 1 DM patients. Results: Hundred twenty-three (14.8%) had positive thyroid Ab. The risk of developing thyroid Ab was increased in girls (HR 2.3; 95% CI 1.6 - 3.2, p < 0.0001). Thirty-three (3.9%) patients had positive endomysium Ab (3.1% in girls and 3.5% in boys, p = NS). Adrenal Ab was detected in 5 patients. The DQA1*0301-DQB1*0301 haplotype was more prevalent in patients with thyroid Ab (p = 0.0281); DQA1*301-DQB1*302 and DQA1*501-DQB1*201 in patients with endo- mysium Ab (p = 0.0251 and p < 0.0001). All patients with adrenal Ab were DQA1*301-DQB1*302 positive. Conclusions: Type 1D patients should be screened annually for thyroid autoimmunity and celiac disease. The DQA1*0301-DQB1*0301 haplotype seems to confer susceptibility to thyroid autoimmunity, DQA1*301-DQB1*302 and DQA1*501-DQB1*201 to celiac disease and DQA1*301-DQB1*302 to adrenal autoimmunity.
Objective and subjective evaluation of an advanced motorcycle riding simulator
Vittore Cossalter,Roberto Lot,Stefano Rota
European Transport Research Review , 2010, DOI: 10.1007/s12544-010-0041-2
Abstract: The development work done by University of Padova provides an innovative and reliable tool for the validation of a motorcycle riding simulator.
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