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Search Results: 1 - 10 of 898 matches for " Montserrat Baiget "
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Molecular Detection of Peripheral Blood Breast Cancer mRNA Transcripts as a Surrogate Biomarker for Circulating Tumor Cells
Adriana Lasa, Arnal Garcia, Carmen Alonso, Pilar Millet, Mónica Cornet, Teresa Ramón y Cajal, Montserrat Baiget, Agusti Barnadas
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074079
Abstract: Circulating tumor cells (CTCs) are becoming a scientifically recognized indicator of primary tumors and/or metastasis. These cells can now be accurately detected and characterized as the result of technological advances. We analyzed the presence of CTCs in the peripheral blood of patients with metastatic breast cancer by real-time reverse-transcription PCR (RT-qPCR) using a panel of selected genes. The analysis of a single marker, without an EpCAM based enrichment approach, allowed the positive identification of 35% of the metastatic breast cancer patients. The analysis of five genes (SCGB2, TFF1, TFF3, Muc1, KRT20) performed in all the samples increased the detection to 61%. We describe a sensitive, reproducible and easy to implement approach to characterize CTC in patients with metastasic breast cancer.
Servei d'alerta d'informació NewsAgent
Baiget, Clara
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2001,
Abstract: S exposa l experiència NewsAgent for library and information professionals, un servei de difusió selectiva de la informació (DSI) dirigit als professionals del món de la biblioteconomia i la documentació, per posar-los al dia amb notícies del seu interès. També es mostra l origen i els objectius del servei, la planificació i el desenvolupament i es fa un balan del funcionament.
The NewsAgent alerting service
Baiget, Clara
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2001,
Abstract: S exposa l experiència NewsAgent for library and information professionals, un servei de difusió selectiva de la informació (DSI) dirigit als professionals del món de la biblioteconomia i la documentació, per posar-los al dia amb notícies del seu interès. També es mostra l origen i els objectius del servei, la planificació i el desenvolupament i es fa un balan del funcionament.
25 a os de teledocumentación en Espa a
Baiget, T.
Revista Espa?ola de Documentación Científica , 1998,
Abstract: November 1998 commemorates the 25th anniversary of the installation of the first Spanish terminal for online information retrieval. The author remembers some historic data and analyses the evolution of this technology that arrived to Spain through two separated actions: One leaded in 1973 by INTA (National Institute of Aerospace Technology), depending on the Ministry of Air (currently integrated in Defense) and CIDC (Consortium of Information and Documentation of Catalonia), with the economic support of FUNDESCO (Foundation for the Development of the Social Function of the Communications), depending on Telefónica. The other one was leaded in 1975, by CID (Information and Documentation Centre), currently CINDOC (Scientific Information and Documentation Centre), of the CSIC (Higher Council for Scientific Research). Finally the evolution of the hosts and the progressive vanishing of the classical online technologies in the new internet context is commented. En noviembre de 1998 se han cumplido 25 a os de la instalación del primer terminal de teledocumentación o de acceso en línea a bases de datos en nuestro país. El autor recuerda algunos datos históricos y analiza el desarrollo y evolución de esta tecnología, cuya entrada en Espa a tuvo lugar por dos acciones separadas: Una llevada a cabo en 1973 por el INTA (Instituto Nacional de Técnica Aeroespacial), del entonces Ministerio del Aire (actualmente integrado en Defensa) y el desaparecido CIDC (Consorcio de Información y Documentación de Catalunya) con la ayuda de FUNDESCO (Fundación para el Desarrollo de la Función Social de las Comunicaciones) de Telefónica, en 1973. Y otra en 1975, por el CID (Centro de Información y Documentación), actualmente CINDOC (Centro de Información y Documentación Científica), del CSIC (Consejo Superior de Investigaciones Científicas). Finalmente se comenta la evolución de los hosts y la progresiva disolución de las técnicas en línea clásicas en el nuevo contexto de internet.
Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study
Jose Perez de los Cobos, Montserrat Baiget, Joan Trujols, Nuria Sinol, Victor Volpini, Enrique Banuls, Francesc Calafell, Elena Luquero, Elisabeth del Rio, Enric Alvarez
Behavioral and Brain Functions , 2007, DOI: 10.1186/1744-9081-3-25
Abstract: We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients (207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects (98 males and 47 females).The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls (P = 0.011, odds ratio = 5.48, 95% CI 1.26–23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls (24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07–2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender (odds ratio = 1.77, 95% CI 1.15–2.70).Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males.A better understanding of the etiology of heroin dependence is crucial for improving the prevention and treatment of this severe mental disorder. Genes that could be risk factors for heroin dependence have not been consistently identified; however, genetic epidemiology studies have shown that they do have an impact. These studies, with one exception [1], also suggest that such genetic factors are mainly nonspecific, because they also confer vulnerability to other substance use disorders (SUD) [2-4].The gene coding for the dopamine receptor D2 (DRD2) could be involved in heroin dependence and other SUD as a nonspecific genetic factor, because opioids and other substances of abuse induce some of their rewarding effects through the mesolimbic dopamine system [5,6]. Preclinical research supports this hypothesis. An absence of opioid-rewarding effects has been reported in mice lacking DRD2 [7].The DRD2 TaqI A is a SNP with two variants: A1, the less frequent allele, and A2. The A1 allele is associated with a reduction in the density of D2 receptors at the str
Three novel and the common Arg677Ter RP1 protein truncating mutations causing autosomal dominant retinitis pigmentosa in a Spanish population
María Gamundi, Imma Hernan, María Martínez-Gimeno, Miquel Maseras, Blanca García-Sandoval, Carmen Ayuso, Guillermo Anti?olo, Montserrat Baiget, Miguel Carballo
BMC Medical Genetics , 2006, DOI: 10.1186/1471-2350-7-35
Abstract: Denaturing gradient gel electrophoresis (DGGE) analysis and direct genomic sequencing were used to evaluate the 5' coding region of exon 4 of the RP1 gene for mutations in 150 unrelated index adRP patients. Ophthalmic and electrophysiological examination of RP patients and relatives according to pre-existing protocols were carried out.Three novel disease-causing mutations in RP1 were detected: Q686X, K705fsX712 and K722fsX737, predicting truncated proteins. One novel missense mutation, Thr752Met, was detected in one family but the mutation does not co-segregate in the family, thereby excluding this amino acid variation in the protein as a cause of the disease. We found the Arg677Ter mutation, previously reported in other populations, in two independent families, confirming that this mutation is also present in a Spanish population.Most of the mutations reported in the RP1 gene associated with adRP are expected to encode mutant truncated proteins that are approximately one third or half of the size of wild type protein. Patients with mutations in RP1 showed mild RP with variability in phenotype severity. We also observed several cases of non-penetrant mutations.Retinitis pigmentosa (RP) is a common inherited retinopathy that affects more than one million people worldwide. Clinical findings in RP include night blindness, loss of peripheral vision and progressive degeneration of the retina that usually culminates in severe visual impairment or complete blindness [1]. The disease is characterized by abnormal or absent responses on electroretinography (ERG) and is associated with retinal atrophy, bone spicule-like pigmentary deposits and attenuation of retinal vessels. RP can be inherited in autosomal dominant, autosomal recessive, X linked [2-5] or digenic forms [6]. Several genes have been identified by linkage studies or candidate gene screening for each of these RP types [7] , although the majority remain unknown [8]. Autosomal dominant retinitis pigmentosa (adRP) ac
Morfologia verbal aranesa: les desinències de l'imperfet d'indicatiu
Aitor Carrera i Baiget
Llengua & Literatura , 2005, DOI: 10.2436/l&l.vi.1162
Abstract:
ICSEP 2004. II Taller Latinoamericano: Recursos y posibilidades de la publicación electrónica
Baiget, Tomás
Revista Espa?ola de Documentación Científica , 2004,
Abstract:
Online Information
Baiget, Tomás
Revista Espa?ola de Documentación Científica , 2002,
Abstract:
The impact of information on society (Michael W. Hill)
Baiget, Tomás
Revista Espa?ola de Documentación Científica , 2001,
Abstract:
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