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Search Results: 1 - 10 of 411263 matches for " Mohammed S. T. Makki "
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Synthetic Approach for Novel Fluorine Substituted α-Aminophosphonic Acids Containing 1,2,4-Triazin-5-One Moiety as Antioxidant Agents  [PDF]
Mohammed S. T. Makki, Reda M. Abdel-Rahman, Abdulrahman S. Alharbi
International Journal of Organic Chemistry (IJOC) , 2018, DOI: 10.4236/ijoc.2018.81001
Abstract: Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2-amino-5-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (1) followed by ammonilysis to give the corresponding 3-amino-derivative 3. Condensation of compound 3 with nitro/halogenated aromatic aldehydes yielded the Schiff bases 4. The simple addition of diethyl phosphonate to compound 4 produced the α-amino phosphonates 5. Acidic hydrolysis of compound 5 produced the fluorine substituted α-amino acids derivatives 6. Structures of the new compounds have been established with the help of elemental analysis and spectral measurements. Also, the products evaluated as antioxidants, where the fluorinated α-amino phosphonic acids 6 are more active than the other synthesized systems.
Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents  [PDF]
Mohammed S. T. Makki, Dina A. Bakhotmah, Reda M. Abdel-Rahman
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.21009
Abstract: Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.
Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Amino Phenyl)-3-Thioxo-1,2,4-Triazin-5(2H, 4H)One and Their Related Alkylated Systems as Molluscicidal Agent as against the Snails Responsible for Bilharziasis Diseases  [PDF]
Abeer N. Al-Romaizan, Mohammed S. T. Makki, Reda M. Abdel-Rahman
International Journal of Organic Chemistry (IJOC) , 2014, DOI: 10.4236/ijoc.2014.42017
Abstract: New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazin-3,5-Dionne (20) derivatives obtained. Structures of the new products are established by elemental and spectral data. The new targets obtained screened as Molluscicidalagents against Biomophlaria Alexandrina snails responsible for Bilharziasis diseases, in compare with Baylucide as standard drug.
Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity  [PDF]
Reda M. Abdel-Rahman, Mohammed S. T. Makki, Abeer N. Al-Romaizan
International Journal of Organic Chemistry (IJOC) , 2014, DOI: 10.4236/ijoc.2014.44028
Abstract: Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with π-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by MS, IR, UV-VIS, CH, N, and 1H/13CNMR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.
Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitriles and the Related Derivatives as Photochemical Probe Agents for Inhibition of Vitiligo Disease  [PDF]
Mohammed S. T. Makki, Dina A. Bakhotmah, Reda M. Abdel-Rahman, Mohammed S. El-Shahawy
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.223043
Abstract: A new biocidal agents fluorine substituted-3-thioxopyrimidine-5-carbonitriles (2-9) and/or the related fluorine substi- tuted pyrimido (4,5-d) pyrimidines (10-14) were synthesized by the cycloaddition of fluorinated β- arylidine malo- nonitriles (1a-c) followed by a nucleophilic attack against α,β-bifunctional reagents in different conditions. Structures of the fluorine targets were characterized by their elemental analysis and spectral data (UV, IR, 1H NMR, 13C NMR and mass measurements) and further evaluated as photochemical probe for inhibition of Vitiligo, it was found that compounds 5, 9, 11 and 12 exhibited high potency over the investigated compounds.
Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents
Mohammed Saleh I. T. Makki,Reda M. Abdel-Rahman,Hassan M. Faidallah,Khalid Ali Khan
Journal of Chemistry , 2013, DOI: 10.1155/2013/862463
Abstract:
Microstructural Evaluation and Mechanical Properties of an Al-Zn-Mg-Cu-Alloy after Addition of Nickel under RRA Conditions  [PDF]
Haider T. Naeem, Kahtan S. Mohammed
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.411088
Abstract:

The effects of nickel in improving the mechanical properties and microstructural of Al-Zn-Mg-Cu alloys produced by semi-direct chill casting were investigated. Aluminium alloys were homogenized at different temperatures conditions, which aged at 120°C for 24 h (T6 temper), and retrogressed at 180°C for 30 min and then re-aged at 120°C for 24 h (RRA). The results of the microstructural analyses showed that with adding nickel to aluminium alloy, nickel-rich dispersoid particles were formed, such as Al7Cu4Ni, Al4Ni3, Al75Ni10Fe15, Al3Ni2, and Al50Mg48Ni7. Intermetallics compounds within the matrix alloy led to dispersion and fine-grain mechanisms which prevent the recrystallization and grain growth. Enhancement of mechanical properties of the alloys study is obtained through the precipitation hardening of alloying elements of the base alloy besides Ni-bearing dispersoid particles. The microstructure of these alloys were examined through optical and scanning electron microscopy along with energy dispersive X-ray and X-ray

Exploration, Characterization and Phylogenetic Studies in Wild Mangifera indica Relatives  [PDF]
Makki Ramachandra Dinesh, Kundapura Venkataramana Ravishankar, P. Nischita, B. S. Sandya, B. Padmakar, S. Ganeshan, R. Chithiraichelvan, T. V. R. S. Sharma
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.613217
Abstract: Exploratory surveys were carried out in the Andamans and Nicobar group of islands during 2006 and 2014 to locate wild species viz. Mangifera andamanica King, Mangifera camptosperma Pierre and Mangifera griffithii Hook. Not much variation was observed for fruit shape and size for the species Mangifera andamanica, which was endemic to this region. The species M. griffithii has been reported to be only in Mt. Harriet. However, another plant of M. griffithii in the Shoalbay region was found during the second survey. The foliage & fruit characteristics of the two specimens were similar, with a slight difference in the morphological features, which could be attributed to their origin from seeds. The DNA finger printing carried out showed minor changes in the species. The phylogenetic relationships amongst five Mangifera species viz. M. indica, M. griffithii, M. camptosperma, M. odorata and M. andamanica were analyzed by employing chloroplast markers viz., petB-petD intergenic spacer, rps16 gene, trnL-trnF intergenic spacer and nuclear marker—External Transcribed Spacer (ETS). The nuclear markers and chloroplast markers based on phylogenetic analysis showed that the common mango M. indica L. was closely related to M. griffithii and M. camptosperma, which belonged to subgenus Mangifera. However, M. odorata
Synthesis of New Bioactive Sulfur Compounds Bearing Heterocyclic Moiety and Their Analytical Applications
Mohammad. S. T Makki,Reda. M.Abdel-Rahman,Mohammad.S. El-Shahawi
International Journal of Chemistry , 2011, DOI: 10.5539/ijc.v3n1p181
Abstract: Some new bioactive sulfur compounds bearing heterocyclic nitrogen moieties such as 3- imino –2-thioxo-4,5-dihydro- thiazolidin – 4-one (3), 3-imino – 2-thioxo -3,4,5,6-tetrahydro-1, 3-thiazine-4, 6- (2 H)dione (4), N- substituted – pyrazol -3,5-dione (10) , 1,3 –disubstituted -2-thioxo-pyrimidin-4,6 –dione (11) and di –(3, 5-diaminopyrazolin-1-yl)thioketone (13) derived from dithioc formic acid hydrazide (1) and thiocarbohydrazide (7) were prepared via condensation of compound 1 or 7 with acyclic and cyclic oxo compounds (e.g. aldehydes and ketones) in 1:1 and 1:2 molar ratios, and addition of iso thiocyanate or treatment with active methylene compounds followed by ring closing reactions in different media (Schemes I & II). The biocidal effect of some compounds towards some bacteria and fungi was evaluated. Compound 4 was used as selective chelating agent for spectrophotometric determination of mercury (II) ions. The limit of detection (LOD) and quantification (LOQ) of the developed spectrophotometric method were found to be equal to 0.16 and 0.52 μg mL-1 mercury (II), respectively. Compound 4 was also physically immobilized onto polyurethane foam (PUFs) and was successfully used as solid sorbent in packed column for removal of mercury (II) ions from wastewater.
4-(3-Methyl-4,5-dihydro-1H-benzo[g]indazol-1-yl)benzenesulfonamide
Abdullah M. Asiri,Hassan M. Faidallah,Abdulrahman O. Al-Youbi,Mohamad S. I. T. Makki
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811033186
Abstract: In the title compound, C18H17N3O2S, the aromatic ring bearing the sulfamide unit is aligned at 61.65 (1)° with respect to the pyrrole ring; its amino group forms N—H...N and N—H...O hydrogen bonds to neighboring molecules, generating sheets in the ac plane.
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