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Search Results: 1 - 10 of 465992 matches for " Mohammed A. Junaid "
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Classification Using Two Layer Neural Network Back Propagation Algorithm  [PDF]
K. A. Mohamed Junaid
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.78104
Abstract: Worldwide breast cancer is the most common form of cancer death occurring in 12.6% of women. This paper presents a cost effective approach to classify the normal, malignant and benign tumor using two layer neural network back propagation algorithm. Back propagation algorithm is used to train the neural network. Parallelization techniques speed up the computation process and as a result two layer neural networks outperform the previous work in terms of accuracy. Breast cancer tumor database used for the testing purpose is from the CIA machine learning repository. The highest accuracy of 97.12% is achieved using the two layer neural network back propagation algorithm.
Microarray Analysis Reveals Higher Gestational Folic Acid Alters Expression of Genes in the Cerebellum of Mice Offspring—A Pilot Study
Subit Barua,Salomon Kuizon,Kathryn K. Chadman,W. Ted Brown,Mohammed A. Junaid
Brain Sciences , 2015, DOI: 10.3390/brainsci5010014
Abstract: Folate is a water-soluble vitamin that is critical for nucleotide synthesis and can modulate methylation of DNA by altering one-carbon metabolism. Previous studies have shown that folate status during pregnancy is associated with various congenital defects including the risk of aberrant neural tube closure. Maternal exposure to a methyl supplemented diet also can alter DNA methylation and gene expression, which may influence the phenotype of offspring. We investigated if higher gestational folic acid (FA) in the diet dysregulates the expression of genes in the cerebellum of offspring in C57BL/6 J mice. One week before gestation and throughout the pregnancy, groups of dams were supplemented with FA either at 2 mg/kg or 20 mg/kg of diet. Microarray analysis was used to investigate the genome wide gene expression profile in the cerebellum from day old pups. Our results revealed that exposure to the higher dose FA diet during gestation dysregulated expression of several genes in the cerebellum of both male and female pups. Several transcription factors, imprinted genes, neuro-developmental genes and genes associated with autism spectrum disorder exhibited altered expression levels. These findings suggest that higher gestational FA potentially dysregulates gene expression in the offspring brain and such changes may adversely alter fetal programming and overall brain development.
Optimization of Chassis of an All Terrain Vehicle
D.Nagarjuna,Junaid Mohammed Farooq,,A.S.N.Saiteja,,P.Siddhartha Sri Teja
International Journal of Innovative Technology and Exploring Engineering , 2013,
Abstract: In the case of vehicles, the term chassis means the frame plus the running gear like engine, transmission, driveshaft, differential, and suspension. An all-terrain vehicle (ATV), also known as a quad, quad bike, three-wheeler, or four-wheeler, is defined by the American National Standards Institute (ANSI) as a vehicle that travels on low pressure tires, with a seat that is straddled by the operator, along with handlebars for steering control. As the name implies, it is designed to handle a wider variety of terrain than most other vehicles. This paper deals with design of chassis frame for an All Terrain Vehicle and its Optimization. Various loading tests like Front Impact, Rear Impact, Side Impact, Roll over test etc have been conducted on the chassis and the design has been optimized by reducing the weight of the chassis.
A Critical Tryptophan and Ca2+ in Activation and Catalysis of TPPI, the Enzyme Deficient in Classic Late-Infantile Neuronal Ceroid Lipofuscinosis
Salomon Kuizon,Kathleen DiMaiuta,Marius Walus,Edmund C. Jenkins Jr,Marisol Kuizon,Elizabeth Kida,Adam A. Golabek,Daniel O. Espinoza,Raju K. Pullarkat,Mohammed A. Junaid
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011929
Abstract: Tripeptidyl aminopeptidase I (TPPI) is a crucial lysosomal enzyme that is deficient in the fatal neurodegenerative disorder called classic late-infantile neuronal ceroid lipofuscinosis (LINCL). It is involved in the catabolism of proteins in the lysosomes. Recent X-ray crystallographic studies have provided insights into the structural/functional aspects of TPPI catalysis, and indicated presence of an octahedrally coordinated Ca2+.
Increasing Maternal or Post-Weaning Folic Acid Alters Gene Expression and Moderately Changes Behavior in the Offspring
Subit Barua, Kathryn K. Chadman, Salomon Kuizon, Diego Buenaventura, Nathan W. Stapley, Felicia Ruocco, Umme Begum, Sara R. Guariglia, W. Ted Brown, Mohammed A. Junaid
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101674
Abstract: Background Studies have indicated that altered maternal micronutrients and vitamins influence the development of newborns and altered nutrient exposure throughout the lifetime may have potential health effects and increased susceptibility to chronic diseases. In recent years, folic acid (FA) exposure has significantly increased as a result of mandatory FA fortification and supplementation during pregnancy. Since FA modulates DNA methylation and affects gene expression, we investigated whether the amount of FA ingested during gestation alters gene expression in the newborn cerebral hemisphere, and if the increased exposure to FA during gestation and throughout the lifetime alters behavior in C57BL/6J mice. Methods Dams were fed FA either at 0.4 mg or 4 mg/kg diet throughout the pregnancy and the resulting pups were maintained on the diet throughout experimentation. Newborn pups brain cerebral hemispheres were used for microarray analysis. To confirm alteration of several genes, quantitative RT-PCR (qRT-PCR) and Western blot analyses were performed. In addition, various behavior assessments were conducted on neonatal and adult offspring. Results Results from microarray analysis suggest that the higher dose of FA supplementation during gestation alters the expression of a number of genes in the newborns’ cerebral hemispheres, including many involved in development. QRT-PCR confirmed alterations of nine genes including down-regulation of Cpn2, Htr4, Zfp353, Vgll2 and up-regulation of Xist, Nkx6-3, Leprel1, Nfix, Slc17a7. The alterations in the expression of Slc17a7 and Vgll2 were confirmed at the protein level. Pups exposed to the higher dose of FA exhibited increased ultrasonic vocalizations, greater anxiety-like behavior and hyperactivity. These findings suggest that although FA plays a significant role in mammalian cellular machinery, there may be a loss of benefit from higher amounts of FA. Unregulated high FA supplementation during pregnancy and throughout the life course may have lasting effects, with alterations in brain development resulting in changes in behavior.
Study on the Effect of Neem (Azadirachta indica) Leaves Smoke in Controlling Airborne Bacteria in Residential Premises
Saeed A. Khan,Junaid Aslam
Current Research in Bacteriology , 2008,
Abstract: The effect of smoke produced by burning of neem leaves (Azadirachta indica) was studied for controlling airborne bacteria in four rooms of house premise viz., kitchen, dinning hall and two meeting halls in Dubai. Petri plates containing with bacterial agar medium were sterilized in an autoclave and placed at Cassella airborne bacterial silt for monitoring. Bacterial colonies developed in those petri plates which were exposed to ambient environment, whereas no bacteria colony were seen in petri plates exposed to neem leaves smoke treated environments. Maximum bacterial colonies were developed in kitchen followed by dinning hall and the meeting rooms (majlis) in the ambient environment. Neem leaves smoke treatment resulted in controlling bacterial growth on bacterial agar medium petri plates. Studied revealed that neem leaves smoke has antibactericidal properties and could be used for controlling airborne bacterial contamination in the residential premise.
Firearm Injuries Presenting to a Tertiary Care Hospital of Karachi, Pakistan
Muazzam Nasrullah,Junaid A Razzak
Journal of Injury and Violence Research , 2009,
Abstract: Background: Violence is a public health problem in low and middle income countries. Our study attempted to define the circumstances, risk groups, extent and severity of firearm-related injuries in patients coming to the Aga Khan University Hospital (AKUH) Karachi, Paki stan. Methods: This was a retrospective study conducted in the department of Emergency Medicine (EM) at AKUH Karachi, Pakistan. Past medical records of all patients who were injured by firearms and were presented to the AKUH Emergency Department (ED) from June 2002 till May 2007 were reviewed. Data were recorded on the basic demographics of injured, length of hospital stay, body parts injured and the outcome (alive vs. dead). Results: Total of 286 patients with firearm injuries were identified. Majority of them were males (92%; n=264). More than half of the patients (63%) were in the age group of 21-40 years. Upon arrival to the hospital 85% (n=243) of patients had Glasgow Coma Scale (GCS) ≥ 13. The mean injury severity score (ISS) was found to be 6 (SD ±4). The length of hospital stay of patients ranged from 0 to 54 days with a mean of 7 days. Lower limb were the most affected body parts (30%, n=86) followed by abdomen pelvis (27%, n=77). Seven percent (n=21) of the patient who were brought to the hospital were labeled as “deceased on arrival”. Most of the injuries were caused during the act of robbery (40%, n=103) in the city. Conclusions: Robbery was the most common cause of firearm inju ries. Lower limb, abdomen and pelvis were the most affected body regions. Educational efforts, and individual, community and societal approaches are needed to alleviate firearm-related injuries.
THEORIES AND FACTORS AFFECTING MUCOADHESIVE DRUG DELIVERY SYSTEMS: A REVIEW
Alexander Amit,Sharma Sharad,Ajazuddin,Khan Mohammed Junaid
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Bioadhesion is an interfacial phenomenon in which two materials, at least one of which is biological, are held together by means of interfacial forces. When the associated biological system is mucous, it is called mucoadhesion. This property of certain polymeric systems have got place in the drug delivery research in order to prolong contact time in the various mucosal route of drug administration, as the ability to maintain a delivery system at a particular location for an extended period of time has a great appeal for both local action as well as systemic drug bioavailability. A complete and comprehensive theory that can predict adhesion based on the chemical and/or physical nature of a polymer is not yet available. Several theories have been proposed to explain the fundamental mechanisms of adhesion such as glues, adhesives, and paints, have been adopted to study the mucoadhesion. Mucoadhesion is a complex process and numerous theories have been presented to explain the mechanisms involved. These theories include mechanical-interlocking, electrostatic, diffusion–interpenetration, adsorption and fracture processes. They are Electronic theory, Adsorption theory, Wetting theory, Diffusion theory, Fracture theory. The objective of the study is to explain the different mechanisms involved in mucoadhesion and various factors affecting mucoadhesion.
In Vitro Chromosomal Aberration Frequency by Electrofishing on Poecilia latipinna (Sailfin Molly) Fishes in Southern of Iraq  [PDF]
Mohammed A. Abd Ali, Mohammed H. Mohammed, Marwa K. Sadeq
American Journal of Molecular Biology (AJMB) , 2018, DOI: 10.4236/ajmb.2018.82010
Abstract: The present studies describe Chromosomal aberration effects of electrofishing, which were evaluated on Poecilia latipinna, located in Shat Al-Arab river in Al-garmma city (south of Iraq). The electrofishing derive used in work is simulated to that used in the commercial fishing. The apparatus generates voltage ranged from 40 to 280 volts. Nine bearers of Poecilia latipinna sailfin molly fish in chromosomal analysis were divided into three treatments. The first were a control, the fishes of the second were exposed to 110 volts (10 seconds), and final groups were exposed to 110 volts (15 seconds). Mitotic index of the electrofishing with a control for each group decreased with increasing exposed time in somatic cell kidney tissue of Poecilia latipinna. The chromosome
Anti-CD-20 Therapy in Refractory Adult Still’s Disease  [PDF]
Reem Hamdy A. Mohammed
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2012, DOI: 10.4236/ojra.2012.22002
Abstract: Adult Still’s disease is a relatively rare form of rheumatoid arthritis with systemic inflammatory features. The prevalence is around 1.5 cases per 100,000 - 1000,000. In the current case we display a 30-year-old male patient with refractory adult still’s disease who suffered recurrent attacks of fever 39.5°C, arthritis in proximal interphalangeal joints (PIPs), wrists, tempromandibular joints (TMJs), knees and ankles, stitching chest pain, dyspnea, erythematous rash over the trunk, sore throat, weight loss (15 Kilograms in 4 months). The patients’ disease remained uncontrolled despite of synthetic disease modifying anti-rheumatic drugs and repeated intramuscular corticosteroid injections. Laboratory workup revealed erythrocyte sedimentation rate (ESR) of 95, C-reactive protein (CRP) of 100 mg/L, hemoglobin 10.5 gm%, leukocytosis 12,000/microlitre, mild elevation of liver function tests and dyslipidemia. Serology revealed negative rheumatoid factor, anti-nuclear antibody titre of 1:80, elevated serum ferritin 4000 micrograms/litre. The patient was started on rituximab (375 mg/m2), prednisolone 20 mg/day and selective Cox-2 inhibitor. Follow up for over three months following the completion of his pulse therapy, revealed no relapse of fever or fatigue, with morning stiffness of 5 - 10 minutes, VAS of 3, DAS28 of 3.8, HAQDI of 0.62, ESR 23, CRP 4.9, Hb 12.5 gm%, leucocytic count 9000/microlitre, the dose of prednisolone was successfully reduced to a dose of 5 mg/day orally. Conclusion: Anti-CD20 therapy successfully controlled systemic and articular refractory disease with sustained efficacy over a follow up period of up to 24 weeks.
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