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Search Results: 1 - 10 of 104150 matches for " Mohammad W Khan "
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Development and Application of a Validated UHPLC Method for the Determination of Atropine and Its Major Impurities in Antidote Treatment Nerve Agent Auto-Injectors (ATNAA) Stored in the Strategic National Stockpiles  [PDF]
Cheng H. Yen, Adil Mohammad, Miah Schneider, Salwa K. Poole, Bryan Lowry, Brenda W. Mc Curdy, Patrick J. Faustino, Saeed R. Khan
Pharmacology & Pharmacy (PP) , 2017, DOI: 10.4236/pp.2017.81002
Abstract: The development and implementation of advanced analytical technologies is essential for extending the expiry for complex drug products stored in the Strategic National Stockpiles. Consequently, a novel Ultra High-Performance Liquid Chromatographic (UHPLC) method has been developed for the analysis of atropine and its respective impurities to support the analytical research platform for auto-injectors. This study is part of a larger research effort to improve the efficiency and broaden the applicability of advanced analytical methods for medical counter-measure medications. The current HPLC compendial methodology for atropine sulfate injection requires an analysis time of 40 minutes for atropine. In comparison, the novel gradient UHPLC method required only 8 minutes to evaluate both atropine and its major pharmaceutical impurities. Improved separation was achieved on a Waters Acquity UHPLC BEH C18 1.7 μm, 2.1 × 100 mm column employing gradient elution of mobile phase solvent A (0.1% H3PO4) and solvent B (0.1% H3PO4, 90% ACN, and 10% H2O). The method was validated according to USP Category I requirements for assay. The daily standard calibration curves were linear over a concentration range from 50 μg/mL to 250 μg/mL with a correlation coefficient of >0.999. The detection limit (LOD) and quantitation limit (LOQ) were 3.9 μg/ml and 13.1 μg/ml, respectively. Resolution results indicate that atropine and the following impurities, degradants and a preservative can also be separated and analyzed using this proposed method: noratropine, 4,4’-di-hy-droxydiphenyl ether, 2,4’-dihydroxydiphenyl ether, 4-bromophenol, 4-hydro-xyatropine, tropic acid, apoatropine HCl, atropic acid, hydroquinone, nitroethane, phenol and catechol. The UHPLC method demonstrated enhanced selectivity and significantly reduced the analysis time when compared with the traditional USP compendial HPLC method. The method was successfully applied to the evaluation of atropine in ATNAA auto-injectors lots from the Strategic National Stockpiles.
Xeroderma Pigmentosum with Desquamative Gingivitis a Rare Case Report and Detailed Review of Literature  [PDF]
Shamimul Hasan, Mohammad Abbas Khan
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14025
Abstract: In xeroderma pigmentosum, a rare genodermatosis, transmitted as an autosomal recessive disorder, excessive solar damage to the skin develops at an early age. The disease is characterized by cutaneous, ocular, neurological and oral changes. Oral features in the form of early development of Squamous cell carcinoma, usually at the lower lip and tip of the tongue may be seen. The disorder is associated more commonly in populations where marriage of close blood relatives is common. Treatment of the disorder includes avoidance of Ultra violet radiation, topical application of 5 fluorouracil to treat actinic keratoses, and regular evaluation by an optholmologist, dermatologist, and neurologist. Genetic counseling is an important aspect as an increased incidence of consanguineous marriages have been reported with this disorder. Here, we report an interesting case of xeroderma pigmentosum in an 18 year old male patient who presented with characterstic desquamation of gingiva, fissured tongue and geoghraphic tongue.
Design and Evaluation of Solar Inverter for Different Power Factor Loads  [PDF]
Mohammad Ahmad, B. H. Khan
Energy and Power Engineering (EPE) , 2012, DOI: 10.4236/epe.2012.45042
Abstract: This paper analyzes and compares the performance of a new inverter topology with two types of input sources: 1) Solar PV source and 2) Ideal dc source (battery). The simulation is done in SIMULINK/MATLAB Software. It is shown that when the solar panel is connected, spikes are obtained in output voltage waveforms. These spikes are eliminated by inserting a capacitor. The capacitor is chosen for a particular power factor which is optimum with respect to cost, size and power quality. Total Harmonic Distortion, Active Power, Reactive Power, RMS Voltage and RMS Current are measured for different load power factor. Finally these results are compared with those obtained using battery with same input voltage magnitude. This Paper shows that for Solar Panel Circuit, THD, P and Q are less for 0.8 and above power factor, however below 0.8 PF, the THD, active and reactive power transfer are more. This means that the performance of Solar Panel in the proposed circuit topology is seen to be better as compared to the same circuit with battery within a range of power factor.
A Study on B-Spline Wavelets and Wavelet Packets  [PDF]
Sana Khan, Mohammad Kalimuddin Ahmad
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.519287
Abstract: In this paper, we discuss the B-spline wavelets introduced by Chui and Wang in [1]. The definition for B-spline wavelet packets is proposed along with the corresponding dual wavelet packets. The properties of B-spline wavelet packets are also investigated.
Some Results on Wavelet Frame Packets  [PDF]
Sana Khan, Mohammad Kalimuddin Ahmad
Advances in Pure Mathematics (APM) , 2014, DOI: 10.4236/apm.2014.411069
Abstract: The aim of this paper is to study wavelet frame packets in which there are many frames. It is a generalization of wavelet packets. We derive few results on wavelet frame packets and have obtained the corresponding frame bounds.
Software Defect Prediction Using Supervised Machine Learning and Ensemble Techniques: A Comparative Study  [PDF]
Abdullah Alsaeedi, Mohammad Zubair Khan
Journal of Software Engineering and Applications (JSEA) , 2019, DOI: 10.4236/jsea.2019.125007
Abstract: An essential objective of software development is to locate and fix defects ahead of schedule that could be expected under diverse circumstances. Many software development activities are performed by individuals, which may lead to different software bugs over the development to occur, causing disappointments in the not-so-distant future. Thus, the prediction of software defects in the first stages has become a primary interest in the field of software engineering. Various software defect prediction (SDP) approaches that rely on software metrics have been proposed in the last two decades. Bagging, support vector machines (SVM), decision tree (DS), and random forest (RF) classifiers are known to perform well to predict defects. This paper studies and compares these supervised machine learning and ensemble classifiers on 10 NASA datasets. The experimental results showed that, in the majority of cases, RF was the best performing classifier compared to the others.
Helping Primary School Teachers in the Mountainous Valley of Chitral Pakistan to Enhance Students’ Learning through Questioning
Mohammad Khan
International Journal of Academic Research in Business and Social Sciences , 2012,
Abstract: This paper highlights efforts being made to help two primary school teachers introduce questioning as a teaching strategy to maximize learning capacity of their students. Findings of the study indicate that provision of constant technical support is essential in getting the teachers conceptualized and internalized the importance, types and techniques of effective classroom questioning. It further indicates positive changes in the classroom practices of the research participants, as they started planning and executing more interactive lessons through incorporating questions of various levels for the learners. Change in teachers’ attitude towards questioning was also visible. They started believing that questioning is a powerful learning and teaching strategy as compared to a technique for silencing the learners to avoid disruption, which they perceived and used previously.
RETRACTED: Numerical Assessment of Prandtl Number Effect on Transient Heat Flux Distribution Imposed on Nuclear Reactor Pressure Vessel by Application of PECM in a Volumetrically Heated Molten Pool  [PDF]
Mohammad Khan
Engineering (ENG) , 2019, DOI: 10.4236/eng.2019.118035
Abstract:

Short Retraction Notice

There are some errors in the discussion and conclusion part.

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. Aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

The full retraction notice in PDF is preceding the original paper which is marked \"RETRACTED\".

Enhanced Glutamatergic and Decreased Gabaergic Synaptic Appositions to GnRH Neurons on Proestrus in the Rat: Modulatory Effect of Aging
Mohammad Khan,Liesl De Sevilla,Virendra B. Mahesh,Darrell W. Brann
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010172
Abstract: Previous work by our lab and others has implicated glutamate as a major excitatory signal to gonadotropin hormone releasing hormone (GnRH) neurons, with gamma amino butyric acid (GABA) serving as a potential major inhibitory signal. However, it is unknown whether GABAergic and/or glutamatergic synaptic appositions to GnRH neurons changes on the day of the proestrous LH surge or is affected by aging.
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid
Mojgan Zadeh, Mohammad W Khan, Yong Goh, Kurt Selle, Jennifer L Owen, Todd Klaenhammer, Mansour Mohamadzadeh
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-7
Abstract: To better understand the molecular mechanisms utilized by the intestinal microbiota and their gene products to induce or subvert inflammation, specifically the effect(s) of altered surface layer protein expression on the LTA-mediated pro-inflammatory response, the Lactobacillus acidophilus surface layer protein (Slp) genes encoding SlpB and SlpX were deleted resulting in a SlpB- and SlpX- mutant that continued to express SlpA (assigned as NCK2031).Our data show profound activation of dendritic cells by NCK2031, wild-type L. acidophilus (NCK56), and purified Staphylococcus aureus-LTA. In contrary to the LTA-deficient strain NCK2025, the LTA-expressing strains NCK2031 and NCK56, as well as S. aureus-LTA, induce pro-inflammatory innate and T cell immune responses in vivo. Additionally, neither NCK2031 nor S. aureus-LTA supplemented in drinking water protected mice from DSS-colitis, but instead, induced significant intestinal inflammation resulting in severe colitis and tissue destruction.These findings suggest that directed alteration of two of the L. acidophilus NCFM-Slps did not ameliorate LTA-induced pro-inflammatory signals and subsequent colitis.The intestinal immune system must co-exist with resident commensal microorganisms while maintaining the ability to defend against potential microbial challenge. This immune tolerance is a highly regulated process comprised of a myriad of biological checkpoints necessary to maintain homeostasis between the host and the gut microbiota [1]. In instances of inflammatory bowel disease (IBD), this tolerance between immune cells and intestinal bacteria is disrupted; however, causes of this tolerance breakdown have not yet been determined [2,3]. Although the etiology of IBD is still unknown, exaggerated inflammation induced by activated innate immune cells via their interaction with the microbiota and their gene products, as well as infiltrating CD4+ IFNγ+ T cells, likely play key roles in uncontrolled inflammation and tissue dest
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