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Search Results: 1 - 10 of 12889 matches for " Mohammad Sharifzadeh "
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Education of Pharmaceutical Sciences in Iran
Mohammad Sharifzadeh
Iranian Journal of Pharmaceutical Research , 2008,
An analytical performance comparison of exchanged traded funds with index funds: 2002-2010
Mohammad Sharifzadeh,Simin Hojat
Quantitative Finance , 2011,
Abstract: Exchange Traded Funds (ETFs) have been gaining increasing popularity in the investment community as is evidenced by the high growth both in the number of ETFs and their net assets since 2000. As ETFs are in nature similar to index mutual funds, in this paper we examined if this growing demand for ETFs can be explained through their outperformance as compared to index mutual funds. We considered the population of all ETFs with inception dates prior to 2002 and then for each ETF found all the passive index mutual funds that had the same investment style as the selected ETF and had inception date prior to 2002. Within each investment style we matched every ETF with all the passive index funds in that investment style and compared the performances of the matched pairs in terms of Sharp Ratios and risk adjusted buy and hold total returns for the period 2002-2010. We then applied the Wilcoxon signed rank test to examine if ETFs had better performances than index mutual funds during the sample period. Out of the 230 paired matches of all the styles, ETFs outperformed index mutual funds in 134 of the times in terms of Sharpe Ratio, however, the test of the hypothesis showed no statistically significant difference between ETFs and index funds performances in terms of Sharpe ratio. Out of the 230 paired matches of all the styles, ETFs outperformed index mutual funds in 125 of the times in terms of risk adjusted buy and hold total return, however, the test of hypothesis showed no statistically significant difference between ETFs and index funds performances in terms of risk adjusted buy and hold total return. These findings indicate there is statistically no significant difference between ETFs and passive index mutual funds performances at the fund level and investors' choice between the two is related to product characteristics and tax advantages.
Anti-Ulcerogenic Activity of the Pomegranate Peel (Punica granatum) Methanol Extract  [PDF]
Ghazaleh Moghaddam, Mohammad Sharifzadeh, Gholamreza Hassanzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.410A008

Pomegranate (Punica granatum L.) belongs to genera Punica and family Punicaceae. It is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. However, to our knowledge, no study has been conducted to evaluate this therapeutic property. In the present study the antiulcerogenic effects of pomegranate peel methanol extract, was tested on male Wistar albino rats. Oral pretreatment with peel extracts (25, 50 and 100 mg/kg) for 15 days protected the gastric mucosa against the damage induced by indomethacin (50 mg/kg). The incidence of ulceration in the control group was 100%. The best results were found in a dosage of 50 mg/kg in sour summer cultivar which inhibited the peptic ulcerin comparison with indomethacin induced gastric ulcer group. Lowest ulcer index (5.4 ± 0.55), an apparent decrease in the infiltration of polymorphonuclear leukocytes and hemorrhage were observed after administration of sour summer extracts (50 mg/kg). In conclusion present study showed that pomegranate peel extract, especially sour summer, has curative potential as an antiulcer, possibly via its high antioxidant activity. These results from pomegranate peel extract can provide an extra income and may contribute about good nutritional values of this product.

Interactive Effects of Acute and Chronic Lithium with Dopamine Receptor Antagonists on Naloxone-Induced Jumping in Morphine-Dependent Mice
Mohammad Sharifzadeh,Homeyra Rezaei,Mohammad Reza Ghamsari
Iranian Journal of Pharmaceutical Research , 2003,
Abstract: In the present study, interactive effects of D1 and D2 dopamine receptors antagonists and different periods of lithium pretreatment on morphine dependence in mice have been investigated. This study was designed to investigate whether the hypothesis that lithium anddopaminergic mechanisms via their effects on phosphoinositide pathways and calcium flux could influence morphine withdrawal response as manifested in the jumping effect. Animals were treated subcutaneously with morphine (50, 50 and 75 mg/kg) three times daily (10 a.m., 1 p.m. and 4 p.m.) for 3 days, and a last dose of morphine (50 mg/kg) was administered on the 4th day. Withdrawal syndrome (jumping) was precipitated by naloxone (5 mg/kg) which was administered intraperitoneally 2h after the last dose of morphine. To study interactive effects of dopamine receptor antagonists and different duration of lithium pretreatment, 10 injection of morphine (3 administrations each day) for dependence and a dose of 5 mg/kg of naloxone for withdrawal induction were employed. SCH 23390 (0.01, 0.02 and 0.05 mg/kg) as a D1 dopamine receptor antagonist and sulpiride (20, 40 and 80 mg/kg) as a D2 dopamine receptorantagonist were able to prevent withdrawal signs precipitated by naloxone (5 mg/kg). Pretreatment of animals with lithium (600 mg/l) for 7, 14, 21 and 28 days, increased jumping induced by naloxone in morphine dependent animals. SCH 23390 did not show any significantalteration on the jumping response in animals pretreated with lithium for 28 days, but the inhibitory effects of sulpiride was significantly decreased in animals received lithium for 28 days. It is concluded that postreceptor mechanism (s) may be involve in the interactions of lithium with dopaminergic system in alteration of naloxone-induced jumping in morphine dependent animals.
Anti-inflammatory Activities of Methanolic Extracts of Stachys persica and Stachys setifera on Rats and Mice
Mohammad Sharifzadeh,Kurdistan Sharifzadeh,Mahnaz Khanavi,Abbas Hadjiakhoondi
International Journal of Pharmacology , 2005,
Abstract: The aim of this study was to evaluate the anti-inflammatory activities of total methanolic extracts isolated from aerial parts of Stachys persica and Stachys setifera. The anti-inflammatory properties of the extracts were assessed by using two well-characterized inflammatory models, carrageenan-induced paw edema and formalin test in rats and mice. Intraperitoneal injections of the extracts 60 min before carrageenan injection caused significant inhibition on carrageenan-induced paw edema over the dose range 50-200 mg kg-1. The extract of Stachys persica showed more inhibitory effect especially with higher doses (100 and 200 mg kg-1). In the formalin test, intraperitoneal injections of different doses (50, 100 and 200 mg kg-1) of either Stachys persica or Stachys setifera 30 min before formalin injection did not show any inhibitory effects in the first phase (0-10 min) of the formalin-induced pain, but all three doses of the extracts revealed a significant (p<0.01) blockade of the second phase (20-30 min) nociception. The anti-inflammatory properties of both extracts were comparable with indomethacin as a potent non-steroidal anti-inflammatory drug. In conclusion, the present findings provide further evidences for inhibitory effects of Stachys persica and Stachys setifera in inflammatory processes via possible interactions with cyclooxygenase products.
DARU : Journal of Pharmaceutical Sciences , 2006,
Abstract: In this study the reactivity of methandrostenolone or [(17b)-17-hydroxy-17-methylandrosta-1, 4-diene-3-one], as a dienophil in a Diels-Alder type cycloaddition reaction was investigated. The purpose of this approach was to investigate whether the 1-dehydro position of methandrostenolone 1 undergoes a cycloaddition reaction with dienes, such as 1, 3 butadiene or cyclopentadiene, and to investigate the biological behavior of the reaction adducts, i.e, compound 3 {(17b)-17-hydroxy-17-methyl androsta [1a, 2a] cyclohex 3’, 4-diene-3-one} and compound 4 {(17b)-17-hydroxy-17-methyl androsta [1a, 2a] cyclohex (2’,5’ methylene) 3’, 4-diene-3-one}, relative to compound 1. The results indicated that thedDiels-Alder reactionddid notpproceed under the usual circumstances of high pressure and temperature, but could proceed in the presence of a Lewis acid (AlCl3). The structures of compounds 3 and 4 were confirmed by spectroscopic methods. The androgenic behavior of compounds 3 and 4 in comparison to compound 1 in the apomorphine test indicated that both compounds were almost devoid of androgenic activity, but prevented apomorphine mediated penile erection in male rats in a similar manner as cyproterone acetate.
"Anticonvulsant Activities of New 1,4-dihydropyridine Derivatives Containing 4-nitroimidazolyl Substituents "
Abbas Shafiee,Noushin Rastkari,Mohammad Sharifzadeh
DARU : Journal of Pharmaceutical Sciences , 2004,
Abstract: Anticonvulsant activity of Alkyl, cycloalkyl and arylalkyl ester analogues of nifedipine in which the ortho-nitro phenyl group at position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl substituent, were determined against pentylenetetrazole-induced seizures in mice. The anticonvulsant effects of the compounds were evaluated by the measurement of seizure latency and duration. Significant differences were observed between treated animals with control group and nifedipine in seizure duration. Our results show that most of the compounds had similar activity to the reference drug nifedipine. In addition, compounds 6a, 6b, 6f, 6g, 6h, 8e, 8f, 8g , 8h and 8i were more active than the reference drug nifedipine
DARU : Journal of Pharmaceutical Sciences , 2000,
Abstract: In this study the hypothesis that aminoglycoside antibiotics and lithium may influence apomorphine-induced licking via their effects on phosphoinositide pathways and calcium stores were investigated in male rats. Subcutaneous administration of apomorphine (0.1,0.25 and 0.5 mg/kg) to rats induced licking in a dose-dependent manner and the maximum response was obtained by the dose of 0.5 mg/kg of the drug. Intracerebroventricular injections of amikacin (5, 25 and 50 ug/rat) and gentamicin (10, 20 and 40 ug/rat) decreased the apomorphine-induced licking significantly. Pretreatment of animals with lithium (600 mg/1) for 7,14 and 21 days increased licking induced by apomorphine. The inhibitory effects of amikacin and high dose of gentamicin were not affected by lithium pretreatment for 14 and 28 days. These findings indicate the possible involvement of phosphoinositide cascade in alterations of apomorphine-induced licking by aminoglycoside antibiotics and lithium in the brain. Also it is suggested that type and dose of aminoglycoside antibiotics and duration of lithium administration probably have different effects on responses mediated by phosphoinositide hydrolysis.
Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
Asieh Hosseini, Mohammad Sharifzadeh, Seyed Mahdi Rezayat, et al
International Journal of Nanomedicine , 2010, DOI: http://dx.doi.org/10.2147/IJN.S11643
Abstract: enefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy Original Research (7856) Total Article Views Authors: Asieh Hosseini, Mohammad Sharifzadeh, Seyed Mahdi Rezayat, et al Published Date July 2010 Volume 2010:5 Pages 517 - 523 DOI: http://dx.doi.org/10.2147/IJN.S11643 Asieh Hosseini1, Mohammad Sharifzadeh1, Seyed Mahdi Rezayat2, Gholamreza Hassanzadeh3, Shokoufeh Hassani1, Maryam Baeeri1, Vahid Shetab-Bushehri4, Dmitry A Kuznetsov5, Mohammad Abdollahi1 1Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran; 2Faculty of Advanced Science and Technology in Medicine, Tehran University of Medical Sciences and Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 5Department of Medicinal Nanobiotechnologies, N. I. Pirogoff Russian State Medical University, Moscow, Russian Federation Abstract: Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of 25Mg-PMC16 nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. 25Mg-PMC16 (0.5 lethal dose50 [LD50]) was administered intravenously in two consecutive days before intraperitoneal injection of STZ (45 mg/kg). 24Mg-PMC16 and MgCl2 were used as controls. Blood 2,3-diphosphoglycerate (2,3-DPG), oxidative stress biomarkers, adenosine triphosphate (ATP) level in dorsal root ganglion (DRG) neurons were determined as biomarkers of DN. Results indicated that 2,3-DPG and ATP decreased whereas oxidative stress increased by induction of DN which all were improved in 25Mg-PMC16-treated animals. No significant changes were observed by administration of 24Mg-PMC16 or MgCl2 in DN rats. It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of 25Mg-PMC16 by release of Mg and increasing ATP acts protectively.
Effect of 17- Estradiol on the Expression of Inducible Nitric oxide Synthase in Parent and Tamoxifen Resistant T47D Breast Cancer Cells
Seyed Nasser Ostad,Andisheh Maneshi,Mohammad Sharifzadeh,Ebrahim Azizi
Iranian Journal of Pharmaceutical Research , 2009,
Abstract: Indirect evidence suggests that estrogen is involved in the etiology of breast cancer. Estrogen is also thought to modulate nitric oxide (NO) in human breast tumor tissue via regulation of inducible nitric oxide synthase (iNOS). Objectives of this study were to determine whether estradiol (E2) affects iNOS expression level in breast cancer cells and to study the effect of various concentrations of E2 on cell proliferation. Immunocytochemical technique was employed to assess iNOS expression level. Proliferation of parent and 10-6M tamoxifen resistant cells (T47D/TAMR-6) were assessed by MTT assay in the presence of E2. Addition of E2 (10-12 to 10-8 M) increases the expression of iNOS in parent cells, but not T47D/TAMR-6, Further increase in concentrations of E2 (10-8 to 10-4 M) again decreases theexpression of iNOS in parent cells, but increase that of the T47D/TAMR-6 cells. Expression of iNOS in parent cells in a medium containing 1% serum (low serum) is less than the cells grown in a medium containing 10% FBS (normal serum). This trend was not seen inT47D/TAMR-6 cells. The results of these experiments may indicate that increasing of iNOS expression decreases the viability of parent cells whilst increasing the number of T47D/TAMR-6.
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