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Search Results: 1 - 10 of 731477 matches for " Mohammad A. M. Ahmed "
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Insulin Resistance, Visceral Adiposity Index and TyG Index in Genotype-4 Chronic HCV Patients and Their Relation to Hepatic Histopathology  [PDF]
Eman A. Sabet, Asmaa N. Mohammad, Laila M. Yousef, Ahmed R. H. Ahmed, Abeer Sheneef
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.610030
Abstract: Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Vis-ceral adiposity index (VAI) and (TyG) index are newly developed indices for assess-ment of metabolic syndrome (MS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and Methods: 78 chronic HCV-infected patients proven by PCR, viral genotyping and hepatic histopathology, and 67 healthy controls were enrolled. Presence of MS, Homeostasis Model Assessment for IR esti-mation (HOMA-IR), TyG index, and VAI were assessed. Results: HOMA-IR, TyG and frequency of MS were significantly higher in patients’ group (p < 0.0001 for each) in comparison to controls. In HCV patients, increased fasting blood glucose (FBG) was the only strong predictor of severe hepatic necro-inflammation. High FBG, older age, female sex, high AST, TyG, VAI, serum lipids abnormalities and presence of MS were all associated with severe fibrosis on univariate regression analysis. Only high AST, TyG, VAI and LDL were independent predictors of severe fibrosis. A model using the 4 parameters showed a strong validity in predicting advanced hepatic fibrosis (AUC 0.801; CI: 0.705 - 0.897, p < 0001). Female sex, high BMI, VAI, LDL and TG values are all significantly associated with moderate/severe steatosis on univariate analysis. Among them, high BMI and LDL are the strong predictors (AUC 0.738; CI 0.625 - 0.851, p = 0.002). Conclusion: HCV genotype 4 is significantly associated with MS and increased values of HOMA IR and TyG index. TyG index and VAI are valuable simple indices that could predict the histopathological changes in Egyptian CHC pa-tients.
Could Bladder Inflation Prior to Cesarean Section Prevent Urinary Tract Injury in High Risk Group? A Randomized Controlled Trial  [PDF]
Abd El-Naser Abd El-Gaber Ali, Mohammad A. M. Ahmed, Mustafa M. Khodry, Ahmed M. Abbas
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.92021
Abstract: Background: Accidental urinary tract particularly bladder injury during cesarean delivery has a significant maternal morbidity, as it may lead to extended operative time, infection of urinary tract and sometimes development of urinary tract fistulae. Objective: To find out the efficacy of urinary bladder inflation immediately prior to cesarean section (CS) procedure in minimizing incidence of accidently urinary tract injury in high risk patients. Setting: Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt. Duration: From August 2017 to November 2018. Study Design: A prospective randomized controlled trial. Methods: Seventy six pregnant women recruited from attendants of outpatient antenatal care unit of obstetrics and gynecology department who planned for cesarean delivery and carried one or more risk factors for urinary tract injury. Patients randomly were classified into 2 groups (group I included 38 cases, underwent bladder inflation using triple way Foley’s catheter immediately before CS and group II included 38 cases, and underwent bladder deflation with 2 ways Foley’s catheter immediately before CS. Results: The overall incidence of urinary tract injury was significantly higher in group II (7 cases = 18.4%) than in group I (2 cases = 5.2%) with
New Method for Preparation of 1-Amidoalkyl-2-Naphthols via Multicomponent Condensation Reaction Utilizing Tetrachlorosilane under Solvent Free Conditions  [PDF]
Samy B. Said, Mohammad M. A. Mashaly, Ahmed M. Sheta, Saad S. Elmorsy
International Journal of Organic Chemistry (IJOC) , 2015, DOI: 10.4236/ijoc.2015.53019
Abstract: An efficient and direct procedure for the synthesis of amidoalkylnaphthol derivatives employing a multi-component and one-pot condensation reaction of 2-naphthol, aromatic aldehyde and ace-tonitrile in the presence of tetrachlorosilane (TCS). A binary reagent from (TCS)/ZnCl2 was used upon applying benzonitrile.
Evaluation of Charcot Neuroarthropathy in Diabetic Foot Disease Patients at Tertiary Hospital  [PDF]
Ahmed M. A. Kensarah, Nisar Haider Zaidi, Abdulhaleem Noorwali, Hager Aref, Ahmed Mohammed Makki, Afaf Ghunaim, Wail Tashkandi, Sara Mohammad Beayari, Adel Johari
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.76036
Abstract: Purpose: To evaluate Charcot neuroarthropathy in diabetic foot patients at tertiary hospital. Methods and Material: It is a retrospective study from 2005 to 2015 of Charcot foot patients in diabetic patients admitted in King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Sixty-four patients were admitted as diabetic foot disease and were studied by reviewing patients records of demography, pain, discharge, duration of disease, duration and types of diabetes IDDM [Insulin Dependant Diabetes Mellitus] NIDDM [Non Insulin Dependent Diabetes Mellitus], history of trauma, peripheral vascular disease, obesity, hypertension, co-morbid conditions, previous surgery, involvement of fore foot/midfoot/hindfoot, deformity, ulcer and treatment like casts, offloading devices, pharmacological like biphosphonates, debridement, osteotomy, arthrodesis, exostectomy, and amputation. Results: Majority of patients were males (81.2%). Mean age was 61.75 years. Pain was reported in 25% of patients, numbness in 12.5%, foot deformity in 23.4%, pus discharge in 73.4%, difficulty in walking in 12.5%, and 10.9% had history of trauma. Majority of patients were NIDDM 68.8%, IDDM 31.3%, (62.5% had DM more than 10 years and 36.9% had DM less than 10 years), controlled DM in 21.9% and uncontrolled DM in 73.4%, nephropathy in 46.3%, neuropathy in 59.4%, retinopathy in 40.6%, cardiomyopathy in 48.4% and vasculopathy in 56.3%. Charcot arthropathy was in 28.1% of cases and forefoot was involved in 65.5%, midfoot in 4.7% and hindfoot/ankle in 21.9%. It was forefoot which was mainly involved in Charcot joint disease. It was demonstrated by X-rays which showed subluxation in 40.6%, dislocation in 54.7%, disorganized foot joints in 42.2%, bone resorption in 23.4%, osteomyelitis in 14.1%, fractures in 50%, joint collapse in 39.1% and destruction of articular surfaces in 37.5%. Debridement was done in 25% of cases while 75% of patients underwent some sort of amputation. 14.1% of patients underwent above knee amputation, 10.9% below knee amputation, 10.9% transmetatarsal and 39.1% toe amputation. Debridement and amputation were the main treatment offered. Conclusions: Diabetic patients with Charcot joint disease pose great challenge in management. Emphasis should be given for early detection, investigations and prompt treatment. Treatment should be tailored according to stage of disease and patient occupation.
Antioxidant, Anti-Lipoxygenase and Cytotoxic Activity of Leptadenia pyrotechnica (Forssk.) Decne Polyphenolic Constituents
Mohammad A. Khasawneh,Hanan M. Elwy,Alaaeldin A. Hamza,Nael M. Fawzi,Ahmed H. Hassan
Molecules , 2011, DOI: 10.3390/molecules16097510
Abstract: Leptadenia pyrotechnica Forssk is a traditional medicinal herb used for treatment of inflammatory diseases and cancer. In this research, the aqueous ethanolic crude extract of Leptadenia pyrotechnica aerial parts, along with its ethyl acetate, n-butanol and water partitioning fractions were evaluated for their antioxidant capacity, polyphenolic content, anti-inflammatory and anti-cancer properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and β-carotene bleaching assays.The ethyl acetate fraction exhibited the highest polyphenolic content (252.27 mg gallic acid/g) and the best antioxidant activity (1.2, 0.57, 0.45 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Furthermore, the same extract showed appreciable anti-inflammatory via lipoxygenase (LOX) inhibitory activity (IC50 = 1.41 μg/mL). Moreover, the ethyl acetate fraction also showed the strongest cytotoxic effect (IC50 = 43.16 μg/mL) against MCF-7 human breast cancer cell line. These results suggest that this plant may be considered an interesting source of compounds with antioxidant, anti-inflammatory and anti-cancer properties for therapeutic, nutraceutical and functional food applications.
Generation of electron beams from a laser-based advanced accelerator at Shanghai Jiao Tong University
Ahmed M. M. Elsied,Nasr A. M. Hafz,Song Li,Mohammad Mirzaie,Thomas Sokollik,Jie Zhang
Physics , 2014,
Abstract: At Shanghai Jiao Tong University, we have established a research laboratory for advanced acceleration research based on high-power lasers and plasma technologies. In a primary experiment based on the laser wakefield acceleration (LWFA) scheme, multi-hundred MeV electron beams having a reasonable quality are generated using 20-40 TW, 30 femtosecond laser pulses interacting independently with helium, neon, nitrogen and argon gas jet targets. The laser-plasma interaction conditions are optimized for stabilizing the electron beam generation from each type of gas. The electron beam pointing angle stability and divergence angle as well as the energy spectra from each gas jet are measured and compared.
Thermodynamic Investigation and Mixed Ligand Complex Formation of 1,4-Bis-(3-aminopropyl)-piperazine and Biorelevant Ligands
Ahmed A. El-Sherif,Mohamed R. Shehata,Mohamed M. Shoukry,Mohammad H. Barakat
Bioinorganic Chemistry and Applications , 2012, DOI: 10.1155/2012/984291
Abstract: Thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) and its metal complexation with some divalent metal ions were determined in aqueous solution at constant ionic strength (0.1?M NaNO3) using a potentiometric technique. The order of –ΔG0 and –ΔH0 was found to obey , in accordance with the Irving-Williams order. The formation equilibria of zinc (II) complexes and the ternary complexes Zn(BAPP)L, where L?=?amino acid, amides, or DNA constituents), have been investigated. Ternary complexes are formed by a simultaneous mechanism. The concentration distribution of the complexes in solution was evaluated as a function of pH. Stoichiometry and stability constants for the complexes formed are reported and discussed. The stability of ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameter Δlog K. 1. Introduction Metal complexes of biologically important ligands are sometimes more effective than free ligands [1]. It is not surprising, therefore, that many authors have studied the coordination compounds of several central atoms. Mixed ligand complexes have a key role in biological chemistry [2] because the mixed chelation occurs commonly in biological fluids as millions of potential ligands are likely to compete for metal ions in vivo [3]. These create specific structures [4] and have been implicated in the storage and transport of active substances through membranes. Among these ligands are piperazine and its derivatives. Some piperazine derivatives were found to inhibit acute human immune deficiency HIV virus from chronically and latently infected cells containing proviral DNA [5]. Also the antimalarial activities of piperazine derivatives are also known [6]. The investigation of metal complexes of piperazine compounds will support their biological activity. The study of ternary complexes of transition metal ions with amino acids, peptides, or DNA units has been the focus of increasing research effort [7–10], which has revealed the role of metal ions at the molecular level. These types of complexes are implicated in the storage and transport of metal ions and of active substances through membranes. So, it is worthwhile to assemble information on their formation, stability, and structure and on the mutual influence of two ligands bound to the same metal ion. Zinc(II), among other transition metal ions, plays a vital role in biological processes. Zinc deficiency can cause unusual disorders in the development of the body, disorders in the metabolic system and prostate gland,
Application of a Few Waxy Materials on the Release of Naproxen from Polyethylene Glycol Based Suppositories
Sharif Mohammad Shaheen,Abdul Khalek Molla,Maruf Ahmed,A.K.M. Motahar Hossain
Pakistan Journal of Biological Sciences , 2005,
Abstract: Applications of various percentages (0, 2, 4, 8, 12 and 16%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Naproxen (NP) from Polyethylene Glycol 4000 (PEG)-based suppositories were studied in order to reduce rectal mucosal damage and also to investigate their release pattern. Naproxen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of NP and almost 65% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Two percent GMS containing PEG-based suppositories liberated about 69.0% of the drug within 6 h whereas maximum 45.0 and 32.0% of drug were liberated from % SA and % CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order CA>SA>GMS. Utilizing this capability of the additives, sustained release suppositories of Naproxen could be formulated.
Factors Influencing Infant and Child Mortality in Bangladesh
Ahmad Kabir,Mohammad Shahidul Islam,Muhammad Shibbir Ahmed,M. A. Khalique Barbhuiya
Journal of Medical Sciences , 2001,
Abstract: This study, based on 1993-94 Bangladesh Demographic and Health Survey (BDHS), attempts to identify important factors influencing infant and child mortality. Application of Cox`s proportional hazard model suggest that socio-economic status of the parents are associated with child survival. The factors that have received the most attention are maternal education, sanitation and access to safe drinking water. For instance, risk of infant mortality is 13% lower among the women having primary education and 25% lower among the women having secondary or higher education than those having no education. It was observed that 35 and 29% lower among the households having safe drinking water and good sanitary facilities, respectively than those who do not have such facilities. Similarly, risk of child mortality decreases with increased female education and wider access to safe drinking water and good sanitary facilities. So attention should be given to female education and expansion of public health system in order to reduce the risk of infant and child mortality.
Carbon Nanotubes Synthesis via Arc Discharge with a Yttria Catalyst
M. I. Mohammad,Ahmed A. Moosa,J. H. Potgieter,Mustafa K. Ismael
ISRN Nanomaterials , 2013, DOI: 10.1155/2013/785160
Abstract: A facile method is proposed to use a computer controlled Arc discharge gap between graphite electrodes together with an yttria-nickel catalyst to synthesize carbon nanotubes under an Ar-H2 gases mixture atmosphere by applying different DC currents and pressure. This produces carbon nanotubes with decreased diameters and increased length. XRD evidence indicated a shift toward higher crystallinity nanotubes. Yields of the CNTs after purification were also enhanced. 1. Introduction There has been intensive and increased research into the production of carbon nanotubes in recent years, as these novel nanoparticles with unique their properties are promising new advances and applications in a diverse number of areas, such as electronics, reinforced composite functionalized materials, and biomedical applications to name but a few. There are typically three major routes for such synthesis of carbon nanotubes: arc discharge, laser ablation, and chemical vapor deposition. The arc discharge technique involves an easy setup, and it is possible to obtain high yields [1]. This was the method originally used by Iijima [2] to produce multi-walled carbon nanotubes. The arc discharge is a very simple technique and is capable of massive production of both multiwalled CNTs and single-walled CNTs [3]. Arc discharge is a popular method for the production of SWNTs, and high quality SWNTs commonly collect around the cathode for easy harvesting after completion of the process [4]. The carbon arc technique for generating MWNTs appears very simple, but obtaining high yields of tubes can be difficult and requires careful control of the experimental conditions. In the most common laboratory scale production scheme, the direct current (DC) arc operates at a 1 to 4?mm wide gap between two graphite electrodes, which are typically between 6 and 12?mm in diameter and are vertically or horizontally installed in a water-cooled chamber filled with helium gas at subatmospheric pressure. Helium gas and DC current are important parameters to maximize the yield in the process [5]. Zhao et al. [6] used H2-Ar atmospheres comprising 60% Ar-40% H2 under a pressure of 266.6?mbar in their work, while Luo et al. [7] and Sun et al. [8] utilised high purity hydrogen at a pressure 799.9?mbar to optimize the yield in the process. Farhat et al. [9], Hai-yan et al. [10], and Sugai et al. [11] all successfully employed an Ar atmosphere to optimize the yield of the nanotubes produced. The position of the electrode axis does not noticeably affect the MWNT quality or quantity. The 50–250?mm long positive
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