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Search Results: 1 - 10 of 9025 matches for " Mohamed Yousfi "
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The association of Crohn’s disease with celiac disease  [PDF]
Iliass Charif, Mohamed El Abkari, Adil Ibrahimi, Mounia El Yousfi, Mounia El Yousfi
Open Journal of Gastroenterology (OJGas) , 2012, DOI: 10.4236/ojgas.2012.24036
Abstract: We report two cases of a man and a woman whose association of Crohn’s disease (CRD) and celiac disease (CD) was evident and significant. The characteristic of our patients was the young age of discovery, and the localization of the CRD which was different in the two cases: colic localization in the woman and ileal stenosing in the man. The diagnosis of MCO was confirmed by the histological study of the jejunal biopsies in both cases and by serologies (anti-gliadines Antibody) in one case. Through these two observations, we insist on the singularity of the association of the celiac disease to the Crohn’s disease and on the complex etiopathogenesis of CRD which could have common points with that of CD. This fact can help us to understand more the two diseases and thereafter master their management.
Twenty Traditional Algerian Plants Used in Diabetes Therapy as Strong Inhibitors of α-Amylase Activity
Ihcen Khacheba,Amar Djeridane,Mohamed Yousfi
International Journal of Carbohydrate Chemistry , 2014, DOI: 10.1155/2014/287281
Abstract: In the present work, we have studied the inhibitory effects of aqueous and alcoholic extracts of six Algerian medicinal plants known by their therapeutic virtues against diabetes. The total phenolic compounds content, assayed using Folin-Ciocalteu’s reagent, of the samples ranged from 0.183?mg/g to 43.088?mg/g and from 1.197?mg/g to 7.445?mg/g, expressed as gallic acid equivalent (GAE), for the, respectively, whereas the total flavonoids concentrations, detected using 2% of the aluminium chloride, ranged from 0.41?mg/g to 11.613?mg/g and from 0.0097?mg/g to 1.591?mg/g, expressed as rutin equivalents (RE), for the aqueous and methanolic extracts, respectively. The major plants were found to inhibit enzymatic activities of Aspergillus oryzae-amylase in a concentration dependent manner. The values of the inhibition constants ( ) have been determined according to the Dixon and Lineweaver-Burk methods. The results showed that the values were less than 55?ppm for the all extracts. A strong inhibition was found in the phenolic extract of Salvia officinalis with a of 8?ppm. 1. Introduction Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative lack of resistance to insulin. It is characterized by hyperglycemia and accompanied by various chronic vascular complications [1–3]. About 171 million people worldwide have diabetes, which is likely to be more than double by 2030 and around 3.2 million deaths every year are attributable to complication of diabetes, six deaths every minute [4, 5]. One therapeutic approach to decrease the hyperglycemia is to retard and reduce the digestion and absorption of ingested carbohydrate hydrolyzing enzymes (such as α-amylase and/or α-glucosidase) in the digestive organs [6–10]. The inhibition of enzymes involved in the digestion of carbohydrates can significantly decrease the postprandial increase of blood glucose after a mixed carbohydrate diet by delaying the process of carbohydrate hydrolysis and absorption [6, 11–13]. Therefore, safer natural amylase and glucosidase inhibitors have been reported from plant sources [14–16]. Arising from their biodiversity and their wealth of active ingredients, plants have been used from antiquity as sources of medicament against various diseases. These properties are usually attributed to secondary metabolites that are the subject of a lot of research in this field. This is particularly the case of polyphenol plants that are widely renowned in therapeutics as anti-inflammatories, enzyme inhibitors, and antioxidants, particularly flavonoids [6, 17–19]. Plant
Experimental Investigation of Effects of Electric Operating Parameters on Pulsed Corona Discharges in Humid Air at Atmospheric Pressure  [PDF]
Hasna Guedah, Alyen Abahazem, Nofel Merbahi, Mohamed Yousfi, Karim Saber, Ahmed Ihlal
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2018, DOI: 10.4236/jasmi.2018.84005
The present work is devoted to electrical and optical study of a point-plane atmospheric pressure corona discharge reactor in humid air powered by pulsed high voltage supply. The corona current and the injected energy are analyzed as a function of several parameters such as applied voltage and humidity rate. Then, investigations based on emission spectroscopy analysis were used in UV range (from 200 nm to about 400 nm). The main observed excited species were the second positive (SPS), the first negative (FNS) systems and OH(A-X) rotational bands. The latter band was used to simulate the rotational temperature (Tr), whereas the N2+ (FNS) band was used to determine the vibrational temperature (Tv). The electron temperature (Te ) is determined from the ratio of line intensities of the spectral bands of both N2+ FNS at 391.4 nm and N2SPS at 394.4 nm. The rotational, vibrational and electronic temperatures are analyzed as a function of above parameters (applied voltage, frequency and hygrometry rate) near the anodic tip. As well we study the axial variation of electronic temperature for a fixed applied voltage at 6.4 kV, frequency at 10 kHz and 100% of humidity. It is found that the rotational, vibrational and electronic temperatures increased with increasing applied voltage, frequency and humidity rate. The increase of rate hygrometry for an inter-electrode distance fixed at 10 mm causes an increase in both the amplitude of the corona current discharge and the energy injected in corona discharge. This is indicative of more intense reactive plasma while increasing hygrometry rate.
Predictors of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis  [PDF]
Iliass Charif, Kaoutar Saada, Ihsane Mellouki, Mounia El Yousfi, Dafr Allah Benajah, Mohamed El Abkari, Adil Ibrahimi, Nourdin Aqodad
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.37056

The upper gastrointestinal bleeding from esophageal or gastric varices is the most dangerous complication of portal hypertension. The purpose of this study was to identify the predictors of early rebleeding and mortality after a bleeding episode. Patients and Methods: It was a retrospective study including 215 patients admitted in our department of hepatology and gastroenterology at the Hassan II University Hospital of Fez, from January 2001 to January 2010. Results: The mean age of our patients was 51 years. Thirty percent of patients had cirrhosis due to virus (B or C). The majority of patients (79%) had only esophageal varices. Fifty patients (23%) had a bleeding recurrence. Twenty-five patients (11.5%) died during the first ten days, of which 52% had presented rebleeding (p = 0.01). In 30% of cases, the rebleeding was secondary to a fall of pressure ulcers. Univariate analysis showed that early mortality of patients was significantly associated with advanced age (p = 0.018), low prothrombin time (PT) (p = 0.022), low serum sodium (p = 0.03), low platelet count (p = 0.05), and elevated transaminases (p = 0.02). Conclusion: The survival of cirrhotic patients after a bleeding episode was influenced by advanced age, a low rate of PT, of serum sodium, and of the platelet count, and elevated transaminases.


Predictors of Intra-Hospital Mortality in Patients with Cirrhosis  [PDF]
Iliass Charif, Kaoutar Saada, Ihssane Mellouki, Mounia El Yousfi, Dafrallah Benajah, Mohamed El Abkari, Adil Ibrahimi, Nourdin Aqodad
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.43021
Abstract: Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in literature. Several studies have demonstrated independent predictors of mortality. The aim of this work is indeed to identify these predictors. Patients and Methods: We conducted a retrospective study of 1080 cirrhotic patients hospitalized in our department of gastroenterology and hepatology between January 2001 and August 2010. A descriptive study of the study population was performed, and a univariate analysis looking for an association between intra-hospital mortality, and clinical, biological, etiological and sociodemographic characteristics of our patients. Results: The average age of our patients was 54 years, with an equal number of men and women. 41.1% of patients had cirrhosis secondary to hepatitis C and 18.5% had cirrhosis secondary to hepatitis B. 26.1% of our patients were CHILD C. Intra-hospital mortality was 8.7% (97 deaths) with a mean of 23.4 ± 35.8 months. Univariate analysis showed that the intra-hospital mortality was significantly associated with higher age (p = 0.049) as well as the reasons for admissions like hepatic encephalopathy, and hematemesis (p < 0.0001), melena, jaundice and ascites (p = 0.001). Among the biological parameters analyzed in univariate analysis, significant associations with mortality were objectified for high white blood cell count (p = 0.035), and high serum bilirubin and creatinine (p < 0.0001); low rate of prothrombin time (PT) (p < 0.0001), of albumin (p = 0.0001) and of serum sodium (p < 0.0001). Among the complications analyzed, significant associations with mortality were objectified for jaundice, ascites (p = 0.001), hemorrhagic decompensation, hepatic encephalopathy, and spontaneous bacterial peritonitis (p < 0.001). Univariate analysis of the etiology of cirrhosis objectified significant associations for cirrhosis secondary to hepatitis B (p = 0.001) and hepatitis C (p = 0.022). Multivariate analysis objectified four independent predictors of mortality: hepatic encephalopathy, infection (hyper leukocytosis ≥ 10,000/mm3), renal failure (serum creatinine ≥ 15 mg/l) and hyponatremia. Conclusion: In our series, we identified four independent predictors of intra-hospital mortality in cirrhotic patients: hepatic encephalopathy, infection, renal failure and hyponatremia.
Evolutionary Profile of Severe Acute Ulcerative Colitis in Chronic Inflammatory Bowel Diseases  [PDF]
Hakima Abid, Fatima Babakhouya, Ihssane Mellouki, Mounia El Yousfi, Noureddine Aqodad, Dafr Allah Benajah, Adil Ibrahimi, Mohamed El Abkari
Open Journal of Gastroenterology (OJGas) , 2018, DOI: 10.4236/ojgas.2018.83012
Abstract: Background: Severe acute colitis is a common complication of inflammatory bowel disease (IBD). Their diagnosis is based on clinical, laboratory, endoscopic and radiological. The severe acute colitis is a medical and surgical emergency; its mortality is 1% to 3%. The management should be swift and coordinated, upon admission, between medical and surgical teams. Methods: This is a retrospective study in Gastroenterology Service at the University Hospital HASSAN II Fez, over a period of 10 years (2005-2015). We included all patients admitted for severe acute colitis; all the epidemiological, clinical, endoscopic, histological, and therapeutic monitoring of patients were collected. Results: We collected 123 patients. Their average age was 35 years (16 - 70). It was a female predominance (sex ratio F/M = 1.19). 54 patients were admitted for an inaugural severe acute colitis (43%), while 69 patients were known carriers of IBD (56%). All patients were admitted to an array of severe acute colitis according to the criteria of Truelove and Witts modified. 9 patients were operated urgently because there was the presence of complications (5 cases of perforation, 3 cases of massive rectal bleeding, and one patient with an abscess in the right iliac fossa). Corticosteroids intravenously was administered to 114 patients, 74 patients (64%) had remission. Patients who have not responded to corticosteroids IV (N = 40): 1) 12 patients received treatment with oral cyclosporine: the remission rate was 66%. 2) 8 patients were put under Infliximab: The response rate was 75%. 3) Patients who have not responded to a second-line treatment underwent subtotal colectomy with a dual stoma. 4) The surgery was indicated as a second-line treatment in 20 patients who all received a subtotal colectomy with double stoma; totalizing colectomy and ileoanale anastomosis ware made in 4 patients. The mortality rate is higher in our series (12%) mainly postoperatively; it is due to the delayed admission of patients, which promotes the development of complications. Conclusion: Acute Severe Ulcerative Colitis is a medical and surgical emergency that requires a multidisciplinary approach; medical treatment is the basis of initial treatment; but surgery must always be indicated at the right time avoiding increasing the death rate, this rate is important in our series.
Physiological Responses of Wild and Cultivated Barley to the Interactive Effect of Salinity and Iron Deficiency
Sabeh Yousfi,Hayet Houmani,Fethia Zribi,Chedly Abdelly,Mohamed Gharsalli
ISRN Agronomy , 2012, DOI: 10.5402/2012/121983
Abstract: Literature on the separate effects of salinity and inadequate Fe supply on plant growth and nutrient uptake, concentration, and distribution is abundant but little is known about the interactive effects of these two abiotic constraints. Here, we investigated the interactive effect of iron availability and salinity on physiological responses of cultivated and wild barley (Hordeum vulgare and H. maritimum resp.). Seedlings of both species were grown for 9 days, under complete nutrient solution with or without iron supply. Then, NaCl treatment was applied at different concentrations (0, 100, 200, and 300?mM) for 60 hours. After salt exposure, shoot water content of H. vulgare was significantly reduced as compared to H. maritimum. Furthermore, Na+ accumulation in shoots increased parallel to increasing NaCl concentration in the medium. However, the increase was significantly higher in H. vulgare than in H. maritimum. These responses were associated with lower Fe absorption efficiency photosynthetic parameters in both species. The reduction was significantly higher in cultivated than in wild barley. Moreover, phytosiderophore exudation was enhanced in both species by direct (iron free medium) or indirect iron limitation (salt-induced iron limitation). Such a stimulation of phytosiderophore release was genotype and salt level dependant. 1. Introduction It is well documented that hindrance effect of high soil alkalinity on plant growth is related to nutrients availability limitation; particularly of iron [1]. Under such tricky environmental conditions, higher plants induce special mechanisms for iron acquisition, involving a plasma membrane H+-ATPase to increase root proton release capacity and a plasma membrane Fe(III) chelate reductase to reduce Fe(III) chelates at root surface (strategy I) as well as an enhancement of phytosiderophore secretion to the rhizosphere, parallel to an induction of an Fe(III)-phytosiderophore complex transport system (strategy II) [2]. Salinity also presents several challenges to plant growth, including the decrease of the osmotic potential of the growing medium, a specific ion toxicity [3], and nutrient deficiencies and disorders [4]. Iron limitation and high-salinity stress have thus far been regarded as separate growth-limiting factors. Yet, the interaction effect of both stresses is little known. However, in sodic soils where pH and Na+ concentration is high, the solubility of micronutrients is low [5, 6]. According to Gupta et al. [7], in alkaline soils, the pH usually increases with an increase in salinity due to the
The morphological analysis of Arabic verbs by using the surface patterns
A. Yousfi
International Journal of Computer Science Issues , 2010,
Abstract: In this article, we present a new system of morphological analysis using the surface patterns of the word to be analyzed. This approach required in the initial phase a classification of all Arabic verb roots by using the morphological rules of these last, and the second phase is the construction of data base of conjugated surface patterns. This system is capable to analyze all Arabic verbs by decomposing the word to the prefixes, suffixes and roots. This approach has been tested on a corpus of 4000 verbs, the results were encouraging, and the error rate is 4%.
Introduction of the speaking rate in the model of speech recognition
Abdellah Yousfi,Abdelouafi Meziane
International Journal of Mathematics and Mathematical Sciences , 2002, DOI: 10.1155/s0161171202010141
Abstract: We propose an improvement to the centisecond TLHMM model (Meziane, 1999) applied to the sound duration. Indeed, the distribution of the sound duration depends on the speaking rate. An adaptation in a post-processing step is needed. This adaptation is studied by proposing a model of the speaking rate based on average syllabic duration. The experiments elaborated on a set of BDSONS show the interest of this approach. This work is a continuation of those by Meziane (1999) and Suaudeau (1994).
Optimal Control of a Delayed HIV Infection Model with Immune Response Using an Efficient Numerical Method
Khalid Hattaf,Noura Yousfi
ISRN Biomathematics , 2012, DOI: 10.5402/2012/215124
Abstract: We present a delay-differential equation model with optimal control that describes the interactions between human immunodeficiency virus (HIV), CD4+ T cells, and cell-mediated immune response. Both the treatment and the intracellular delay are incorporated into the model in order to improve therapies to cure HIV infection. The optimal controls represent the efficiency of drug treatment in inhibiting viral production and preventing new infections. Existence for the optimal control pair is established, Pontryagin’s maximum principle is used to characterize these optimal controls, and the optimality system is derived. For the numerical simulation, we propose a new algorithm based on the forward and backward difference approximation. 1. Introduction Human immunodeficiency virus (HIV) is a lentivirus that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are several other ways the infection can transfer, for example, open wound, saliva, and ulcers. There are some antiretroviral (ARV) drugs available nowadays which help the immune system in preventing the infection due to HIV even though it is not possible to cure it. Reverse transcriptase inhibitors (RTIs) are one of the chemotherapies which oppose the conversion of RNA of the virus to DNA (reverse transcription), so that the viral population will be minimum and on the other hand the CD count remains higher and the host can survive. Another one is the protease inhibitors (PIs) which prevent the production of viruses from the actively infected CD T cells. In the literature, many mathematical models have been developed in order to understand the dynamics of HIV infection [1–6]. In addition, optimal control methods have been applied to the derivation of optimal therapies for this HIV infection [7–13]. All these methods are based on HIV models which ignore the intracellular delay by assuming that the infectious process is instantaneous; that is, in the very moment that the virus enters an uninfected cell, this one starts to produce virus particles, and we know that this is not biologically reasonable. In this paper, we consider the mathematical model for HIV infection with intracellular delay and cell-mediated immune response presented by Zhu and Zou in [6] and we introduce two controls, one simulating effect of RTIs and the other control simulating effect of PIs, incorporating drug efficacy. The intracellular delay represents the time needed for infected cells to produce virions after
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