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Search Results: 1 - 10 of 469396 matches for " Mohamed A. Salem "
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Validity of Upper Gastro-Intestinal Endoscopic Screening in HCV Cirrhotic Patients Awaiting Antiviral Therapy  [PDF]
Salem Y. Mohamed, Bassim A. Gaballah, Mohamed H. Emara
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.512029
Abstract: Background and Aim: The Egyptian Ministry of Health initiated a nationwide HCV treatment program with the newly developed oral antiviral therapies and formulated national guidelines for treatment allocation which gave favor for patients with advanced fibrosis and early cirrhosis. One of the recommendations for treatment was upper Gastro-intestinal (GIT) endoscopy. This study aimed at estimating the prevalence of varices among those patients and judging the validity of this national recommendation. Methods: This study was carried out at gastrointestinal endoscopy units, Zagazig University Hospitals through the year 2014. The epidemiologic, clinical features and endoscopic findings of patients undergoing preparation for HCV therapy were analyzed. Endoscopic classifications of esophageal and gastric varices were carried out after the Italian liver cirrhosis project and Sarin’s classification respectively. Results: Totally 1143 patients performed upper GIT endoscopy as preparation for HCV treatment. This comprised 22% of all patients undergoing upper GIT endoscopy over that year. There was a fourfold rise in percentage of patients undergoing endoscopy for sofosbuvir-based therapy in this year (22%) when compared to assessment for Interferon/Ribavirin combination therapy (5%) in the previous year. A total of 361 patients had no esophageal or gastric varices. Small sized (grade I), medium sized (grade II) and large sized (grade III) varices were reported in 301, 188 and 293 patients respectively. Thirty patients (2.6%) had gastric varices. The prevalence of varices was higher in Child B in comparison to Child A (statistically not significant, p = 0.243). Conclusion: Screening endoscopy for early cirrhotic patients awaiting oral anti-HCV therapy is valid.
Sphincter Saving Surgeries for Locally Advanced Low Rectal Cancer after Neoadjuvant Chemoradiation  [PDF]
Mohamed A. E. Salem, Hamza A. Hamza, Gamal Amira, Abeer E. Ibrahium, Ahmed A. S. Salem
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47143

Background: Rectal cancer accounts for the largest distribution within one anatomical region of the large bowel, with approximately one third of all CRC located within the rectum. The Golden standard treatment of primary rectal cancer is curative surgical resection; however, a fine balance remains between disease cure and restoration of gastrointestinal continuity. Combined modality has proven efficacy in many malignant tumors with advantage of organ preservation. Methods: Forty nine (49) patients with low rectal carcinoma were included in a prospective study, between Jan 2007 and Jan 2012. Preoperative chemoradiation was administrated to all patients and subjected to different techniques of sphincter saving surgery. Stage I and Stage IV disease at diagnosis were excluded from the study. Results: Forty nine patients were included in the study. 27 (55%) patients were male and 22 (45%) were female; the age ranges from 23 years to 70 years with the median age 46 years. The main presenting symptoms were bleeding per rectum and tenesmus, Stage II 18 patients (36.7%), stage III 31 patients (63.3%). Complete clinical and pathological response in 3 patients (6%), and complete clinical response with only microscopically residual carcinoma in 20 patients (41%), partial response in 18 patients (36.7%), and no significant response in 8 patients (16%) 7 from 8 were mucoid carcinoma. Low anterior resection (LAR) in 22 patients (44.9%), Hartman’s procedure in 4 patients (8.1%), Coloanal pull-through (COP) was done in 19 patients (38.9%) and perineal colostomy in 4 patients (8.1%). For patients with colo-anal pull-through technique complete dehiscent and retraction observed in 2 cases, Major leakage in one case, stenosis in 4 cases. Conclusion: There is tendency of colorectal cancers to affect younger groups. Most

Experimental Study of Filling Ratio Effect on the Thermal Performance in a Multi-Heat Pipe with Graphene Oxide/Water Nanofluids  [PDF]
Mohamed Salem, Tarek A. Meakhail, Magdy A. Bassily, Shuichi Torii
World Journal of Nano Science and Engineering (WJNSE) , 2016, DOI: 10.4236/wjnse.2016.64014
Abstract: This experimental study is performed to investigate heat transfer performance of a multi-heat pipe cooling device in the condition of different filling ratios (40%, 60%, 80% and 100%) and different constant heat fluxes (10 - 30 W). Here, pure water (distilled water) and graphene oxide (GO)/water nanofluids are employed respectively as working fluid. GO/water nanofluids were synthesized by the modified Hummers method with 0.05%, 0.10%, 0.15%, and 0.20% volume concentrations. Multi-heat pipe is fabricated from copper; the heating and cooling sections are the same size and both are connected by four circular parallel tubes. Temperature fields and thermal resistance are measured for different filling ratio, heat fluxes and volume concentrations. The results indicated that the thermal performance of heat pipe increased with increasing the concentration of GO nanoparticles in the base fluid, while the maximum heat transfer enhancement was observed at 0.20% volume concentration. GO/water nanofluids showed lower thermal resistance compared to pure water; the optimal thermal resistance was obtained at 100% filling charge ratio with 0.20% volume concentration. Studies were also demonstrated that heat transfer coefficient of the heat pipe significantly increases with increasing the input heat flux and GO nanoparticles concentration.
Psychiatric Aspects of Infectious Diseases  [PDF]
Amir Mufaddel, Abdelaziz A. Omer, Mohamed Omar Salem
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.43027

Psychiatric symptoms can be associated with several systemic and central nervous system infections and they can be the initial presenting symptoms, occurring in the absence of neurological symptoms in some disorders as in some cases of viral encephalitis. They could also be part of the clinical picture in other cases such as psychosis or mood symptoms secondary to brucellosis or toxoplasmosis. Late-onset neuropsychiatric complications may also occur several years following the infection such as in the case of subacute sclerosing panencephalitis due to measles. Some Infectious diseases may have possible etiological role for major psychiatric disorders, based on yet unconfirmed reports for viral infectious diseases (e.g. Influenza virus and HSV-1) which are thought to have risk for developing schizophrenia and psychosis. Neuropsychiatric adverse effects can occur due to drugs (e.g. mefloquine, interferon-alpha) that are used for treatment of infectious diseases. Psychiatric symptoms can also be reactivated resulting from chronic, complicated and serious infections such as HIV that can lead to depression, anxiety or adjustment disorders, although CNS involvement can also be a possible etiological factor. Patients suffering from primary and severe psychiatric disorders are at increased risk of contracting infection; that is mainly related to high risk behaviors in patients with mania or schizophrenia. It is also important to consider that the co-occurrence of psychiatric symptoms and infection can be incidental (i.e. infectious diseases can occur in psychiatric patients regardless of the above mentioned factors). Early identification of the underlying etiology for organic/secondary psychiatric symptoms is essential for appropriate intervention and early treatment of the primary condition that could be the etiology of psychiatric symptoms so as to avoid unnecessary long-term psychiatric treatment and to avoid complications of possible misdiagnosis or delayed diagnosis of the primary condition.

Space-Time Cross-Mapping and Application to Wave Scattering
Mohamed A. Salem,Christophe Caloz
Physics , 2015,
Abstract: Causality creates an asymmetry between space and time, even though the wave equation treats them on equal footing. In this work, we leverage this asymmetry to construct a cross-mapping between space and time. This cross-mapping is applied to simplify scattering in space-varying media, by eliminating the infinite reflections between interfaces. The method is shown to transform the implicit transfer matrix method into an explicit method for the analysis of electromagnetic field scattering by a stratified medium.
Manipulating light at distance by a metasurface using momentum transformation
Mohamed A. Salem,Christophe Caloz
Physics , 2013, DOI: 10.1364/OE.22.014530
Abstract: A momentum conservation approach is introduced to manipulate light at distance using metasurfaces. Given a specified field existing on one side of the metasurface and specified desired field transmitted from the opposite side, a general momentum boundary condition is established, which determines the amplitude, phase and polarization transformation to be induced by the metasurface. This approach, named momentum transformation, enables a systematic way to synthesize metasurfaces with complete control over the reflected and transmitted fields. Several synthesis illustrative examples are provided: a vortex hypergeometric-Gaussian beam and a "delayed-start" accelerated beam for Fresnel region manipulation, and a pencil beam radiator and a holographic repeater for Frauenhofer region manipulation.
Electromagnetic Fields Radiated by a Circular Loop with Arbitrary Current
Mohamed A. Salem,Christophe Caloz
Physics , 2014, DOI: 10.1109/TAP.2014.2368579
Abstract: We present a rigorous approach to compute the electromagnetic fields radiated by a thin circular loop with arbitrary current. We employ a polar transmission representation along with a Kontorovich-Lebedev transform to derive integral representations of the field in the interior and exterior regions of a sphere circumscribing the loop. The convergence of the obtained expressions is discussed and comparisons with full-wave simulation and other methods are shown.
The Relativistic Mechanic Theory of the String  [PDF]
Mohamed Salem
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.64040
Abstract: In this article, a novel speculative method is used to derive the relativistic mechanic that governs the motion of the vibrating string within the compactified-dimensions spacetime. This mechanic claims that the relativistic mechanic of the special relativity should be only valid for the motion within the familiar four-dimensional spacetime. However, our novel mechanic is valid for the motion within the compactified-dimensions spacetime predicted by the string theory. The equations of this new mechanic show that the vibrating string can move within the compactified dimensions in a speed that is faster than light. It is also shown that this new relativistic mechanic goes to the classical Newtonian mechanic whenever the speed of the vibrating string is much less than the speed of light. Since the proposed mechanic does not prohibit the existence faster than light motion, it may uncover some of the mysteries regarding the string theory, such as the existence of tachyon and time travel. The main goal of this paper is to show that the motion within the compactified-dimensions spacetime obeys a different relativistic mechanic that will provide a startling and revolutionary perspective on the universe and answer some of the fundamental questions posed in the modern physics.
Intravenous Fluorouracil versus Oral Capecitabine: Postoperative Chemoradiation for Gastric Cancer  [PDF]
H. Abbas, Shimaa Ahmed, Ahmed A. S. Salem, Mohamed Abou Elmagd Salem, Mahmoud Hussin, Wessam A. El Sherief
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.611103
Abstract: Purpose: Aim of this prospective, phase III trial was to compare the efficacy and toxicity of intravenous fluorouracil and oral capecitabine when given concurrently with radiation in adjuvant sitting for adenocarcinoma of the stomach after gastrectomy with D2 resection. Patients and Method: The study included 60 patients having histologically proven adenocarcinoma of the stomach or gastroesophageal junction; stage T2-4 N0-3 M0 after gastrectomy with D2 lymph node dissection. Eligible patients were randomly assigned to receive adjuvant radiotherapy concurrently with intravenous fluorouracil [arm A] or oral capecitabine [arm B]. Results: Ten patients cannot complete their whole treatment course because of either progressive [4 patients; 2 arm A and 2 arm B] or G 3 toxicity [1 patient] or refuse to complete their treatment [5 patients; 3 arm A and 2 arm B]. Patients received fluorouracil have significant increase grade 3 or 4 hematological [neutropenia] and gastrointestinal (diarrhoea, anorexia, and vomiting). During a median follow-up period of 24 months, the 2-year disease free and overall survivals in this study were 60% and 63.3%, for groups A and B respectively, while overall survival were 63.3% and 70% for groups A and B respectively without significant differences. Conclusion: Oral capecitabine concurrently with radiation therapy has comparable efficacy and favourable toxicity profile when compared to infusion fluorouracil as postoperative adjuvant therapy for gastric adenocarcinoma.
Image-Guided Radiotherapy Dose Escalation in Intermediate and High Risk Cancer Prostate Patients and Its Effect on Treatment Toxicity  [PDF]
Mohsen S. Barsoum, Azza Mohamed Nasr, Ikram Hamed Mahmoud, Salem E. Salem, Rasha A. Elawady, Shaimaa Abdelallem, Ahmed Awad
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.86050
Abstract: Purpose: To study the effect of escalating radiation dose; in intermediate and high risk prostate cancer patients; via online image-guidance on acute toxicities. Patients and Methods: thirty-eight prostate cancer patients were treated by using simultaneous integrated boost-intensity modulated radiation therapy (SIB-IMRT) with online image guided correction via kilo voltage cone beam computed tomography (KV-CBCT)/electronic portal imaging device (EPID) of trans-rectal ultrasound (TRUS)-inserted intraprostatic gold fiduciary markers. High-risk patients received a median dose of 80.5 Gy to prostate and 56 Gy to pelvic nodes in 35 fractions over 7 weeks. Intermediate-risk patients received a similar prostate dose over the same overall treatment time. Acute toxicity (bladder, rectal and bowel symptoms) was reported once weekly during the radiation course and up to 3 months from the end of the radiation course. Results: The image guided (IG)-IMRT allows escalating the radiation dose delivered to the prostate through minimizing the margin of setup error to less than 0.5 cm with subsequent sparing of nearby organs at risk. Out of thirty-eight patients, no patient developed >grade 1 acute rectal toxicity, 7.9% of patients experienced grade 3 urinary toxicity and there was no reported small intestinal toxicity. Conclusion: Escalating the radiation dose more than 80 Gy in intermediate and high risk prostate cancer patients was safe and not associated with grade 3 - 4 RTOG toxicity when guided by online verification of intra-prostatic fiducial markers.
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