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Search Results: 1 - 10 of 199 matches for " Mogens Aalund "
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Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Regine Bergholdt, Zenia M St?rling, Kasper Lage, E Olof Karlberg, Páll í ólason, Mogens Aalund, J?rn Nerup, S?ren Brunak, Christopher T Workman, Flemming Pociot
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-11-r253
Abstract: Complex traits like type 1 diabetes (T1D) are generally believed to be under the influence of multiple genes interacting with each other to confer disease susceptibility and/or protection. Identification of susceptibility genes in complex genetic diseases, however, poses many challenging problems. The contribution from single genes is often limited and genetic studies generally do not offer clues about the functional context of a gene associated with a complex disorder. A recent report demonstrated the feasibility of constructing functional human gene networks (using, for example, expression and Gene Ontology (GO) data [1]), and using these in prioritizing positional candidate genes from non-interacting susceptibility loci for various heritable disorders [2]. It was shown that the obvious candidate genes were not always involved, and that taking an unbiased approach in assessing candidate genes using functional networks may result in new, non-obvious hypotheses that are statistically significant.One of the strongest indications of functional association is the presence of a physical interaction between proteins [3] and several reports have shown that proteins involved in the same phenotype are likely to be part of the same functional module (that is, protein sub-network) [4-6]. With this in mind, it seems reasonable to expect that, in many cases, components contributing to the same complex diseases will be members of the same functional modules, especially if the disease is associated with multiple genetic loci that show statistical indication for epistasis. This indicates that in the case of complex disorders a feasible strategy would be to search for groups of interacting proteins that together lead to significant association with the disease in question. However, a strategy searching for loci showing genetic interaction (epistasis) integrated with a search for protein networks spanning the epistatic regions and subsequent significance ranking of these networks ha
On-demand sedation with propofol for colonoscopy—A prospective pilot study of the influence on short-term memory, psychomotor function and postural stability*  [PDF]
Mogens R?rb?k Madsen
Open Journal of Clinical Diagnostics (OJCD) , 2013, DOI: 10.4236/ojcd.2013.33023
Abstract: Background: After sedated colonoscopy, patients are discharged on the basis of their subjective judgment that they have recovered, corroborated by the nursing staff. The aim of this study was to assess objectively whether patients were in fact fully recovered at the time of discharge, and to demonstrate whether the methods of testing applied could detect any influence of sedation on short-term memory, psychomotor function and postural stability. Methods: Twenty-two patients were investigated. At the beginning of the procedure, a defined bolus of propofol/alfentanil was given intravenously. During the procedure, an additional bolus was injected one or more times as requested by the patient. After colonoscopy, the patients stayed in the recovery room until the patients judged that they had recovered completely, which was also the judgement of the nursing staff at that time. Before colonoscopy and again before discharge, tests were performed of short-term memory, psychomotor function and postural stability (balance). Results: A positive correlation was found between the duration of colonoscopy and the amount of sedative given (p < 0.03). No differences in short-term memory or postural control were found when measurements obtained before and after colonoscopy were compared. Reaction time was prolonged significantly after colonoscopy (p < 0.01), which was mainly due to prolongation of perception time (p < 0.003). No correlation was found between the observed reduction in psychomotor function and the amount of sedative given. Conclusions: The introduction of ultrashort-acting sedative and hypnotic agents has facilitated out-patient colonoscopy. However, although they feel that they have recovered fully, some patients are still affected by the sedative at the time of discharge, as demonstrated by tests of short-term memory, reaction time and postural stability.
Fri ter. Om de italienske lokalradioer
Mogens Schmidt
Massekultur & Medier , 1981,
Abstract: Fri ter. Om de italienske lokalradioer
Gerd Z. Nordst m: Bildspr k och bildanalys
Mogens Schmidt
Massekultur & Medier , 1984,
Hvad vi kan l re, er ikke til at b re. Om de italianske networks
Mogens Schmidt
Massekultur & Medier , 1983,
Abstract: Hvad vi kan l re, er ikke til at b re. Om de italianske networks
Erlend Hovland (red.): Vestens musikkhistorie. Fra 1600 til v r tid. Oslo: Cappelen Damm, 2012. Erlend Hovland (red.): Vestens musikkhistorie. Fra 1600 til v r tid. Oslo: Cappelen Damm, 2012.
Mogens Christensen
InFormation : Nordic Journal of Art and Research , 2012, DOI: 10.7577/information.v1i2.410
Surrounding Risks
Mogens Steffensen
Risks , 2013, DOI: 10.3390/risks1010043
Abstract: Research in insurance and finance was always intersecting although they were originally and generally viewed as separate disciplines. Insurance is about transferring risks between parties such that the burdens of risks are borne by those who can. This makes insurance transactions a beneficial activity for the society. It calls on detection, modelling, valuation, and controlling of risks. One of the main sources of control is diversification of risks and in that respect it becomes an issue in itself to clarify diversifiability of risks. However, many diversifiable risks are not, by nature or by contract design, separable from non-diversifiable risks that are, on the other hand, sometimes traded in financial markets and sometimes not. A key observation is that the economic risk came before the insurance contract: Mother earth destroys and kills incidentally and mercilessly, but the uncertainty of economic consequences can be more or less cleverly distributed by the introduction of an insurance market.
Pricing American Options Using Transition Probabilities: A Dynamical Systems Approach  [PDF]
Rocio Elizondo, Pablo Padilla, Mogens Bladt
Open Journal of Statistics (OJS) , 2015, DOI: 10.4236/ojs.2015.56056

We give a new way to price American options by using Samuelson’s formula. We first obtain the option price corresponding to a European option at time t, weighing it by the probability that the underlying asset takes the value S at time t. We then use Samuelson’s formula with this factor which is given by the solution of the Fokker-Planck (Kolmogorov) equation for the transition probability density. The main advantage of this approach is that we can systematically introduce the effect of macroeconomic factors. If a macroeconomic framework is given by a dynamical system in the form of a set of ordinary differential equations we only have to solve a partial differential equation for the transition probability density. In this context, we verify, for the sake of consistency, that this formula coincides with the Black-Scholes model and compare several numerical implementations.

Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality
Mogens Helweg Claesson
Journal of Tropical Medicine , 2011, DOI: 10.1155/2011/706304
Abstract: A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits of Bacillus Calmette-Guerin (BCG) vaccination. From an immunological point of view, we hypothesise that the adverse effects of DTwP vaccine may occur because of the Th2-polarising effect of the aluminium phosphate adjuvant in the vaccine and because intramuscular administration of the vaccine may cause chronic inflammation at the site of injection. However, the Th1-polarising effect of BCG is likely to be beneficial. Sexual dimorphism affecting immune functions and vitamin A supplementation may influence both the deleterious and beneficial nonspecific effects of immunisation. 1. Background The paper discusses the immunology behind the reported nonspecific effects of DTwP and BCG vaccination: increased childhood mortality rates after DTwP and decreased mortality rates after BCG vaccination given during the course of the WHO recommended vaccine programs implemented in Guinea-Bissau and other low-income countries [1, 2]. Both the detrimental and the beneficial effects of vaccination are strongest in females [3–7]. We speculate here that vaccine-induced changes in innate and adaptive immunity may play a role. 2. DTwP Vaccine According to the WHO recommendations children in low-income countries are vaccinated against diphtheria, tetanus, and pertussis at 6, 10, and 14 weeks of age. Most countries use a whole-cell Bordetella pertussis vaccine. A typical DTwP vaccine dose (0.5?mL) from the Serum Institute of India contains diphtheria toxoid (25?Lf), tetanus toxoid (5?Lf), and pertussis toxoid (4?IU), aluminium phosphate (1.5?mg), and a preservative, thiomersal (0.01%). Aluminium phosphate acts primarily as an antigen-adsorbing and Th2-polarizing adjuvant [8]. Intramuscular vaccine injection results in a palpable sore induration at the site of injection in 70% of children. In 9% of the children the induration lasts 4 weeks and there is a significant correlation between local reactivity and fever (J. Agergaard, personal communication). 3. Increased Mortality after DTwP Vaccination The major causes of death in general among children in Guinea-Bissau are related to gastrointestinal infections with diarrhoea and dehydration, pneumonia and septicaemia, whereas the risk of death
Blocking Gibbs sampling in the mixed inheritance model using graph theory
Mogens Lund, Claus Jensen
Genetics Selection Evolution , 1999, DOI: 10.1186/1297-9686-31-1-3
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